標(biāo)題: Titlebook: Neoplastic Transformation in Human Cell Culture; Mechanisms of Carcin Johng S. Rhim,Anatoly Dritschilo Book 1991 Springer Science+Business [打印本頁(yè)] 作者: frustrate 時(shí)間: 2025-3-21 18:54
書目名稱Neoplastic Transformation in Human Cell Culture影響因子(影響力)
書目名稱Neoplastic Transformation in Human Cell Culture影響因子(影響力)學(xué)科排名
書目名稱Neoplastic Transformation in Human Cell Culture網(wǎng)絡(luò)公開(kāi)度
書目名稱Neoplastic Transformation in Human Cell Culture網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書目名稱Neoplastic Transformation in Human Cell Culture被引頻次
書目名稱Neoplastic Transformation in Human Cell Culture被引頻次學(xué)科排名
書目名稱Neoplastic Transformation in Human Cell Culture年度引用
書目名稱Neoplastic Transformation in Human Cell Culture年度引用學(xué)科排名
書目名稱Neoplastic Transformation in Human Cell Culture讀者反饋
書目名稱Neoplastic Transformation in Human Cell Culture讀者反饋學(xué)科排名
作者: monologue 時(shí)間: 2025-3-21 22:38
Comparison of Human Versus Rodent Cell Transformation: Importance of Cell Aging the information gained from animal studies will extend to humans. However, a fundamental difference must exist between human and rodents in terms of neoplastic development because cancers generally arise in rodents after a few years whereas the same cancers require decades in humans. For example, t作者: 啞巴 時(shí)間: 2025-3-22 04:28 作者: backdrop 時(shí)間: 2025-3-22 06:06
Use of Immortalized Human Keratinocytes for the Study of Squamous Differentiation and Mutagenesis system for quantification of DNA damage at a defined genetic locus and 2) determine new epithelial-specific phenotypes associated with malignant conversion. HK lines RHEK-1 and HPK-1A were established by immortalization by a hybrid of adenovirus 12 and simian virus 40 (Ad12-SV40) (1) or human papil作者: 外貌 時(shí)間: 2025-3-22 09:50 作者: 獨(dú)特性 時(shí)間: 2025-3-22 15:45 作者: Gerontology 時(shí)間: 2025-3-22 17:37
Polyamine Metabolism in Human Epidermal Keratinocytes Transformed with AD12-SV40, HPV16-DNA and K-, though the specific role of these amines is still not well understood at the molecular level, recent studies have shown that their concentration is highly regulated and that polyamines are necessary for normal cell growth and differentiation (see reviews 1 – 3). The pathway of polyamine biosynthesis作者: agenda 時(shí)間: 2025-3-23 00:51
Transformation of Human Diploid Fibroblasts by Radiation and Oncogenestransformation .. Whether the progeny of this cell will eventually give rise to an invasive, malignant tumor depends upon a number of host and tissue factors. The malignant transformation of cells . is also a complex, multi-step process by which normal cells acquire the various phenotypic characteri作者: 期滿 時(shí)間: 2025-3-23 04:36
Ionizing Radiation-Mediated Protein Kinase C Activation and Gene Expressiont. Genes encoding transcription factors are expressed immediately after x-ray exposure in the absence of de novo protein synthesis. c-., c-. and Egr-1 are expressed following irradiation of human normal tissue cells and tumor cell lines. Radiation-mediated expression of these immediate early genes i作者: 弄臟 時(shí)間: 2025-3-23 05:33 作者: neutralize 時(shí)間: 2025-3-23 13:30
Neoplastic Transformation of Human Epithelial Cells by Ionizing Radiationhowever, very litter studies on radiogenic transformation of human epithelial cells, especially with high-LET radiation. Using energetic heavy ions, we have been able to transform human epidermal keratinocytes and mammary epithelial cells to various stages of transformation. Both cell lines are immo作者: Hemoptysis 時(shí)間: 2025-3-23 16:45
Effects of Ionizing Radiation on Human Papillomavirus Immortalized Human Bronchial Epithelial Cellsport on the radiogenic transformation of human epithelial cells (1). We have established immortalized, non-tumorigenic human bronchial epithelial cell lines following transfection with human papillomaviruses (HPV) 16 or 18 (2) and are employing them in experiments designed to identify genetic mechan作者: Insubordinate 時(shí)間: 2025-3-23 20:10 作者: 護(hù)航艦 時(shí)間: 2025-3-24 01:19
An Inherited P53 Point Mutation in a Cancer Prone Family with Li-Fraumeni Syndromeibroblast DNAs from four family members--the proband, his brother, their father and a paternal aunt, yielded an identical point mutation in codon 245 in only one allele of the p53 gene. This mutation, involving G to A transition (G.C -> G.C) leads to substitution of aspartic acid for glycine at that作者: 不愛(ài)防注射 時(shí)間: 2025-3-24 02:29
p53, a Direct Target of Mutational Activation by Chemical Carcinogens?of tumor suppressor genes as negative regulators of cell growth is believed to lead to tumor development. Loss of function of these genes may occur in the germ line, their absence predisposing the individual to cancer. More frequently, progressive loss of function in tumor suppressor genes occurs th作者: corporate 時(shí)間: 2025-3-24 08:39 作者: molest 時(shí)間: 2025-3-24 13:57
Immortalization and Tumorigenic Transformation of Normal Human Cervical Epithelial Cells Transfectedfrom foreskin or cervix were transfected with recombinant human papillomavirus (HPV) DNAs and a series of immortal cell lines were established. These cell lines contained integrated and transcriptionally active HPV DNAs, they were not tumorigenic in nude mice, and they retained the ability to underg作者: Tremor 時(shí)間: 2025-3-24 15:36 作者: sigmoid-colon 時(shí)間: 2025-3-24 20:21 作者: pacifist 時(shí)間: 2025-3-25 00:06 作者: Conflict 時(shí)間: 2025-3-25 05:15 作者: 爭(zhēng)吵加 時(shí)間: 2025-3-25 09:29
Deficient DNA Repair, an Early Step in Neoplastic Transformation of Human Cells in Cultureenes. Continued cell proliferation alone leads to hyperplasia and benign growths. Deficient repair of DNA damage provides the genomic instability that can result in production of new genetic variants characterizing malignant neoplasia.作者: 高興去去 時(shí)間: 2025-3-25 15:24 作者: 諷刺 時(shí)間: 2025-3-25 18:52 作者: Infelicity 時(shí)間: 2025-3-25 22:47
Use of Immortalized Human Keratinocytes for the Study of Squamous Differentiation and Mutagenesislomavirus type 16 DNA (HPV16) (3), respectively. Malignant conversion was achieved by transfection with an activated . oncogene (2,4). RHEK-1 and HPK-1A are immortal but nontumorigenic, whereas RHEK-1/ras and HPKlA/ras produce aggressively growing tumors in nude mice (Table 1).作者: figment 時(shí)間: 2025-3-26 01:59 作者: 心神不寧 時(shí)間: 2025-3-26 05:43 作者: 散步 時(shí)間: 2025-3-26 09:57
https://doi.org/10.1007/978-1-4612-0411-4Activation; DNA; aging; cancer; cancer research; carcinogenesis; carcinoma; cell; cell culture; mutation; onco作者: Vulnerable 時(shí)間: 2025-3-26 13:38
p53, a Direct Target of Mutational Activation by Chemical Carcinogens?of tumor suppressor genes as negative regulators of cell growth is believed to lead to tumor development. Loss of function of these genes may occur in the germ line, their absence predisposing the individual to cancer. More frequently, progressive loss of function in tumor suppressor genes occurs through an accumulation of somatic mutations.作者: foodstuff 時(shí)間: 2025-3-26 17:52 作者: 付出 時(shí)間: 2025-3-26 21:39 作者: Omnipotent 時(shí)間: 2025-3-27 03:06 作者: 宇宙你 時(shí)間: 2025-3-27 06:29
William E. Fahl,William H. Brondyk,Hua-Ming Jin,Craig W. Stevens,Carsten-Peter Carstens,Gregory C. K作者: 草率女 時(shí)間: 2025-3-27 09:25 作者: 不溶解 時(shí)間: 2025-3-27 16:42 作者: avulsion 時(shí)間: 2025-3-27 21:47
P. Thraves,S. Reynolds,Z. Salehi,W. K. Kim,J. H. Yang,J. S. Rhim,A. Dritschilo作者: 千篇一律 時(shí)間: 2025-3-28 00:43
James C. Willey,Jim Greene,Alberec Bressoud,Peter Cerutti,Tom Hei,Nancy Wang,David Maillie,Chris Cox作者: 描繪 時(shí)間: 2025-3-28 04:37
J. S. Greenberger,J. Lief,P. Anklesaria,M. A. Sakakeeny,D. English,D. Crawford,T. J. FitzGerald作者: SPER 時(shí)間: 2025-3-28 08:22
S. Srivastava,Z. Zou,K. Pirollo,D. Tong,V. Sykes,K. Devadas,J. Miao,Y. Chen,W. Blattner,E. H. Chang作者: Frequency 時(shí)間: 2025-3-28 11:47 作者: 愛(ài)哭 時(shí)間: 2025-3-28 18:34
Jonathan A. Rhim,Jonathan Vogel,Chang-Min Kim,Gilbert Jay,Johng S. Rhim作者: 聽(tīng)寫 時(shí)間: 2025-3-28 22:30
Studies of Mutagen-Activated Genes which Confer Anchorage-Independence: the , Gene as a Modelvely growing tumors (9), and, consistent with this, the anchorage-independent cell clones senesce at passage levels similar to non-anchorage-independent cell clones (6). When neo-plastic transformation is viewed in the context of a multiple-step transition from normal to neoplastic cell (10), mutage作者: 定點(diǎn) 時(shí)間: 2025-3-29 02:46 作者: insecticide 時(shí)間: 2025-3-29 07:09
Polyamine Metabolism in Human Epidermal Keratinocytes Transformed with AD12-SV40, HPV16-DNA and K-, llels the proliferation response. In addition to the possibility of rapidly changing their rate of polyamine synthesis, cells are equipped with an effective pathway for degradation of spermidine and spermine. The first, and rate-limiting, step in this degradation is an acetylation of the polyamines,作者: 我就不公正 時(shí)間: 2025-3-29 08:21
Ionizing Radiation-Mediated Protein Kinase C Activation and Gene Expressionvation and immediate early gene induction may represent initial common events which are then followed by rare presumably mutational processes which result in neoplastic transformation. The potential importance of this finding is demonstrated by the recent report that PKC inhibitors partially suppres作者: 口味 時(shí)間: 2025-3-29 15:23
Detection of Transforming Genes from Radiation Transformed Human Epidermal Keratinocytes by a Tumoricyte system led us to determine the potential of X-rays as a carcinogenic agent in human epithelial cells and to characterize the molecular events involved in the development of a radiation-induced malignancy.作者: 宣傳 時(shí)間: 2025-3-29 18:05 作者: exophthalmos 時(shí)間: 2025-3-29 20:25
An Inherited P53 Point Mutation in a Cancer Prone Family with Li-Fraumeni Syndromeave differently as compared to the mutant p53 previously detected in transformed cells. Given the inherited nature of this p53 mutation, the demonstrated role of p53 in tumorigenesis and the location of mutation in a region of the gene known to be critical for its function, it appears that we have i作者: guzzle 時(shí)間: 2025-3-30 00:36
Immortalization and Tumorigenic Transformation of Normal Human Cervical Epithelial Cells Transfectedrmation of squamous carcinomas when cells were innoculated in nude mice. Thus, HPV-immortalized cervical cells are an appropriate model for studying the importance of specific environmental or host factors in cervical malignancy.作者: Stable-Angina 時(shí)間: 2025-3-30 04:11 作者: 江湖騙子 時(shí)間: 2025-3-30 08:27
adiation carcinogenesis. 4. Multistep nature of human cell carcinogenesis. 5. Role of activated and suppressor oncogenes in neoplastic trans- formation. The workshop was organized by J. S. Rhim and A. Dritschilo (cochairmen), G. Jay, J. little, M. McCormick, R Tennant, and R R Weischelbaum. There were 32 spea978-1-4612-6750-8978-1-4612-0411-4作者: Aggregate 時(shí)間: 2025-3-30 13:56 作者: Bumptious 時(shí)間: 2025-3-30 19:33
,Soviet Education: Travellers’ Tales,es and polytechnics and discussed issues of mutual and specific concern with eminent Soviet educationists such as Kairov, Markushevich, Zubov, Menchinskaya, Luria and Leont’ev. Before my visits many of my presuppositions were based on long discussions with Nicholas Hans and accounts of the system by作者: Left-Atrium 時(shí)間: 2025-3-30 21:55
Stammzellen: Einsatz in der Nephrologie,eshalb, da die Drehzahlabweichung von der Synchrondrehzahl im Dauerbetrieb klein ist) als auch als drehzahlver?nderbarer Antrieb mit Umrichterspeisung (Kümmel 1985, 1986). Weiter wird die Besonderheit der doppeltgespeisten Asynchronmaschine mit rotorseitigem Umrichter vor allem als Generator für Windturbinen erl?utert.作者: boisterous 時(shí)間: 2025-3-31 00:51
Harmonisation and Road Freight Transport,TP. The nature of the harmonisation process in this instance is clearly very important, the emphasis of Title IV being on harmonised action by the Member States themselves within a common framework rather than actions undertaken by the central Community institutions.作者: 1FAWN 時(shí)間: 2025-3-31 06:50
A Practical Approach to Developing Applications with Reusable Services,or effective methods for developing client applications. In this paper, we propose a systematic process for developing applications with reusable services. It consists of four phases, and each phase is given practical instructions.作者: CT-angiography 時(shí)間: 2025-3-31 10:06 作者: Ringworm 時(shí)間: 2025-3-31 14:23
Sven Jocheml results obtained as a function of . for a few particles and the low temperature behaviors obtained as a function of the carrier density .. in two dimensional electron gases. Notably, the new “exotic state of matter” numerically observed at low energies in small clusters occurs at the same intermed作者: 欲望 時(shí)間: 2025-3-31 18:49 作者: 開(kāi)始從未 時(shí)間: 2025-3-31 22:33
Anja Oenning. The book is intended for the undergraduate student who has some prior familiarity with microeconomics. However, the book is also useful for graduate students and professionals, economists and non-economists, 978-1-4419-3988-3978-0-387-29368-4作者: 包庇 時(shí)間: 2025-4-1 03:49
Nutzfahrzeugdieselmotorenn mittelschweren und schweren NFZ eingesetzt. Im Gegensatz dazu werden in den leichten NFZ Dieselmotoren eingesetzt, die meist von PKW‐Motoren abgeleitet sind. Diese werden dann als Light‐Duty‐Motoren bezeichnet.作者: –scent 時(shí)間: 2025-4-1 07:31
Michael J. Toddon dem Nachweis des Gelebthabens, wenn auch nur w?hrend einer allerkürzesten Zeitspanne, geht aber, wie schon angedeutet, von der Justiz aus. Der Strafrichter braucht den Nachweis bei fraglichem Kindsmord, der Zivilrichter bei manchen Fragen des Erbrechts. Der Mediziner denkt daran, da? gleich nach 作者: Gnrh670 時(shí)間: 2025-4-1 11:21
