作者: 充氣女 時(shí)間: 2025-3-21 21:31 作者: giggle 時(shí)間: 2025-3-22 01:26 作者: UNT 時(shí)間: 2025-3-22 04:46
Structure and Chemistry of Microtubules,ring slightly in electrophoretic motility. While the shape and many properties of MT proceed from the assembly of these tubulins, other proteins are closely associated with them: these play a role in tubulin assembly and in many interactions of MT with other cell constituents.作者: 危機(jī) 時(shí)間: 2025-3-22 11:17 作者: 迫擊炮 時(shí)間: 2025-3-22 15:15 作者: 側(cè)面左右 時(shí)間: 2025-3-22 19:30 作者: grovel 時(shí)間: 2025-3-22 23:06 作者: 擔(dān)心 時(shí)間: 2025-3-23 02:17 作者: 整理 時(shí)間: 2025-3-23 06:03
Pierre Dustininoids in regulating myeloid cell proliferation and differentiation, a brief review of retinoid metabolism and actions that is directly relevant for understanding the information presented in this chapter is provided below. The reader is also referred to earlier chapters of this volume for more deta作者: MINT 時(shí)間: 2025-3-23 11:16 作者: overwrought 時(shí)間: 2025-3-23 14:46 作者: BET 時(shí)間: 2025-3-23 19:23 作者: JECT 時(shí)間: 2025-3-24 01:26
Pierre Dustints the acquisition of neoplastic properties … It is highly probable that the epithelium of gland ducts, respiratory mucosa, and genitourinary tract have secretory functions, so that we conclude that the [retinoid] deficiency results in loss of specific chemical functions of the epithelia concerned, 作者: Invertebrate 時(shí)間: 2025-3-24 05:28
Pierre Dustin of different retinoid receptors in different tissues. The complexities of this system will continue to present challenges in predicting the net biological effects of particular therapeutic interventions in the clinical setting. The recent demonstrations of the negative regulation by all-. retinoic 作者: Default 時(shí)間: 2025-3-24 07:59
Pierre Dustintachment and minimizing complications; these include myopia, visual field constriction, and anterior segment ischemia. With anti-VEGF therapy, recurrences well after the due date and consequent smoldering ROP require vigilant and prolonged outpatient monitoring. Herein, a review of retinal vascular 作者: 進(jìn)步 時(shí)間: 2025-3-24 13:26 作者: 嚙齒動(dòng)物 時(shí)間: 2025-3-24 16:18 作者: Receive 時(shí)間: 2025-3-24 20:41 作者: 飾帶 時(shí)間: 2025-3-25 01:56 作者: 責(zé)問(wèn) 時(shí)間: 2025-3-25 03:19 作者: obeisance 時(shí)間: 2025-3-25 08:35
Introduction,the work on colchicines and other mitotic poisons, the literature on microtubules was, 8 years ago, already increasing at an impressive rate. However, this monograph, which, contrary to other works on microtubules, tried to cover the whole field of research, from the fundamentals of the tubulin mole作者: 燒瓶 時(shí)間: 2025-3-25 12:48
From the Introduction to the First Edition,tubule” was coined by Slautterback some 14 years ago [6], and already in 1966 the ubiquity of these structures was mentioned in a fundamental article written by Porter [5]. Microtubules (MT) are present in all eukaryotic cells with the single exception of the anucleated red blood cells of most mamma作者: 思想靈活 時(shí)間: 2025-3-25 15:57 作者: Synapse 時(shí)間: 2025-3-25 21:48 作者: 直覺(jué)好 時(shí)間: 2025-3-26 03:43 作者: FLEET 時(shí)間: 2025-3-26 07:24 作者: 石墨 時(shí)間: 2025-3-26 09:20 作者: 新鮮 時(shí)間: 2025-3-26 13:29 作者: FLOUR 時(shí)間: 2025-3-26 19:35
Cell Shape,seen during mitosis (cf. Chap. 10); on the other hand, they may act as supporting structures in various cells and in differentiated organelles, such as cilia, axopodia, cytopharyngeal baskets. MT are also associated with various types of cell movements, as in ciliary beating, secretion, neuroplasmic作者: 高度 時(shí)間: 2025-3-27 00:14
Cell Movement,n many ways, some of which are related to the presence of MT. These alone could only provide changes of place through their growth — pushing apart for instance the polar structures in mitosis — and perhaps by disassembling, leaving place for displacements of other structures. While the most primitiv作者: Genetics 時(shí)間: 2025-3-27 04:38 作者: addict 時(shí)間: 2025-3-27 09:13
Neurotubules and Neuroplasmic Transport, As described in Chapter 2, brain has become one of the favorite sources of tubulin for biochemical studies. Most of the problems associated with the function of MT are apparent in the study of nerve cells: their role in maintaining the shape of the long cytoplasmic extensions, axons and dendrites, 作者: Conducive 時(shí)間: 2025-3-27 12:49 作者: preservative 時(shí)間: 2025-3-27 16:43 作者: 減至最低 時(shí)間: 2025-3-27 21:06 作者: nascent 時(shí)間: 2025-3-28 01:55 作者: Cirrhosis 時(shí)間: 2025-3-28 04:09
Pierre Dustinn. In essence, leukemic cells fail to differentiate and are stalled at a particular step of hematopoietic maturation and are unable to complete their development into functional blood cells with a finite life cycle. They are thus said to possess a “differentiation block.” Pharmacological override of作者: Hangar 時(shí)間: 2025-3-28 07:48 作者: 瘋狂 時(shí)間: 2025-3-28 10:38 作者: indigenous 時(shí)間: 2025-3-28 16:43 作者: 擔(dān)心 時(shí)間: 2025-3-28 20:08 作者: Awning 時(shí)間: 2025-3-29 02:49 作者: 條約 時(shí)間: 2025-3-29 05:15 作者: hair-bulb 時(shí)間: 2025-3-29 10:13 作者: progestogen 時(shí)間: 2025-3-29 14:43
Pierre Dustin little doubt that the basic, physiological role of retinoids is to control proliferative activity in the various secretory and ductular epithelial tissues of the body. This has been known since the original classic observations of Wolbach and Howe (15) on the pathogenesis and histogenesis of vitami作者: obstinate 時(shí)間: 2025-3-29 15:46
Pierre Dustin of epithelial tissues (54, 58), but it cannot replace retinal to support the visual function and reproduction (15, 19). Epidemiological study and evidence from experimental animals indicate a close association between retinoic acid deficiency and enhanced susceptibility to chemical carcinogenesis o作者: 禮節(jié) 時(shí)間: 2025-3-29 20:16 作者: 奴才 時(shí)間: 2025-3-30 00:57
Pierre Dustin a major homeostatic role. The authors of this monograph have provided an overview of the current understanding of retinoid biology with particular reference to the use of this class of agents in the prevention and treatment of malignancy. It is clear from the discussions in this book that, although作者: 賄賂 時(shí)間: 2025-3-30 04:36
Pierre Dustinpotentially devastating neonatal retinal disease worldwide. It is distinguished from standard ROP by its posterior location, aggressive tempo, and high vascular activity/VEGF burden. Current treatment for Type 1 retinopathy of prematurity is guided by landmark multicenter prospective studies (CRYO-R作者: Obituary 時(shí)間: 2025-3-30 08:47 作者: magnate 時(shí)間: 2025-3-30 15:48 作者: Adulterate 時(shí)間: 2025-3-30 16:48
General Physiology of Tubulins and Microtubules,MT in the living cell and its abnormalities. The relations of MT with various cell organelles should be considered, and interesting relations with viruses and intracellular parasites will also be described.作者: 拱形大橋 時(shí)間: 2025-3-30 21:45
Secretion,lchicine, VLB, VCR, deuterium oxide) and two years following, similar findings concerning the thyroid gland were observed by two groups working independently [100, 162]. Some of this work on the relation of MT to secretory activities was done in Brussels, and led our laboratory to a renewed interest in tubulin and MT poisons.作者: 隱藏 時(shí)間: 2025-3-31 02:17 作者: 徹底檢查 時(shí)間: 2025-3-31 06:54
MT and MT Poisons in Pathology and Medicine, could be the cause of anomalies of MT. This is particularly apparent in complex structures such a cilia and flagella, where many pathological conditions are known. There also may be some changes in the tubulin cytoskeleton of malignant cells, although this study has so far produced contradictory findings.作者: 藥物 時(shí)間: 2025-3-31 13:16
Post-Script and Outlook,ed proteins, comparable in this aspect to the histones, but have evidently undergone mutations since the origin of the first “prototubulin” molecule — perhaps a billion years ago — from which the various . and . tubulins diverged.作者: GLUT 時(shí)間: 2025-3-31 14:37 作者: 用不完 時(shí)間: 2025-3-31 18:34
Book 1984Latest edition the work on col- chicine and other mitotic poisons, the literature on microtubules was, 8 years ago, already increasing at an impressive rate. However, this monograph, which, contrary to other works on microtubules, tried to cover the whole field of research, from the fundamentals of the tubulin mo
