作者: MOAN 時間: 2025-3-21 20:59
https://doi.org/10.1007/978-3-319-52673-7bacterial toxins; cyclic nucleotides; mass spectrometry; nucleotidyl cyclases; protein kinases; signal tr作者: finale 時間: 2025-3-22 04:29 作者: admission 時間: 2025-3-22 07:44 作者: aviator 時間: 2025-3-22 09:33
Roland SeifertThis book gives insight into latest findings in this emerging field of research.First book to be published on non-canonical cyclic nucleotides.Provides comprehensive coverage of topic and will present作者: 脫落 時間: 2025-3-22 15:07 作者: 熱情的我 時間: 2025-3-22 20:45 作者: 協(xié)迫 時間: 2025-3-22 22:27 作者: PRE 時間: 2025-3-23 03:54
,3′,5′-cIMP as Potential Second Messenger in the Vascular Wall,ediated by stimulation of Rho kinase. Based on these findings, cIMP appears to meet most, if not all, of the criteria required for it to be accepted as a “second messenger,” at least in the vascular wall.作者: 挫敗 時間: 2025-3-23 06:29 作者: 多產(chǎn)子 時間: 2025-3-23 11:57 作者: Crater 時間: 2025-3-23 17:55 作者: 忍耐 時間: 2025-3-23 21:45
K. Adam Morrow,Dara W. Frank,Ron Balczon,Troy Stevens作者: 混亂生活 時間: 2025-3-24 01:02
Claudius Marondedze,Aloysius Wong,Ludivine Thomas,Helen Irving,Chris Gehring作者: Homocystinuria 時間: 2025-3-24 04:25
Robin Lorenz,Daniela Bertinetti,Friedrich W. Herberg作者: 釘牢 時間: 2025-3-24 07:13 作者: 許可 時間: 2025-3-24 11:09 作者: 刀鋒 時間: 2025-3-24 15:01 作者: 后退 時間: 2025-3-24 19:50
cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Ceive to cCMP and cUMP abundance may point to the existence of hitherto unidentified cCMP- and cUMP-generating NCs. The broad occurrence of cCMP and cUMP in vertebrates and the distinct cNMP patterns suggest specific roles of these cNMPs in the regulation of numerous cell functions.作者: 補(bǔ)角 時間: 2025-3-25 02:44
cCMP and cUMP in Apoptosis: Concepts and Methods,human K-562 cells, which are known to be multidrug-resistant, cCMP and cUMP had no effect. Summarized in this chapter are the initiation of apoptosis by cCMP and cUMP regarding the various apoptotic pathways, the enzymes involved in apoptosis, as well as the most relevant methods for the detection a作者: Cholecystokinin 時間: 2025-3-25 03:36 作者: pus840 時間: 2025-3-25 07:59
The , Y: A Promiscuous Nucleotidyl Cyclase Edema Factor and Virulence Determinant,tes activates protein kinases A and G and causes phosphorylation of endothelial microtubule associated protein tau. Phosphorylation is a stimulus for tau release from microtubules, leading to microtubule instability. Phosphorylated tau accumulates inside endothelium as a high molecular weight, oligo作者: PATRI 時間: 2025-3-25 14:15
Cyclic Nucleotide Monophosphates in Plants and Plant Signaling,omparing the reactive oxygen species (ROS) response of cAMP and cGMP to that elicited by the noncanonical cCMP or cIMP. The results show that particularly cIMP can induce significant ROS production. To answer, at least in part, the second question, we have evaluated homology models of experimentally作者: acrimony 時間: 2025-3-25 16:47
cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors,The focus of this chapter is the general cyclic nucleotide-binding properties of both kinases as well as the selectivity for cAMP or cGMP, respectively. Furthermore, we discuss the binding affinities and activation potencies of noncanonical cyclic nucleotides.作者: 柳樹；枯黃 時間: 2025-3-25 22:50 作者: 單獨(dú) 時間: 2025-3-26 03:05 作者: 作繭自縛 時間: 2025-3-26 06:28 作者: exophthalmos 時間: 2025-3-26 12:23 作者: novelty 時間: 2025-3-26 15:11
8-Nitro-cGMP: A Novel Protein-Reactive cNMP and Its Emerging Roles in Autophagy,base. This modification, termed “protein .-guanylation,” is known to regulate the physiological functions of several important proteins. Furthermore, 8-nitro-cGMP participates in the regulation of autophagy. For example, in antibacterial autophagy (xenophagy), .-guanylation accumulates around invadi作者: Chauvinistic 時間: 2025-3-26 17:14
Medicinal Chemistry of the Noncanonical Cyclic Nucleotides cCMP and cUMP, role of cyclic pyrimidine nucleotides. Meanwhile, for this purpose new cCMP and cUMP derivatives have been developed, and already known analogs have been resynthesized and highly purified. This chapter summarizes early medicinal chemistry work on cCMP and cUMP and analogs thereof, followed by a des作者: monologue 時間: 2025-3-26 22:08
Holistic Methods for the Analysis of cNMP Effects,sponses label-free and in an unbiased fashion with the advantage to detect concealed aspects of cell signaling that are arduous to access via traditional biochemical assay approaches. In this chapter, we introduce the dynamic mass redistribution (DMR) technology to explore cell signaling beyond esta作者: attenuate 時間: 2025-3-27 03:27 作者: Anticoagulants 時間: 2025-3-27 07:48 作者: Odyssey 時間: 2025-3-27 13:12
cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Ceand regulate numerous cell functions via specific effector molecules. In contrast, the existence of the cyclic pyrimidine nucleotides cCMP and cUMP has been controversial for many years. The development of highly specific and sensitive mass spectrometry methods has enabled the unequivocal detection 作者: packet 時間: 2025-3-27 16:07
cCMP and cUMP in Apoptosis: Concepts and Methods,erentiation, proliferation, and apoptosis. The latter is a highly regulated process of programmed cell death wherein several regulatory proteins, like those belonging to the Bcl-2 family, are involved. The initiation of apoptosis is regulated by three different pathways: the intrinsic or mitochondri作者: NAVEN 時間: 2025-3-27 18:33
Mammalian Nucleotidyl Cyclases and Their Nucleotide Binding Sites,y, as substrates. mACs (nine human isoenzymes), sAC, and sGC differ in their overall structures owing to specific membrane-spanning and regulatory domains but consist of two similarly folded catalytic domains C1 and C2 with high structure-based homology between the cyclase species. Comparison of ava作者: Instrumental 時間: 2025-3-27 22:50
The , Y: A Promiscuous Nucleotidyl Cyclase Edema Factor and Virulence Determinant, 3 secretion system effectors, as it is present in approximately 90% of Pseudomonas isolates. ExoY has adenylyl cyclase activity that is dependent upon its association with a host cell cofactor. However, recent evidence indicates that ExoY is not just an adenylyl cyclase; rather, it is a promiscuous作者: 混合,攙雜 時間: 2025-3-28 03:35 作者: Mercantile 時間: 2025-3-28 09:32
cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors,ficities for cyclic nucleotides. Both enzymes harbor conserved cyclic nucleotide-binding (CNB) domains. Differences in amino acid composition of these CNB domains mediate cyclic nucleotide selectivity in PKA and PKG, respectively. Recently, the presence of the noncanonical cyclic nucleotides cCMP an作者: 流眼淚 時間: 2025-3-28 11:03 作者: Bernstein-test 時間: 2025-3-28 15:28 作者: growth-factor 時間: 2025-3-28 18:50 作者: acrophobia 時間: 2025-3-29 00:13 作者: 省略 時間: 2025-3-29 06:59
,3′,5′-cIMP as Potential Second Messenger in the Vascular Wall,egarded as true “second messengers” in the vascular wall, despite the presence of other cyclic nucleotides in different tissues. Among these noncanonical cyclic nucleotides, inosine 3′,5′‐cyclic monophosphate (cIMP) is synthesized by soluble guanylyl cyclase in porcine coronary arteries in response 作者: 破裂 時間: 2025-3-29 09:21
,Discovery and Roles of 2′,3′-cAMP in Biological Systems,in the renal venous perfusate from isolated, perfused kidneys detected a large signal at the same m/z transition (330 → 136) as 3′,5′-cAMP but at a different retention time. Follow-up experiments demonstrated that this signal was due to a positional isomer of 3′,5′-cAMP, namely, 2′,3′-cAMP. Soon the作者: glucagon 時間: 2025-3-29 15:29
8-Nitro-cGMP: A Novel Protein-Reactive cNMP and Its Emerging Roles in Autophagy,in the presence of reactive oxygen species (ROS), reacts with biomolecules to produce nitrated cGMP derivatives. 8-Nitro-cGMP was the first endogenous cGMP derivative discovered in mammalian cells (2007) and was later found in plant cells. Among the six nitrogen atoms in this molecule, the one in th作者: LAPSE 時間: 2025-3-29 16:57 作者: Flounder 時間: 2025-3-29 20:03
Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides,c monophosphate (cCMP) and uridine 3′,5′-cyclic monophosphate (cUMP) have been hampered by the lack of highly specific and sensitive analytic methods for these analytes. In addition, the existence of 2′,3′-cNMP besides 3′,5′-cNMP has been described recently. HPLC coupled with tandem mass spectrometr作者: 重畫只能放棄 時間: 2025-3-30 03:08 作者: Vldl379 時間: 2025-3-30 06:25 作者: 天真 時間: 2025-3-30 11:45 作者: 法律的瑕疵 時間: 2025-3-30 15:27
The Nazi Revolution and the Second World Wartatorial powers acquired by Hitler were, initially, acquired by adherence to democratic forms. Yet for all this, the Weimar Republic really ended its existence the day Hitler became Chancellor, and the activities of Hitler and his supporters from then onward amounted to a political revolution.作者: Malaise 時間: 2025-3-30 18:54
Concentration-action Relations I,lass-reinforced polymer systems, for example, with strains to break on the order of 20 percent for uniaxial loading in off-axis directions are now in common use in a variety of applications, including Naval structures. An example of such behaviour for three different strain rates is shown in Fig. 1.作者: 坦白 時間: 2025-3-31 00:30 作者: Keratectomy 時間: 2025-3-31 02:02
The Physics of LEED, “kinematic” theory (single-scattering theory) to explain LEED intensity vs. energy curves (IV-curves). Background information about the development and application of LEED, including experimental questions, will be found in Refs. [2,4–9].作者: multiply 時間: 2025-3-31 08:26 作者: 彎彎曲曲 時間: 2025-3-31 13:13 作者: Senescent 時間: 2025-3-31 13:49 作者: vocation 時間: 2025-3-31 19:20
E. Lepp?koski but as the RAF heads into the next century as part of the new joint service structure, the emphasis will be on littoral warfare. In this environment, the need for the RAF to maintain a strong maritime force is obvious.作者: 厭食癥 時間: 2025-4-1 00:17
978-3-031-20170-7The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl作者: vitrectomy 時間: 2025-4-1 05:03 作者: Left-Atrium 時間: 2025-4-1 06:50
The History of Vascular Neurosurgery: A Journey of Evolution and Revolutionve imaging to intraoperative optics, from creative microsurgical approaches to innovative endovascular techniques, vascular neurosurgery has brought a plethora of challenges to the practitioners of this art and science, and throughout its history, the neurosurgeon and the many collaborators and scientists have responded.
