作者: 圓錐體 時間: 2025-3-21 20:25
Molecular Microfluorometry: Converting Arbitrary Fluorescence Units into Absolute Molecular Concentrapid and efficient, and at synapses it helps terminate signaling. Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na. flux to uphill transmitter flux. NETs, for example, attenuate signaling at adrenergic synapses by efficie作者: wall-stress 時間: 2025-3-22 01:08
Structure/Function Relationships in Serotonin Transporter: New Insights from the Structure of a Bacget for important therapeutic drugs and psychostimulants. SERT catalyzes the influx of 5-HT together with Na. and Cl. in a 1:1:1 stoichiometry. In the same catalytic cycle, there is coupled efflux of one K. ion. SERT is one member of a large family of amino acid and amine transporters that is believ作者: hemoglobin 時間: 2025-3-22 05:51 作者: 背帶 時間: 2025-3-22 11:16
Currents in Neurotransmitter Transporters,ned with three distantly related transporters have also been interpreted as supportive of this model, because conformational correlates were visualized (inward-facing conformation, occluded state). However, the experimental evidence is overwhelmingly in favour of a more complex mode of operation: Tr作者: bypass 時間: 2025-3-22 13:38 作者: aesthetician 時間: 2025-3-22 19:38
The Diverse Roles of Vesicular Glutamate Transporter 3,ase glutamate by exocytosis. However, several cell populations (serotonin and dopamine neurons) have been demonstrated to release glutamate in vitro and do not obviously express these transporters. Rather, these neurons express a novel, third isoform that in fact appears confined to neurons generall作者: 周興旺 時間: 2025-3-22 21:28 作者: unstable-angina 時間: 2025-3-23 04:41 作者: BARK 時間: 2025-3-23 05:58 作者: 廢除 時間: 2025-3-23 11:42
The Dopamine Transporter: A Vigilant Border Control for Psychostimulant Action,ral properties of psychostimulants for nearly three decades. The primary means by which dopamine transmission in the synapse is terminated is via the dopamine transporter (DAT), the presynaptic plasmalemmal protein that is responsible for the reuptake of released dopamine. Numerous abused as well as作者: kyphoplasty 時間: 2025-3-23 14:48
Oligomerization of Neurotransmitter Transporters: A Ticket from the Endoplasmic Reticulum to the Pls from the synaptic cleft, these transporters terminate signalling and affect duration and intensity of neurotransmission. Thus, a lot of work has been invested in the determination of the cellular compartment to which neurotransmitter transporters localize. In particular, the polarized distribution作者: 首創(chuàng)精神 時間: 2025-3-23 19:07 作者: 健忘癥 時間: 2025-3-23 22:34 作者: Detonate 時間: 2025-3-24 03:58
Regulation of Vesicular Monoamine and Glutamate Transporters by Vesicle-Associated Trimeric G Proteterminals or in secretory vesicles by the activity of specific transporters of the plasma and the vesicular membrane, respectively. In the central nervous system the postsynaptic response depends—amongst other parameters—on the amount of neurotransmitter stored in a given vesicle. Neurotransmitter p作者: NATAL 時間: 2025-3-24 08:27
Human Genetics and Pharmacology of Neurotransmitter Transporters,redby transporters into presynaptic neurons, a major mode of their inactivation in the brain. Genetic studies of human biogenic amine transporter genes, including the dopamine transporter (hDAT; .), the serotonin transporter (hSERT; .), and the norepinephrine transporter (hNET; .) have provided insi作者: 一再困擾 時間: 2025-3-24 11:25
ADHD and the Dopamine Transporter: Are There Reasons to Pay Attention?,. The presynaptic DA transporter (DAT) inactivates DA following release and provides a route for non-exocytotic DA release (efflux) triggered by amphetamines. The synaptic role of DATs first established through antagonist studies and more recently validated through mouse gene-knockout experiments, r作者: 自戀 時間: 2025-3-24 17:18
Inactivation of 5HT Transport in Mice: Modeling Altered 5HT Homeostasis Implicated in Emotional Dys of human behavioral and psychiatric disorders but are also fundamental in the development novel therapeutic strategies. As an example, inactivation of the serotonin (5HT) transporter (.) gene in mice expanded our view of adaptive 5HT uptake regulation and maintenance of 5HT homeostasis in the devel作者: LEERY 時間: 2025-3-24 20:27 作者: CRUE 時間: 2025-3-25 00:18 作者: 死貓他燒焦 時間: 2025-3-25 04:33 作者: 雪崩 時間: 2025-3-25 10:51 作者: 愛好 時間: 2025-3-25 13:11 作者: 畸形 時間: 2025-3-25 17:59
Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/n/image/664577.jpg作者: Palpate 時間: 2025-3-25 21:23 作者: 文件夾 時間: 2025-3-26 02:14 作者: pester 時間: 2025-3-26 06:09 作者: Water-Brash 時間: 2025-3-26 09:21
Zn2+ Modulation of Neurotransmitter Transporters,d to be an important tool for studying the molecular function of these proteins. We also interpret the current available data on Zn.-binding sites in the context of the recently published crystal structures. Moreover, we review how the identification of endogenous Zn.-binding sites has indirectly su作者: anatomical 時間: 2025-3-26 14:33
Molecular Microfluorometry: Converting Arbitrary Fluorescence Units into Absolute Molecular Concent with transporters, largely because the techniques that have been successful in discovering transporter agonists and antagonists do not yield detailed kinetic information. Mechanistic data are for the most part restricted to global parameters, such as . . and . ., measured from large populations of 作者: Additive 時間: 2025-3-26 20:25
,The Importance of Company: Na+ and Cl? Influence Substrate Interaction with SLC6 Transporters and Ovity. Coordination of ions can involve a number of residues, and portions of the substrate and coupling ion binding sites can be distal in space in the tertiary structure of the transporter, with other portions that are close in space thought to be crucial for the coupling process. The reactivity wi作者: 懸崖 時間: 2025-3-27 00:59
Extraneuronal Monoamine Transporter and Organic Cation Transporters 1 and 2: A Review of Transport nsport very many compounds. However, our knowledge about actual substrates is rather limited. 1-Methyl-4-phenylpyridinium (MPP.) is an excellent substrate for all three carriers, with clearances typically in the range of 20-50 μl min. mg protein.. The secondbest general substrate is tyramine with a 作者: 向下 時間: 2025-3-27 02:49 作者: 美麗的寫 時間: 2025-3-27 08:16 作者: savage 時間: 2025-3-27 09:38
The Dopamine Transporter: A Vigilant Border Control for Psychostimulant Action,rs, share several characteristics with classical ligand-gated ion channels. In addition, substrates for transport promote redistribution of DAT away from the plasma membrane, while transport inhibitors such as cocaine disrupt this process. In addition, presynaptic autoreceptors for dopamine have bee作者: Enervate 時間: 2025-3-27 14:48
Oligomerization of Neurotransmitter Transporters: A Ticket from the Endoplasmic Reticulum to the Plthe coatomer coat proteins that are needed for ER-to-Golgi trafficking. In this review, we will start with a brief description on transporter oligomerization that underlies ER-to-Golgi trafficking, followed by an introduction to ER-to-Golgi trafficking of neurotransmitter transporters. Finally, we w作者: 繼而發(fā)生 時間: 2025-3-27 18:03
Acute Regulation of Sodium-Dependent Glutamate Transporters: A Focus on Constitutive and Regulated stead, glutamate is cleared by a family of Na.-dependent transport systems that are found on glial processes that sheath the synapse and found on the pre- and postsynaptic elements of neurons. These transporters ensure crisp excitatory transmission by maintaining synaptic concentrations below those 作者: Irrigate 時間: 2025-3-27 23:15
Regulation and Dysregulation of Glutamate Transporters,sms of a number of neurodegenerative diseases. A dysfunction of the glutamate transporter is thought to contribute to cell death during excitotoxicity. Therefore, efforts have been made to understand the regulation of glutamate transporter function. Transporter activity can be regulated in different作者: Sleep-Paralysis 時間: 2025-3-28 02:26 作者: Watemelon 時間: 2025-3-28 09:06
Human Genetics and Pharmacology of Neurotransmitter Transporters,bute to individual differences in behavior and neuropsychiatric disorders. This chapter summarizes current knowledge of transporters with a focus on genomic variations, expression variations, pharmacology of protein variants, and known association with human diseases.作者: neolith 時間: 2025-3-28 12:17 作者: 上下倒置 時間: 2025-3-28 17:09
Inactivation of 5HT Transport in Mice: Modeling Altered 5HT Homeostasis Implicated in Emotional Dysctions in the rodent, nonhuman primate, and human brain during critical periods of development and adult life, more in-depth knowledge of the molecular mechanisms implicated in these fine-tuning processes is currently evolving. Moreover, demonstration of a joint influence of the . variation and envi作者: 媒介 時間: 2025-3-28 19:35
Lessons from the Knocked-Out Glycine Transporters,an diseases, glycine encephalopathy and hyperekplexia. Selective GlyT inhibitors have been shown to modulate neurotransmission and might constitute promising therapeutic tools for the treatment of psychiatric and neurological disorders such as schizophrenia and pain. Therefore, pharmacological and g作者: 拖債 時間: 2025-3-29 01:05
Structure/Function Relationships in Serotonin Transporter: New Insights from the Structure of a Bacansporters. In light of the new structure, previous results with SERT have been re-interpreted, providing new insight into the substrate binding site, the permeation pathway, and the conformational changes that occur during the transport cycle.作者: DUST 時間: 2025-3-29 05:43 作者: Tonometry 時間: 2025-3-29 09:10 作者: comely 時間: 2025-3-29 14:22 作者: Ceremony 時間: 2025-3-29 17:49 作者: 護身符 時間: 2025-3-29 22:54 作者: blight 時間: 2025-3-30 03:23 作者: 溫室 時間: 2025-3-30 04:40
Formation of jets in extragalactic radio sources,speed, density, magnetic fields, collimation) must be related in a way to the properties of the very central object and its accretion disk. Early models of jet formation were based on pure hydrodynamic acceleration in the funnels of geometrically thick tori. For sub-Eddington luminosities such flows作者: 秘密會議 時間: 2025-3-30 11:00
Avoiding Full Extension Field Arithmetic in Pairing Computationse complexity of operations in . dominates the complexity of the operations that occur in the lower degree subfields. Consequently, full extension field operations have the greatest effect on the runtime of Miller’s algorithm. Many recent optimizations in the literature have focussed on improving the作者: 感激小女 時間: 2025-3-30 13:39 作者: NIP 時間: 2025-3-30 17:54 作者: Perineum 時間: 2025-3-30 21:51
Magneto-Optic Drive Systems,m noise from the laser, the media, and the electronics, and these additive noise sources will be summarised in a later chapter. Eight commercial 130mm drives will be compared in terms of capacity, data transfer rate, average access time, and disk rotation speed.作者: 斜 時間: 2025-3-31 01:06
Classification and Forecastingnting any nonlinear functions. The decision tree technique is appropriate for the solution of classification problems. The artificial neural network method is suitable for the solution of both classification and forecasting problems.作者: ALB 時間: 2025-3-31 07:57
G. A. Di Carlo,Pietro Boccardo,V. Fissoreeren, wo sein Eingreifen nicht unentbehrlich erscheinen, ja sogar als eine Verdoppelung der T?tigkeit der Ministerien und der Gesamtheit der Hochschulinstitutionen angesehen werden konnte? Wenn man eine Me?zahl für die Dynamik des bilateralen Hochschulaustauschs geben will, kann man darauf hinweisen作者: 強制性 時間: 2025-3-31 10:01 作者: anachronistic 時間: 2025-3-31 14:50
Mineral Nutrition of Forest Trees: A Regional Surveyypotheses to account for needle loss have included water stress (Ulrich 1981), fungal attack (Rehfuess and Rodenkirchen 1984) and frost damage (Rehfuess and Bosch 1986; Friedlanda et al. 1984), all of which may be influenced by the K nutrition of trees. In addition, Klein (1981) has shown that the r作者: 一大群 時間: 2025-3-31 21:28 作者: blackout 時間: 2025-4-1 00:37 作者: 我沒有強迫 時間: 2025-4-1 03:13 作者: 鳥籠 時間: 2025-4-1 09:39
2192-1091 Bio-Magnesium.Serves as an inclusive resource for Magnesium .Magnesium Biomaterials?provides a succinct up-to-date overview of Magnesium biomaterial development, critically examines the types of in vitro experiments that may be performed, and investigates the numerous variables that affect Magnesium
