作者: 我要沮喪 時(shí)間: 2025-3-21 22:14
Neurodegenerative Diseases978-3-319-57193-5Series ISSN 2190-5215 Series E-ISSN 2190-5223 作者: 構(gòu)成 時(shí)間: 2025-3-22 00:28
Clinical Aspects of Alzheimer’s Diseaseimer’s disease and provides an overview of the clinical syndromes associated with Alzheimer pathology and their associated neuroimaging findings. This chapter also reviews the neuropathology and genetics of Alzheimer’s disease and concludes by discussing current work undertaken to identify suitable in vivo biomarkers for the disease.作者: cravat 時(shí)間: 2025-3-22 07:23
Philip Beart,Michael Robinson,Nicholas J. MaragakiDiscusses molecular and cellular aspects of neurodegeneration in a contemporary context.Includes both basic research and clinical perspectives.Evaluates modern research methods and contributions作者: 領(lǐng)先 時(shí)間: 2025-3-22 12:09 作者: COMA 時(shí)間: 2025-3-22 15:32 作者: 警告 時(shí)間: 2025-3-22 17:02 作者: 敲竹杠 時(shí)間: 2025-3-22 23:27
Clinical Aspects of Alzheimer’s Diseaseimer’s disease and provides an overview of the clinical syndromes associated with Alzheimer pathology and their associated neuroimaging findings. This chapter also reviews the neuropathology and genetics of Alzheimer’s disease and concludes by discussing current work undertaken to identify suitable 作者: 可觸知 時(shí)間: 2025-3-23 04:10
Parkinson’s Disease: Basic Pathomechanisms and a Clinical Overviewisease. The majority of existing treatments target motor symptom control. Over the last two decades the impact of the genetic contribution to PD has been appreciated. Significant discoveries have been made, which have advanced our understanding of the pathophysiological and molecular basis of PD. In作者: BURSA 時(shí)間: 2025-3-23 06:15
Huntington’s Disease: Pathogenic Mechanisms and Therapeutic Targetsptoms, cognitive deficits culminating in dementia, and the movement disorder epitomised by motor signs such as chorea. HD is caused by a CAG repeat expansion encoding an extended tract of the amino acid glutamine in the huntingtin protein. This polyglutamine expansion appears to induce a ‘change of 作者: 新陳代謝 時(shí)間: 2025-3-23 12:55 作者: 積習(xí)已深 時(shí)間: 2025-3-23 15:53
Motoneuron Disease: Basic Scienceis of voluntary and respiratory muscles. The unprecedented rate of discoveries over the last two decades have broadened our knowledge of genetic causes and helped delineate molecular pathways. Here we critically review ALS epidemiology, genetics, pathogenic mechanisms, available animal models, and i作者: Negotiate 時(shí)間: 2025-3-23 19:19
Motoneuron Disease: Clinicalere is significant heterogeneity with regard to anatomical and temporal disease progression. Importantly, more recent advances in genetics have revealed new causative genes to the disease. New efforts have focused on the development of biomarkers that could aid in diagnosis, prognosis, and serve as 作者: 壓倒性勝利 時(shí)間: 2025-3-24 00:19 作者: JECT 時(shí)間: 2025-3-24 06:05 作者: 清晰 時(shí)間: 2025-3-24 08:27
Stroke: Basic and Clinicalssel. Now, advances in clot retrieval (stentriever), in concert with tPA, heralds new optimism for ischemic stroke victims, but adds more pressure to identify therapies that will minimize hypoxic damage, protect compromised cells, and promote rehabilitation. In the past preclinical investigations ha作者: 健談的人 時(shí)間: 2025-3-24 13:16
Epileptic Encephalopathies as Neurodegenerative Disordersn, resulting in a broad range of neurological and non-neurological comorbidities. The concept of epileptic encephalopathies entails that the encephalopathy aspect of the overall condition is primarily driven by the epileptic activity of the disease, which often manifests as specific and pathological作者: 舞蹈編排 時(shí)間: 2025-3-24 17:18
Neurodegeneration and Pathology in Epilepsy: Clinical and Basic Perspectivested electrographic seizures. These most prominently include neuron loss and an increase in astrocyte number and size but may also include enhanced blood–brain barrier permeability, the formation of new capillaries, axonal sprouting, and central inflammation. In animal models in which seizures are ei作者: 粗糙 時(shí)間: 2025-3-24 20:39
Prion Diseaseslular prion protein, with the misfolded conformers constituting an infectious unit referred to as a “prion”. Prions can spread within an affected organism by directly propagating this misfolding within and between cells and can transmit disease between animals of the same and different species. Prio作者: dysphagia 時(shí)間: 2025-3-24 23:32
Leukodystrophy: Basic and Clinicalher of myriad of supporting cells or tissues. With recent developments in neuroimaging, their presence is becoming increasingly noted even in situations where they were not suspected. More importantly, new genetic tools have improved our ability to diagnose. An understanding of pathogenesis is still作者: DIS 時(shí)間: 2025-3-25 05:02 作者: 抱負(fù) 時(shí)間: 2025-3-25 08:22
Cell Death Mechanisms of Neurodegenerations and oxidative stress, protein misfolding and translational dysfunction, autophagy and microglia activation. This indicates that although the original cause may differ in individual diseases or even subtypes of certain disorders, these disrupted common cell functions and signaling, together with ag作者: 激怒某人 時(shí)間: 2025-3-25 13:06
dungsbereiche recht gro?. So gibt es einen Konsens über wichtige Trends der sozialstrukturellen Entwicklung (Zuw?chse an Einkommen und Bildung, Bedeutung des Sozialstaats, Erosion klassischer sozialmoralischer Milieus, Ver?nderung der Geschlechterverh?ltnisse); umstritten sind eher die Gewichtung di作者: 長(zhǎng)矛 時(shí)間: 2025-3-25 16:26 作者: 賠償 時(shí)間: 2025-3-25 21:53 作者: 暴發(fā)戶 時(shí)間: 2025-3-26 00:53 作者: 歌唱隊(duì) 時(shí)間: 2025-3-26 04:56
Lynette J. Tippett PhD, DipClinPsych,Henry J. Waldvogel PhD,Russell G. Snell PhD,Jean-Paul Vonsattel das Lebensstilkonzept seit zwei Jahrzehnten als Alternative zu Konzepten der Klassen- und Schichtungsforschung in der Diskussion steht, ist der Ertrag der Lebensstilforschung als recht mager zu bezeichnen. So konstatiert Peter Hartmann (1999: 12): ?In den letzten Jahren l??t sich zumindest in der S作者: 防水 時(shí)間: 2025-3-26 08:34 作者: 安撫 時(shí)間: 2025-3-26 14:07 作者: Herd-Immunity 時(shí)間: 2025-3-26 18:53
Katherine Buzzard B.Sc. (Hons.), Ph.D., M.B.B.S.,Wing Hei Chan M.Phil.,Trevor Kilpatrick M.B.B.S., Pragestellungen der Sozialstrukturanalyse finden ebenso Beachtung wie jüngere Forschungsfelder. Der vorliegende Sammelband vereint innovative Beitr?ge lateinamerikanischer und weiterer Forscher*innen zu den bedeutendsten Dimensionen der gegenw?rtigen Sozialstrukturen. Damit liegt erstmalig in deutsch作者: 缺陷 時(shí)間: 2025-3-26 21:00 作者: mitral-valve 時(shí)間: 2025-3-27 05:04 作者: COLON 時(shí)間: 2025-3-27 05:25 作者: receptors 時(shí)間: 2025-3-27 11:46 作者: 吵鬧 時(shí)間: 2025-3-27 17:09 作者: mechanical 時(shí)間: 2025-3-27 19:09
Victoria E. Johnson,William Stewart,John D. Arena,Douglas H. Smith M.D. konkreten M?glichkeiten mit einer individualisierenden Perspektive, welche die Einzelnen als Eigentümer:innen dieser M?glichkeiten adressiert. Dass diese komplexe Figur eines abstrakten Eigentums alltagspraktisch anschlussf?hig ist, liegt an den historisch wirkm?chtigen Formen, welche unser Verst?n作者: 要控制 時(shí)間: 2025-3-28 00:00 作者: 過時(shí) 時(shí)間: 2025-3-28 02:48
Jing Fan Ph.D,Ted M. Dawson M.D., Ph.D.,Valina L. Dawson Ph.D.n auch zunehmend eine theoretische Herausforderung dar. Das liegt darin begründet, dass zwar detaillierte und historisch genaue empirische Darstellungen vorliegen, diese aber von politischen Einsch?tzungen und Wertungen durchzogen sind und in ihren Problemstellungen stark variieren (vgl. .). Zudem i作者: floodgate 時(shí)間: 2025-3-28 06:33
Alzheimer’s Disease: Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Nease pathophysiology. Here, we introduce the neurobiology and genetic features of Alzheimer’s and describe what we have learned from studies employing mouse models and patient-derived induced pluripotent stem cells.作者: GET 時(shí)間: 2025-3-28 12:33 作者: Oscillate 時(shí)間: 2025-3-28 17:32
Book 2017future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an作者: Mets552 時(shí)間: 2025-3-28 22:00
2190-5215 es.Evaluates modern research methods and contributionsProvides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal bra作者: BIPED 時(shí)間: 2025-3-28 23:40 作者: Ischemia 時(shí)間: 2025-3-29 06:50 作者: 通情達(dá)理 時(shí)間: 2025-3-29 08:15
Neurodegeneration and Pathology in Epilepsy: Clinical and Basic Perspectiveshile epilepsy has long and correctly been?considered an electrical disorder, the vascular system likely plays an important causal role in the neurodegeneration and pathology that occur as a consequence of repeated seizures.作者: biopsy 時(shí)間: 2025-3-29 14:32
Parkinson’s Disease: Basic Pathomechanisms and a Clinical Overvieween appreciated. Significant discoveries have been made, which have advanced our understanding of the pathophysiological and molecular basis of PD. In this chapter we outline current knowledge of the clinical aspects of PD and the basic mechanistic understanding.作者: DENT 時(shí)間: 2025-3-29 17:08 作者: 全神貫注于 時(shí)間: 2025-3-29 20:24 作者: 衰老 時(shí)間: 2025-3-29 23:55
Motoneuron Disease: Clinicalpharmacodynamics markers. Although traditional pharmaceuticals continue to undergo trials for ALS, new therapeutic strategies including stem cell transplantation studies, gene therapies, and antisense therapies targeting some of the familial forms of ALS are gaining momentum.作者: 性冷淡 時(shí)間: 2025-3-30 05:12
Stroke: Basic and Clinicalve been poor at predicting potential clinical therapy, but they have contributed enormously to understanding post-stroke pathology. Current clinical trials (.) anticipate a broad range of approaches: from hypothermia, to cell therapy, to neuroprotection.作者: 針葉 時(shí)間: 2025-3-30 10:10
gspolitiken in Angriff. Diese sozialen, politischen und kulturellen Umbrüche machten sich auch in?den Sozialstrukturen der Region bemerkbar. Der Band analysiert wichtige Entwicklungen, rezente Ph?nomen978-3-658-34427-6978-3-658-34428-3作者: 設(shè)想 時(shí)間: 2025-3-30 16:02 作者: Migratory 時(shí)間: 2025-3-30 16:47
Fiona Kumfor M(Clin. Neuropsych.), Ph.D.,Glenda M. Halliday B.Sc. (Hons.), Ph.D.,Olivier Piguet M.A.作者: 非實(shí)體 時(shí)間: 2025-3-30 22:04 作者: 幸福愉悅感 時(shí)間: 2025-3-31 02:30 作者: 臆斷 時(shí)間: 2025-3-31 05:19 作者: 茁壯成長(zhǎng) 時(shí)間: 2025-3-31 10:23
Multiple Sclerosis: Basic and Clinicalntified. While immune-directed therapies can reduce the frequency of relapses and development of new lesions, they have little effect upon remyelination and nerve cell repair. This presents the next big challenge in MS therapeutics; complementing immune targeted therapies with strategies that direct作者: chuckle 時(shí)間: 2025-3-31 14:18 作者: cliche 時(shí)間: 2025-3-31 20:16 作者: 軍械庫(kù) 時(shí)間: 2025-3-31 23:50 作者: EVADE 時(shí)間: 2025-4-1 03:56
