作者: Costume 時(shí)間: 2025-3-21 21:57
Daniela Galimberti,Elio ScarpiniIncludes four new chapters on recent developments.Translational (from bench to bedside) approach.Covers neurodegeneration in classically non-degenerative disorders作者: 哄騙 時(shí)間: 2025-3-22 00:44 作者: 半圓鑿 時(shí)間: 2025-3-22 05:04
https://doi.org/10.1007/978-3-319-72938-1Alzheimer‘s; Amyotrophic Lateral Sclerosis; Frontotemporal Lobar Degeneration; dementia; neurodegenerati作者: 大雨 時(shí)間: 2025-3-22 10:24 作者: inscribe 時(shí)間: 2025-3-22 16:28 作者: 閃光東本 時(shí)間: 2025-3-22 20:09 作者: 使更活躍 時(shí)間: 2025-3-22 21:12 作者: 有斑點(diǎn) 時(shí)間: 2025-3-23 04:43 作者: amygdala 時(shí)間: 2025-3-23 06:45 作者: Estimable 時(shí)間: 2025-3-23 10:40
Giulia Grande M.D.,Davide L. Vetrano M.D.,Francesca Mangialasche M.D., Ph.D.ive L?sungen der Wirtschafts- und Sozialpolitik erforderlich, die an einen Wachstumsbegriff anknüpfen, der durch ein nachhaltiges Wachstum gekennzeichnet ist und diesbezüglich sozial?konomisch gestaltet werden kann. Die kritische Auseinandersetzung über ?konomische Leitbilder und Idealkonstruktionen作者: 閑聊 時(shí)間: 2025-3-23 15:43 作者: 斗爭 時(shí)間: 2025-3-23 19:39 作者: recede 時(shí)間: 2025-3-23 23:42 作者: 艱苦地移動(dòng) 時(shí)間: 2025-3-24 03:53
L. Bonanni,R. Franciotti,S. Delli Pizzi,A. Thomas,M. OnofrjMagnoliaceae, and Lauraceae. To date about 8000 compounds have been reported. They consist of a C15 backbone with numerous modifications resulting in a variety of structures but with the common feature of a γ-lactone ring. They are classified in four major groups: germacranolides, eudesmanolides, gu作者: CHASM 時(shí)間: 2025-3-24 08:43 作者: inveigh 時(shí)間: 2025-3-24 12:30 作者: 填滿 時(shí)間: 2025-3-24 16:24
Vanessa Carvalho,Carlota Vicente Cunha,Jo?o MassanoMagnoliaceae, and Lauraceae. To date about 8000 compounds have been reported. They consist of a C15 backbone with numerous modifications resulting in a variety of structures but with the common feature of a γ-lactone ring. They are classified in four major groups: germacranolides, eudesmanolides, gu作者: 外科醫(yī)生 時(shí)間: 2025-3-24 22:55 作者: 多嘴多舌 時(shí)間: 2025-3-25 02:50 作者: CREEK 時(shí)間: 2025-3-25 07:22
Genetics and Epigenetics in the Neurodegenerative Disorders of the Central Nervous System,y an insidious onset during adulthood, after which they progress at different rates, ultimately leading to severe physical disability or death. The symptoms are often common among the different disorders: dementia is not only peculiar of Alzheimer’s disease (AD) or frontotemporal dementia (FTD), but作者: WAX 時(shí)間: 2025-3-25 08:27 作者: 復(fù)習(xí) 時(shí)間: 2025-3-25 14:45
,Genetic Complexity of Early-Onset Alzheimer’s Disease,Alzheimer’s disease (AD), the most prevalent form of dementia, is important to manage the challenges of aging populations. So far, genetic analyses of families with autosomal dominant AD, presenting with early-onset dementia (<65?years of age), have found three causal genes: ., ., and .. Genetics is作者: GIBE 時(shí)間: 2025-3-25 17:09
,Genetic Risk Factors for Complex Forms of Alzheimer’s Disease,heritance. In fact, these forms of AD result from a combination of genetic and environmental factors, with the estimated heritability ranging from 58 to 79%. This chapter reviews the large body of research on genetic risk factors in AD. Linkage analyses and candidate gene association studies have no作者: 勛章 時(shí)間: 2025-3-25 19:59 作者: Cumbersome 時(shí)間: 2025-3-26 02:20
,Risk Factors and Prevention in Alzheimer’s Disease and Dementia,nces at both individual and societal levels. Since so far no effective curative drugs have been found, the identification of modifiable factors to reduce the risk of cognitive decline remains a public health priority. Up to one-third of AD cases worldwide can be attributable to the presence of seven作者: Eeg332 時(shí)間: 2025-3-26 05:28
Diagnosis of Frontotemporal Dementia, frontotemporal dementia (bvFTD), associated with behavioural and executive deficits; non-fluent variant primary progressive aphasia (nfPPA), with progressive deficits in speech, grammar, and word output; and semantic variant primary progressive aphasia (svPPA), which is a progressive disorder of se作者: 投射 時(shí)間: 2025-3-26 09:29 作者: 遭受 時(shí)間: 2025-3-26 12:37 作者: 牙齒 時(shí)間: 2025-3-26 18:19
,Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models,c and knockout mice have contributed to understanding neurodegenerative processes in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). While initial models for AD and FTLD based on mutations in APP and tau have been generated more than a decade ago, identification of novel genes作者: 遷移 時(shí)間: 2025-3-27 00:42 作者: 進(jìn)入 時(shí)間: 2025-3-27 01:37
,Biomarkers for Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Imaging,ng, structural and functional information on the brain tissue damage contributes to define the diagnosis of the major forms of dementia since their early clinical stages. From the research side, quantitative neuroimaging techniques have contributed in clarifying some critical pathophysiological aspe作者: 顯而易見 時(shí)間: 2025-3-27 05:49
Genotypic and Phenotypic Heterogeneity in Amyotrophic Lateral Sclerosis,. Although genetic studies have partially elucidated the genetic background of the disease, a large part of ALS heritability is still missing. In this chapter, we discuss the major genes implicated in the pathogenesis of motor neuron diseases; the clinical, pathological, and genetic links between AL作者: STYX 時(shí)間: 2025-3-27 11:45
Lewy Body Dementia,h Lewy bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade. The revised DLB consensus criteria now distinguish clearly between clinical features and diagnostic b作者: 條約 時(shí)間: 2025-3-27 17:04 作者: 攀登 時(shí)間: 2025-3-27 19:22
Neurodevelopmental and Neurodegenerative Alterations in the Pathophysiology of Schizophrenia: Focusrespect to the etiology of schizophrenia, as for other major psychoses, the gene–environment interaction seems to be the most accredited model. In particular, alterations in the immune system have been repeatedly reported, involving both the unspecific and specific pathways of the immune system and 作者: Arresting 時(shí)間: 2025-3-28 00:28
,Parkinson’s Disease: Contemporary Concepts and Clinical Management,veral risk and protective factors have been recently identified, providing potential for the research and implementation of preventive strategies. Although most cases remain sporadic, various monogenic forms of PD have been described, including autosomal dominant (e.g., LRRK2, SNCA, VPS35, EIF4G1, C作者: inspiration 時(shí)間: 2025-3-28 02:50
Neurodegeneration and Multiple Sclerosis,disabilities from cognitive decline, behavioral and mood disorders to problems with movement, co-ordination, and sensory dysfunction. Neurodegeneration is a major and growing public health issue which in its broadest sense embraces classical neurodegenerative disorders such as Alzheimer’s disease an作者: Trabeculoplasty 時(shí)間: 2025-3-28 07:13
Diagnosis of Frontotemporal Dementia, dementia. Advances in clinical, imaging, and molecular characterisation have increased the accuracy of the diagnosis of frontotemporal dementia. Updated diagnostic criteria have been developed and are now widely used. Recognition and accurate diagnoses of FTD subtypes will aid the neurologist in the management of patients.作者: admission 時(shí)間: 2025-3-28 14:20 作者: 連鎖,連串 時(shí)間: 2025-3-28 18:33
,Genetic Complexity of Early-Onset Alzheimer’s Disease,ia. We provide an overview for the molecular genetic findings available for early-onset AD; discuss how this knowledge can be applied in clinical practice and highlight strategies to detect novel AD genes.作者: 大喘氣 時(shí)間: 2025-3-28 21:47 作者: isotope 時(shí)間: 2025-3-29 00:15
,Risk Factors and Prevention in Alzheimer’s Disease and Dementia, and healthy lifestyles. In this chapter, we summarize the major findings concerning risk and protective factors for dementia and AD, based on current epidemiological evidence from observational and interventional studies. We also discuss the impact of ongoing interventional studies testing the effect of preventive measures for dementia and AD.作者: pancreas 時(shí)間: 2025-3-29 03:25
Autosomal Dominant Frontotemporal Lobar Degeneration: From Genotype to Phenotype,nd age at disease onset. In addition, other genes are linked to rare cases of familial FTLD. Moreover, the use of next-generation sequencing approach allowed the identification of disease modifier (risk) genes such as common variants in the transmembrane protein 106b.作者: 最后一個(gè) 時(shí)間: 2025-3-29 10:45 作者: 小口啜飲 時(shí)間: 2025-3-29 14:34 作者: effrontery 時(shí)間: 2025-3-29 19:20
Rare Dementias,a great importance, since some of them are treatable and reversible dementias..This chapter presents a comprehensive summary of etiologies, clinical presentation, typical features, diagnostic strategies, and treatments of known uncommon dementias.作者: 教唆 時(shí)間: 2025-3-29 19:43 作者: 哭得清醒了 時(shí)間: 2025-3-30 02:38
,Diagnosis of Alzheimer’s Disease Typical and Atypical Forms,tion, are currently implemented by the use of biomarkers and neuroimaging data. Moreover, the possibility of atypical forms, presenting with the involvement of different cortical areas, is taken into consideration..Herein, the main diagnostic tools for AD are revised; atypical AD presentations and possible diagnostic pitfalls are also discussed.作者: 啤酒 時(shí)間: 2025-3-30 05:17
,Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models, involved in disease has markedly increased the spectrum of available FTLD mouse models. This chapter provides an overview of APP and tau-based mouse models of AD and FTLD and how these models have advanced our understanding of disease mechanisms as well as discusses more recent FTLD models of novel disease genes.作者: BROOK 時(shí)間: 2025-3-30 08:38 作者: flex336 時(shí)間: 2025-3-30 14:06
Neurodegeneration and Multiple Sclerosis,d Parkinson’s disease, as well as multiple sclerosis (MS), diabetes, and acute brain injury among many other conditions. This chapter discusses the clinical and pathophysiological features of neurodegeneration in MS.作者: 的是兄弟 時(shí)間: 2025-3-30 17:32
Genetics and Epigenetics in the Neurodegenerative Disorders of the Central Nervous System,will offer the biomedical sciences new insight for the study of neurodegenerative diseases, multifactorial complex, and rare diseases. In this chapter, an overview of the current genetic and epigenetic progresses in AD, FTD, PD, and ALS, reached by the application of the new genetic technologies, wi作者: 影響深遠(yuǎn) 時(shí)間: 2025-3-30 23:11 作者: 變形 時(shí)間: 2025-3-31 03:07
Genetic Risk Factors for Sporadic Frontotemporal Dementia,tive strategy is to perform genome-wide association studies (GWAS) to highlight risk-loci. These then need to be further genetically and functionally characterize through, for example, targeted re-sequencing and expression quantitative trait loci (eQTL), to name a few methods..This chapter focuses o作者: AV-node 時(shí)間: 2025-3-31 05:41
,Fluid Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia,rliest stages of neurodegenerative diseases, better biomarkers for distinct proteinopathies, and the creation of universally accepted guidelines specifying the role of fluid biomarkers in relation to clinical measures and neuroimaging findings.作者: hieroglyphic 時(shí)間: 2025-3-31 12:09
Neurodevelopmental and Neurodegenerative Alterations in the Pathophysiology of Schizophrenia: Focusdentify the roots of the disorder during brain development, with consequences that do not become clinically evident until adolescence or early adulthood. On the other hand, longitudinal cohort studies on schizophrenic patients demonstrated a progressive loss of grey matter, more evident in the front
