作者: indubitable 時間: 2025-3-21 22:37
NMDA Receptor Protocols978-1-59259-683-6Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: homocysteine 時間: 2025-3-22 03:35
Min LiIncludes supplementary material: 作者: glans-penis 時間: 2025-3-22 05:35
and digital journals have focused on the study of games, books on gaming have gushed out of university and trade presses, peer-reviewed articles have been fruitful and multiplied, professional orga-nizations have been founded, and countless presentations have been deliv-ered at numerous academic con作者: Diluge 時間: 2025-3-22 12:37 作者: 開始發(fā)作 時間: 2025-3-22 16:20 作者: granite 時間: 2025-3-22 18:16 作者: 疲憊的老馬 時間: 2025-3-22 21:47
Mark A. Varney,Fen-Fen Lin,Christine Jachec,Sara P. Rao,Stephen D. Hess,Edwin C. Johnson,G?nül Veli? chapters that illustrate overlooked methodologies applied t.This book examines the reception of rhetoric and the rhetoric of reception. By considering salient rhetorical traits of rhetorical utterances and texts seen in context, and relating this to different kinds of reception and/or audience use 作者: Synthesize 時間: 2025-3-23 03:04
Erik A. Whitehorn,William J. Dower,Min Li chapters that illustrate overlooked methodologies applied t.This book examines the reception of rhetoric and the rhetoric of reception. By considering salient rhetorical traits of rhetorical utterances and texts seen in context, and relating this to different kinds of reception and/or audience use 作者: CLASH 時間: 2025-3-23 07:58 作者: 美學(xué) 時間: 2025-3-23 09:46
Ian J. Reynolds,Terre A. Sharmang a specifically rhetorical approach to argumentation.Demon.This book contains 20 essays tracing the work of David Zarefsky, a leading North American scholar of argumentation from a rhetorical perspective.?The essays cohere around 4 general themes: objectives for studying argumentation rhetorically作者: arthrodesis 時間: 2025-3-23 17:20 作者: 嘲笑 時間: 2025-3-23 20:24 作者: Fermentation 時間: 2025-3-23 22:59 作者: 否認(rèn) 時間: 2025-3-24 06:24 作者: 無法取消 時間: 2025-3-24 08:09
Antonio V. Ferrer-Montiel,Mauricio Montale examination of the role of sociocultural-historical theory developed by Vygotsky. This book puts forward the supposition that the major assumptions of sociocultural-historic theory are essential to understanding the theory’s application to mathematical pedagogy, which explores issues relevant to l作者: flaggy 時間: 2025-3-24 12:47 作者: Arable 時間: 2025-3-24 16:23 作者: Musculoskeletal 時間: 2025-3-24 21:02 作者: 災(zāi)難 時間: 2025-3-25 00:33 作者: 包庇 時間: 2025-3-25 07:10 作者: 身體萌芽 時間: 2025-3-25 11:08 作者: INCH 時間: 2025-3-25 14:59
Expression of Extracellular N-Terminal Domain of NMDA Receptor in Mammalian Cells,ional channels can be produced with only the NR1 subunit. These single-subunit channels, exhibit many of the key properties found in native channels including the direct permeability of calcium, voltage-dependent Mg. blockade of the ion channel, and binding sites for modulators, such as Zn., glycine作者: 水土 時間: 2025-3-25 17:48
Immunocytochemistry of NMDA Receptors, immunoperoxidase for light microscopy (LM), the same for electron microscopy (EM), and postembedding immunogold (.–.). General versions of these techniques, as well as related techniques (immunofluorescence, immunocytochemistry of cultures) have been discussed and compared for immunolabeling of all作者: 冷漠 時間: 2025-3-25 22:10
The Use of Ligand Binding in Assays of NMDA Receptor Function, receptor measured NMDA-sensitive [.H]glutamate binding (.. for review). However, [.H]glutamate has relatively low affinity for the receptor, and is also a substrate for transport processes in brain membranes, which can make it difficult to isolate receptor binding from ligand sequestration. The rec作者: CAGE 時間: 2025-3-26 03:44
Calmodulin Modification of NMDA Receptors,ceptor ion channels (.). We demonstrated that calmodulin specifically binds to two distinct sites (CBS1 and CBS2) localized in the C-terminus of the NR1 subunits, causing a fourfold decrease in the channel open probability (.). The CBS1 (.. for calmodulin: 80 n.) covers most of the C-terminal region作者: maudtin 時間: 2025-3-26 06:19 作者: 宣稱 時間: 2025-3-26 08:57
Redox Sensitivity of NMDA Receptors,voked responses. In contrast, after oxidation, NMDA-evoked responses are decreased in size. In recent years, as endogenous sources of oxidizing and reducing agents have been discovered, redox modulation of protein function has been recognized to be an important physiologic, as well as pathologic mec作者: accrete 時間: 2025-3-26 14:49 作者: 逢迎春日 時間: 2025-3-26 19:41
NMDA Receptor Pharmacology and Analysis of Patch-Clamp Recordings,ed from whole-cell recordings and (.) analysis of single-channel recordings. Whole-cell currents are the average response of a large population of channels, whereas single-channel recordings document the gating behavior of a single protein. Analysis of single-channel recordings details the effects o作者: LAY 時間: 2025-3-26 22:55 作者: 心胸狹窄 時間: 2025-3-27 02:21 作者: Ointment 時間: 2025-3-27 06:02
High-Throughput Functional Detection of NMDA Receptor Activity,ificity. The increasing number of entities in pharmaceutical company compound libraries, frequently surpassing 10., dictates the use of a high-throughput screening (HTS) process. In practice, large numbers of individual compounds are quickly tested for their ability to interact with, and affect a ch作者: 柔美流暢 時間: 2025-3-27 12:22
The Use of Ligand Binding in Assays of NMDA Receptor Function,and to use because of nonspecific binding. The identification of MK801 (dizocilpine) and thienylphencyclidine (TCP) as highly potent and very selective inhibitors of NMDA receptor function (.–.) brought the possibility of ligand binding to NMDA receptors into the mainstream.作者: 非秘密 時間: 2025-3-27 16:38
NMDA Receptor Pharmacology and Analysis of Patch-Clamp Recordings,evel can be used as a basis for comparison with whole-cell concentration-response curves. This procedure allows the investigator to compare the effects of a variety of drugs at the molecular level using a well-established set of tools developed for analysis of macroscopic responses.作者: instulate 時間: 2025-3-27 18:43 作者: Charlatan 時間: 2025-3-28 00:46
Expression of Extracellular N-Terminal Domain of NMDA Receptor in Mammalian Cells,, and polyamines (.). The NR1 subunit consists of two functionally distinct regions: a large amino-terminal extracellular domain containing the putative agonist binding site and a hydrophobic core consisting of four transmembrane-spanning domains that participate in the formation of the ion-conducting pathway.作者: 美學(xué) 時間: 2025-3-28 05:56 作者: AXIOM 時間: 2025-3-28 06:51
Book 1999g assays for nontherapeutic lead selection. The topics range from cDNA cloning to in vitro and in vivo investigation of the channel complex in the mammalian brain. Additional topics include the biochemical analysis of the channel protein and the construction of various heterologous systems for both 作者: 不可知論 時間: 2025-3-28 11:53 作者: ABASH 時間: 2025-3-28 15:00 作者: 慷慨援助 時間: 2025-3-28 20:20
Stable Expression of Human NMDA Receptors in Cultured Mammalian Cells,ation of these channels has been implicated in several pathophysiological conditions, such as stroke and epilepsy. Therefore, NMDA receptors represent relevant molecular targets for therapeutic agents in the treatment of stroke, epilepsy, head trauma, and pain (.–.).作者: 相容 時間: 2025-3-28 23:43
High-Throughput Functional Detection of NMDA Receptor Activity,put screening (HTS) process. In practice, large numbers of individual compounds are quickly tested for their ability to interact with, and affect a change in, a previously identified and validated target protein. The heterologous expression of cloned receptor proteins in defined cell lines provides the specificity of the interaction.作者: expeditious 時間: 2025-3-29 04:33
Ian J. Reynolds,Terre A. Sharmaitics and governance. All these topics are addressed in this book..Each of the conceptual essays includes brief application to specific cases, and five extended case studies are also presented in this volume. T978-3-319-37938-8978-3-319-05485-8Series ISSN 1566-7650 Series E-ISSN 2215-1907 作者: 不能和解 時間: 2025-3-29 09:11 作者: 馬賽克 時間: 2025-3-29 15:23 作者: Thyroxine 時間: 2025-3-29 19:15
Susumu Kawamoto,Satoshi Hattori,Shigeo Uchino,Masayoshi Mishina,Kenji Okudaut to reflect the dynamic of emotion and perception, the movement from outward deception or misconstruction to inward substance, good or bad — a movement figured by Plato, and subsequently by Erasmus, as the opening of a Silenus (see below), and one which makes the pleasure of discovery integral to 作者: 代理人 時間: 2025-3-29 20:12
Paul L. Chazot,Miroslav Cik,F. Anne Stephensonwhich we will look at in the next chapter. It will also be helpful, in a second section, to represent the widely different purposes and occasions to which emotive persuasion was applied, in this case instancing the relationship of preacher and congregation, subject and prince, feminine and masculine作者: 沙草紙 時間: 2025-3-30 01:07
Ronald S. Petralia,Robert J. Wentholdterns and schemes of argumentation in public reasoning, and the influence of debate on politics and governance. All these topics are addressed in this book..Each of the conceptual essays includes brief application to specific cases, and five extended case studies are also presented in this volume. T作者: saturated-fat 時間: 2025-3-30 07:35 作者: 天賦 時間: 2025-3-30 11:37
Robert J. Wenthold,Jaroslav Blahos II,Kyung-Hye Huh,Ronald S. Petraliaterns and schemes of argumentation in public reasoning, and the influence of debate on politics and governance. All these topics are addressed in this book..Each of the conceptual essays includes brief application to specific cases, and five extended case studies are also presented in this volume. T作者: Brochure 時間: 2025-3-30 16:17 作者: 淡紫色花 時間: 2025-3-30 19:52 作者: 文字 時間: 2025-3-30 20:59 作者: 泄露 時間: 2025-3-31 01:58
Martin Donal Cunningham,Sara Mary Cunninghame communication, and other features within the realm of rhetorical argumentation. This book is relevant to students and researchers in linguistics, rhetoric, philosophy, argumentation studies, and communication studies..Previously published in .Argumentation. Volume 34, issue 3, September 2020.978-3-031-18804-6978-3-031-18802-2作者: Polydipsia 時間: 2025-3-31 08:25
ently been applied to the operation of voluntary associations and we are still in the process of mapping the dimensions of the market framework. However, we devote a whole chapter to the discussion of the market framework and its com-plex effects upon the voluntary sector because, as we will argue i作者: Boycott 時間: 2025-3-31 12:03
Transient Expression of Functional NMDA Receptors in Mammalian Cells,ptors are unknown, a convenient model system in which to study the properties of defined cloned NMDA receptor subtypes and thus to compare them with their in vivo counterparts is their expression in mammalian cells. This permits the pharmacological, functional and biochemical characterization of eit作者: 冒號 時間: 2025-3-31 14:47
Calmodulin Modification of NMDA Receptors,nificance and molecular mechanisms of interaction between calmodulin and NMDA receptors. This chapter is a stepwise description of our laboratory protocols used in studying the modulation of NMDA receptors by calmodulin. We hope that the protocols will help people investigate the issue and evaluate 作者: Tailor 時間: 2025-3-31 19:48 作者: 項目 時間: 2025-3-31 22:31
Redox Sensitivity of NMDA Receptors,iewed here. For a recent summary of the molecular data, .... If the cysteine sulfhydryls possess a sufficient redox potential, oxidizing agents can react to form adducts on single thiol groups, or if two free sulfhydryl groups are vicinal (in close proximity), disulfide bonds may possibly be formed.作者: insurgent 時間: 2025-4-1 05:02
In Vitro Selection of Peptides Acting on NMDA Receptors,produced by the method described in . in this volume (.). Individual isolates from the enriched pools were then characterized by a phage ELISA to identify clones that bound specifically to NR1. The sequence of peptides displayed by phage that bound to receptor was deduced by sequencing the cloned ol作者: Endemic 時間: 2025-4-1 08:11
Determination of Membrane Topology of Glutamate Receptors,xtracellular domains, owing to the fact that the glycosyl transferases are localized to the lumen of the endoplasmatic reticulum. Demonstration of functional .-linked glycosylation therefore provides a definitive measure of extracellular localization. Alternative approaches that do not rely on alter
