標題: Titlebook: Novel Inhibitors of Leukotrienes; Giancarlo Folco,Bengt Samuelsson,Robert C. Murphy Book 1999 Springer Basel AG 1999 asthma.cell.developme [打印本頁] 作者: autoantibodies 時間: 2025-3-21 16:25
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書目名稱Novel Inhibitors of Leukotrienes被引頻次
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書目名稱Novel Inhibitors of Leukotrienes讀者反饋
書目名稱Novel Inhibitors of Leukotrienes讀者反饋學(xué)科排名
作者: BIPED 時間: 2025-3-21 21:06
,The development of zafirlukast (Accolate?) and the Zeneca series of peptidyl-leukotriene receptor a LrE.. Together they account for the biological activity of slow-reacting substance of anaphylaxis (SRS-A), which was discovered nearly 40 years ago when it was distinguished from histamine by its ability to produce a slowly developing and long-lasting contraction of isolated guinea pig ileum [2].作者: 我不重要 時間: 2025-3-22 01:47 作者: DNR215 時間: 2025-3-22 07:47
1422-7746 es a new approach in presenting information of particular interest to both scientists and clinicians in the fields of asthma, inflammation and allergic diseases.978-3-0348-9736-5978-3-0348-8703-8Series ISSN 1422-7746 Series E-ISSN 2296-4525 作者: 詞匯 時間: 2025-3-22 11:15 作者: incarcerate 時間: 2025-3-22 14:00
Metabolism of leukotrienes and formation of new leukotriene structures,pathways involved in metabolic processing are common to a host of other endogenous biochemical substances, in particular eicosanoids such as prostaglandins and thromboxanes. However, there are several enzymes rather specific for certain leukotrienes, suggesting a more unique role for such metabolic events mediated by these enzymes.作者: LASH 時間: 2025-3-22 18:12 作者: adequate-intake 時間: 2025-3-23 01:08 作者: 四指套 時間: 2025-3-23 03:01
The development of iralukast: A member of the Novartis series of cysteinyl leukotriene antagonists,lukast (AccolateTM, ICI 204,219) and montelukast (SingulairTM, MK 0476) are available on the market as treatment for asthma [1–6]. Further compounds, such as iralukast (CGP 45715A) are in development for this indication [7,8].作者: Militia 時間: 2025-3-23 06:50
Book 1999w chapters on the main aspects of basic and applied leukotriene research are written by leading specialists in the field, and the volume takes a new approach in presenting information of particular interest to both scientists and clinicians in the fields of asthma, inflammation and allergic diseases.作者: Protein 時間: 2025-3-23 11:47
Leukotriene A4 hydrolase: A key enzyme in chemotactic leukotriene formation, by LTC. synthase, to produce 5(.)-hydroxy-6(.)-.-glutathionyl-7,9-.-11,14-.-. acid (LTC.). This review will focus on the biochemistry and molecular biology of LTA. hydrolase, the enzyme catalyzing the final step in the biosynthesis of the potent chemotaxin LTB., an important mediator of inflammation.作者: GET 時間: 2025-3-23 15:31 作者: Prophylaxis 時間: 2025-3-23 20:04
LTB4 receptor antagonists,ribe studies on the more interesting compounds that have been synthesized with particular emphasis on those that have entered clinical trial and then address some issues of concern to investigators working in this area.作者: squander 時間: 2025-3-23 23:57 作者: 遭遇 時間: 2025-3-24 03:27 作者: Fulsome 時間: 2025-3-24 06:53
Entry rate and metabolic handling of LTC4 in the human circulation,se in patients with asthma and other disease states characterized by an inflammatory component. In this regard, urinary LTE. excretion rates have been extensively used over the last 5 years, following demonstration that the intravenous infusion [1–3] or inhalation [4] of LTC. is accompanied by dose-dependent increments in LTE. excretion.作者: 骨 時間: 2025-3-24 11:55
Leukotrienes and aspirin-intolerant asthma,his is a distinct clinical syndrome, called aspirin-induced asthma, or aspirin-intolerant asthma (AIA). It affects about 10% of adult patients with asthma, more often women than men, but is rare in asthmatic children [1–3].作者: PANIC 時間: 2025-3-24 17:50 作者: 表示向前 時間: 2025-3-24 20:41 作者: 鋼盔 時間: 2025-3-25 02:42
Novel Inhibitors of Leukotrienes978-3-0348-8703-8Series ISSN 1422-7746 Series E-ISSN 2296-4525 作者: 悶熱 時間: 2025-3-25 04:11 作者: 障礙物 時間: 2025-3-25 10:06 作者: Apraxia 時間: 2025-3-25 15:25 作者: 中古 時間: 2025-3-25 18:45
Physiological and pathophysiological activities of leukotrienes,rest turned also to other tissues and organ systems, with the ultimate goal of disclosing specific targets for the different LTs. It is now generally accepted that the LTs collectively provoke contraction of vascular and nonvascular smooth muscle, increased vascular permeability, and accumulation an作者: 教義 時間: 2025-3-25 21:55
Genetic polymorphisms of 5-LO,hat 5-LO products contribute to a variable extent in the overall pathogenesis of asthma. As a result of these differences, patients overexpressing 5-LO, and therefore 5-LO products, will be more responsive to 5-LO inhibition, whereas other patients whose disease is less dependent on 5-LO activity wi作者: Vsd168 時間: 2025-3-26 03:09
Leukotrienes in nocturnal asthma,lows. The leukotrienes must (i) be able to cause the symptoms and pathophysiologic changes of nocturnal asthma, (ii) be made by the cells present in the airways of nocturnal asthmatics, (iii) be measured in asthmatics at night during symptoms and correlate with disease severity and (iv) be blocked b作者: PURG 時間: 2025-3-26 05:27 作者: FLAG 時間: 2025-3-26 12:25
Sally E. Wenzelll of the new tools available to the service of science, for example:-particle accelerators, magnetic resonance, electron microscopy, lasers - have entered the general arsenal following a period of adaptation. Like them, the rocket is now a classical instrument, and gives information even to those f作者: irritation 時間: 2025-3-26 13:16 作者: 柳樹；枯黃 時間: 2025-3-26 18:05 作者: 背帶 時間: 2025-3-26 21:12
Randy L. Bellvides some qualitative evidence of the feasibility of investor-State arbitration as an adjudicative process, capable of accommodating various scientific, fact-finding, expert-driven, and interdisciplinary methodologies towards resolving questions raised by either host States or investors concerning environmental protection.作者: LOPE 時間: 2025-3-27 02:07
Peter R. Bernsteinnciples to confront the challenges posed by global environmental challenges, especially climate change, and urgently rethink the capitalist model of development that has given rise to extensive environmental destruction.作者: macabre 時間: 2025-3-27 07:58 作者: 仲裁者 時間: 2025-3-27 10:24
Eric S. Silverman,Kwang H. In,Tucker Collins,Jeffrey M. Drazen作者: 聯(lián)想 時間: 2025-3-27 15:27 作者: Limerick 時間: 2025-3-27 18:21
Uwe P. Tittmann,Francesco Patalano,Barbara A. Ziehmer,Andreas von Sprecher,Michael A. Bray作者: 流動性 時間: 2025-3-28 01:58 作者: 針葉類的樹 時間: 2025-3-28 04:17 作者: Measured 時間: 2025-3-28 07:40
Leukotriene A4 hydrolase: A key enzyme in chemotactic leukotriene formation,ipid mediators exert a wide range of biological effects, for example activation of leukocytes and contraction of smooth muscles, particularly in the airways, and microcirculation. In the biosynthesis of leukotrienes, free arachidonic acid is converted by 5-lipoxygenase into 5(S)-.-5,6-oxido-7,9-.-11作者: 禁止,切斷 時間: 2025-3-28 11:40
Metabolism of leukotrienes and formation of new leukotriene structures,gely in reduced or terminated biological activity, thus making metabolism a major process limiting leukotriene action . The majority of the enzymatic pathways involved in metabolic processing are common to a host of other endogenous biochemical substances, in particular eicosanoids such as prostagla作者: Preamble 時間: 2025-3-28 15:34
Receptors for cysteinyl-leukotrienes: Targets for new drugs, as an antagonist of slow reacting substance of anaphylaxis (SRS-A) when it was not yet known that the latter was composed mainly of LTs [1]. Subsequently, the recognition of strict structural requirements for LT action [2, 3], their high potency (in the nM range) and the development of a number of 作者: judiciousness 時間: 2025-3-28 19:49
Targeted disruption of 5-lipoxygenase,as targeted gene inactivation, or in the common vernacular, gene knockout, has vaulted into the forefront of biology during the 1990s as the prime means to assess specific gene function [3, 4]. The technique involves cloning the murine gene of interest (or portion thereof), preparing a gene-targetin作者: CAMP 時間: 2025-3-29 01:30
Transcellular biosynthesis of leukotrienes: A unique mode of cell communication, as well as of the enzymes involved in their synthesis. Leukotriene (LT) biosynthesis results from two different enzymatic processes: (i) a primary oxidation by 5-lipoxygenase (5-LO), a protein possessing a dioxygenase activity necessary for the synthesis of 5-hydroperoxyeicosatetraenoic acid (5-HPE作者: Canary 時間: 2025-3-29 06:19 作者: parasite 時間: 2025-3-29 10:27
Entry rate and metabolic handling of LTC4 in the human circulation,se in patients with asthma and other disease states characterized by an inflammatory component. In this regard, urinary LTE. excretion rates have been extensively used over the last 5 years, following demonstration that the intravenous infusion [1–3] or inhalation [4] of LTC. is accompanied by dose-作者: constitute 時間: 2025-3-29 13:30
Genetic polymorphisms of 5-LO,ons in the expression of 5-LO have important implications in the pathogenesis of diseases characterized by excess leukotriene production. In a clinical trial with zileuton about 50% of patients have shown a sustained improvement in FEV. (force expiratory volume at 1 sec) of ≥ 10% in response to 5-LO作者: Delectable 時間: 2025-3-29 19:17
Leukotrienes and aspirin-intolerant asthma,his is a distinct clinical syndrome, called aspirin-induced asthma, or aspirin-intolerant asthma (AIA). It affects about 10% of adult patients with asthma, more often women than men, but is rare in asthmatic children [1–3].作者: plasma-cells 時間: 2025-3-29 20:33 作者: 忘川河 時間: 2025-3-30 00:38
Leukotrienes and allergic asthma,n asthma (Fig.1), the link between allergic asthma and leukotrienes is particularly strong. Thus, long before the identification of the leukotriene constituents of slow-reacting substance (SRS), it was evident that antigen challenge was an effective cause of the release of SRS from perfused animal l作者: barium-study 時間: 2025-3-30 05:44
,The development of zafirlukast (Accolate?) and the Zeneca series of peptidyl-leukotriene receptor amed because they were first isolated from leukocytes and they have an unusual triene-containing chemical structure. The peptidyl-or cysteinyl-leukotrienes are a subclass that contains a peptide moiety attached to the leukotriene backbone. There are three major cysteinyl-leukotrienes — LTC., LTD. and作者: 祖?zhèn)髫敭a(chǎn) 時間: 2025-3-30 09:47
,The development of zileuton (ZYFLO?) and the N-hydroxyurea class of 5-lipoxygenase inhibitors,r define the biology of inflammation and allergy and provided the first new approach to asthma therapy in decades. The leukotriene research at Abbott Laboratories for the most part has concentrated on biosynthetic inhibitors, most notably the N-hydroxyurea class of inhibitors. These compounds, parti作者: Epidural-Space 時間: 2025-3-30 13:39 作者: SPER 時間: 2025-3-30 16:37
The development of iralukast: A member of the Novartis series of cysteinyl leukotriene antagonists,ct by antagonizing the bronchoconstrictive, mucus secretory and inflammatory effects of these leukotrienes [1–8]. Pranlukast (OnonTM, ONO-1078), zafirlukast (AccolateTM, ICI 204,219) and montelukast (SingulairTM, MK 0476) are available on the market as treatment for asthma [1–6]. Further compounds, 作者: ovation 時間: 2025-3-30 22:31
LTB4 receptor antagonists, on characterizing the structure and biological activities of the molecule and determining the mechanism of its biosynthesis and catabolism. Much of this research focused on the relationship between the leukotriene and neutrophils [2–5]. First attempts to synthesize antagonists of the LTB. receptor 作者: Humble 時間: 2025-3-31 04:36 作者: 梯田 時間: 2025-3-31 05:50 作者: DEAF 時間: 2025-3-31 09:32 作者: 懶惰民族 時間: 2025-3-31 14:02 作者: 防銹 時間: 2025-3-31 19:31 作者: 被詛咒的人 時間: 2025-4-1 01:11
William T. Jacksony simplified and symmetric nonlinear models, with some notable pioneering exceptions. We hope that a Universe dominated by elementary particle relics will be largely understandable in such simple terms, and, with the COBE observation of CMB anisotropy, there is hope that our wishes will be realized.作者: Dawdle 時間: 2025-4-1 02:45
