標(biāo)題: Titlebook: Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate; Yves Christen,Alain Isra?l,Frédéric Checler Conference proceedings 200 [打印本頁] 作者: OAK 時(shí)間: 2025-3-21 18:53
書目名稱Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate影響因子(影響力)
書目名稱Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate影響因子(影響力)學(xué)科排名
書目名稱Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate網(wǎng)絡(luò)公開度
書目名稱Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate被引頻次
書目名稱Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate被引頻次學(xué)科排名
書目名稱Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate年度引用
書目名稱Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate年度引用學(xué)科排名
書目名稱Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate讀者反饋
書目名稱Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate讀者反饋學(xué)科排名
作者: 逢迎春日 時(shí)間: 2025-3-21 21:23 作者: 開玩笑 時(shí)間: 2025-3-22 02:34
978-3-642-62767-5Springer-Verlag Berlin Heidelberg 2002作者: 空洞 時(shí)間: 2025-3-22 05:03 作者: JIBE 時(shí)間: 2025-3-22 10:46
on; it is not a complete theory of executive agency. It traces a link between the performance of an individual executive, which the theory postulates is a function of the executive’s ability, motivation and work opportunity, and corporate performance, which it contends is a function of the performan作者: Stable-Angina 時(shí)間: 2025-3-22 15:26 作者: finale 時(shí)間: 2025-3-22 19:47 作者: 小鹿 時(shí)間: 2025-3-23 01:11 作者: 迷住 時(shí)間: 2025-3-23 05:11 作者: 浮夸 時(shí)間: 2025-3-23 05:56
Control of Notch Activity by the Ubiquitin-Proteasome Pathway,eolytic cleavage releases the intracellular part of the receptor, which translocates to the nucleus and acts as a transcriptional activator. Though Notch-induced transcription of genes has been extensively reported, its endogenous nuclear form has seldom been visualized. We report that the nuclear i作者: 爭吵加 時(shí)間: 2025-3-23 11:39
,New Non-Peptidic Inhibitors of γ-Secretase Abolish Aβ Production Without Modifying Notch Cleavage,lytic activities responsible for the release of the N- and C-termini of Aβ peptides, respectively (for review, see .). A consensus now exists concerning β-secretase, a novel type of membrane-bound aspartyl protease recently discovered by several teams and referred to as BACE1 (β-site APP-cleaving en作者: Diastole 時(shí)間: 2025-3-23 15:53 作者: 允許 時(shí)間: 2025-3-23 18:19
Missorting of the Dendritic Cell Adhesion Molecule Telencephalin in Presenilin-Deficient Neurons,ch intracellular domain. The presenilins are therefore implicated in such diverse processes as the neurodegeneration in Alzheimer’s disease and the regulation of Notch signaling. The question remains whether other type I transmembrane proteins or pathways are subject to presenilin-mediated proteolys作者: 發(fā)酵劑 時(shí)間: 2025-3-23 22:23
,βAPP Processing, its Biology and Alzheimer’s Disease, Protein (APP) by two sequential proteolytic events. Although APP proteolysis has been extensively studied because of its relevance to AD, its biologic function remains enigmatic. In this paper I propose a model in which processing of APP, under control of presenilins, generates an intracellular pep作者: LATHE 時(shí)間: 2025-3-24 03:20 作者: 季雨 時(shí)間: 2025-3-24 08:36
,PS1 Interacts With and Facilitates β-Catenin Turnover,’s disease (AD). Presenilins are polytopic membrane proteins that are predicted to span the membrane six to eight times (reviewed in .). The mechanisms by which the mutations cause early onset AD are unknown. The prevailing hypothesis centers on altered γ-secretase activity that generates the C-term作者: 刻苦讀書 時(shí)間: 2025-3-24 11:46
,δ-Catenin, Presenilin, and the Synaptic-Adherens Junction Complex, in the Armadillo (Arm) repeat superfamily with sequence similarity to the adherens junction protein p120.. δ-Catenin can be immunoprecipitated as a complex with other components of the adherens junction, including cadherin and β-catenin, from transfected cells and brain. The ectopic expression of δ作者: Euphonious 時(shí)間: 2025-3-24 16:09
Vascular Smooth Muscle Cells Are the Primary Target of the Events Leading from Notch3 Mutations to atter lesions and diffuse alterations of the small cerebral arteries characterized by major alterations of vascular smooth muscle cells, which ultimately disappear. We recently established that CADASIL is due to mutations in the Notch3 gene..Precise mechanisms that lead from Notch3 mutations to the 作者: spinal-stenosis 時(shí)間: 2025-3-24 20:43
Notch Signaling in the Brain: More than Just a Developmental Story,udies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of adult-onset neurological disorders, such as the presenilinlinked form of Alzheimer’s disease (AD) and cerebral arteriopathy CADASIL. Here we present an overview of Notch作者: FATAL 時(shí)間: 2025-3-25 02:42
Control of Notch Activity by the Ubiquitin-Proteasome Pathway,ecule could stabilize intracellular Notch 1 and enhance its transcriptional activity, but had no effect on inactive, membrane-anchored forms of the receptor. We then demonstrated that SEL-10 specifically interacts with nuclear forms of Notchl and that this interaction requires a phosphorylation even作者: 啤酒 時(shí)間: 2025-3-25 05:02
Presenilins, APP, and Notch: Proteolysis from Womb to Tomb,eptor, a critical signaling event during cell fate decision in embryonic development. Transition-state analogue γ-secretase inhibitors also block the intramembranous cleavage of Notch, and the transmembrane aspartates of presenilins are required for this proteolysis as well. Thus, presenilins appear作者: expunge 時(shí)間: 2025-3-25 08:05
Missorting of the Dendritic Cell Adhesion Molecule Telencephalin in Presenilin-Deficient Neurons,phalin is exclusively expressed in neurons of the telencephalic region, where it is abundantly expressed at the somatodendritic plasmamembrane. Functionally, telencephalin is, like notch, involved in neurite outgrowth. Interestingly, telencephalin is also involved in long-term potentiation. We confi作者: Peak-Bone-Mass 時(shí)間: 2025-3-25 13:17
,PS1 Interacts With and Facilitates β-Catenin Turnover,retase activity. Thus, presenilins are required for the transmembrane cleavage of both APP and Notch to generate Aβ and the Notch intracellular domain, respectively. This activity has been coined “regulated intramembrane proteolysis” (.) and is discussed in greater depth elsewhere by Rawson in this 作者: 碎石 時(shí)間: 2025-3-25 18:53
,δ-Catenin, Presenilin, and the Synaptic-Adherens Junction Complex,in involves direct contact between the highly conserved juxtamembrane region of the cadherin carboxy terminus and the Arm-repeat of δ-catenin. The interaction with synaptic elements may involve the PDZ binding domain. In developing mouse brain, staining with δ-catenin antibodies is prominent towards作者: capsule 時(shí)間: 2025-3-25 22:02
Vascular Smooth Muscle Cells Are the Primary Target of the Events Leading from Notch3 Mutations to des associate to form a heterodimer. In normal human adult tissues, Notch3 expression is essentially restricted to the vasculature, with Notch3 being detected exclusively in the smooth muscle cells. In CADASIL tissues. there is a dramatic and selective accumulation of the Notch3 ectodomain at the me作者: 愛哭 時(shí)間: 2025-3-26 00:57
macro-economic circumstances in which a business is situated at any particular point in time, is primarily the domain of economists and strategy scholars. Work opportunity might be an area which network theorists would like to investigate, but may also in part be a random factor or a matter of luck.作者: brother 時(shí)間: 2025-3-26 07:39
A. Petit,F. Bihel,C. Alves da Costa,O. Pourquié,Y.-H. Suh,J.-L. Kraus,F. Checler macro-economic circumstances in which a business is situated at any particular point in time, is primarily the domain of economists and strategy scholars. Work opportunity might be an area which network theorists would like to investigate, but may also in part be a random factor or a matter of luck.作者: 防水 時(shí)間: 2025-3-26 12:17 作者: Postmenopause 時(shí)間: 2025-3-26 14:34
,A Presenilin Dependent S3-Like γ-Secretase Cleavage of the β-Amyloid Precursor Protein,作者: 多節(jié) 時(shí)間: 2025-3-26 17:51
Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate作者: Comedienne 時(shí)間: 2025-3-27 00:47 作者: 悲觀 時(shí)間: 2025-3-27 03:18 作者: MAUVE 時(shí)間: 2025-3-27 06:35 作者: organic-matrix 時(shí)間: 2025-3-27 11:33 作者: Ordnance 時(shí)間: 2025-3-27 17:28 作者: 要素 時(shí)間: 2025-3-27 20:53 作者: Digitalis 時(shí)間: 2025-3-28 00:47 作者: restrain 時(shí)間: 2025-3-28 03:20
,βAPP Processing, its Biology and Alzheimer’s Disease,c function remains enigmatic. In this paper I propose a model in which processing of APP, under control of presenilins, generates an intracellular peptide that regulates the cellular threshold to apoptosis.作者: 細(xì)胞膜 時(shí)間: 2025-3-28 07:38 作者: 樹上結(jié)蜜糖 時(shí)間: 2025-3-28 12:44
Conference proceedings 2002ative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early 作者: deriver 時(shí)間: 2025-3-28 16:13
,Regulated Intramembrane Proteolysis — New Lessons from Lipid Metabolism and the Unfolded Protein Re is involved in cellular signaling. Examples of Rip occur in both prokaryotes and eukaryotes, indicating that the phenomenon arose early in evolution. Here we consider recent results that shed additional light on the occurrence and mechanistic details of Rip.作者: Rotator-Cuff 時(shí)間: 2025-3-28 19:14 作者: Rinne-Test 時(shí)間: 2025-3-29 02:22 作者: 馬具 時(shí)間: 2025-3-29 07:06 作者: fatty-acids 時(shí)間: 2025-3-29 09:14 作者: 制定 時(shí)間: 2025-3-29 14:55
,An “Umbrella Perspective” of Water: The Hermeneutics of Hydrology,ly pause and reassess how these finite presentations of water have been interpreted. This notion invites the application of a “hermeneutic” approach, or the science or art of interpretation (beyond the interpretation of statistics).作者: CLAN 時(shí)間: 2025-3-29 19:27 作者: 鄙視讀作 時(shí)間: 2025-3-29 23:14
Managing in Britain and Germanyersuchen konnten Schwinger und ich brauchbare Zahlen dadurch erhalten, da? die Verbrennungsprodukte zuvor über glühendes Platinblech und dann über Porzellanperlen geleitet wurden, die mit natriumbisulfit-haltiger Sodal?sung befeuchtet waren.作者: Bouquet 時(shí)間: 2025-3-30 02:29
Michael J. Gavazzi,Steven G. McNulty,Johnny L. Boggs,Sara E. Strickland,David C. ChojnackyM. This component was not as abundant in bog porewaters. SUVA, determined at 254 nm, was strongly correlated with lower aromaticity in deep fen samples relative to deep bog samples as determined by .H-NMR. Aromatic and carbohydrate components represented up to 70% of deep bog DOM but comprised a muc作者: synovium 時(shí)間: 2025-3-30 07:58 作者: Forehead-Lift 時(shí)間: 2025-3-30 09:40
Asmaa Aljuhani,Arunima Srivastava,James P. Cronin,Jany Chan,Raghu Machiraju,Anil V. Parwani) parental characteristics like criminality (Farrington, 1978; Glueck and Glueck, 1950; McCord and McCord, 1958); (d) subject characteristics like daring, low IQ, and poor school attainment, poor social skills and poor peer acceptance (Farrington, 1978; Janson, 1982; Roff, 1972; Wirt et al., 1972).作者: 頂點(diǎn) 時(shí)間: 2025-3-30 14:49 作者: Negligible 時(shí)間: 2025-3-30 18:48 作者: 流出 時(shí)間: 2025-3-30 22:57
