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標(biāo)題: Titlebook: New Trends in Pharmacokinetics; Aldo Rescigno,Ajit K. Thakur Book 1991 Plenum Press, New York 1991 drug.drug development.kinetics.metaboli [打印本頁]

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作者: 相容    時間: 2025-3-21 22:29
https://doi.org/10.1007/978-1-4684-8053-5drug; drug development; kinetics; metabolism; pharmacokinetics; pharmacology; receptor; research
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978-1-4684-8055-9Plenum Press, New York 1991
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作者: 巨大沒有    時間: 2025-3-22 15:39

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Implications of Stereoselectivity in Clinical Pharmacokinetics,e stereochemical pure due to the stereospecificity of biological synthesis. By contrast, most of the drugs with a chiral center produced by chemical synthesis are only available as racemates, since chemical synthesis usually leads to a racemate unless stereospecific synthesis is employed [Roth & Kleemann, 1982; Simonyi, 1984].
作者: Gossamer    時間: 2025-3-23 00:50
ooed and vulgar, he was to God’s messengers an unwelcome distraction from the serious tasks of building a mission and winning souls. ‘He came and staid for some time, but during our interview gave such specimens of depravity as excited a wish for him never more to come under our roof’, the missionar
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Alan J. Fischman,Robert H. Rubin,H. William Strausse victims’ torture (or “fire”) beyond death so that they remain an “abhorring unto all flesh,” unto the inhabitants of Gilead who have to witness both the process and aftermath of their violent deaths. Read against Isaiah 66:24, the Gileadean Wall realizes in dull but alarming technical detail the v
作者: HERTZ    時間: 2025-3-24 02:44
B. Mazière,M. Mazière,J. Delforge,A. Syrota from “after,” the interpretive stakes suddenly become higher. Taking Conant’s lead, we can now imagine Kafka in the space of utter ruin the responses to this moment represent—from the American campaign to spread democracy and “l(fā)iberation” to the attendant atrocities of terrorism and state-sanctione
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作者: 不成比例    時間: 2025-3-24 12:02
The Usefulness of Pharmacokinetics in the Development of Antineoplastic and Anti-Aids Agents, is the goal of this chapter to illustrate the successful use of pharmacokinetics in the development of two such therapeutic agents which have recently been introduced to the clinic as approved therapies: Carboplatin as an antineoplastic agent and Zidovudine as an anti-AIDS agent. Through these exam
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作者: Vital-Signs    時間: 2025-3-24 21:02
Pitfalls in Pharmacokinetic Modeling of Monoclonal Antibody Biodistribution in Man,80% on the average). In addition, one of the major advantages of this procedure has been shown to be the ability of detecting distant tumor lesions in about one-third of patients who are apparently “tumor-free” as classified by other, noninvasive diagnostic techniques; therefore, for some specific f
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D. Krewski,R. T. Burnett,W. Ross of students who might otherwise oppose learning about the contexts, lives, and predicaments of marginalized persons living in various intersections of gender, race, ethnicity, national origin, immigration stat978-3-031-31712-5978-3-031-31713-2Series ISSN 2195-3104 Series E-ISSN 2195-3112
作者: 泥沼    時間: 2025-3-25 18:56
the Friendly Islands. Within a short time of going ashore, the missionaries encountered the three Europeans known to be living in Tonga. Two were Irishmen, John Connelly and Morgan Bryan, while the third was an Englishman, Londoner Benjamin Ambler. Connolly and Ambler lived on Tongatapu, while Brya
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David E. Schaferdesert for forty years. In this tradition, the desert is a realm of enlarged spirit and liberating transformations. As the story begins, the tribe that descended to Egypt with Jacob is now a “swarming” (.) mass. “Fruitful and multiplying,” the descendants of Jacob are also fully assimilated to their
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Alan J. Fischman,Robert H. Rubin,H. William Strauss’s earlier promise of salvation for the faithful with a somber warning of the eternal punishment awaiting the rebellious. The second, an early passage from Margaret Atwood’s dystopian novel ., details one macabre function of the city wall encircling the Republic of Gilead, an authoritarian theocracy
作者: Comprise    時間: 2025-3-27 02:13
B. Mazière,M. Mazière,J. Delforge,A. Syrota. of a Kafka story,”. we as an audience are transplanted from Franz Kafka’s penal colony into the electoral college. The Harrow, the murderous instrument of a lost system of justice that destroys and is ultimately destroyed by the officer who mourns this lost system in Kafka’s story, becomes here th
作者: FLIRT    時間: 2025-3-27 07:37
Pharmacokinetics: Unfolding of a Concept,rman pediatrician, in his book “Der Blutspiegel” [Dost, 1953], but the concept had been around for a long time before that. The object of Pharmacokinetics is the study of absorption, distribution, and elimination of drugs; but, since the existence of Pharmacology, it has been known that drugs are ab
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The Usefulness of Pharmacokinetics in the Development of Antineoplastic and Anti-Aids Agents, cytotoxic agents such as antineoplastic drugs and antiviral agents directed against HIV (human immunodeficiency virus) the path is similar. Clinicians deliver and patients take experimental treatments with the hope of therapeutic benefit in the face of a life threatening illness. In most cases, the
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Imaging Techniques in Pharmacology,s of soil, or toxins. These drugs are “designed”, rather than “discovered.” Following identification of a likely compound in-vitro, careful studies are performed in animal models to determine the pharmacokinetics and pharmacodynamics of the drug. Once identified as safe and efficacious in animal tri
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Pitfalls in Pharmacokinetic Modeling of Monoclonal Antibody Biodistribution in Man,reasingly accepted as a routine diagnostic procedure, particularly for staging patients with cancer. In fact, even though the diagnostic potentials of immunoscintigraphy have been explored for diverse applications including cardiovascular diseases (for the detection of thrombi or of damaged myocardi
作者: 釘牢    時間: 2025-3-29 04:58
Interspecies Scaling in Pharmacokinetics,pharmacokinetics” signifies the prediction of . chemical disposition behavior in untested species from the experimental observations made in one or more species. Interspecies scaling of the pharmacokinetic processes (i.e., uptake, distribution and clearance) of chemicals can be performed by (1) allo
作者: 過去分詞    時間: 2025-3-29 09:32
Implications of Stereoselectivity in Clinical Pharmacokinetics,e stereochemical pure due to the stereospecificity of biological synthesis. By contrast, most of the drugs with a chiral center produced by chemical synthesis are only available as racemates, since chemical synthesis usually leads to a racemate unless stereospecific synthesis is employed [Roth & Kle
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Pharmacokinetics: Unfolding of a Concept,g the effects on the organism they are administered to. Pharmacokinetics as such can be therefore considered a new discipline only since more sophisticated methods have been introduced to study the kinetic properties of drugs. These quantitative methods have been offered by Analytical Chemistry, by Physical Chemistry, and by Applied Mathematics.
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作者: MERIT    時間: 2025-3-31 05:10
Statistical Foundations of Pharmacokinetic Modeling,are useful in describing the absorption, uptake, distribution, metabolism and elimination of xenobiotic agents, particularly with respect to temporal levels of the compound of interest in blood and other tissues.
作者: Cosmopolitan    時間: 2025-3-31 12:27
Trends in the Pharmacokinetics of Drug-Receptor Interactions,ke receptors [Kirk, Raven, and Schofield, 1983], and of the greatest mathematician up to the time of Isaac Newton, Archimedes of Syracusa (d. 212 BCE), who, unlike his predecessors, did not disdain to use approximate methods to achieve a practical result [Struik, 1987]
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