作者: narcissism 時(shí)間: 2025-3-21 21:20 作者: Ancillary 時(shí)間: 2025-3-22 01:56 作者: 攀登 時(shí)間: 2025-3-22 07:08
Conference proceedings 1994of mechanisms. Such chemicals often produce tumours only in a single organ species, and there are a few common locations which are affected most often. For example, in male rats, certain carcinogens bind to az globulin to form a complex which 11 accumulates in the kidney tubular cells, which is foll作者: Infect 時(shí)間: 2025-3-22 10:10
0947-6075 most often. For example, in male rats, certain carcinogens bind to az globulin to form a complex which 11 accumulates in the kidney tubular cells, which is foll978-3-662-03024-0978-3-662-03022-6Series ISSN 0947-6075 作者: languid 時(shí)間: 2025-3-22 15:44 作者: 消極詞匯 時(shí)間: 2025-3-22 19:49 作者: 顯示 時(shí)間: 2025-3-22 21:27 作者: Cougar 時(shí)間: 2025-3-23 03:01 作者: 山間窄路 時(shí)間: 2025-3-23 07:28
has made significant contributions to not only developing the theories on teaching and learning mathematics through variation, but also providing pathways to putting the variation theory into action in an international context.“This book paints a richly detailed and elaborated picture of both teachi作者: 鬧劇 時(shí)間: 2025-3-23 10:18 作者: esoteric 時(shí)間: 2025-3-23 15:52
P. Amstad,R. Ghosh,G. Shah,Y. Oya,P. Ceruttive to varying levels of entry into generalization. Empirical evidence will be provided to demonstrate this alternative view, which is drawn from the author’s longitudinal work with elementary and middle school children, including several investigations conducted with preservice elementary majors. Tw作者: helper-T-cells 時(shí)間: 2025-3-23 20:34
J. A. Swenbergve to varying levels of entry into generalization. Empirical evidence will be provided to demonstrate this alternative view, which is drawn from the author’s longitudinal work with elementary and middle school children, including several investigations conducted with preservice elementary majors. Tw作者: Intact 時(shí)間: 2025-3-23 22:54 作者: Legion 時(shí)間: 2025-3-24 04:32 作者: endure 時(shí)間: 2025-3-24 08:24
A. Balmain,C. J. Kemp,P. A. Burns,R. Bremner,S. Bryson,M. Clarke,S. Williamson,K. Brown for those whose job requires them to teach in one form or another, and where delivering IR courses is a major part of their working lives...In this context of providing a higher profile for teaching and? learning as applied to IR, the co-editor of this book, Efthimis Efthimiathis, had maintained a 作者: exhibit 時(shí)間: 2025-3-24 12:36 作者: osteoclasts 時(shí)間: 2025-3-24 18:33 作者: 厭煩 時(shí)間: 2025-3-24 19:34
N. R. Drinkwater for those whose job requires them to teach in one form or another, and where delivering IR courses is a major part of their working lives...In this context of providing a higher profile for teaching and? learning as applied to IR, the co-editor of this book, Efthimis Efthimiathis, had maintained a 作者: Ethics 時(shí)間: 2025-3-24 23:36
C. L. Berry for those whose job requires them to teach in one form or another, and where delivering IR courses is a major part of their working lives...In this context of providing a higher profile for teaching and? learning as applied to IR, the co-editor of this book, Efthimis Efthimiathis, had maintained a 作者: 迅速飛過(guò) 時(shí)間: 2025-3-25 03:29
978-3-662-03024-0Springer-Verlag Berlin Heidelberg 1994作者: 能得到 時(shí)間: 2025-3-25 09:26 作者: Recessive 時(shí)間: 2025-3-25 15:17
Nongenotoxic Mechanisms in Thyroid Carcinogenesis,Nongenotoxic mechanisms of thyroid carcinogenesis are of general application and also of potential importance to regulatory toxicology. To understand the way in which administration of xenobiotics can lead to thyroid tumours through a nongenotoxic mechanism it is necessary first to consider the pathophysiology of the thyroid gland.作者: dermatomyositis 時(shí)間: 2025-3-25 19:49
Ernst Schering Foundation Symposium Proceedingshttp://image.papertrans.cn/n/image/667274.jpg作者: Extemporize 時(shí)間: 2025-3-25 20:31
https://doi.org/10.1007/978-3-662-03022-6DNA; Hormone; breast cancer; cancer; carcinogenesis; cell; hormones; kidney; liver; liver tumor; prevention; to作者: Agnosia 時(shí)間: 2025-3-26 03:46 作者: antenna 時(shí)間: 2025-3-26 04:31
Conference proceedings 1994sis, underlining the complexity of the topic. The clarity of the view that all carcinogens act by mutating DNA, origin- ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer. There is 作者: LINE 時(shí)間: 2025-3-26 11:43
,α2μ-Globulin Mediated Male Rat Kidney Carcinogenesis,ans. Research from several laboratories has elucidated the mechanism responsible for this remarkable sex- and species-specific disease. This understanding of mechanisms led the EPA (1991) to conclude that renal tumors mediated through α. should not be used in human risk assessment.作者: 粘連 時(shí)間: 2025-3-26 15:18 作者: Defraud 時(shí)間: 2025-3-26 20:20
The Interaction of Genes and Hormones in Murine Hepatocarcinogenesis,nt of more common malignancies because of the low effective penetrance of such genes and the large variation in environmental factors that influence cancer development in humans. Animal models provide a powerful approach to the identification and characterization of such risk-modifier genes.作者: MONY 時(shí)間: 2025-3-27 00:32
Evaluating Carcinogenic Risks,ly related to the way many defend their articles of faith than to the way in which data are evaluated objectively. Nevertheless, in the selection of hazards for evaluation, public opinion will and should be influential.作者: palpitate 時(shí)間: 2025-3-27 01:45 作者: 匯總 時(shí)間: 2025-3-27 07:14
Nongenotoxic Chemical Carcinogens: Evidence for Multiple Mechanisms,hanisms, such as by generating oxidative products which can damage DNA. This paper will focus on the minimalist definition of mutagenicity and how it may aid in identifying and understanding chemicals which operate through nonmutagenic mechanisms to induce cancer.作者: 牢騷 時(shí)間: 2025-3-27 12:48
Nongenotoxic Carcinogenesis in the Liver, is not only a problem in rodents, and assessment of human health risks is urgently required. For this purpose we need to know the relevant .biological effects of these agents in rodent and human liver as well as the mechanisms underlying carcinogenesis.作者: helper-T-cells 時(shí)間: 2025-3-27 14:40 作者: 有雜色 時(shí)間: 2025-3-27 21:44
The Role of Genotoxic and Nongenotoxic Agents in Multistage Carcinogenesis of Mouse Skin,n attempts to enter a suicide pathway, which is a frequent primary response to DNA-damaging agents. All of this must, of course, take place within the correct target cell, i.e., either a stem cell with a naturally extended lifespan, or a more committed cell which can acquire an extended lifespan upon exposure to a carcinogenic stimulus.作者: 重力 時(shí)間: 2025-3-28 01:25
Nongenotoxic Chemical Carcinogens: Evidence for Multiple Mechanisms,For the purpose of this discussion a minimalist definition of a genotoxic carcinogen will be used. This definition includes chemicals which possess one of the structural alerts, generally indicative of electrophilic potential (Miller and Miller 1977) defined by Ashby (1985; Tennant and Ashby 1991), 作者: COW 時(shí)間: 2025-3-28 04:50
Oxidative Damage and Carcinogenesis,nts are ubiquitous in our natural environment but they can also be formed in the tissue by endogenous cellular mechanisms (Cerutti 1985; Kozumbo et al. 1985; Cerutti and Trump 1991). Oxidants can introduce structural damage to DNA, leading to chromosomal aberrations and point mutations. Point mutati作者: foppish 時(shí)間: 2025-3-28 09:52
DNA Damage by Free Radicals. Mechanism, Meaning and Measurement,H.O.), and hypochlorous acid (HOC1), the latter being generated by the enzyme myeloperoxidase in neutrophils (for reviews, see di Guiseppi and Fridovich 1984; Halliwell and Gutteridge 1989; Weiss 1989). Exposure of living organism to background levels of ionizing radiation leads to homolytic fission作者: coalition 時(shí)間: 2025-3-28 10:55
,α2μ-Globulin Mediated Male Rat Kidney Carcinogenesis, dogs, and monkeys do not develop this disease when exposed to agents which cause this syndrome in male rats (Borghoff et al. 1990; Alden 1986; Swenberg et al. 1989; Halder et al. 1985). Likewise, there are no data suggesting that these agents cause protein droplet accumulation in the kidneys of hum作者: 思想靈活 時(shí)間: 2025-3-28 15:49
Nongenotoxic Carcinogenesis in the Liver,mprise a diverse group of important drugs and environmental pollutants. Examples are shown in Table 1 (Schulte-Hermann 1985; Schulte-Hermann et al. 1990b). Some agents, for example, certain steroids, have been associated with tumor formation in . liver (Schulte-Hermann 1985; Schulte-Hermann et al. 1作者: 小鹿 時(shí)間: 2025-3-28 19:03 作者: forestry 時(shí)間: 2025-3-29 00:00 作者: 邊緣 時(shí)間: 2025-3-29 06:25 作者: Adornment 時(shí)間: 2025-3-29 07:36
Peroxisome Proliferation and Hepatocarcinogenesis,e characterised by their content of catalase and a number of hydrogen peroxide-generating oxidase enzymes (Cohen and Grasso 1981; Reddy and Lalwani 1983). Like mitochondria, peroxisomes contain a complete fatty acid β-oxidation cycle (Lazarow and DeDuve 1976). In rat liver peroxisomes are normally s作者: cleaver 時(shí)間: 2025-3-29 11:43
Peroxisome Proliferators Mimic an Endogenous Inducer and Inactivate a Transcriptional Repressor in 1967). These compounds, which include the barbiturates, aromatic hydrocarbons and peroxisome proliferators, also induce cytochrome P450s. The prokaryote, . ATCC 14581, possesses a P450 (BM-3) active in fatty acid metabolism which introduces hydroxyl groups at the ω-1,2,3 position of fatty acids. BM-作者: grounded 時(shí)間: 2025-3-29 17:28
The Interaction of Genes and Hormones in Murine Hepatocarcinogenesis,etinoblastoma, Wilm’ s tumor, or familial adenomatous polyposis (Friend et al. 1986; Rose et al. 1990; Kinzler et al. 1991). However, human genetic studies have been less effective in identifying “risk-modifier” genes that may increase by 5- to 50-fold an individual’s susceptibility to the developme作者: 共棲 時(shí)間: 2025-3-29 20:46 作者: Somber 時(shí)間: 2025-3-30 00:10
tructional approaches from others. Students from East Asia, such as China and Japan, have consistently outperformed their counterparts in the West. Yet, Bianshi Teaching (teaching with variation) practice, which has been commonly used in practice in China, has been hardly shared in the mathematics e作者: 粗俗人 時(shí)間: 2025-3-30 08:05
R. W. Tennantn generalization. While research results drawn from investigations conducted with different age-level groups have sufficiently demonstrated varying shifts in structural awareness and competence, which influence the eventual shape of an intended generalization, such shifts, however, are not necessari作者: boisterous 時(shí)間: 2025-3-30 08:37
P. Amstad,R. Ghosh,G. Shah,Y. Oya,P. Ceruttin generalization. While research results drawn from investigations conducted with different age-level groups have sufficiently demonstrated varying shifts in structural awareness and competence, which influence the eventual shape of an intended generalization, such shifts, however, are not necessari作者: 明確 時(shí)間: 2025-3-30 15:25 作者: 鞭打 時(shí)間: 2025-3-30 18:27 作者: Limited 時(shí)間: 2025-3-30 23:56 作者: Aprope 時(shí)間: 2025-3-31 03:18 作者: 大炮 時(shí)間: 2025-3-31 07:55
