標(biāo)題: Titlebook: Organotypic Models in Drug Development; Monika Sch?fer-Korting,Silvya Stuchi Maria-Engler, Book 2021 Springer Nature Switzerland AG 2021 o [打印本頁] 作者: 全體 時(shí)間: 2025-3-21 17:45
書目名稱Organotypic Models in Drug Development影響因子(影響力)
書目名稱Organotypic Models in Drug Development影響因子(影響力)學(xué)科排名
書目名稱Organotypic Models in Drug Development網(wǎng)絡(luò)公開度
書目名稱Organotypic Models in Drug Development網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Organotypic Models in Drug Development被引頻次
書目名稱Organotypic Models in Drug Development被引頻次學(xué)科排名
書目名稱Organotypic Models in Drug Development年度引用
書目名稱Organotypic Models in Drug Development年度引用學(xué)科排名
書目名稱Organotypic Models in Drug Development讀者反饋
書目名稱Organotypic Models in Drug Development讀者反饋學(xué)科排名
作者: convert 時(shí)間: 2025-3-22 00:16 作者: 帶來墨水 時(shí)間: 2025-3-22 00:30
0171-2004 he research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.?.978-3-030-70065-2978-3-030-70063-8Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: Glutinous 時(shí)間: 2025-3-22 08:09 作者: 誹謗 時(shí)間: 2025-3-22 09:56 作者: constitutional 時(shí)間: 2025-3-22 15:51
Book 2021earch in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.?.作者: Nebulous 時(shí)間: 2025-3-22 20:38 作者: 菊花 時(shí)間: 2025-3-22 23:33 作者: DAMP 時(shí)間: 2025-3-23 03:22
978-3-030-70065-2Springer Nature Switzerland AG 2021作者: mendacity 時(shí)間: 2025-3-23 06:20
Organotypic Models in Drug Development978-3-030-70063-8Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: growth-factor 時(shí)間: 2025-3-23 12:07
Wolfram-Hubertus Zimmermannrmance and reliable solutions. At the end of this thorough and complex preliminary analysis the reader sees the true benefits and limitations of more traditional voltage control solutions, and gains an understa978-1-4471-7165-2978-1-4471-6636-8Series ISSN 1430-9491 Series E-ISSN 2193-1577 作者: Neutropenia 時(shí)間: 2025-3-23 14:50
Hans Christian Hennies,Yves Poumayalued functions, vector differential operators, tangent and normal vectors, straight lines, planes, intersections and rotating vectors. The new chapters are about the history, differentiating vector-valued func978-1-4471-7507-0978-1-4471-7505-6作者: commensurate 時(shí)間: 2025-3-23 21:20 作者: ECG769 時(shí)間: 2025-3-24 00:56
How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Developmentn morphology and drug target expression. Moreover, disease models differ from normal models in the expression of relevant biomarkers. As a result, qualified test methods can discriminate effects of treatment standards and the effects of weakly effective or ineffective substances. Observer-blind read作者: 有效 時(shí)間: 2025-3-24 05:15 作者: cinder 時(shí)間: 2025-3-24 09:55
In Vitro Models of the Blood-Brain Barrier for possible species differences. The blood-brain barrier is a dynamic, highly selective barrier formed by brain capillary endothelial cells. One of its main tasks is the maintenance of homeostasis in the CNS. The function of the barrier is regulated by cells of the microenvironment and the shear s作者: 使腐爛 時(shí)間: 2025-3-24 14:23
Neural In Vitro Models for Studying Substances Acting on the Central Nervous Systemeuronal and mixed neuronal/astrocyte models, in vitro cultures of microglia, as well as CNS disease models and considers new developments in the field, more specifically the use of brain organoids and 3D bioprinted in vitro models for safety and efficacy evaluation.作者: epicondylitis 時(shí)間: 2025-3-24 17:24 作者: anachronistic 時(shí)間: 2025-3-24 20:01
Disease Models: Lung Models for Testing Drugs Against Inflammation and Infectionting the essential hands-on techniques for the setup of in vitro models, we intend to combine these with already successful and interesting model approaches to serve as some guideline for the development of future models. The overall goal is to maximize time and cost-efficacy and to minimize attriti作者: perjury 時(shí)間: 2025-3-24 23:20 作者: 省略 時(shí)間: 2025-3-25 05:49
Immunocompetent Human Intestinal Models in Preclinical Drug Development, organoids, and microfluidic devices to study inflammatory and immune-related responses are highlighted. While current cell culture models lack the cellular and molecular complexity observed in vivo, the emphasis is put on how these models can be used to improve preclinical drug development for inf作者: anthesis 時(shí)間: 2025-3-25 10:51 作者: 陶醉 時(shí)間: 2025-3-25 15:38 作者: 動作謎 時(shí)間: 2025-3-25 17:56 作者: CHAR 時(shí)間: 2025-3-25 20:11
anagement. It also makes a connection to regulatory developments (for example, Solvency II). The reader should have a basic knowledge of probability and familiarity with mathematical concepts. It is intended for working actuaries and quantitative risk managers as well as actuarial students..作者: 行業(yè) 時(shí)間: 2025-3-26 03:13
Susanne N. Kolle,Robert Landsiedelanagement. It also makes a connection to regulatory developments (for example, Solvency II). The reader should have a basic knowledge of probability and familiarity with mathematical concepts. It is intended for working actuaries and quantitative risk managers as well as actuarial students..作者: Isolate 時(shí)間: 2025-3-26 04:32
Monika Sch?fer-Korting,Christian Zoschkeored various methods proposed in different fields, including image processing, pattern recognition, computer vision, and artificial intelligence to find solution to text detection in video. Finally, this chapter discusses potential applications of video text detection.作者: affect 時(shí)間: 2025-3-26 12:32 作者: 無彈性 時(shí)間: 2025-3-26 14:55
sed. The dependence of the nose shape on the on-load tap changer (OLTC) and the over-excitation limit (OEL) dynamics, and the load characteristics and differences with or without SVR are clearly evidenced. The fact that voltage instability appears to be strongly influenced by power system dynamics i作者: Spinal-Fusion 時(shí)間: 2025-3-26 18:42
Winfried Neuhaussed. The dependence of the nose shape on the on-load tap changer (OLTC) and the over-excitation limit (OEL) dynamics, and the load characteristics and differences with or without SVR are clearly evidenced. The fact that voltage instability appears to be strongly influenced by power system dynamics i作者: 危險(xiǎn) 時(shí)間: 2025-3-26 22:21
Ellen Fritsche,Julia Tigges,Julia Hartmann,Julia Kapr,Melania Maria Serafini,Barbara Vivianised. The dependence of the nose shape on the on-load tap changer (OLTC) and the over-excitation limit (OEL) dynamics, and the load characteristics and differences with or without SVR are clearly evidenced. The fact that voltage instability appears to be strongly influenced by power system dynamics i作者: 挑剔小責(zé) 時(shí)間: 2025-3-27 01:51 作者: 積習(xí)已深 時(shí)間: 2025-3-27 07:28 作者: scotoma 時(shí)間: 2025-3-27 12:19
Zhong Li,Shiqi Xiang,Eileen N. Li,Madalyn R. Fritch,Peter G. Alexander,Hang Lin,Rocky S. Tuanaccess book so that anyone interested in the visualization of time and time-oriented data can read it. Second, the entire content has been revised and expanded to represent state-of-the-art knowledge. The chapter on interaction support now includes advanced methods for interacting with visual repres作者: HERTZ 時(shí)間: 2025-3-27 16:42
érica Aparecida de Oliveira,Colin R. Goding,Silvya Stuchi Maria-Englerere first discussed by Fucik [.] and Dancer [., .]. The situation now is more delicate because unbounded and periodic solutions can coexist. After this brief review of published results we shall analyze in detail the problem of boundedness for a forced linear oscillator which bounces elastically aga作者: 詞匯表 時(shí)間: 2025-3-27 18:26
Regine Schneider-Stock,Domenico Ribattiere first discussed by Fucik [.] and Dancer [., .]. The situation now is more delicate because unbounded and periodic solutions can coexist. After this brief review of published results we shall analyze in detail the problem of boundedness for a forced linear oscillator which bounces elastically aga作者: kidney 時(shí)間: 2025-3-27 22:43
Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh skin and the eyes. A single in vitro model may be limited to address one or few molecular or cellular events leading to adverse outcomes. Hence, in many instances their regulatory use involves the combination of several in vitro models to assess the hazard potential of test substance. A so-called d作者: 充滿人 時(shí)間: 2025-3-28 03:18 作者: 闖入 時(shí)間: 2025-3-28 09:10
Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future D for almost 40 years. In this chapter, the topic of commercial in vitro tissue models is described, taking RhS models as an example. The need for highly standardised models is evident for regulatory testing purposes, e.g. the classification and labelling of chemicals and formulations, as well as for作者: PIZZA 時(shí)間: 2025-3-28 13:48 作者: 悠然 時(shí)間: 2025-3-28 16:39
Neural In Vitro Models for Studying Substances Acting on the Central Nervous Systeme.g., interspecies variation are reflected in the high number of drug attrition rates, especially in central nervous system (CNS) diseases. Therefore, human-based neural in vitro models for studying safety and efficacy of substances acting on the CNS are needed. Human iPSC-derived cells offer such a作者: 尊重 時(shí)間: 2025-3-28 20:23 作者: 到婚嫁年齡 時(shí)間: 2025-3-28 23:55 作者: 濃縮 時(shí)間: 2025-3-29 05:40
Skin Disease Models In Vitro and Inflammatory Mechanisms: Predictability for Drug Developmenty reproducibility and predictability. Traditionally, such models include animal models, mainly rodents, and cellular models. While animal models are highly useful in many studies, they are being replaced by human cellular models in more and more approaches amid recent technological development due t作者: 敲詐 時(shí)間: 2025-3-29 09:37 作者: 約會 時(shí)間: 2025-3-29 11:23
Tissue Engineering for Musculoskeletal Regeneration and Disease Modelingd up novel approaches to repair musculoskeletal defects in a fast and/or efficient manner. Biomaterials, cells, and signaling molecules constitute the tissue engineering triad. In the past 40?years, significant progress has been made in developing and optimizing all three components, but only a very作者: induct 時(shí)間: 2025-3-29 19:16 作者: Generalize 時(shí)間: 2025-3-29 20:36
The CAM Assay as an Alternative In Vivo Model for Drug Testingti-cancer drug effects. Literature about the CAM assay as an alternative in vivo cancer xenograft model according to the 3R principles has exploded in the last 3?years. Following a summary of the basic knowledge about the chicken embryo, we compare advantages and disadvantages with the classical mou作者: 步兵 時(shí)間: 2025-3-29 23:59
unexpected given the nature of research in these disciplines but the need to obtain and process large amounts of data, to gather this from disparate locations and then to link and disseminate this information in a manner that challenges researchers and informs the wider public which is both a challe作者: Mystic 時(shí)間: 2025-3-30 07:27 作者: maroon 時(shí)間: 2025-3-30 08:52
Susanne N. Kolle,Robert Landsiedelcal internal control and classical risk management are used. Therefore the approach taken is necessarily interdisciplinary. Indeed, there is a new dynamically developing field for actuaries as a result of the emphasis now on the measurement of risk..This book provides the required basic knowledge fo作者: burnish 時(shí)間: 2025-3-30 15:08
Monika Sch?fer-Korting,Christian Zoschkeave shown that humans often pay first attention to text over other objects in a video as text helps in getting semantics relevant to the content of the video. With this in mind, this chapter introduces research in video text detection. It first reviews relevant literature and then discusses characte作者: CESS 時(shí)間: 2025-3-30 19:25
Helena Kandarova,Patrick J. Haydenave shown that humans often pay first attention to text over other objects in a video as text helps in getting semantics relevant to the content of the video. With this in mind, this chapter introduces research in video text detection. It first reviews relevant literature and then discusses characte作者: 搜尋 時(shí)間: 2025-3-30 22:33
tarting point. Evidence is also given to the significant contribution of power system voltage control loops (AVR and SVR) to electromechanical oscillation stability, to counteract the tendency to associate voltage control with voltage stability alone. These preliminary clarifications help us differe
