標(biāo)題: Titlebook: Nitrates III; Cardiovascular Effec P. R. Lichtlen,H.-J. Engel,H. J. C. Swan (Director Conference proceedings 1981 Springer-Verlag Berlin He [打印本頁(yè)] 作者: Encounter 時(shí)間: 2025-3-21 18:17
書(shū)目名稱(chēng)Nitrates III影響因子(影響力)
作者: 農(nóng)學(xué) 時(shí)間: 2025-3-21 22:22
Comparative Haemodynamic and Pharmacokinetic Investigations After Oral Isosorbide-2-mononitrate and The metabolites isosorbide-2-mononitrate (IS-2-MN) and 5-mononitrate (IS-5-MN) are demonstrable in the plasma for several hours at concentrations which are but slowly decreasing, in contrast to those measured after oral isosorbide dinitrate, (ISDN) [2].作者: Pander 時(shí)間: 2025-3-22 01:36
Newer Methods of Administration of Nitrates to Man to Give a More Predictable Therapeutic ResponseIsosorbide dinitrate (ISDN) given orally is extensively metabolised by “first pass” metabolism, less than 3% appearing unchanged in the blood using this route. However, the two mononitrate metabolites are active and thus probably contribute significantly to the observed effects when ISDN is given orally.作者: 菊花 時(shí)間: 2025-3-22 07:01 作者: eucalyptus 時(shí)間: 2025-3-22 09:59
Induction and Inhibition of Organic Nitrate MetabolismOrganic nitrate vasodilators, such as glyceryl trinitrate (GTN) or isosorbide dinitrate (ISDN), are denitrated by the glutathione (GSH) S-transferases (EC 2.5.1.18) according to the general scheme [3]:RONO.+GSH→RHO+HNO.+GSSG.作者: terazosin 時(shí)間: 2025-3-22 13:32
978-3-642-68087-8Springer-Verlag Berlin Heidelberg 1981作者: neurologist 時(shí)間: 2025-3-22 20:49 作者: 積習(xí)難改 時(shí)間: 2025-3-22 23:49 作者: Confound 時(shí)間: 2025-3-23 05:16
Fate of Isosorbide Mononitrates in Manegimen, the duration of action, and the relationship between plasma concentration and effect are still under discussion. In an attempt to solve some of these problems, a pharmacologic and/or therapeutic role for the nitrated metabolites of substances such as glyceryl trinitrate and isosorbide dinitrate has been postulated.作者: 指令 時(shí)間: 2025-3-23 08:40 作者: 挫敗 時(shí)間: 2025-3-23 11:28
Plasma Concentrations and Hemodynamic Effects of Percutaneously Administered Nitroglycerin and Isoso healthy volunteers in whom we monitored the plasma concentrations and hemodynamic effects and assured the tolerability of nitroglycerin (NTG) and isosorbide dinitrate (ISDN) administered in the form of ointments.作者: Statins 時(shí)間: 2025-3-23 16:05 作者: 撤退 時(shí)間: 2025-3-23 20:02
Pharmacokinetics — Pharmacodynamics and the Bioavailability of Organic Nitrate Drug Productsed directly from blood pressure, blood glucose, intraocular pressure, pupil size, heart rate, and clotting times, respectively. That such measures can be used for quantitative pharmacokinetic analysis and the computation of absolute biovailabilities has been demonstrated [5]. The growing sophisticat作者: 消耗 時(shí)間: 2025-3-23 23:56 作者: 天真 時(shí)間: 2025-3-24 02:44
Tolerance to Circulatory and Clinical Effects of Nitratest was demonstrated in animals that the nitrates underwent extensive first-pass hepatic metabolism and that systemic drug levels were low [9]. However, demonstrations in man that oral isosorbide dinitrate (ISDN) prolonged hemodynamic effects [5] and improved exercise tolerance in angina pectoris [6] 作者: PANG 時(shí)間: 2025-3-24 08:16
Pharmacokinetics of Isosorbide Dinitrate in Human Subjects 7, 10] has facilitated study of the pharmacokinetics of this drug; the plasma levels obtainable after oral and sublingual doses of standard and sustained-release formulations and after topical applications of ointments are now well documented [1, 2, 8, 12].作者: 低能兒 時(shí)間: 2025-3-24 11:29
Pharmacokinetics of Isosorbide Mononitrates in Human Subjectsmononitrate and isosorbide 2-mononitrate (Fig. 1) [2], each of which is pharmacologically active [6]. In humans, about 10% of an oral dose of isosorbide dinitrate is excreted as both free and conjugated isosorbide 5-mononitrate, and about 1% is excreted as the 2-mononitrate [2]. After oral doses of 作者: 防水 時(shí)間: 2025-3-24 18:28
Plasma Concentrations and Hemodynamic Effects of Percutaneously Administered Nitroglycerin and Isoso healthy volunteers in whom we monitored the plasma concentrations and hemodynamic effects and assured the tolerability of nitroglycerin (NTG) and isosorbide dinitrate (ISDN) administered in the form of ointments.作者: insincerity 時(shí)間: 2025-3-24 20:04 作者: 使長(zhǎng)胖 時(shí)間: 2025-3-25 02:16 作者: 駁船 時(shí)間: 2025-3-25 04:24 作者: gentle 時(shí)間: 2025-3-25 11:20 作者: occult 時(shí)間: 2025-3-25 13:31
Digital Pulse Plethysmography: a Sensitive Test of the Pharmacodynamics of Nitrates — Reproducibilitn, a magnification of the area under the pulse curve as well as a deepening of the incisura can be observed. These variations show characteristic time-effect relations after administration of different nitrate preparations. For this reason, it has been concluded that these variations might be indica作者: 潛伏期 時(shí)間: 2025-3-25 16:11 作者: CLAIM 時(shí)間: 2025-3-25 21:25 作者: AER 時(shí)間: 2025-3-26 02:42
F. Seidel,D. Michelh intake of sugars may be related with an increased risk of several disorders including dental caries, obesity, cardiovascular disease, diabetes, gout, fatty liver disease, some cancers, components of the metabolic syndrome, and hyperactivity. Added sugar in processed foods are used to sweeten, to i作者: 剛開(kāi)始 時(shí)間: 2025-3-26 06:41 作者: NIB 時(shí)間: 2025-3-26 12:20
P. R. Imhof,B. Ott,A. Weiss,L.-C. Chu,L. F. Chasseaud sweetening power. All cells of the human body can use glucose as an energy substrate, and most can also use fatty acids. In contrast, most cells cannot use directly fructose, and this substrate needs first to be converted into lactate, glucose, or fatty acids in the gut, liver, and kidneys. Cells o作者: FORGO 時(shí)間: 2025-3-26 15:33
W. Rudolph,R. Blasini,K.-L. Froer,U. Bruegmann,A. Mannes,D. Hallimals, marine organisms, and microorganisms as potential medicinal agents. This chapter of research is an effort to highlight the phytochemical/chemical constituents of an ancient medicinal plant . and their pharmacological importance. . is an old age medicinal plant that belongs to Leguminosae/Faba作者: faculty 時(shí)間: 2025-3-26 20:21 作者: ALLAY 時(shí)間: 2025-3-26 22:29 作者: antidote 時(shí)間: 2025-3-27 03:58 作者: 懸掛 時(shí)間: 2025-3-27 07:20
D. Brunner,J. Weisbord,N. Meshulam,S. Margulisw with the Massachusetts Teacher of the Year began with the question “Do you think kids are eating too much sugar?”. Her reply emphasized that she doesn’t allow candy because it makes children jumpy and hyperactive. This response is typical of many parents. Many families independently undertake diet作者: modish 時(shí)間: 2025-3-27 10:06 作者: 碳水化合物 時(shí)間: 2025-3-27 17:03 作者: chuckle 時(shí)間: 2025-3-27 18:08
Pharmacokinetics of Isosorbide Mononitrates in Human Subjectsundetectable levels [1]. Thus, isosorbide 5-mononitrate may make a major contribution to the “l(fā)ong-acting” antianginal activity of isosorbide dinitrate. This makes a study of the pharmacokinetics of isosorbide 5-mononitrate necessary.作者: 易于交談 時(shí)間: 2025-3-28 01:39
Effects of Acute and Chronic Administration of Isosorbide Dinitrate, Sustained-Release Form, in Patiaintained efficacy [1, 3, 9]. Apparently discrepant are the withdrawal symptoms, resulting from developed tolerance and observed in industrial workers chronically exposed to nitrates, the mechanism of which has been attributed to a resetting of vascular reactivity [7].作者: creditor 時(shí)間: 2025-3-28 02:14
Digital Pulse Plethysmography: a Sensitive Test of the Pharmacodynamics of Nitrates — Reproducibilittors of nitrate bioavailability. To study the feasibility of this method for application in pharmacologic investigations of nitrates we evaluated the reproducibility of measurements and dose-effect relationships with digital pulse plethysmography.作者: 不規(guī)則 時(shí)間: 2025-3-28 09:21
t that their favorable effects in angina pectoris were described by Brunton and by Murrell in the Lancet more than 100 years ago. As expected, a host of new information has been collected since the two previous symposia on nitrates held in Stockholm in 1975 and Berlin in 1978. New insights were gain作者: 消音器 時(shí)間: 2025-3-28 13:27 作者: 仔細(xì)閱讀 時(shí)間: 2025-3-28 14:42
Echocardiographic Assessment of Different Doses of Oral Isosorbide Dinitrate in Patients with and wihe investigations of possible tolerance with the corollary of increasing doses with time make it necessary to obtain reproducible, repetitive, and noninvasive methods of assessment of hemodynamic effects of nitrates.作者: Indebted 時(shí)間: 2025-3-28 19:45 作者: 致命 時(shí)間: 2025-3-28 23:55 作者: 截?cái)?nbsp; 時(shí)間: 2025-3-29 03:51
P. R. Lichtlen,H.-J. Engel,H. J. C. Swan (Director作者: 方舟 時(shí)間: 2025-3-29 10:32 作者: Cursory 時(shí)間: 2025-3-29 11:27
Pharmacokinetics — Pharmacodynamics and the Bioavailability of Organic Nitrate Drug Productsnse profiles that resemble blood level versus time curves. Often, several response variables versus time profiles can be resolved from the recording of a single signal such as evoked and spontaneous electroencephalography (EEG), electrocardiography (ECG), plethysmography, electroenterogastrography (作者: 確認(rèn) 時(shí)間: 2025-3-29 16:05 作者: Metastasis 時(shí)間: 2025-3-29 21:26 作者: EXULT 時(shí)間: 2025-3-30 02:12 作者: progestogen 時(shí)間: 2025-3-30 07:59 作者: 常到 時(shí)間: 2025-3-30 10:32 作者: HATCH 時(shí)間: 2025-3-30 13:00 作者: CHURL 時(shí)間: 2025-3-30 17:41 作者: OPINE 時(shí)間: 2025-3-30 22:40
A. H. Beckettntain a healthy weight. Consumers who want a sweet taste without added energy can choose from five FDA-approved non-nutritive sweeteners based on their personal taste preference and the intended use (e.g., for cooking or for tabletop use). Non-nutritive sweeteners, when substituted for nutritive swe作者: judicial 時(shí)間: 2025-3-31 03:44
P. R. Imhof,B. Ott,A. Weiss,L.-C. Chu,L. F. Chasseaud they first release into the systemic circulation as lactate and glucose. When these pathways become saturated, fructose is converted into fatty acids through de novo lipogenesis, and newly synthetized fatty acids are either secreted into the blood as very low density lipoproteins – triglycerides – 作者: 紅腫 時(shí)間: 2025-3-31 08:39 作者: Verify 時(shí)間: 2025-3-31 11:05
A. Distante,A. L’Abbate,C. Palombo,C. Michelassi,D. Rovai,M. A. Morales,F. Sabino,E. Moscarelli,M. Lt to accommodate for the computerized age. Today they are applied in Israel regarding any form of child nudity and child pornography. The Israeli law and jurisprudence do not define obscenity. Like the substantive law, Israeli procedural law is largely unimpressed by cyberspace. Some investigatory p作者: 揮舞 時(shí)間: 2025-3-31 14:38 作者: ADAGE 時(shí)間: 2025-3-31 18:28
