標(biāo)題: Titlebook: New Targets in Inflammation; Inhibitors of COX-2 Nicolas Bazan,Jack Botting,John Vane Conference proceedings 1996 Springer Science+Busines [打印本頁(yè)] 作者: HARDY 時(shí)間: 2025-3-21 16:59
書(shū)目名稱New Targets in Inflammation影響因子(影響力)
書(shū)目名稱New Targets in Inflammation影響因子(影響力)學(xué)科排名
書(shū)目名稱New Targets in Inflammation網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱New Targets in Inflammation網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱New Targets in Inflammation被引頻次
書(shū)目名稱New Targets in Inflammation被引頻次學(xué)科排名
書(shū)目名稱New Targets in Inflammation年度引用
書(shū)目名稱New Targets in Inflammation年度引用學(xué)科排名
書(shū)目名稱New Targets in Inflammation讀者反饋
書(shū)目名稱New Targets in Inflammation讀者反饋學(xué)科排名
作者: 陳腐的人 時(shí)間: 2025-3-21 22:36 作者: stress-response 時(shí)間: 2025-3-22 02:26 作者: erythema 時(shí)間: 2025-3-22 06:36
Adhesion molecules as targets for therapy in rheumatoid arthritis,enules and mononuclear cells in the circulation, mediated by a variety of adhesion molecules, govern the entry of inflammatory cells into the tissues.. Interference with these interactions, therefore, might be effective in the therapy of RA.作者: Trabeculoplasty 時(shí)間: 2025-3-22 12:11 作者: Platelet 時(shí)間: 2025-3-22 15:54
atory group. In 1971 Vane pro- posed that both the beneficial and toxic actions of these drugs was through inhibition of prostaglandin synthesis. The recent discovery that prostaglandins responsible for pain and other symptoms at inflammatory foci are synthesized by an inducible cyclooxygenase (COX-作者: 帶子 時(shí)間: 2025-3-22 19:34
Cyclooxygenase-2 and intestinal cancer,exhibit chemoprotective effects as judged by a reduction in the frequency and number of premalignant and malignant lesions. Recently, Jacoby et al.. reported a decrease in tumour number in Min (multiple intestinal neoplasia) mice treated with piroxicam.作者: 等級(jí)的上升 時(shí)間: 2025-3-23 00:11 作者: granite 時(shí)間: 2025-3-23 05:10
Structure of prostaglandin H2 synthase-1 (COX-1) and its NSAID binding sites,c acid to form the intermediate PGG., and a peroxidase activity which reduces the hydroperoxide moiety of PGG. to the corresponding alcohol and produces PGH... This PGН. is acted upon by other enzymes to produce the final hormone product, which is secreted from the cell.作者: 鉗子 時(shí)間: 2025-3-23 07:54 作者: 無(wú)法治愈 時(shí)間: 2025-3-23 10:55 作者: biopsy 時(shí)間: 2025-3-23 16:38
Blockade of inflammatory hyperalgesia and cyclooxygenase-2,tentiates the intraplantar effect of IL-l. or carrageenan, suggesting that induction of COX-2 is a limiting process in the development of inflammatory hyperalgesia. Induction of COX-2 is typically inhibited by corticosteroids. In our system IL-1. -induced hyperalgesia is inhibited by dexamethasone t作者: 要控制 時(shí)間: 2025-3-23 18:23
Brain COX-2 in experimental models of epilepsy and stroke: signalling pathways leading to enhanced s. BN 50730, an intracellular PAF antagonist., blocks PAF-induced COX-2 expression. We therefore tested the effectiveness of BN 50730 in blocking induction of COX-2 mRNA and protein expression in vivo. The two models used were focal cerebral ischaemia using the suture model of middle cerebral artery作者: 薄荷醇 時(shí)間: 2025-3-23 23:14
New highly selective cyclooxygenase-2 inhibitors,ning the protein in the endoplasmic reticulum. The main significant difference between COX-2 and COX-1 is that COX-2 can be induced transiently over a >50-fold range by a variety of agents, including cytokines, phorbol esters, hormones, serum and lipopolysaccharide. This induction can be inhibited b作者: 群居男女 時(shí)間: 2025-3-24 05:15 作者: 先驅(qū) 時(shí)間: 2025-3-24 10:02
Clinical experience with meloxicam, a selective COX-2 inhibitor,e NSAIDs are selective for COX-1 or are equipotent against both COX-1 and COX-2. NSAIDs such as meloxicam, which are more selective for COX-2 than for COX-1, have been developed and are efficacious in the treatment of rheumatic disease. Drugs which are highly selective for COX-2 are presently being 作者: 陰謀小團(tuán)體 時(shí)間: 2025-3-24 13:16 作者: 不能平靜 時(shí)間: 2025-3-24 16:14 作者: epicardium 時(shí)間: 2025-3-24 22:02
in clinical trials gastric and renal toxicities are less. Highly selective COX-2 inhibitors, perhaps designed with knowledge of the crystal structures of COX-I and COX-2, are also available. Other experimental studies, including those in animals lacking effective genes for COX-lor COX-2 and in experimental c978-94-010-6265-7978-94-011-5386-7作者: macrophage 時(shí)間: 2025-3-25 00:28 作者: invulnerable 時(shí)間: 2025-3-25 06:25 作者: 高調(diào) 時(shí)間: 2025-3-25 10:44 作者: 逢迎春日 時(shí)間: 2025-3-25 14:14
M. Pairet,L. Churchill,G. Engelhardthe propagation of sexism and gender disadvantage in the academy, this important book will appeal to students and scholars of sexism in higher education as wellas all those committed to working towards gender e/quality.978-3-030-04852-5Series ISSN 2524-6445 Series E-ISSN 2524-6453 作者: 永久 時(shí)間: 2025-3-25 15:48 作者: Watemelon 時(shí)間: 2025-3-25 21:35
N. G. Bazan,V. M. Marcheselli,G. Allan,K. Van Meter,J. P. Moiseshe propagation of sexism and gender disadvantage in the academy, this important book will appeal to students and scholars of sexism in higher education as wellas all those committed to working towards gender e/quality.978-3-030-04852-5Series ISSN 2524-6445 Series E-ISSN 2524-6453 作者: 前奏曲 時(shí)間: 2025-3-26 03:08
M. F. Brownerh parts of the book. The authors have chosen to retain the legal and economic specifics in order to ensure usability in both areas. This book predominantly addr978-3-8349-2419-3978-3-8349-8692-4Series ISSN 2945-879X Series E-ISSN 2945-8803 作者: EXPEL 時(shí)間: 2025-3-26 06:26 作者: 確認(rèn) 時(shí)間: 2025-3-26 11:36 作者: 營(yíng)養(yǎng) 時(shí)間: 2025-3-26 12:42
S. G. Morham,R. Langenbach to consumers. This is the case in general and within telecommunications. Economically, broadband can be considered from two perspectives: The perspective of public good (where a specific level of area-wide broadband access is guaranteed to each citizen by the state) and the competition-based perspe作者: 散開(kāi) 時(shí)間: 2025-3-26 20:26 作者: 使成核 時(shí)間: 2025-3-27 00:24
H. Fenner to consumers. This is the case in general and within telecommunications. Economically, broadband can be considered from two perspectives: The perspective of public good (where a specific level of area-wide broadband access is guaranteed to each citizen by the state) and the competition-based perspe作者: coagulation 時(shí)間: 2025-3-27 01:52
W. Boltenn of . those steps were followed. Teachers’ reports also signalled that such focus on ‘doing’ was predominantly shaped in the form of comprehension tasks, as the following excerpt summarises: ‘I would incorporate it [listening] into a lesson, a topic area that I’m doing and then perhaps do a blank f作者: 殺蟲(chóng)劑 時(shí)間: 2025-3-27 07:09 作者: 聯(lián)邦 時(shí)間: 2025-3-27 11:50
R. N. Dubois,A. Radhika,J. Shao,M. Tsujii,H. Sheng,O. Kobyashi,R. D. Beauchamp,C. S. Williamsn of . those steps were followed. Teachers’ reports also signalled that such focus on ‘doing’ was predominantly shaped in the form of comprehension tasks, as the following excerpt summarises: ‘I would incorporate it [listening] into a lesson, a topic area that I’m doing and then perhaps do a blank f作者: JOT 時(shí)間: 2025-3-27 15:59
P. A. Wardn of . those steps were followed. Teachers’ reports also signalled that such focus on ‘doing’ was predominantly shaped in the form of comprehension tasks, as the following excerpt summarises: ‘I would incorporate it [listening] into a lesson, a topic area that I’m doing and then perhaps do a blank f作者: 初次登臺(tái) 時(shí)間: 2025-3-27 21:41
P. E. Lipsky,A. F. Kavanaugh,H. Schulze-Koops,L. S. Davisn of . those steps were followed. Teachers’ reports also signalled that such focus on ‘doing’ was predominantly shaped in the form of comprehension tasks, as the following excerpt summarises: ‘I would incorporate it [listening] into a lesson, a topic area that I’m doing and then perhaps do a blank f作者: 易于 時(shí)間: 2025-3-28 00:38 作者: CULP 時(shí)間: 2025-3-28 03:23 作者: 難聽(tīng)的聲音 時(shí)間: 2025-3-28 08:20
Differential target tissue presentation and COX-2/COX-1 inhibition by non-steroid anti-inflammatory influenced by a lack of reliable scientific data on individual agents with respect to gastrointestinal (GI) tolerability or detrimental effects on cartilage metabolism. This has led to a number of unsubstantiated marketing claims about NSAIDs.作者: 燈絲 時(shí)間: 2025-3-28 11:23 作者: 心痛 時(shí)間: 2025-3-28 16:28
https://doi.org/10.1007/978-94-011-5386-7Prostaglandin; cancer; cytokine; inflammation; research作者: 厭食癥 時(shí)間: 2025-3-28 19:26
The history of anti-inflammatory drugs and their mechanism of action, salicylates are constituents of several plants long used as medicaments. About 3500 years ago the Egyptian Ebers papyrus recommended the application of a decoction of the dried leaves of myrtle to the abdomen and back to expel rheumatic pains from the womb. A thousand years later Hippocrates recomm作者: 健忘癥 時(shí)間: 2025-3-28 23:12 作者: 外貌 時(shí)間: 2025-3-29 06:35
Differential inhibition of cyclooxygenases 1 and 2 by NSAIDs,onstration that inhibition of prostanoid synthesis through cyclooxygenase blockade is the mechanism of action of aspirin and related NSAIDs., it had been widely accepted that a common mechanism of action can explain both therapeutic and side effects of NSAIDs (Figure 1). The discovery of two isoform作者: 壓艙物 時(shí)間: 2025-3-29 09:47 作者: 使迷惑 時(shí)間: 2025-3-29 12:32
Brain COX-2 in experimental models of epilepsy and stroke: signalling pathways leading to enhanced ucts such as arachidonic acid., diacylglycerols. and platelet-activating factor (PAF)., increased glutamate release, and elevation of intracellular free calcium levels. Phospholipase activation and the release of bioactive lipids from membrane phospholipid pools represent part of an intrinsic neural作者: 倔強(qiáng)一點(diǎn) 時(shí)間: 2025-3-29 19:32
New highly selective cyclooxygenase-2 inhibitors,yme) and COX-2 (inducible enzyme).. COX-1 has been cloned from a number of sources including mouse, man and sheep.. COX-2 was originally identified as a v-.-inducible gene product in chicken fibroblasts and as a phorbol ester-inducible early gene product in murine 3T3 cells.. These proteins were rec作者: pus840 時(shí)間: 2025-3-29 20:39 作者: d-limonene 時(shí)間: 2025-3-30 02:00
X-ray crystal structure of human cyclooxygenase-2, through inhibition of the enzyme prostaglandin H synthase., also referred to as cyclooxygenase (COX). The discovery of an inducible COX enzyme (COX-2), distinct from the constitutively expressed enzyme (COX-1)., has led to the suggestion that a new generation of safer NSAIDs may be developed in the作者: 規(guī)章 時(shí)間: 2025-3-30 06:00 作者: ARK 時(shí)間: 2025-3-30 12:15
Expression and regulation of cyclooxygenase-2 in synovial tissues of arthritic patients,istic histopathological changes include infiltration of synovial tissues with mononuclear inflammatory cells, marked proliferation of synovial lining cells and sub-lining fibroblast-like cells and genesis of new supporting blood vessels. Inflammation of synovial tissue causes pain and swelling of jo作者: 強(qiáng)制令 時(shí)間: 2025-3-30 13:05 作者: Dri727 時(shí)間: 2025-3-30 18:47 作者: 盤(pán)旋 時(shí)間: 2025-3-30 21:43
Enzymatic regulation of the prostaglandin response in a human model of inflammation, to as cyclooxygenase (COX), is a bisfunctional protein, which catalyses the first committed step in the formation of PG and thromboxanes by the sequential cyclooxygenation and peroxidation of arachidonic acid (AA) to PGH... PGH. is then converted to specific PGs by distinct cell specific synthases 作者: 歡騰 時(shí)間: 2025-3-31 02:41 作者: 舔食 時(shí)間: 2025-3-31 07:09 作者: 奇思怪想 時(shí)間: 2025-3-31 11:05 作者: EXALT 時(shí)間: 2025-3-31 15:58
icient simulation using RQMC is to structure problems toreveal a small set of important variables, their number being theeffective dimension, while the other variables collectively arerelatively insignificant. Another is smoothing. The book provides manyillustrations of both keys, in particular for 作者: 骯臟 時(shí)間: 2025-3-31 20:24 作者: intolerance 時(shí)間: 2025-3-31 22:19
P. J. Lolle tools for resistance that can be deployed by individuals aThis book harnesses the expertise of women academics who have constructed innovative approaches to challenging existing sexual disadvantage in the academy. Countering the prevailing postfeminist discourse, the contributors to this volume ar
