作者: 地名詞典 時(shí)間: 2025-3-21 20:43 作者: Anonymous 時(shí)間: 2025-3-22 01:19
Pharmacological and Toxicological Significance of the Organic Cation Transporters OCT and MATE: Druhelia, OCT2 mediates uptake of the drugs such as metformin or cimetidine at basolateral membrane, and MATE1 and MATE2-K mediated the secretion of cationic and zwitterionic drugs at brush-border membrane. In the liver, OCT1 are expressed on the sinusoidal membrane and MATE1 are expressed on the canal作者: Criteria 時(shí)間: 2025-3-22 07:50
Genetic Variability in Organic Cation Transporters: Pathophysiological Manifestations and Consequen of plasma and organ concentrations of endogenous molecules and drugs. Hence, genetic variants in the organic cation transporters may confer susceptibility to diseases and may cause variations in drug pharmacokinetics, efficacy and toxicity..This chapter gives a structured overview of the genetic va作者: receptors 時(shí)間: 2025-3-22 11:17
Physiological and Pathophysiological Regulation of Transporters for Organic Cations,oss plasma membranes in a driving force dependent and saturable manner. These transporters are responsible for the cellular uptake and extrusion of many cationic drugs and toxins and therefore prerequisite for their metabolism, therapeutical actions, but also for their negative side effects. Togethe作者: explicit 時(shí)間: 2025-3-22 13:46 作者: 蠟燭 時(shí)間: 2025-3-22 20:19 作者: 恃強(qiáng)凌弱的人 時(shí)間: 2025-3-22 21:28 作者: Fortify 時(shí)間: 2025-3-23 04:19 作者: Amnesty 時(shí)間: 2025-3-23 06:42 作者: 燕麥 時(shí)間: 2025-3-23 10:58 作者: 誹謗 時(shí)間: 2025-3-23 14:10 作者: 按時(shí)間順序 時(shí)間: 2025-3-23 21:38
Introduction to the Cellular Transport of Organic Cations,llular drug delivery and, considering their high expression in excretory organs, together with MATEs are responsible for drug excretion. For this reason, OCTs and MATEs can be important determinants of drug efficacies and also toxicities. OCTNs are transporters involved in the cellular uptake of sub作者: Mingle 時(shí)間: 2025-3-23 22:41
Functional Properties of Organic Cation Transporter OCT1, Binding of Substrates and Inhibitors, and of tertiary structures that were modeled according to lactose permease which belongs to the MFS. Considering rOCT1 and rOCT2 as OCT prototypes, and assuming that all transporters of the MFS undergo similar interhelical movements during transport, a model for the translocation mechanism of OCTs is p作者: 挑剔小責(zé) 時(shí)間: 2025-3-24 05:51
Pharmacological and Toxicological Significance of the Organic Cation Transporters OCT and MATE: Dru cisplatine or oxaliplatin were affected by substrate specificities of renal OCT2 and MATEs. OCTs and MATEs play important roles for drug efficacies and toxicities especially in the liver and the kidney.作者: commensurate 時(shí)間: 2025-3-24 09:21 作者: 服從 時(shí)間: 2025-3-24 11:18 作者: 我悲傷 時(shí)間: 2025-3-24 18:47 作者: 團(tuán)結(jié) 時(shí)間: 2025-3-24 22:54
Translational Relevance of Animal Models for the Study of Organic Cation Transporter Function,ty, levels of mRNA and/or protein expression, sensitivity to inhibitors, and regulation. In comparison with animal models, in the human organs some OCTs are absent, others exhibit different localization in the cell membrane domains and different levels of expression, sensitivity to inhibitors, and r作者: maroon 時(shí)間: 2025-3-25 01:10
Role of Transporters for Organic Cations in Plants for Environmental Cycling of Pharmaceutical Resis. Due to the large number of pharmaceuticals present in the environment, it is important to understand the uptake and translocation mechanisms involved that can lead to accumulation of biological active compounds in feed and food.作者: 感染 時(shí)間: 2025-3-25 04:25 作者: 遺忘 時(shí)間: 2025-3-25 10:08
Organic Cation Transporters (OCTs) as Modulators of Behavior and Mood,involved in particular in behaviors related to osmoregulation, anxiety, stress, antidepressant action and addiction. We summarize in this chapter recent developments on the roles of OCTs in central nervous system, focusing on mood-related behaviors.作者: EVICT 時(shí)間: 2025-3-25 13:13
Book 2016d psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their r作者: 手勢(shì) 時(shí)間: 2025-3-25 18:55 作者: Nomogram 時(shí)間: 2025-3-25 22:13 作者: companion 時(shí)間: 2025-3-26 00:46 作者: CRAMP 時(shí)間: 2025-3-26 05:34 作者: AUGER 時(shí)間: 2025-3-26 11:48
https://doi.org/10.1007/978-3-319-23793-0Cell Membrane; Cytoplasm; Genetics; Molecular biology; Structural biology作者: Chromatic 時(shí)間: 2025-3-26 15:50
978-3-319-79534-8Springer International Publishing Switzerland 2016作者: evasive 時(shí)間: 2025-3-26 18:33
Annahmen bzgl. der Anfangszust?nde getroffen und die Ausgangszust?nde berechnet. Durch Variation der Annahmen k?nnen die errechneten Endzust?nde an die Beobachteten Spuren und Endlagen angepasst werden. Diese Art der Rekonstruktion ist weitestgehend computerunterstützten Verfahren vorbehalten. Bei 作者: 我不明白 時(shí)間: 2025-3-26 23:29 作者: 使熄滅 時(shí)間: 2025-3-27 03:24
Global Descriptors of Convolution Neural Networks for Remote Scene Images Classification,ained from the last fully connected (FC) layer of single CNN without any process have little effect because of high dimensionality. In this paper, we propose a simple enhancing scene-level feature description method for remote sensing scene classification. Firstly, the principal component analysis (作者: 婚姻生活 時(shí)間: 2025-3-27 08:50
Site-Dependent Ground-motion Data Recorded by German Taskforce in Turkey.4). Immediately after both earthquakes seismic stations were temporarily installed within the disaster-struck area. The recording stations provided a unique and comprehensive data base of near-field aftershocks, establishing the basis for elaborating subsoil-dependent attenuation laws for peak grou作者: left-ventricle 時(shí)間: 2025-3-27 13:15 作者: 新陳代謝 時(shí)間: 2025-3-27 15:31 作者: 向宇宙 時(shí)間: 2025-3-27 18:10 作者: BINGE 時(shí)間: 2025-3-28 01:31
Microservices Architecture Pattern, entwickeln zu k?nnen. Es werden hier einige Hinweise gegeben, wo man Informationen zu diesen Themen bekommen kann. Es bleibt aber generell festzuhalten, dass Programmieren nicht aus Büchern gelernt werden kann. Diese k?nnen nur eine Hilfestellung sein, die die praktische Erfahrung aber nicht ersetzen kann.作者: 獨(dú)白 時(shí)間: 2025-3-28 05:56
Using Kahoot as a Learning Tool,swered a questionnaire using a GoogleDocs form. According to the results of the use of the platform, there was an improvement in students’ learning by reviewing and reinforcing the concepts learned in a fun, engaging, motivating and interesting way.作者: Spangle 時(shí)間: 2025-3-28 06:17
,Jane Austen’s Originality: ,hrases like ‘the first modern novelist’, or ‘the first great novelist’, are clearly too simple-minded to do justice either to what went before Jane Austen or to what came after her. If and when such phrases are relevant at all, it must be in a spirit very different from simply asking, Who came first in such-and-such a tradition or .?作者: Cloudburst 時(shí)間: 2025-3-28 14:25
Kai Liu,Penglin Dai,Sang Hyuk Sond for the analysis, as it offers a wide range of tools for the identification and description of the linguistic resources adopted to communicate with both internal and external stakeholders and also for an assessment of whether the utilitarian or the deontological approach is now predominant.作者: 慢跑 時(shí)間: 2025-3-28 14:49 作者: acheon 時(shí)間: 2025-3-28 21:20
Einleitungmisserfolg der Jungen. Inzwischen gibt es auch eine ganze Reihe empirischer Befunde zu geschlechtsspezifischen Bildungsungleichheiten, die einige der diskutierten Hypothesen stützen und andere widerlegen. Dieser Sammelband zielt darauf, einen aktuellen überblick über den sozialwissenschaftlichen Sta作者: chiropractor 時(shí)間: 2025-3-29 02:39
The Cardiac K Current Systemustice served and evidence-based medicine employed to increase the value of medical care for patients?..The section on psychology deals with measuring outcomes from the patient’s perspective and involving patie978-1-4419-4157-2978-0-387-33921-4作者: BLAZE 時(shí)間: 2025-3-29 05:08 作者: Adrenaline 時(shí)間: 2025-3-29 08:48 作者: ALIEN 時(shí)間: 2025-3-29 15:28
