標(biāo)題: Titlebook: Optimization in Drug Discovery; Zhengyin Yan,Gary W. Caldwell Book 2004 Humana Press 2004 [打印本頁] 作者: 側(cè)面上下 時(shí)間: 2025-3-21 17:58
書目名稱Optimization in Drug Discovery影響因子(影響力)
書目名稱Optimization in Drug Discovery影響因子(影響力)學(xué)科排名
書目名稱Optimization in Drug Discovery網(wǎng)絡(luò)公開度
書目名稱Optimization in Drug Discovery網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Optimization in Drug Discovery被引頻次
書目名稱Optimization in Drug Discovery被引頻次學(xué)科排名
書目名稱Optimization in Drug Discovery年度引用
書目名稱Optimization in Drug Discovery年度引用學(xué)科排名
書目名稱Optimization in Drug Discovery讀者反饋
書目名稱Optimization in Drug Discovery讀者反饋學(xué)科排名
作者: 注入 時(shí)間: 2025-3-21 23:18
Use of Caco-2 Cell Monolayers to Study Drug Absorption and Metabolism,nd dietary chemicals. The Food and Drug Administration (FDA) recognized the model system as useful in classifying a compound’s absorption characteristics in the Biopharmaceutics Classification System. In addition to its usefulness as an absorption model, the Caco-2 cells are useful for studying the 作者: antecedence 時(shí)間: 2025-3-22 02:24
Absorption Screening Using the PAMPA Approach,earliest absorption, distribution, metabolism, and excretion (ADME) primary screening of research compounds. PAMPA’s popularity in the industry has risen rapidly. This chapter focuses on state-of-the-art PAMPA methods. Evidence will be cited demonstrating that as far as predicting passive permeabili作者: 星球的光亮度 時(shí)間: 2025-3-22 07:44 作者: Capture 時(shí)間: 2025-3-22 09:36
In Vitro Permeation Study With Bovine Brain Microvessel Endothelial Cells, lines such as Caco-2, MDCK, MDCKII, and LLC-PK have been used to predict in vivo intestinal absorption of drugs. However, there are no well-characterized cell lines available representing the blood-brain barrier. In this chapter, the authors describe the primary culture of bovine brain microvessel 作者: 植物群 時(shí)間: 2025-3-22 13:40 作者: amorphous 時(shí)間: 2025-3-22 20:08 作者: 大笑 時(shí)間: 2025-3-22 22:09 作者: Ablation 時(shí)間: 2025-3-23 01:45
Isothermal Titration Calorimetry Characterization of Drug-Binding Energetics to Blood Proteins,les. In this chapter, the authors describe the use of isothermal titration calorimetry (ITC) to measure the binding energetics of drugs bound to blood proteins (i.e., human serum albumin [HSA] and α-acid glycoprotein [AGP]). The stoichiometry (.), the association-binding constant (..), and the entha作者: 噱頭 時(shí)間: 2025-3-23 06:50
Metabolic Stability Assessed by Liver Microsomes and Hepatocytes,c stability assays, the typical test systems are liver microsomes, liver S9, or hepatocytes (plated or suspended), depending on the goal of the assay. To determine the metabolic stability of a new chemical entity, quantification of the drug candidate from incubate supernatants is required and usuall作者: 煉油廠 時(shí)間: 2025-3-23 11:03
In Vitro Drug Metabolite Profiling Using Hepatic S9 and Human Liver Microsomes,a this organ. In general, drugs are predominantly metabolized by the oxidation of parent drug, which is typically mediated by cytochrome P450 (CYP450) enzymes. To a lesser degree, flavin monooxidation (FMO), as well as the reduction or cleavage of the parent drug via enzymatic (i.e., esterase and am作者: prick-test 時(shí)間: 2025-3-23 16:04 作者: Insufficient 時(shí)間: 2025-3-23 20:32
In Vitro CYP Induction in Human Hepatocytes,nsively as possible. For this reason, laboratories have developed various in vitro techniques that can help to minimize undue investment in developmental compounds that may have undesirable pharmacokinetic properties and/or the potential to cause adverse effects, such as toxicity and drug-drug inter作者: 商店街 時(shí)間: 2025-3-23 23:21 作者: 保守黨 時(shí)間: 2025-3-24 06:20
Evaluation of Cytochrome P450 Inhibition in Human Liver Microsomes, potential. This chapter describes a detailed traditional CYP inhibition protocol for six major isoforms: 1A2, 2C9, 2C19, 2D6, 2E1, and 3A4. Microsomal incubation conditions were optimized and kinetic parameters determined to initially establish the inhibition assay. In CYP inhibition assay, separat作者: 破裂 時(shí)間: 2025-3-24 06:38
Identification of CYP Mechanism-Based Inhibitors,ing the activity of the enzyme(s) that metabolize drug B. Inhibitory drug-drug interactions could result in serious adverse effects, including fatalities in patients receiving multiple medications. Cytochrome P450 superfamily (CYPs) are the major oxidative enzymes that participate in the metabolism 作者: 暫停,間歇 時(shí)間: 2025-3-24 10:45 作者: subordinate 時(shí)間: 2025-3-24 18:30
Covalent DNA Adduct Formation Mediated by Cytochrome P450,s (drugs) to be activated to reactive species, leading to the formation of covalent deoxyribonucleic acid (DNA) adducts. Methods for the isolation of subcellular fractions containing activating enzymes (microsomes or cytosols containing cytochromes P450 or other activating enzymes such as reductases作者: 序曲 時(shí)間: 2025-3-24 21:23
Application of In Vitro Comet Assay for Genotoxicity Testing,eic acid (DNA) damage at the level of individual eukaryotic cells. The types of DNA damage that can be observed with this method are DNA double-strand breaks (DSB) and single-strand breaks (SSB), alkali labile sites (ALS) such as apurinic/apyrimidinic (AP) sites, DNA-DNA and DNA-protein cross-links,作者: Pcos971 時(shí)間: 2025-3-25 01:44 作者: 商業(yè)上 時(shí)間: 2025-3-25 06:38 作者: 仇恨 時(shí)間: 2025-3-25 09:51
Ming Hu,Jie Ling,Huimin Lin,Jun Chenirtschaftslehre umschrieben hat. Die geordnete und systematische Sammlung von Ist-Daten in der Bank-Buchführung reicht danach als Grundlage für Entscheidungen des Managements nicht aus; die Daten sind so auszuwerten, dass sie für Entscheidungszwecke der Banksteuerung dienen k?nnen. Als Entscheidungs作者: Recess 時(shí)間: 2025-3-25 13:20 作者: 健壯 時(shí)間: 2025-3-25 19:29 作者: jocular 時(shí)間: 2025-3-25 20:00 作者: manifestation 時(shí)間: 2025-3-26 04:13 作者: 粗語 時(shí)間: 2025-3-26 04:33 作者: 努力趕上 時(shí)間: 2025-3-26 11:13
Lucinda H. Cohen. Beratung verlangt mehr als nur den Zinssatz zu nennen. Der seit geraumer Zeit vielfach diskutierte Multikanalansatz ben?tigt Technik, ist aber mehr als das Angebot verschiedener Vertriebskan?le (z. B. station?re Gesch?ftsstelle, virtuelles Internet oder per Telefon vielfach über Call-Center, in de作者: Fibrinogen 時(shí)間: 2025-3-26 14:34
Gary W. Caldwell,Zhengyin Yan. Beratung verlangt mehr als nur den Zinssatz zu nennen. Der seit geraumer Zeit vielfach diskutierte Multikanalansatz ben?tigt Technik, ist aber mehr als das Angebot verschiedener Vertriebskan?le (z. B. station?re Gesch?ftsstelle, virtuelles Internet oder per Telefon vielfach über Call-Center, in de作者: 希望 時(shí)間: 2025-3-26 17:55 作者: 豐滿中國 時(shí)間: 2025-3-26 22:00 作者: 沒收 時(shí)間: 2025-3-27 01:39
Michael H. Courtr“ verlaufende Biografien werden zur Ausnahme. Damit einher gehen ver?nderte Erwartungen an eine moderne Bank. Kunden sehen ihren Finanzdienstleister in einer anderen Rolle als noch vor wenigen Jahren. Zum Teil der Politik weit voraus, stellen sich die Menschen heute ihrer Verantwortung für ihre eig作者: dissolution 時(shí)間: 2025-3-27 06:09 作者: 拘留 時(shí)間: 2025-3-27 10:13 作者: objection 時(shí)間: 2025-3-27 15:00
Zhengyin Yan,Gary W. Caldwell. Beratung verlangt mehr als nur den Zinssatz zu nennen. Der seit geraumer Zeit vielfach diskutierte Multikanalansatz ben?tigt Technik, ist aber mehr als das Angebot verschiedener Vertriebskan?le (z. B. station?re Gesch?ftsstelle, virtuelles Internet oder per Telefon vielfach über Call-Center, in de作者: 食道 時(shí)間: 2025-3-27 19:30 作者: 引導(dǎo) 時(shí)間: 2025-3-28 00:54
Naomi Suzuki,Padmaja M. Prabhu,Shinya Shibutanimehr das, was zum überleben wichtig war, sondern alle begannen sich auf Unterschiedliches zu spezialisieren. Auf das, was andere gebrauchen konnten oder sollten. Koordiniert von Markt oder Staat. Nur so konnte jener bunte Strau? an verschiedenartigsten Berufen zu wachsen beginnen, der zur Signatur d作者: Kidnap 時(shí)間: 2025-3-28 05:59 作者: Optometrist 時(shí)間: 2025-3-28 06:26
Bojana ?egura,Metka Filipi?len Entwarnungen zum Trotz vermutlich nur bis zu einer gewissen Grenze, wie Klima- und Ressourcenforscher nicht müde werden darzulegen. Auch die modernen gesellschaftlichen Institutionen wie Markt, Staat und beispielsweise das Mediensystem haben sich als ?u?erst fehlertolerant erwiesen. Nicht jede w作者: correspondent 時(shí)間: 2025-3-28 14:24
Methods in Pharmacology and Toxicologyhttp://image.papertrans.cn/o/image/703246.jpg作者: Conjuction 時(shí)間: 2025-3-28 16:24
Zhengyin Yan,Gary W. CaldwellIncludes supplementary material: 作者: Exclaim 時(shí)間: 2025-3-28 22:16
Optimization in Drug Discovery978-1-59259-800-7Series ISSN 1557-2153 Series E-ISSN 1940-6053 作者: 云狀 時(shí)間: 2025-3-29 02:32 作者: micronutrients 時(shí)間: 2025-3-29 06:27 作者: Proclaim 時(shí)間: 2025-3-29 09:40
Absorption Screening Using the PAMPA Approach,s chapter also discusses how PAMPA has relevance in preformulation research. A detailed PAMPA protocol is presented, with step-by-step instructions for a popular version of the assay, using relatively inexpensive and readily obtainable components.作者: 意外 時(shí)間: 2025-3-29 14:58
An Enzymatic Microplate Assay for Testing P-Glycoprotein Substrates and Inhibitors,erapamil, vinblastine, and progesterone) in addition to its basal ATPase activity. This assay uses a coupled enzyme system with spectrophotometric detection for measurement on P-gp-containing native membrane vesicles. This assay may be performed on 96- or 384-well microplates and is therefore suitable for high-throughput screenings.作者: 虛度 時(shí)間: 2025-3-29 19:25 作者: 放大 時(shí)間: 2025-3-29 22:51 作者: 徹底明白 時(shí)間: 2025-3-30 03:09 作者: 到婚嫁年齡 時(shí)間: 2025-3-30 07:46
In Vitro CYP Induction in Human Hepatocytes, nontransplantable human liver followed by their culture and treatment with new chemical entities and/or known inducers of cytochrome P450. Enzyme induction in cultured human hepatocytes can be assessed by measuring the levels of messenger ribonucleic acid, immunoreactive protein, and/or cytochrome P450 enzyme activity as outlined in this chapter.作者: conscribe 時(shí)間: 2025-3-30 08:55
In Vitro Identification of UDP-Glucuronosyltransferases (UGTs) Involved in Drug Metabolism,ker activities, and chemical inhibition. The primary focus is on identification of the well-characterized hepatic UGTs, including UGTs 1A1, 1A4, 1A6, 1A9, 2B7, and 2B15, although a similar approach potentially could be used for the study of extrahepatic tissues, such as the kidney and gastrointestinal tract.作者: Lobotomy 時(shí)間: 2025-3-30 14:15 作者: Salivary-Gland 時(shí)間: 2025-3-30 17:17
Evaluation of Cytochrome P450 Inhibition in Human Liver Microsomes,C-MS/MS). It is without doubt that results from this in vitro experiment are of great value in lead optimization in drug discovery and development. It is obvious that more efforts are still needed to establish the relevance between in vitro CYP inhibition and drug interactions in the clinic.作者: tenosynovitis 時(shí)間: 2025-3-30 22:51 作者: Nibble 時(shí)間: 2025-3-31 04:03 作者: 敏捷 時(shí)間: 2025-3-31 05:57
In Vitro Permeation Study With Bovine Brain Microvessel Endothelial Cells,endothelial cells (BMECs) lining the interface between the blood and the brain as the model for screening central nervous system (CNS) drug candidates. The culture procedures and measurement of permeability in BMEC can be applied to other model cell lines such as Caco-2, MDCK, and MDCKII cells.作者: Flinch 時(shí)間: 2025-3-31 12:38 作者: 愛哭 時(shí)間: 2025-3-31 13:50
Book 2004bsorption, distribution, metabolism, elimination (ADME), and toxicity issues. Lead optimization in drug discovery, a process attempting to uncover and correct these defects of drug candidates, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate 作者: N防腐劑 時(shí)間: 2025-3-31 20:53 作者: 嚴(yán)重傷害 時(shí)間: 2025-3-31 22:18
pKa, Solubility, and Lipophilicity,ing these three parameters . Because of space limitations, only one method is discussed in detail for each parameter, using chlophedianol as an example. The GLpKa method was used for measuring pK.. The solubility in buffer solutions was measured with liquid chromatography-mass spectrometry (LC-MS) o作者: 貪婪性 時(shí)間: 2025-4-1 05:52 作者: 搜尋 時(shí)間: 2025-4-1 06:46 作者: 懶惰民族 時(shí)間: 2025-4-1 11:17
