標題: Titlebook: Novel Approaches to Selective Treatments of Human Solid Tumors; Laboratory and Clini Youcef M. Rustum Book 1993 The Editor(s) (if applicabl [打印本頁] 作者: 突然 時間: 2025-3-21 20:06
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書目名稱Novel Approaches to Selective Treatments of Human Solid Tumors讀者反饋學(xué)科排名
作者: Cardiac-Output 時間: 2025-3-21 22:41 作者: Alienated 時間: 2025-3-22 01:08
978-1-4613-6060-5The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: 擁擠前 時間: 2025-3-22 06:06 作者: 流動性 時間: 2025-3-22 11:02
0065-2598 Overview: 978-1-4613-6060-5978-1-4615-2488-5Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: Repatriate 時間: 2025-3-22 13:49 作者: Ovulation 時間: 2025-3-22 18:17
Biochemical Modulation of 5-Fluorouracil by Pala: Mechanism of Actionchemical differences between cancer and normal cells are quantitative rather than qualitative. Consequently, anticancer agents have a narrow therapeutic index and, therefore, chemotherapy is frequently toxic to the patient as well as to the tumor.作者: dialect 時間: 2025-3-22 23:40 作者: 喊叫 時間: 2025-3-23 03:55 作者: Expostulate 時間: 2025-3-23 07:42
Cellular Interactions Between the Natural and Unnatural Isomers of 5-Formyltetrahydrofolatelu). All reduced folates have an S chirality at the 6 carbon of the tetrahydropterine ring and the natural and unnatural isomers of 5-formyltetrahydro-folate are designated respectively as (6S)- and ...H.H.PteGlu.. After being used for many years as a rescue agent following high doses of the antifol作者: Mundane 時間: 2025-3-23 13:09
Leucovorin as a Prodrugizes the inhibitory ternary complex formed between the FU active metabolite, FdUMP and thymidylate synthase, resulting in suppression of DNA synthesis or repair.. It has been demonstrated both in animal models. and in humans. that administration of leucovorin results in intratumor elevation of CH.FH作者: 樹木中 時間: 2025-3-23 17:40
Clinical Use of Leucovorin: Intracellular Metabolismand upper aerodigestive system. While many analogs of 5-fluorouracil have been synthesized since the early 1960’s none has supplanted 5-fluorouracil for general clinical use. One of the major focal points of recent investigative work has been efforts to enhance the activity of 5-fluorouracil through作者: Heart-Attack 時間: 2025-3-23 19:15 作者: 清洗 時間: 2025-3-24 00:07
Effects of 5-Fluorouracil on mRNAcols which are dependent upon 5-fluorouracil (FU). The basis for this interest rests largely upon the exquisite sensitivity of the enzyme to the antimetabolite 5-fluorodeoxyuridylate, the demonstration of numerous cell culture effects which can be explained by enzyme inhibition, and increased tumor 作者: 品牌 時間: 2025-3-24 04:21 作者: EVEN 時間: 2025-3-24 09:22 作者: 拱形面包 時間: 2025-3-24 12:10
5-Fluorouracil Combined with the Pure [6S]-Stereoisomer of Folinic Acid in High Doses for Treatment luorouracil (5-FU) and fluorodeoxyuridine (FUdR)] . (1,2,3). Potentiation of the antitumor activity of 5-FU by folinic acid has been demonstrated in patients with gastrointestinal carcinomas (4–10); this has resulted in effective palliative treatment for patients with advanced colorectal adenocarcin作者: 間諜活動 時間: 2025-3-24 17:34
5-Fluorouracil Modulation in Colorectal Carcinoma Experience of German Investigators of FU. Among the modulating agents folinic acid (FA) has been proven to increase response rates, while its impact on patients survival is still questionable.. Nevertheless FU in combination with FA is considered by most oncologists as standard treatment in advanced stages of colorectal cancer. Its 作者: Meditate 時間: 2025-3-24 22:34 作者: 到婚嫁年齡 時間: 2025-3-24 23:48 作者: 謙卑 時間: 2025-3-25 04:14 作者: 與野獸博斗者 時間: 2025-3-25 08:30
Enhanced Cytotoxicity of 5-Fluorouracil Combined with [6RS]Leucovorin and Recombinant Human Interferof intracellular 5,10-methylenetetrahydrofolate (CH.-H.PteGlu.).. Whereas the concentration of this reduced folate may not be rate limiting for thymidylate synthesis ., it may be suboptimal to allow maximal interaction between the FUra metabolite, 5-fluorodeoxyuridylate (FdUMP), and thymidylate synt作者: 樣式 時間: 2025-3-25 13:15 作者: 拱形面包 時間: 2025-3-25 16:16
Biochemical Modulation of 5-Fluorouracil by Pala: Mechanism of Actionchemical differences between cancer and normal cells are quantitative rather than qualitative. Consequently, anticancer agents have a narrow therapeutic index and, therefore, chemotherapy is frequently toxic to the patient as well as to the tumor.作者: 外面 時間: 2025-3-25 21:16 作者: 陰謀小團體 時間: 2025-3-26 03:28
Fluorouracil and Leucovorin in Advanced Breast Cancerced breast cancer. In previously-untreated patients, the combination generates objective responses in over one third of women with a very modest and acceptable toxicity profile. It is also clear that the addition of mitoxantrone or cisplatin to 5-FU and leucovorin produces very effective regimens, t作者: Cholecystokinin 時間: 2025-3-26 07:40 作者: 排名真古怪 時間: 2025-3-26 09:20
Shousong Cao,Zhanggeng Zhang,Patrick J. Creaven,Youcef M. Rustumithic archaeologists and human paleontologists have failed to address the origins of a phenomenon that is both absolutely central to the human way of life and unique to our species. ..In all species of mammals, there are codes (rules, concepts, values, etc.) that govern behavior. Among humans, and o作者: OGLE 時間: 2025-3-26 13:24
Godefridus J. Peters,Giovanni Codacci-Pisanelli,Clasina L. van der Wilt,Jan A. M. van Laar,Kees Smidithic archaeologists and human paleontologists have failed to address the origins of a phenomenon that is both absolutely central to the human way of life and unique to our species. ..In all species of mammals, there are codes (rules, concepts, values, etc.) that govern behavior. Among humans, and o作者: anarchist 時間: 2025-3-26 19:42 作者: BUDGE 時間: 2025-3-26 23:32
D. G. Priest,J. C. Schmitz,T. Walleway of life and unique to our species. ..In all species of mammals, there are codes (rules, concepts, values, etc.) that govern behavior. Among humans, and only among humans, some of these codes are created socially, through interactions among individuals. Human culture is thus an emergent phenomeno作者: 某人 時間: 2025-3-27 02:07 作者: Itinerant 時間: 2025-3-27 06:09
Daniel G. Haller,Myrto Lefkopoulou,John S. Macdonald,Robert S. Mayerway of life and unique to our species. ..In all species of mammals, there are codes (rules, concepts, values, etc.) that govern behavior. Among humans, and only among humans, some of these codes are created socially, through interactions among individuals. Human culture is thus an emergent phenomeno作者: Esalate 時間: 2025-3-27 10:35 作者: EXPEL 時間: 2025-3-27 14:50 作者: Minuet 時間: 2025-3-27 20:25
C. Erlichman,S. Fine,I. Kerr,W. Hoffman,C. Gorg,H.-J. Schmoll,P. Preusser,H.-J. Senn,B. Gustavssonirst English writer to produce book-length works of original criticism. His three critical works—his translation of and preface to René Rapin’s . (1674), . (1678), and . (1693)—were highly regarded by his contemporaries, and earned him a reputation as a formidable critic and scholar. Yet despite the作者: 散布 時間: 2025-3-28 00:27 作者: 獨特性 時間: 2025-3-28 06:08 作者: COW 時間: 2025-3-28 09:16
Sheldon Fineades. This report reviews some of the wealth of chemical, biological and clinical data describing the discovery and development of these compounds. The scientific importance, therapeutic benefit and marketing potential of these compounds have caused an explosion of scientific literature describing t作者: 異端邪說2 時間: 2025-3-28 13:06
Jean L. Grem,Nanette McAtee,James C. Drake,Seth Steinberg,Carmen J. Allegraevelopment of ETFs markets in 12 countries. First, it presents and compares their level of development and provides short characteristics, including their structures and features of the key categories of ETFs used in various countries. Moreover, it describes the main trends of the Asia-Pacific regio作者: 心痛 時間: 2025-3-28 18:02
Joseph A. Sparano,Scott Wadlerevelopment of ETFs markets in 12 countries. First, it presents and compares their level of development and provides short characteristics, including their structures and features of the key categories of ETFs used in various countries. Moreover, it describes the main trends of the Asia-Pacific regio作者: FACT 時間: 2025-3-28 21:37 作者: 武器 時間: 2025-3-28 23:46
Edward Chu,Carmen J. Allegraecurity, innovation, research and economic growth from Servan-Schreiber’s 1960s fears about the transatlantic security technology gap and argues that this narrative became deeply embedded in successive research programs most notably ESPRIT from the 1980s and the security research agenda that began i作者: 向前變橢圓 時間: 2025-3-29 04:06 作者: Classify 時間: 2025-3-29 10:45 作者: 和平 時間: 2025-3-29 14:46 作者: 我怕被刺穿 時間: 2025-3-29 18:52 作者: 彎曲的人 時間: 2025-3-29 20:12
Claus-Henning Kohne-Wompner,Hans-Joachim Schmollredictability of their biological profile but their therapeutic usefulness varies widely dependent upon their physical properties, net hemodynamic effects, duration of action and incidence of side effects. CEBs appear uniquely suited to the treatment of the underlying complexity of cardiovascular disease.作者: TOXIN 時間: 2025-3-30 00:48
James H. Doroshow,Kim Margolin,Lucille Leong,Steven Akman,Robert Morgan Jr.,James Raschko,George Somtion of the European integration process and big, “historical” agreements. In this context, analysis is based on reasons and parameters that prevent EU member states from transferring (more) power to the EU, such as differences between policies, research systems, and preferences of the member states.作者: bibliophile 時間: 2025-3-30 04:26
Janet A. Houghton,David A. Adkins,Peter J. Houghtonversity Press, Oxford, 1998; Stone Sweet A, Sandholtz W, Fligstein N (eds), The institutionalization of Europe. Oxford University Press, Oxford, 2001) – the EDRP is simply an instance of “spillover” from security research to defense research or whether other factors are at play.作者: 表被動 時間: 2025-3-30 08:23
Daniel S. Martinversity Press, Oxford, 1998; Stone Sweet A, Sandholtz W, Fligstein N (eds), The institutionalization of Europe. Oxford University Press, Oxford, 2001) – the EDRP is simply an instance of “spillover” from security research to defense research or whether other factors are at play.作者: Neuropeptides 時間: 2025-3-30 15:10
Comparison of Continuous Infusions and Bolus Injections of 5.Fluorouracil with or without LeucovorinV to both the bolus injections and the continuous infusions, caused a marked increase in gastrointestinal toxicity. In several schedules this increase of toxicity was the only result of the modulatory agent, with no apparent effect on the antitumor activity.作者: Small-Intestine 時間: 2025-3-30 17:04
Cellular Interactions Between the Natural and Unnatural Isomers of 5-Formyltetrahydrofolatelives of 7.5 to 11 hours) and persists at high concentrations for prolonged periods .. Consequently, the possible interactions between the natural and unnatural N.-HCO-H.PteGlu isomers have been studied both experimentally and in the clinic. This paper will summarize available data on the isomers’ c作者: irradicable 時間: 2025-3-31 00:04
Clinical Use of Leucovorin: Intracellular Metabolismate synthase. While each of these mechanisms has been documented to occur in preclinical model systems, few have been shown to be responsible for clinical insensitivity to 5-fluorouracil. Since the underlying molecular mechanism of the catalytic function of thymidylate synthase has been disclosed, s作者: conjunctiva 時間: 2025-3-31 00:58
Effects of 5-Fluorouracil on mRNAfor effects .. A discussion of potentially important issues related to mRNA associated effects is presented. Newly available tools which can be used to address previously undefined issues are also described.作者: Substance-Abuse 時間: 2025-3-31 08:22
Genetic Variation in Thymidylate Synthase Confers Resistance to 5-Fluorodeoxyuridineeficient cells were transfected with cDNAs encoding the two TS polypeptides. Transfectants expressing the variant TS were more resistant to FdUrd cytotoxicity than cells expressing the common TS. Thus, the structural variation in TS reduced enzyme affinity for FdUMP and conferred resistance to FdUrd作者: overreach 時間: 2025-3-31 10:34 作者: 臭名昭著 時間: 2025-3-31 17:08
o lead individuals to behave contrary to their own evolutionary best interests. ..This book describes the emergent nature of human culture. It proposes hypotheses to explain how a phenomenon that is potentially maladaptive for individuals could have evolved, and to explain why culture plays s978-1-4419-4028-5978-0-387-30674-2作者: Jocose 時間: 2025-3-31 18:40 作者: 不能妥協(xié) 時間: 2025-3-31 23:38 作者: CRACY 時間: 2025-4-1 01:51
Jacques Jolivet,Richard Bertrando lead individuals to behave contrary to their own evolutionary best interests. ..This book describes the emergent nature of human culture. It proposes hypotheses to explain how a phenomenon that is potentially maladaptive for individuals could have evolved, and to explain why culture plays s978-1-4419-4028-5978-0-387-30674-2作者: Guileless 時間: 2025-4-1 07:13
C. Erlichman,S. Fine,I. Kerr,W. Hoffman,C. Gorg,H.-J. Schmoll,P. Preusser,H.-J. Senn,B. Gustavssonion of Rymer’s critical works stands almost alone in its effort to examine the critic objectively. But this work has produced little scholarship on Rymer, much less salvaged his reputation as a needling pedant and enemy of Shakespeare.作者: coagulation 時間: 2025-4-1 14:11 作者: dowagers-hump 時間: 2025-4-1 15:14 作者: Muscularis 時間: 2025-4-1 22:11 作者: 健忘癥 時間: 2025-4-2 01:52
D. G. Priest,J. C. Schmitz,T. Wallecan also lead individuals to behave contrary to their own evolutionary best interests. ..This book describes the emergent nature of human culture. It proposes hypotheses to explain how a phenomenon that is potentially maladaptive for individuals could have evolved, and to explain why culture plays s
