標題: Titlebook: Nonclinical Statistics for Pharmaceutical and Biotechnology Industries; Lanju Zhang Book 2016 Springer International Publishing Switzerlan [打印本頁] 作者: Confer 時間: 2025-3-21 18:11
書目名稱Nonclinical Statistics for Pharmaceutical and Biotechnology Industries影響因子(影響力)
書目名稱Nonclinical Statistics for Pharmaceutical and Biotechnology Industries影響因子(影響力)學科排名
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書目名稱Nonclinical Statistics for Pharmaceutical and Biotechnology Industries網(wǎng)絡(luò)公開度學科排名
書目名稱Nonclinical Statistics for Pharmaceutical and Biotechnology Industries被引頻次
書目名稱Nonclinical Statistics for Pharmaceutical and Biotechnology Industries被引頻次學科排名
書目名稱Nonclinical Statistics for Pharmaceutical and Biotechnology Industries年度引用
書目名稱Nonclinical Statistics for Pharmaceutical and Biotechnology Industries年度引用學科排名
書目名稱Nonclinical Statistics for Pharmaceutical and Biotechnology Industries讀者反饋
書目名稱Nonclinical Statistics for Pharmaceutical and Biotechnology Industries讀者反饋學科排名
作者: 樣式 時間: 2025-3-21 20:45 作者: athlete’s-foot 時間: 2025-3-22 02:38 作者: 捏造 時間: 2025-3-22 06:40 作者: 任意 時間: 2025-3-22 09:22
Yang Lu,Katherine Perez-Morera,Rita M. Cantoroten Eigenschwingungen auf unendlich lange Wellen extrapolierten Werte für den Brechungsindex und die Molrefraktion bedeuten, w?hrend n’. und R’. die aus Messungen von n im Sichtbaren extrapolierten Werte von n und R sind.作者: aneurysm 時間: 2025-3-22 13:13
Mohammad Atiar Rahman,Meiyu Shen,Xiaoyu (Cassie) Dong,Karl K. Lin,Yi Tsong作者: 顧客 時間: 2025-3-22 19:25 作者: 吵鬧 時間: 2025-3-22 21:31 作者: 漂亮才會豪華 時間: 2025-3-23 05:14 作者: 起波瀾 時間: 2025-3-23 09:23 作者: 統(tǒng)治人類 時間: 2025-3-23 11:34
General Toxicology, Safety Pharmacology, Reproductive Toxicology, and Juvenile Toxicology Studiescussion of statistical approaches, there are likely to be multiple reasonable approaches. We’ve attempted to cover some of the more common approaches in detail, but we recognize that our treatment is not exhaustive. Where possible, we have provided references for further reading.作者: LUDE 時間: 2025-3-23 16:16 作者: Dissonance 時間: 2025-3-23 21:37 作者: Compass 時間: 2025-3-23 22:47
Book 2016this book aims to introduce readers to important statistical thinking and its application in thesenonclinical areas. The chapters provide as appropriate, a scientific background to the topic, relevant regulatory guidance, current statistical practice, and further research directions. .作者: 暴露他抗議 時間: 2025-3-24 04:46 作者: CON 時間: 2025-3-24 07:42 作者: 走調(diào) 時間: 2025-3-24 13:32 作者: hardheaded 時間: 2025-3-24 16:20
978-3-319-79499-0Springer International Publishing Switzerland 2016作者: EPT 時間: 2025-3-24 22:50 作者: Measured 時間: 2025-3-25 01:59 作者: 失眠癥 時間: 2025-3-25 06:15
Statistics for Biology and Healthhttp://image.papertrans.cn/n/image/667182.jpg作者: 自傳 時間: 2025-3-25 10:36
https://doi.org/10.1007/978-3-319-23558-5Animal studies; Biomarker; Chemistry, manufacturing and controls (CMC); Drug research and development; N作者: esculent 時間: 2025-3-25 12:08
Lanju ZhangProvides the first volume dedicated to nonclinical statistics.Brings together relevant statistical methods for nonclinical research in pharma/biotech industries with a mission promoting nonclinical st作者: 松雞 時間: 2025-3-25 16:25
How To Be a Good Nonclinical Statisticians the scope of this book, there are many accounts in the field of statistics of what it takes to be a good statistician. The goal of this chapter is to focus on specific characteristics for nonclinical statisticians which we believe are essential to be viewed as “good” professionals, either as individual contributors or managers.作者: 碳水化合物 時間: 2025-3-25 23:18
Statistical Methods for Drug Discoveryw key areas: target discovery, compound screening/optimization, and the characterization of important properties. Special attention is paid to working with assay data and phenotypic screens. A discussion of important skills for a nonclinical statistician supporting drug discovery concludes the chapter.作者: gimmick 時間: 2025-3-26 02:29
1431-8776 a/biotech industries with a mission promoting nonclinical st.This book serves as a reference text for regulatory, industry and academic statisticians and also a handy manual for entry level Statisticians. Additionally it aims to stimulate academic interest in the field of Nonclinical Statistics and 作者: Factorable 時間: 2025-3-26 07:06
Clinical Assays for Biological Macromoleculess unique challenges. In this chapter, we review the scientific background of clinical assay development and validation, as well as the common statistical methods used during the life-cycle of assay development.作者: flaggy 時間: 2025-3-26 10:11
Design and Evaluation of Drug Combination Studiesy evaluation. A new index based on Bliss independence is introduced, comparable to the interaction index based on Loewe Additivity. An example data set is used to demonstrate the implementation of these analysis methods. In the final discussion, we point out some future research areas.作者: 完全 時間: 2025-3-26 16:09
Biomarkersilised. In this chapter we shall discuss what biomarkers are, the types of data that they generate and the impact on the subsequent statistical analysis, paying particular attention to the avoidance of false positives in biomarker discovery and confirming the technical performance of assays measuring biomarkers.作者: 蕨類 時間: 2025-3-26 18:29
Introduction to Nonclinical Statistics for Pharmaceutical and Biotechnology Industries nonclinical statistics in pharmaceutical and biotechnology companies. Then we try to define nonclinical statistics, discuss the nonclinical statistical profession, identify possible causes of predicaments in nonclinical statistics, and point out potential directions to change the status quo.作者: Diskectomy 時間: 2025-3-27 00:06
Regulatory Nonclinical StatisticsDA Chemistry Manufacturing, and Control (CMC) Statistics Team. In the second example, we illustrate the research activities of Pharmacological/Toxicological (Pharm-Tox) Statistics Team at FDA with the background and evaluation of multiple pairwise comparisons in animal carcinogenetic studies.作者: Fallibility 時間: 2025-3-27 02:23 作者: 背帶 時間: 2025-3-27 08:32 作者: 刺激 時間: 2025-3-27 09:39
Introduction to Nonclinical Statistics for Pharmaceutical and Biotechnology Industriesies, which provides a natural field for statistics. Clinical statistics is a shining example of how an industry has embraced statistics as an equal partner. However, it is not the case of nonclinical statistics. In this chapter, we give a brief introduction to drug discovery and development process,作者: CAJ 時間: 2025-3-27 15:12
Regulatory Nonclinical Statisticsstical consultation, and statistical methodology development in nonclinical regulations. In this chapter, we provide a brief description of the two teams and provide two examples in statistical research development. In the first example, we describe the historical background and evolution of statist作者: beta-carotene 時間: 2025-3-27 20:05 作者: 輪流 時間: 2025-3-27 22:08 作者: Anecdote 時間: 2025-3-28 02:05
High-Throughput Screening Data Analysisich are sequentially executed to progressively filter out the samples with undesired activities and properties and identify the ones of interest are outlined. The goal of a complete HTS campaign is to identify a validated set of chemical probes from a larger library of small molecules, antibodies, s作者: 割公牛膨脹 時間: 2025-3-28 08:34
GWAS for Drug Discoveryed this basic work will lead to a better understanding of the etiologies of such traits and disorders. In pharmacogenetics, application of GWAS methods is evolving. Here, the traits and disorders of interest derive from the diversity in patient response to medications. It is anticipated that GWAS wi作者: 欺騙手段 時間: 2025-3-28 11:42 作者: 易于 時間: 2025-3-28 15:04 作者: GRE 時間: 2025-3-28 19:14 作者: ANTE 時間: 2025-3-29 02:51
Clinical Assays for Biological Macromoleculesogics. It is, therefore, essential to develop suitable assays for these assessments. However, development of assays for biological macromolecules poses unique challenges. In this chapter, we review the scientific background of clinical assay development and validation, as well as the common statisti作者: VAN 時間: 2025-3-29 03:40
Recent Research Projects by the FDA’s Pharmacology and Toxicology Statistics TeamIn this chapter we summarize some of our recent investigations and findings..We have conducted a simulation study (discussed in Sect.?12.2) to evaluate the increase in Type 2 error attributable to the adoption by some non-statistical scientists within the agency of more stringent decision criteria t作者: prediabetes 時間: 2025-3-29 09:29
Design and Evaluation of Drug Combination Studiess for drug combination studies, with a focus on in vitro experiments. Two reference models Loewe additivity and Bliss independence are used for synergy evaluation. A new index based on Bliss independence is introduced, comparable to the interaction index based on Loewe Additivity. An example data se作者: jumble 時間: 2025-3-29 14:13
Biomarkers differing roles and applications and statistics plays a critical role in their discovery, validation or qualification and how they are applied and utilised. In this chapter we shall discuss what biomarkers are, the types of data that they generate and the impact on the subsequent statistical analys作者: addict 時間: 2025-3-29 18:38 作者: dyspareunia 時間: 2025-3-29 21:11 作者: Instinctive 時間: 2025-3-30 02:47
Max Kuhninduzierte elektrische Moment oder die Polarisierbarkeit des Moleküls bedeutet. Wird das Molekül von dem hochfrequenten Felde einer einfallenden Lichtwelle im Sichtbaren polarisiert, so spricht man von der optischen Polarisierbarkeit α, auch Elektronen-polarisierbarkeit genannt, da nur die Elektrone作者: endoscopy 時間: 2025-3-30 07:25
Yang Lu,Katherine Perez-Morera,Rita M. Cantorinduzierte elektrische Moment oder die Polarisierbarkeit des Moleküls bedeutet. Wird das Molekül von dem hochfrequenten Felde einer einfallenden Lichtwelle im Sichtbaren polarisiert, so spricht man von der optischen Polarisierbarkeit α, auch Elektronen-polarisierbarkeit genannt, da nur die Elektrone作者: 無價值 時間: 2025-3-30 09:38
Chris Harbrondie Sicherheit des Bedienungsmannes bezieht. Haupts?chlich die Druckluftmaschinen, die sehr einfach in ihrem Aufbau sind, haben sich durchgesetzt, und es wird stets als besonderer Vorteil empfunden, da? ihre Funktion mit geringen technischen Allgemeinkenntnissen verst?ndlich ist. Der Vorteil der per作者: 的是兄弟 時間: 2025-3-30 16:22
die Sicherheit des Bedienungsmannes bezieht. Haupts?chlich die Druckluftmaschinen, die sehr einfach in ihrem Aufbau sind, haben sich durchgesetzt, und es wird stets als besonderer Vorteil empfunden, da? ihre Funktion mit geringen technischen Allgemeinkenntnissen verst?ndlich ist. Der Vorteil der per作者: 現(xiàn)代 時間: 2025-3-30 17:29
John Peterson,Stan Altanen, bestrebt, den Kompressor so zu bauen und zu kühlen, da? m?glichst niedrige Austrittstemperaturen zustande kommen. Die im Kompressor erzeugte W?rme kann meist nicht nutzbar gemacht werden. Sie geht w?hrend des Weges der Druckluft zum Verbraucher verloren. Der Bau von Luftkompressoren mit hoher Ve作者: Thyroxine 時間: 2025-3-31 00:29
?Technischer Staat“ als Ideologie und Utopieund neigt daher zu Nachfall und Druck. In einzelnen Feldern, so z. B. im Summerlanddistrikt in Kalifornien, wird der ?lsand sogar schwimmend, so da? das mit Wasser und ?l gefüllte Porenvolumen gr??er ist wie der Inhalt der festen Gesteinsmasse.作者: 不遵守 時間: 2025-3-31 04:27 作者: corpus-callosum 時間: 2025-3-31 05:03
Der V?lkermord in Rwanda und Burundi, ca. 800.000 Menschen (Tutsi und moderate Hutu) verloren innerhalb weniger Wochen unmittelbar durch den V?lkermord ihr Leben, bis Ende September hatten 2,1 Mio. rwandische Hutu im gr??ten und am schnellsten vollzogenen Massenexodus der neueren Geschichte das Land verlassen (zumeist Richtung Zaire, 作者: Commodious 時間: 2025-3-31 11:02 作者: 評論者 時間: 2025-3-31 14:07
Bodenkartierung und Landwirtschaft,utes throughout the country, restricting all activities to online mediums. The shift has affected how students engage with each other, where rather than in-person interaction, they meet through a variety of online tools. In this paper, we discuss how the normal everyday routine of ‘hanging out’ with作者: STANT 時間: 2025-3-31 20:23 作者: RECUR 時間: 2025-3-31 23:20
