標題: Titlebook: Microtubules; Pierre Dustin Book 19781st edition Springer-Verlag Berlin · Heidelberg 1978 Cellular activity.Colchicine.Endoplasmatisches R [打印本頁] 作者: urinary-tract 時間: 2025-3-21 18:22
書目名稱Microtubules影響因子(影響力)
書目名稱Microtubules影響因子(影響力)學科排名
書目名稱Microtubules網(wǎng)絡公開度
書目名稱Microtubules網(wǎng)絡公開度學科排名
書目名稱Microtubules被引頻次
書目名稱Microtubules被引頻次學科排名
書目名稱Microtubules年度引用
書目名稱Microtubules年度引用學科排名
書目名稱Microtubules讀者反饋
書目名稱Microtubules讀者反饋學科排名
作者: anus928 時間: 2025-3-21 22:45 作者: 跑過 時間: 2025-3-22 01:42
Pierre Dustink.This would be the first book focused specifically on this Although rare, retinoblastoma has been at the fore- fortunate; while in the developed world eye preser- front of cancer research and treatment for the last tion has become a priority, developing countries c- three decades. The two-hit hypot作者: Condyle 時間: 2025-3-22 07:19
Pierre Dustink.This would be the first book focused specifically on this Although rare, retinoblastoma has been at the fore- fortunate; while in the developed world eye preser- front of cancer research and treatment for the last tion has become a priority, developing countries c- three decades. The two-hit hypot作者: FOR 時間: 2025-3-22 09:55 作者: 針葉樹 時間: 2025-3-22 15:59
Pierre Dustink.This would be the first book focused specifically on this Although rare, retinoblastoma has been at the fore- fortunate; while in the developed world eye preser- front of cancer research and treatment for the last tion has become a priority, developing countries c- three decades. The two-hit hypot作者: GLEAN 時間: 2025-3-22 20:09
Pierre Dustinetinoic acid-binding proteins (CRABPI and II) (., .) and two forms of cellular retinol-binding proteins (CRBP I and II) (.), each encoded by a separate gene. These cellular retinoid-binding proteins are members of a family of related lipid-binding proteins in which the ligand is enclosed within a de作者: 滲入 時間: 2025-3-23 00:35 作者: 鍍金 時間: 2025-3-23 04:30
Pierre Dustinotein II (CRBP II) (.., and references therein). CRBP is present in a wide variety of tissues, including liver, kidney, and testis. The basic feature of CRBP is the retinol-protein recognition, through which a drastically higher stability for CRBP-bound retinol relative to uncomplexed retinol is ach作者: 胰臟 時間: 2025-3-23 07:55 作者: 悄悄移動 時間: 2025-3-23 12:53
Pierre Dustinamme in the early 1960‘s, the expectation was that the retinoids would have a major impact on oncology. However, the laboratory and clinical experiences of Bollag and his colleagues in Switzerland, Stuttgen and Orfanos in Germany, led to publications on both etretinates (Tigason) and isotretinoin (R作者: 光明正大 時間: 2025-3-23 16:15
Pierre Dustinhan inductive reasoning. Because of this it is not infrequent that we are presented with compounds that are therapeutically effective but whose mode of action remains mysterious. It is worthwhile bearing in mind that it is only in the past 20 or 30 years that we have understood how digitalis and mor作者: Anticoagulant 時間: 2025-3-23 18:06
Pierre Dustindifficulties are presented by bullous ichthyosiform erythroderma (syn. epidermolytic hyperkeratosis) and by non-bullous ichthyosiform eyrthro-derma (syn. lamellar ichthyosis). Intensive topical therapy with emollients and keratolytics provides only limited and short-lived relief in the worst affecte作者: DALLY 時間: 2025-3-24 00:47
Pierre Dustinhan inductive reasoning. Because of this it is not infrequent that we are presented with compounds that are therapeutically effective but whose mode of action remains mysterious. It is worthwhile bearing in mind that it is only in the past 20 or 30 years that we have understood how digitalis and mor作者: Soliloquy 時間: 2025-3-24 04:12 作者: 悲痛 時間: 2025-3-24 08:51
Acknowledgments,ble without the facilities available at the University of Brussels. My warmest thanks go to my secretary, Mrs. D. Libert, who not only typed the final manuscript, but also checked my text for inaccuracies or repetitions, and helped considerably in the preparation of the lists of references. Througho作者: 替代品 時間: 2025-3-24 14:02
Structure and Chemistry of Microtubules, weight. The shape and properties of MT proceed from the linkages of these two closely related molecules. However, other proteins appear to be necessary for tubulin assembly into MT or may become closely linked with MT when these assemble into complex structures such as centrioles, basal bodies, cil作者: 可能性 時間: 2025-3-24 15:57
General Physiology of Tubulins and Microtubules,tubulin in the formation of far more complex organelles, like centrioles and cilia, and the effects of various drugs on MT, some fundamental data about general aspects of MT physiology will be considered: the synthesis of tubulins in the cell; its regulation; the role of nucleating sites for the ass作者: 發(fā)酵 時間: 2025-3-24 19:33 作者: Cytology 時間: 2025-3-25 01:32
Microtubule Poisons,reventing its assembly into MT. It is now indispensable to give further details about the action of these drugs, and of other chemicals which may have, under various conditions, similar effects. In the next chapters, colchicine and other poisons will often be mentioned, in relation to cell movements作者: 樹木中 時間: 2025-3-25 05:13
Cell Shape,tiated organelles, such as axopodia, cilia, cytopharyngeal baskets; on the other hand, in many conditions, they may disassemble into their molecules of tubulin within a short time, and display a considerable lability which is apparently surprizing for a skeletal structure. MT are also associated wit作者: 充氣女 時間: 2025-3-25 10:52 作者: 痛恨 時間: 2025-3-25 15:24
Secretion, Exo- and Endocytosis,r that Lacy . [53] suggested that MT play a role in the secretory activity of the B-cells of the Lan-gerhans islets. They showed that several agents known to modify MT (colchicine, VLB, VCR, and deuterium oxide) inhibited the release of insulin by these cells when stimulated by glucose. Similar find作者: 難理解 時間: 2025-3-25 16:46 作者: 引水渠 時間: 2025-3-25 21:13 作者: Little 時間: 2025-3-26 04:01 作者: 可忽略 時間: 2025-3-26 05:12
Outlook, fraction of the literature has been mentioned—,the task of covering the whole field with the purpose of indicating the well-established facts and the fields in which new research is needed, is by no means easy. MT were born at the time of the great change from pro- to eukaryotes, and for eons have 作者: 寡頭政治 時間: 2025-3-26 11:35 作者: epidermis 時間: 2025-3-26 12:54 作者: grenade 時間: 2025-3-26 17:51
Outlook,bulins have maintained through evolution the property of becoming assembled into MT, which are in many conditions labile structures which can be disassembled when no longer required by the cell. These tubulins are also capable of assembling into other geometrical structures—rings, helices, sheets. M作者: ACTIN 時間: 2025-3-26 22:26 作者: 初學者 時間: 2025-3-27 02:35 作者: 金哥占卜者 時間: 2025-3-27 07:07 作者: 冰河期 時間: 2025-3-27 10:05
Pierre Dustinpproach to the can- to treatment. We hope that in subsequent editions we cer patient; state of the art retinoblastoma treatment will be able to continue to provide updates on such can only be conceived in the context of the multidis- exciting subjects.978-1-4899-7753-3978-0-387-89072-2Series ISSN 1613-5318 Series E-ISSN 2191-0812 作者: obnoxious 時間: 2025-3-27 16:02
Pierre Dustinpproach to the can- to treatment. We hope that in subsequent editions we cer patient; state of the art retinoblastoma treatment will be able to continue to provide updates on such can only be conceived in the context of the multidis- exciting subjects.978-1-4899-7753-3978-0-387-89072-2Series ISSN 1613-5318 Series E-ISSN 2191-0812 作者: CLAP 時間: 2025-3-27 19:24 作者: Antioxidant 時間: 2025-3-28 01:15
Pierre Dustinpproach to the can- to treatment. We hope that in subsequent editions we cer patient; state of the art retinoblastoma treatment will be able to continue to provide updates on such can only be conceived in the context of the multidis- exciting subjects.978-1-4899-7753-3978-0-387-89072-2Series ISSN 1613-5318 Series E-ISSN 2191-0812 作者: commonsense 時間: 2025-3-28 05:33 作者: Detoxification 時間: 2025-3-28 07:43 作者: 或者發(fā)神韻 時間: 2025-3-28 14:19
Pierre Dustin 4-OH-RA and 4-oxo-RA had elimination t. values of 40 and 6 min, respectively. In contrast, CRABP-bound 4-OH-RA and CRABP-bound 4-oxo-RA were essentially metabolically inert. This shows that CRABP does not affect all retinoids similarly and that it could have a profound influence on the steadystate 作者: 小卷發(fā) 時間: 2025-3-28 16:24 作者: Ganglion-Cyst 時間: 2025-3-28 19:43
Pierre Dustinns with other cellular proteins are still uncertain. Recombinant cellular retinoid binding proteins, expressed in . or in eukaryotic cells, are important tools for understanding their role in the cellular uptake of retinol, the sequestration and metabolic degradation of retinoic acid or the transfer作者: congenial 時間: 2025-3-28 23:44 作者: pester 時間: 2025-3-29 06:40
Pierre Dustin(as with the corticosteroids). This is certainly the case with the retinoids. Here are drugs that are active in psoriasis (plaque type, erythro-dermic, pustular and arthropathic), the disorders of keratinization (including the ichthyotic disorders, erythrokeratoderma variabilis and Darier’s disease)作者: 職業(yè) 時間: 2025-3-29 10:17
Pierre Dustinbasis, at least partly because the epithelial effects of the drug make it difficult to maintain strictly double-blind conditions. Another problem in trial design is the need for careful tailoring of the dose for the individual patient. We nevertheless believed that the benefits of etretinate in the 作者: occurrence 時間: 2025-3-29 12:14 作者: optic-nerve 時間: 2025-3-29 19:30 作者: AMEND 時間: 2025-3-29 21:08
Structure and Chemistry of Microtubules,peatedly been described, and help to understand the steps and the factors required for assembly. Tubulins are also associated with guanine nucleotides, possibly with enzymes and with non-protein components: the molecular structure of MT may thus be far more complex than a helical association of protein subunits.作者: 安裝 時間: 2025-3-30 03:41
General Physiology of Tubulins and Microtubules,molecules association, MT themselves may become grouped in various numbers to build, with the help of other proteins, complex structures such as the centrioles, the basal bodies, the cilia, the axonemes, and the mitotic spindle: a detailed survey of these will be given in Chapters 4, 6 and 10.作者: Enervate 時間: 2025-3-30 05:48 作者: 粘土 時間: 2025-3-30 11:34
Secretion, Exo- and Endocytosis,was revived in our laboratory by the research in these two fields carried on in Brussels [69, 78]. Since then, a large number of contributions have shown relations between MT and various modes of cell secretion, and have demonstrated that the integrity of MT is necessary for the cell activities related to the release of secretory granules.作者: 助記 時間: 2025-3-30 13:33
Acknowledgments,ut two years, while performing all the menial jobs of secretary of the Laboratory of Pathology, she remained helpful and smiling, although the number of folders was increasing, and many last-minute changes were necessary. Without her activity, it would have been impossible to meet the deadline imposed by the publisher.作者: 平躺 時間: 2025-3-30 16:44 作者: 警告 時間: 2025-3-30 23:42
The Role of MT in Mitosis,otic growth, cytogenetics, and the production of polyploid or amphidiploid plants. These aspects of “applied? research on mitosis with spindle poisons will not be considered here, and this chapter will be limited to the fundamental problems of the role of MT in mitotic movements.
