標(biāo)題: Titlebook: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery; Gus R. Rosania,Greg M. Thurber Book 2021 Springer Science+Bus [打印本頁] 作者: 突然 時間: 2025-3-21 18:46
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書目名稱Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery影響因子(影響力)學(xué)科排名
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書目名稱Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery被引頻次
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書目名稱Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery讀者反饋
書目名稱Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery讀者反饋學(xué)科排名
作者: 不透明 時間: 2025-3-22 00:10
d plexus secreting cerebrospinal fluid (CSF) into the ventricles and the arachnoid epithelium forming the middle layer of the meninges on the brain surface. There are three key barrier features at each site that control the composition of brain fluids and regulate CNS drug permeation: (i) physical b作者: 朦朧 時間: 2025-3-22 03:04
Kyoung Ah Min,Gus R. Rosaniad plexus secreting cerebrospinal fluid (CSF) into the ventricles and the arachnoid epithelium forming the middle layer of the meninges on the brain surface. There are three key barrier features at each site that control the composition of brain fluids and regulate CNS drug permeation: (i) physical b作者: HALL 時間: 2025-3-22 06:29 作者: 憤慨一下 時間: 2025-3-22 12:42 作者: radiograph 時間: 2025-3-22 16:55 作者: Gentry 時間: 2025-3-22 19:29 作者: mastopexy 時間: 2025-3-23 01:03 作者: gentle 時間: 2025-3-23 03:33
Mikhail D. Murashovociated problems. This interest has arisen not only because of the increasing number of drug dependents but also because of the psychological and sociological causes and consequences of drug abuse. It has become increasingly clear that drug dependencies—such as alcoholism—originate not only in the p作者: homocysteine 時間: 2025-3-23 09:01
Richard W. Horobin,Juan C. Stockertaction between a living organism and a drug, characte- rized by behavioural and other responses that always include a com- pulsion to take the drug on a continuous or periodic basis in order to experience its psychic effects, and sometimes to avoid the discomfort of its absence. Tolerance mayor may 作者: 繁殖 時間: 2025-3-23 11:58 作者: NEXUS 時間: 2025-3-23 16:41 作者: PANG 時間: 2025-3-23 19:45 作者: 高度 時間: 2025-3-23 22:25 作者: 殺人 時間: 2025-3-24 04:01
John J. Rhoden,Christopher M. Wiethoff-- from top administration to newest security guard--is convinced that the fight against addiction is necessary, exciting-- and that victory is possible. From the “frame”, this workshop will move to the “.” of the Addiction Treatment Agent: what is his/her chemical substance experience? --what attit作者: deviate 時間: 2025-3-24 07:29 作者: voluble 時間: 2025-3-24 11:09
Joshua A. Walker,Michelle R. Sorkin,Christopher A. Alabire many who would go further and say that any scientific work of importance is published in English. This book, which is, in effect, the tip of a large iceberg, gives them the lie! In the Soviet Union alone we have a vast wealth of expertise supported by a treasury of books and publications, but it 作者: NUL 時間: 2025-3-24 16:59 作者: 靈敏 時間: 2025-3-24 22:51 作者: Implicit 時間: 2025-3-25 03:10 作者: 闡釋 時間: 2025-3-25 06:11
Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery978-1-0716-1250-7Series ISSN 1557-2153 Series E-ISSN 1940-6053 作者: leniency 時間: 2025-3-25 08:09 作者: seduce 時間: 2025-3-25 12:23
https://doi.org/10.1007/978-1-0716-1250-7Pharmacokinetics; Drug development; Small molecule pharmacology; Biologics; Macromolecule transport; Nano作者: 自然環(huán)境 時間: 2025-3-25 16:56
Book 2021sition of chemicals within cells, which in turn impact the macroscopic pharmacokinetics of chemical agents in the whole organism. The first half of the volume focuses on small organic molecules with drug-like characteristics, while the second half delves into the cellular pharmacokinetics of biologi作者: Glossy 時間: 2025-3-25 22:05
Quantitative Analysis of Intracellular Drug Concentrations in Hepatocytesns, and technical considerations for experimental design, and provide protocols for measuring intracellular unbound drug concentrations and subcellular distribution of xenobiotics in sandwich-cultured hepatocytes and in isolated perfused livers. Additionally, some emerging tools and technologies will be explored briefly.作者: 帶來的感覺 時間: 2025-3-26 01:23 作者: 擁護者 時間: 2025-3-26 05:25
Quantitative Drug Target Imaging Using Paired-Agent Principlesxtract estimates of drug target concentration from paired-agent data under a number of conditions: topical and systemic delivery, and imaging of intravascular, extracellular, and intracellular drug targets.作者: 細查 時間: 2025-3-26 09:39 作者: 招惹 時間: 2025-3-26 13:39
Measurement of Transcellular Transport Rates and Intracellular Drug Sequestration in the Presence ofonally, for the purpose of high-throughput screening of drug candidates during the earliest stages of drug development, transport assays are performed with commercially available, in vitro cell cultures as experimental models. Based on theoretical, physiologically based pharmacokinetics principles, 作者: 簡潔 時間: 2025-3-26 19:26 作者: 微生物 時間: 2025-3-26 22:37 作者: nitric-oxide 時間: 2025-3-27 02:28 作者: 許可 時間: 2025-3-27 08:11 作者: Medley 時間: 2025-3-27 13:12 作者: Chagrin 時間: 2025-3-27 15:04
Quantitative Phenotypic Analysis of Drug Sequestering Macrophage Subpopulationsthogens, and other particles and produce immune effector cytokines. It has also been shown that macrophages sequester xenobiotics, particularly lysosomotropic agents. One of the well-known and best studied lysosomotropic agents is the weakly basic antibiotic clofazimine. Interestingly, not all macro作者: 詞匯 時間: 2025-3-27 17:47
Using an Integrated QSAR Model to Check Whether Small-Molecule Xenobiotics Will Accumulate in Biomemication, is described. The model can also be used to check whether .wanted membrane binding is likely to occur. Xenobiotics considered are fluorescent imaging probes, but the models can also be applied to substances used as biocides or pharmaceuticals. In addition to predicting the targeting of gene作者: 你正派 時間: 2025-3-27 23:08 作者: Ligneous 時間: 2025-3-28 03:00
Overcoming Cellular and Systemic Barriers to Design the Next Wave of Peptide Therapeuticsver 50?years, recent advances in understanding the additional target space afforded by peptide drugs, as well as technical achievements in peptide synthesis and screening have reinvigorated interest in peptide drugs as an addition to our therapeutic tool chest. Indeed, novel combinatorial strategies作者: 一加就噴出 時間: 2025-3-28 07:31 作者: 偽證 時間: 2025-3-28 12:02
Cellular Trafficking of Monoclonal and Bispecific Antibodiesed for broad applications including agonizing or antagonizing cell surface receptors, bridging immune effector cells with cancer cells, and facilitating cell specific uptake of antibody–drug or antibody–oligonucleotide conjugates. Understanding the fate of antibodies and bispecific antibodies after 作者: hypnogram 時間: 2025-3-28 14:35 作者: INERT 時間: 2025-3-28 21:25
Quantitative Determination of Intracellular Bond Cleavagey systems, which drives the subcellular localization and processing of therapeutic cargo. With numerous stimuli-responsive drug delivery systems in development, a quantitative measurement of their intracellular processing is of paramount importance. In this chapter, we discuss methods for determinin作者: 拋射物 時間: 2025-3-29 00:03
Development and Application of a Single Cell-Level PK-PD Model for ADCsonents (i.e., antibody, linker, and payload). Pharmacokinetic and pharmacodynamic (PK-PD) modeling and simulation is a powerful tool that can help with this process. It provides a rigorous understanding of how each ADC-related component impacts whole-body disposition and pharmacology of ADCs, and fa作者: 沙漠 時間: 2025-3-29 06:17 作者: 恩惠 時間: 2025-3-29 08:32
Tracking siRNA–Nanocarrier Assembly and Disassembly Using FRETt guarantee the incorporation of the nucleic acid into nanosized particles, followed by efficient cellular uptake, resistance to the changing physicochemical environment during endolysosomal trafficking and finally the adequate release of its payload in the cytosol of the cell. While the outcome of 作者: 激怒 時間: 2025-3-29 14:44 作者: 上流社會 時間: 2025-3-29 16:42
les in transit. Brain fluids (CSF and brain interstitial fluid) are secreted, flow through particular routes and then drain back into the venous system; this fluid turnover aids central homeostasis and also affects CNS drug concentration. Several CNS pathologies involve changes in the barrier layers作者: 細頸瓶 時間: 2025-3-29 23:10
Kyoung Ah Min,Gus R. Rosaniales in transit. Brain fluids (CSF and brain interstitial fluid) are secreted, flow through particular routes and then drain back into the venous system; this fluid turnover aids central homeostasis and also affects CNS drug concentration. Several CNS pathologies involve changes in the barrier layers作者: exhibit 時間: 2025-3-30 00:04
Joe Bentz BBB model cell lines, which also introduces methodologies for plasma membrane preparations. The expression profile of membrane proteins in cultured cells provides helpful information and new insights for assessing such cells, particularly for in vitro BBB model systems.作者: forthy 時間: 2025-3-30 06:26
Jibin Li,Qing Wang,Ismael J. HidalgoElectron microscopy indicated FUS activated trans-cellular transport, and reversibly affected tight junctions. Transient disruption of the BBB allowed delivery of both small-molecule drugs (Doxorubicin) and large-molecule antibody-based chemotherapeutic (Herceptin). The FUS-induced BBB disruption al作者: 責(zé)任 時間: 2025-3-30 11:52 作者: Abnormal 時間: 2025-3-30 14:47 作者: STERN 時間: 2025-3-30 17:08 作者: 瘙癢 時間: 2025-3-30 20:45 作者: headlong 時間: 2025-3-31 02:04
Richard W. Horobin,Juan C. Stockerthe generally favourable reaction to the recommendations‘ made in the previous year and the gradual acceptance of the new term. In general, in subsequent years the term ‘Drug Dependence‘ has gained increasing acceptance. Yet it would seem that difficulties may arise whatever term and definition may b作者: 使顯得不重要 時間: 2025-3-31 06:04
Dongdong Su,Young-Tae Chang to note the generally favourable reaction to the recommendations‘ made in the previous year and the gradual acceptance of the new term. In general, in subsequent years the term ‘Drug Dependence‘ has gained increasing acceptance. Yet it would seem that difficulties may arise whatever term and definition may b978-94-011-6149-7978-94-011-6147-3作者: Pert敏捷 時間: 2025-3-31 11:56 作者: byline 時間: 2025-3-31 13:23
Jerome Hochman,Tomi Sawyer,Ruchia Duggalal figures. Thus, the federal figures represented only crude and admittedly imprecise prevalence figures. Despite these problems, a profile of the typical heroin user could be constructed. There was a disproportionately high percentage of blacks relative to their numbers in the population; one-half
