標題: Titlebook: New Therapeutic Targets in Rheumatoid Arthritis; Paul-Peter Tak Book 2009 Birkh?user Basel 2009 Arthritis.Chemokine.Drug Target.Interleuki [打印本頁] 作者: Sparkle 時間: 2025-3-21 20:01
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書目名稱New Therapeutic Targets in Rheumatoid Arthritis被引頻次
書目名稱New Therapeutic Targets in Rheumatoid Arthritis被引頻次學科排名
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書目名稱New Therapeutic Targets in Rheumatoid Arthritis年度引用學科排名
書目名稱New Therapeutic Targets in Rheumatoid Arthritis讀者反饋
書目名稱New Therapeutic Targets in Rheumatoid Arthritis讀者反饋學科排名
作者: 駕駛 時間: 2025-3-21 22:13
Yoshiyuki Ohsugi,Tadamitsu Kishimotoungen PRANDTLS, wenn er im damaligen Institut für Angewandte Mechanik am Leinekanal in G?ttingen immer und immer wieder Str?mungen im Wassertank beobachtete und dabei h?ufig genug Ort und Zeit verga?. Auch war es seine Art, sich von seinen überlegungen und Rechnungen- selbst den Zwischenrechnungen - Zeichnung978-3-662-01078-5978-3-662-01077-8作者: 形容詞 時間: 2025-3-22 03:50 作者: 苦澀 時間: 2025-3-22 07:08 作者: extinct 時間: 2025-3-22 10:18
Co-stimulatory pathways in the therapy of rheumatoid arthritis,on protein combining cytotoxic T lymphocyte antigen 4 (CTLA4) and a portion of the Fc domain of human IgG1, has been approved in the United States and the European Union for the treatment of RA. Abatacept may modulate the T cell or the APC to produce several different outcomes within the joint, incl作者: 最初 時間: 2025-3-22 16:07
,Immunobiology of IL-6 — Tocilizumab (humanised anti-IL-6 receptor antibody) for the treatment of rh this therapy has also proved quite effective at improving fever, fatigue and anaemia. No serious adverse events have been reported. At present, several international clinical studies of TCZ are ongoing in more than 4000 patients with active RA in 41 countries. The results are continuing to confirm 作者: 清洗 時間: 2025-3-22 19:08 作者: 免除責任 時間: 2025-3-22 22:31
Role of IL-18 in inflammatory diseases,ivities and has been shown to be safe in patients. Other options for reducing IL-18 activities are inhibitors of capsase-1, human monoclonal antibodies to IL-18, soluble IL-18 receptors and anti-IL-18 receptor monoclonal antibodies.作者: Precursor 時間: 2025-3-23 01:53
Chemokines and chemokine receptors,ptors. Today, most data in this field are obtained from experimental models of arthritis; however, results of some human trials have also become available. Thus, it is possible that a number of specific chemokine and chemokine receptor antagonists will be administered to arthritis patients in the ne作者: Occupation 時間: 2025-3-23 07:39
Targeting the epigenetic modifications of synovial cells, and infectious agents. So far, these factors have been studied almost exclusively as separate agents. However, gene transcription might be affected by ageing and environmental effects (such as nutrition and infections) — without changes in the nucleotide sequence of the underlying DNA. These patter作者: 鋪子 時間: 2025-3-23 09:55
Perspectives in targeted therapy,ombination with methotrexate, use in moderate rather than severe disease, tight control as well as induration and maintenance regimes. Despite therapeutic advances with target therapies a number of unmet needs exist, including a low remission rate, cost and inadequate access as well as the lack of b作者: 金絲雀 時間: 2025-3-23 15:30
Book 2009 inflammatory diseases. Anti-TNF treatment results in cli- cal benefit in a significant proportion of the patients, and it has provided proof of concept for the principle of targeted therapy. Despite the impressive disease-modifying effects of the TNF blockers, not all patients respond, and patients作者: 黃瓜 時間: 2025-3-23 21:49
1422-7746 oportion of the patients, and it has provided proof of concept for the principle of targeted therapy. Despite the impressive disease-modifying effects of the TNF blockers, not all patients respond, and patients978-3-7643-8238-4Series ISSN 1422-7746 Series E-ISSN 2296-4525 作者: jettison 時間: 2025-3-23 23:52 作者: palpitate 時間: 2025-3-24 03:58 作者: Albumin 時間: 2025-3-24 08:58 作者: chapel 時間: 2025-3-24 10:52 作者: Entreaty 時間: 2025-3-24 17:04 作者: 有特色 時間: 2025-3-24 20:36
B cell targets in rheumatoid arthritis,atients with RA using the first licensed agent, rituximab. Recent research has focused on enhancing efficacy using other targets to inhibit B cell function, including other B cell-depleting antibodies and cytokines critical to B cell function. The rationale for new B cell targets is discussed, as we作者: Isolate 時間: 2025-3-25 00:13
Co-stimulatory pathways in the therapy of rheumatoid arthritis, cell populations have not been clinically successful, largely due to the toxicity associated with nonspecific T cell depletion. An alternative approach involves targeting T cell activation, a process that requires two distinct signals. In addition to the cognate interaction between the T cell recep作者: 用肘 時間: 2025-3-25 05:04 作者: 冷淡周邊 時間: 2025-3-25 10:37 作者: LATER 時間: 2025-3-25 15:44
Interleukin-15, adaptive immune system. It binds to a heterotrimeric receptor consisting of the common γ-chain receptor, IL-15/IL-2 receptor β-chain and unique IL-15 receptor α-chain. IL-15 is expressed at the mRNA level in a variety of cell lineages and is expressed as protein as part of the rapid early inflammat作者: Leaven 時間: 2025-3-25 17:34
IL-17 and Th17 cells, key players in arthritis,rged as the best-studied situation to justify the selection of IL-17 as a therapeutic target. By interacting with other proinflammatory cytokines, IL-17 was found to induce bone and cartilage destruction. In 2006, the precise cell source of IL-17 was identified in the mouse. These cells were named T作者: 要塞 時間: 2025-3-25 23:50 作者: 巨大沒有 時間: 2025-3-26 01:03 作者: 創(chuàng)新 時間: 2025-3-26 06:30 作者: 預防注射 時間: 2025-3-26 11:27 作者: farewell 時間: 2025-3-26 13:57 作者: 招募 時間: 2025-3-26 17:17
Perspectives in targeted therapy,lity of animal models for development of targeted therapies, clinical trial design, pharmacodynamics, immunobiology and key pathogenic elements of disease. Studies of chimeric anti-CD4 monoclonal antibodies in RA demonstrated the need for pre-clinical studies to more closely approximate the human th作者: FANG 時間: 2025-3-26 23:29
B cell targets in rheumatoid arthritis,atients with RA using the first licensed agent, rituximab. Recent research has focused on enhancing efficacy using other targets to inhibit B cell function, including other B cell-depleting antibodies and cytokines critical to B cell function. The rationale for new B cell targets is discussed, as well as clinical data.作者: 易彎曲 時間: 2025-3-27 01:27 作者: 撤退 時間: 2025-3-27 06:10 作者: dithiolethione 時間: 2025-3-27 11:33 作者: 邪惡的你 時間: 2025-3-27 14:17
New Therapeutic Targets in Rheumatoid Arthritis978-3-7643-8238-4Series ISSN 1422-7746 Series E-ISSN 2296-4525 作者: Irritate 時間: 2025-3-27 19:14
Paul-Peter TakFocuses on therapeutic targets that have recently been registered or are currently under development..Each chapter discusses the biological rationale in great detail including results from clinical tr作者: 言外之意 時間: 2025-3-27 22:04
Role of IL-1 in erosive arthritis, lessons from animal models,e therapeutic target, in addition to TNF and IL-6. However, IL-1 dependency can be lost under conditions of T cell IL-17 abundance as well as the presence of Toll-like receptor ligands. The latter may underlie the variable responsiveness of rheumatoid arthritis patients to anti-cytokine therapy and warrants combination therapy for optimal control.作者: Fantasy 時間: 2025-3-28 03:42 作者: 僵硬 時間: 2025-3-28 09:48 作者: peritonitis 時間: 2025-3-28 10:41
IL-17 and Th17 cells, key players in arthritis, results previously obtained following the identification of IL-17 as a T cell-derived cytokine. At the same time, additional information was obtained on the other members of the IL-17 family and on the structure of the IL-17 receptor complex. Such knowledge has further extended the choice of possible modalities to control IL-17.作者: 刺耳 時間: 2025-3-28 15:02
Signaling pathways in rheumatoid arthritis,ytokines, proteases, growth factors and chemokines up to harmful levels, leading to an autodestructive process as seen in rheumatoid arthritis. Mapping the hierarchy of these pathways identifies which specific targets can be inhibited to safely reduce the levels of inflammatory molecules and reset the homeostasis of the organism.作者: 偏離 時間: 2025-3-28 22:47 作者: 吹牛需要藝術 時間: 2025-3-29 00:26
Stereotactic Body Radiation Therapy to Liver, other liver directed therapies, like radio frequency ablation or trans arterial chemoembolisation, have failed. In this chapter the evidence for SBRT in these indications is presented, and the complexities of radiotherapy planning and management of patients is discussed.作者: nostrum 時間: 2025-3-29 03:16
,Brückeninstandsetzung und Sanierung, type 2 diabetes and because macrovascular disease is the cause of death in most patients with type 2 as opposed to type 1 (insulinopenic) diabetes, type 2 diabetes will be the focus of our discussion.作者: 加強防衛(wèi) 時間: 2025-3-29 10:19
Yasushi Kawabatad, Orellana and part of the crew went searching for supplies on land. Finally, by the end of 1541, no longer able to proceed on land, they built a boat at the confluence of the Rio Napo and the Rio Aguárico and followed the river current. After sailing the unknown his boat reached the mouth of the r作者: CANT 時間: 2025-3-29 14:17 作者: Heresy 時間: 2025-3-29 18:02
Mohammad Kazem Haki,Christine Legnerlgorithms for optimization with continuous (not integer) variables. The discussion presents the underlying theory without always focusing on formal mathematical proofs978-1-4939-8379-7978-1-4939-7055-1Series ISSN 0884-8289 Series E-ISSN 2214-7934 作者: 狂熱語言 時間: 2025-3-29 20:59
,Messgr?ssen des Human Capital, ist, WAS und WOZU etwas gemessen werden soll. Diese Reihenfolge verhindert auch, dass man sich vorschnell auf Messgr?ssen beschr?nkt, die aus irgendeinem Grunde schon erhoben werden oder zu denen sehr einfach Daten erh?ltlich sind.作者: DEAWL 時間: 2025-3-30 03:25 作者: Compass 時間: 2025-3-30 04:47
Book 1983re workers are more educated now than ever before, and more and more people seem to look to work as a personal outlet, rather than just a source of income. We saw our small, egalitarian work organizations as providing settings in which people were especially likely to v vi PREFACE find work satisfyi
