標(biāo)題: Titlebook: Novel Approaches to the Treatment of Alzheimer’s Disease; Edwin M. Meyer,James W. Simpkins,Jyunji Yamamoto Book 1989 Springer Science+Busi [打印本頁(yè)] 作者: JOLT 時(shí)間: 2025-3-21 19:27
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作者: Hyperopia 時(shí)間: 2025-3-21 21:37
https://doi.org/10.1007/978-1-4684-5727-8Alzheimer‘s disease; Pet; aging; biology; brain; cortex; growth; neurobiology; pharmaceutical; receptor作者: Extricate 時(shí)間: 2025-3-22 02:27 作者: 堅(jiān)毅 時(shí)間: 2025-3-22 06:10
A Brain-Enhanced Chemical Delivery System for Gonadal Steroids: Implications for Neurodegenerative Don the brain: (i) during the critical period of fetal/neonatal life these hormones affect permanently some features of the brain structure and function which result in neuronal differentiation and (ii) during the adult life exert their effects in a modulatory, reversible mode that influence adult brain function.作者: 現(xiàn)代 時(shí)間: 2025-3-22 11:42
978-1-4684-5729-2Springer Science+Business Media New York 1989作者: BLANC 時(shí)間: 2025-3-22 13:59 作者: Predigest 時(shí)間: 2025-3-22 17:49
s, discover new territories, and invent new technologies.? "Pressure knapping" is?the common term for?one method?of creating stone tools, where a larger device or blade specifically made for this purpose is use to press out the stone tool.? Pressure knapping was invented in different locations and a作者: 高度表 時(shí)間: 2025-3-22 21:57
Kenneth A. Jacobson,Barton J. Bradbury,Jesse Baumgoldt cultural and historical periods.Updates the current resear.Human development is a long and steady process that began with stone tool making.? Because of this skill, humans were able to adapt to climate changes, discover new territories, and invent new technologies.? "Pressure knapping" is?the comm作者: 抱負(fù) 時(shí)間: 2025-3-23 01:45 作者: 罐里有戒指 時(shí)間: 2025-3-23 07:00 作者: 非實(shí)體 時(shí)間: 2025-3-23 12:43
Katsuo Toide,Takashi Arimas, discover new territories, and invent new technologies.? "Pressure knapping" is?the common term for?one method?of creating stone tools, where a larger device or blade specifically made for this purpose is use to press out the stone tool.? Pressure knapping was invented in different locations and a作者: ADOPT 時(shí)間: 2025-3-23 14:26
William J. Jackson,Karey Elrod,Jerry J. Buccafuscot cultural and historical periods.Updates the current resear.Human development is a long and steady process that began with stone tool making.? Because of this skill, humans were able to adapt to climate changes, discover new territories, and invent new technologies.? "Pressure knapping" is?the comm作者: 克制 時(shí)間: 2025-3-23 20:50 作者: Prosaic 時(shí)間: 2025-3-23 23:00 作者: frivolous 時(shí)間: 2025-3-24 05:29 作者: Anthem 時(shí)間: 2025-3-24 09:14 作者: Heretical 時(shí)間: 2025-3-24 12:32
Lawrence R. Williams,Karen S. Jodelis,Melody R. Donald,Henry K. Yipt cultural and historical periods.Updates the current resear.Human development is a long and steady process that began with stone tool making.? Because of this skill, humans were able to adapt to climate changes, discover new territories, and invent new technologies.? "Pressure knapping" is?the comm作者: Genteel 時(shí)間: 2025-3-24 15:24 作者: CURT 時(shí)間: 2025-3-24 22:18
Eugene M. Johnson Jr.,David P. Martin,Beth K. Levy,Jason Y. Changs, discover new territories, and invent new technologies.? "Pressure knapping" is?the common term for?one method?of creating stone tools, where a larger device or blade specifically made for this purpose is use to press out the stone tool.? Pressure knapping was invented in different locations and a作者: 新手 時(shí)間: 2025-3-25 00:23
Patricia Ann Walicket cultural and historical periods.Updates the current resear.Human development is a long and steady process that began with stone tool making.? Because of this skill, humans were able to adapt to climate changes, discover new territories, and invent new technologies.? "Pressure knapping" is?the comm作者: chronicle 時(shí)間: 2025-3-25 04:31
Dalia M. Araujo,Paul A. Lapchak,Jean-Guy Chabot,Remi Quiriont cultural and historical periods.Updates the current resear.Human development is a long and steady process that began with stone tool making.? Because of this skill, humans were able to adapt to climate changes, discover new territories, and invent new technologies.? "Pressure knapping" is?the comm作者: 前面 時(shí)間: 2025-3-25 08:45 作者: Deceit 時(shí)間: 2025-3-25 15:07
Marcus E. Brewster,Cynthia Robledo-Luiggi,Akio Miyakeb,Emil Pop,Nicholas Bodorve seen, this was also reflected upon by the constitutionalist programme, which at first aimed at organizing public opinion. Long-standing family connections, school friendships and student contacts played an equally important part in this operation as professional friendships, social intercourse wi作者: Spongy-Bone 時(shí)間: 2025-3-25 16:41
Kenji Matsuyama,Choichiro Miyazaki,Masataka Ichikawaarskoe Selo Lyceum scheduled to open in October. In July, Kunitsyn successfully passed examinations qualifying him for the degree of adjunct professor (.) of philosophical and political sciences, which were conducted jointly by the Councils of the Pedagogical Institute and the Academy of Sciences. B作者: amplitude 時(shí)間: 2025-3-25 23:20
James W. Simpkins,Mohamad H. Rahimy,Nicholas Bodor from the first years of Alexander I’s reign, his liberal reforms met with suspicion among the traditional-minded nobility—a sentiment that gradually grew into a vocal opposition to both liberal innovations and Western influences in Russia. Conservatism was far from a homogeneous movement; it includ作者: 混合,攙雜 時(shí)間: 2025-3-26 01:07 作者: 我不死扛 時(shí)間: 2025-3-26 07:32 作者: Compassionate 時(shí)間: 2025-3-26 11:11 作者: MELON 時(shí)間: 2025-3-26 16:23
Muscarinic Receptors, Phosphoinositide Hydrolysis, and Neuronal Plasticity in the Hippocampusell known for their amnestic effects, support the cholinergic hypothesis of memory (Bartus et al? 1982). Several biochemical and electrophysiological responses to muscarinic agonist stimulation have been described in the hippocampus, including reduction of a calcium-dependent potassium current (IK.)作者: grenade 時(shí)間: 2025-3-26 18:56 作者: Evolve 時(shí)間: 2025-3-27 00:50
Delayed Matching-to-Sample in Monkeys as a Model for Learning and Memory Deficits: Role of Brain Nicxcept higher apes. In addition, spontaneous and conditioned behavior exhibited by the monkey is more similar to that of the human than any other laboratory animal.. Therefore, behavioral tasks which tap the higher cognitive abilities of these nonhuman primates may provide information more relevant t作者: 輕浮思想 時(shí)間: 2025-3-27 04:54 作者: 馬具 時(shí)間: 2025-3-27 05:37
Potential Pharmacological Use of Neurotrophic Factors in the Treatment of Neurodegenerative Diseasesctors. These neurotrophic factors stimulate mechanisms necessary for survival, neurite growth and functions related to transmitter production and release. Nerve growth factor (NGF) is the first and best characterized neurotrophic factor and serves as a paradigm for more recently discovered molecules作者: Tractable 時(shí)間: 2025-3-27 11:36
The Use of Reaggregating Cell Cultures And Immortalized Central Nervous System Cells to Study Cholinent and maintenance of neural connections is supported by neural trophic factors, trophic dysfunction represents one possible pathogenetic mechanism for such neurological and age-associated diseases. This laboratory has utilized primary reaggregating cell cultures and developed immortalized central 作者: 賄賂 時(shí)間: 2025-3-27 17:40
Approaches to Gene Therapy in the CNS: Intracerebral Grafting of Fibroblasts Genetically Modified toease phenotypes ., an approach that has been named gene therapy (1). In an ideal gene therapy system, the new genetic information would be applied directly to the affected tissue. This direct approach has not yet been attempted, because the current methods of gene transfer are limited to replicating作者: 放大 時(shí)間: 2025-3-27 18:49
Exogenous Nerve Growth Factor Stimulates Choline Acetyltransferase Activity in Basal Forebrain of Ax maintenance in the adult (1,2). NGF has been found to have a similar role in the mammalian central nervous system (CNS) (3). NGF was first implicated in CNS function when Schwab et al. (4) found specific retrograde transport of exogenous NGF from cerebral and hippocampal cortices to neuronal cell b作者: 不知疲倦 時(shí)間: 2025-3-27 22:39
Neuronotrophic Factors, Gangliosides and Their Interaction: Implications in the Regulation of Nervou extrinsic factors. Like any living system, the nervous system represents a dynamic organization, whose various elements are in a continual state of change due to interactions not only with one another, but also with their extraneural environment. Neurons are exposed to such influences from cells wi作者: 細(xì)菌等 時(shí)間: 2025-3-28 03:26
Suppression of Active Neuronal Death by Immune Interferonically well characterized and of proven physiological significance (1). NGF is necessary for the survival and function of sympathetic and neural crest-derived sensory neurons. It is becoming clear that NGF is also important for the basal forebrain cholinergic neurons in CNS (2), a cell group involve作者: CAB 時(shí)間: 2025-3-28 08:42
Basic Fibroblast Growth Factor, an Example of a Multifunctional Trophic Factor with Neurotrophic Act injury or during aging have been ascribed to deficiencies of trophic factors (1). For many years, the only known neurotrophic factor (NTF) was nerve growth factor (NGF). Studies with NGF have led to significant insights into neuronal cell biology and development, particularly in the peripheral nerv作者: 野蠻 時(shí)間: 2025-3-28 13:32 作者: chassis 時(shí)間: 2025-3-28 15:09
Metabolic Support of Neural Plasticity: Implications for the Treatment of Alzheimer’s Diseasere the atrophied neocortex and perhaps even replace some of the lost information. Such a glamorous cure for Alzheimer’s disease carries with it a hidden requirement, one that has been relatively neglected in this area of research. The addition of cortical tissue late in life will impose new metaboli作者: 松果 時(shí)間: 2025-3-28 19:15
Brain-Enhanced Delivery of Anti-Dementia Drugsloss. This insidious and pernicious malady is expected to strike 20% of all individuals over the age of eighty (Bartus et al., 1982), an important and growing demographic block. At present the etiological basis of SDAT is unknown and work has been aimed at palliative treatments to increase the quali作者: bonnet 時(shí)間: 2025-3-29 00:28 作者: 和平 時(shí)間: 2025-3-29 03:51
A Brain-Enhanced Chemical Delivery System for Gonadal Steroids: Implications for Neurodegenerative Don the brain: (i) during the critical period of fetal/neonatal life these hormones affect permanently some features of the brain structure and function which result in neuronal differentiation and (ii) during the adult life exert their effects in a modulatory, reversible mode that influence adult br作者: ESPY 時(shí)間: 2025-3-29 10:22 作者: ferment 時(shí)間: 2025-3-29 14:18 作者: follicle 時(shí)間: 2025-3-29 15:50
Kenneth A. Jacobson,Barton J. Bradbury,Jesse Baumgold important reference for anyone studying the Paleolithic, Mesolithic, and Neolithic periods, lithic studies, technologies, and more generally, cultural transmission..978-1-4899-9110-2978-1-4614-2003-3作者: 種子 時(shí)間: 2025-3-29 23:20
Abraham Fisher,Rachel Brandeis,Ishai Karton,Zipora Pittel,Shlomit Dachir,Michal Sapir,Y. Grunfeld,Ah important reference for anyone studying the Paleolithic, Mesolithic, and Neolithic periods, lithic studies, technologies, and more generally, cultural transmission..978-1-4899-9110-2978-1-4614-2003-3作者: addition 時(shí)間: 2025-3-30 00:26
William J. Jackson,Karey Elrod,Jerry J. Buccafusco important reference for anyone studying the Paleolithic, Mesolithic, and Neolithic periods, lithic studies, technologies, and more generally, cultural transmission..978-1-4899-9110-2978-1-4614-2003-3作者: 烤架 時(shí)間: 2025-3-30 06:23 作者: Chandelier 時(shí)間: 2025-3-30 09:19
Franz Hefti important reference for anyone studying the Paleolithic, Mesolithic, and Neolithic periods, lithic studies, technologies, and more generally, cultural transmission..978-1-4899-9110-2978-1-4614-2003-3作者: SLING 時(shí)間: 2025-3-30 13:28 作者: evasive 時(shí)間: 2025-3-30 17:05
Michael B. Rosenberg,Mark H. Tuszynski,Kazunari Yoshida,Theodore Friedmann,Fred H. Gage important reference for anyone studying the Paleolithic, Mesolithic, and Neolithic periods, lithic studies, technologies, and more generally, cultural transmission..978-1-4899-9110-2978-1-4614-2003-3作者: 無(wú)節(jié)奏 時(shí)間: 2025-3-30 20:57 作者: mechanism 時(shí)間: 2025-3-31 01:45 作者: Pandemic 時(shí)間: 2025-3-31 05:50
Patricia Ann Walicke important reference for anyone studying the Paleolithic, Mesolithic, and Neolithic periods, lithic studies, technologies, and more generally, cultural transmission..978-1-4899-9110-2978-1-4614-2003-3作者: 失敗主義者 時(shí)間: 2025-3-31 11:25
Dalia M. Araujo,Paul A. Lapchak,Jean-Guy Chabot,Remi Quirion important reference for anyone studying the Paleolithic, Mesolithic, and Neolithic periods, lithic studies, technologies, and more generally, cultural transmission..978-1-4899-9110-2978-1-4614-2003-3作者: 不整齊 時(shí)間: 2025-3-31 16:43
AF102B: A Novel M1 Agonist as a Rational Treatment Strategy in Alzheimer’s Diseasen which project to the cerebral cortex and hippocampus (reviews 1–3). This degeneration is associated with a marked reduction of presynaptic cholinergic indices in these brain regions involved in cognitive processes (5). Somewhat conflicting results were reported regarding muscarinic receptors in AD作者: laparoscopy 時(shí)間: 2025-3-31 19:00
Muscarinic Receptors, Phosphoinositide Hydrolysis, and Neuronal Plasticity in the Hippocampusas obscured the relationship between biochemical and electrophysiological responses to muscarinic agonists. In addition, the relationship between muscarinic action on specific membrane ionic conductances, especially IKm, and neuronal action potential generation, is not clear.作者: 服從 時(shí)間: 2025-3-31 22:11
Effects of Cholinergic Drugs on Extracellular Levels of Acetylcholine and Choline in Rat Cortex, Hipstriatum. No significant changes in the choline levels of these three brain regions were observed after administration of nicotine..The present approach permits the direct detection of changes in ACh and choline levels in the extracellular space of discrete brain areas of experimental animals. These作者: 有節(jié)制 時(shí)間: 2025-4-1 03:08 作者: 突襲 時(shí)間: 2025-4-1 08:44
Muscarinic and Nicotinic Receptors in Alzheimer’s Disease: Rationale for Cholinergic Drug Treatmentntrast to muscarinic receptors, results concerning the fate of neuronal nicotinic receptor populations in AD cortex are more consistent. These studies indicate that the density of nicotinic receptors, at least in cortical structures, is severely reduced in AD (3,5,13,14). It is essential to de-termi作者: AUGUR 時(shí)間: 2025-4-1 13:52 作者: 混沌 時(shí)間: 2025-4-1 14:28
Approaches to Gene Therapy in the CNS: Intracerebral Grafting of Fibroblasts Genetically Modified toveral advantages over other current methods of gene transfer (2): 1) infection by retrovirus vectors is extremely efficient for a broad range of cell types and species, with up to 100% of the target cells expressing the transgene; 2) the viral genomes have a relatively large capacity for foreign DNA作者: 詞根詞綴法 時(shí)間: 2025-4-1 20:56
