標題: Titlebook: Microdomains in the Cardiovascular System; Viacheslav Nikolaev,Manuela Zaccolo Book 2017 Springer International Publishing AG 2017 microdo [打印本頁] 作者: EXERT 時間: 2025-3-21 18:10
書目名稱Microdomains in the Cardiovascular System影響因子(影響力)
書目名稱Microdomains in the Cardiovascular System影響因子(影響力)學科排名
書目名稱Microdomains in the Cardiovascular System網(wǎng)絡公開度
書目名稱Microdomains in the Cardiovascular System網(wǎng)絡公開度學科排名
書目名稱Microdomains in the Cardiovascular System被引頻次
書目名稱Microdomains in the Cardiovascular System被引頻次學科排名
書目名稱Microdomains in the Cardiovascular System年度引用
書目名稱Microdomains in the Cardiovascular System年度引用學科排名
書目名稱Microdomains in the Cardiovascular System讀者反饋
書目名稱Microdomains in the Cardiovascular System讀者反饋學科排名
作者: 廢止 時間: 2025-3-21 22:47 作者: ambivalence 時間: 2025-3-22 02:25 作者: pacific 時間: 2025-3-22 07:00 作者: leniency 時間: 2025-3-22 08:56
Viacheslav Nikolaev,Manuela ZaccoloFirst book comprehensively reviewing signaling microdomains in the cardiovascular system.Thoroughly explains important cellular events and mechanisms.Highlights the role of microdomains in cardiovascu作者: Instinctive 時間: 2025-3-22 16:01
Membrane Microdomains and cAMP Compartmentation in Cardiac Myocytesnt subcellular locations. Caveolae, which represent a specific subset of lipid rafts, can dynamically attract or exclude specific signaling proteins through a variety of mechanisms to create highly localized and self-sufficient multi-molecular signaling complexes. Furthermore, disruption of this org作者: 使長胖 時間: 2025-3-22 18:33 作者: 大約冬季 時間: 2025-3-22 22:30 作者: 無瑕疵 時間: 2025-3-23 03:01
Cyclic Nucleotide Phosphodiesterases and Compartmentation in Normal and Diseased Hearty hypertension. However, these drugs do not seem efficient in heart failure with preserved ejection fraction. There is experimental evidence that these PDEs as well as other PDE families including PDE1, PDE2 and PDE9 may play important roles in cardiac diseases such as hypertrophy and heart failure.作者: 極肥胖 時間: 2025-3-23 07:53
cAMP Compartmentalisation and Hypertrophy of the Heart: ‘Good’ Pools of cAMP and ‘Bad’ Pools of cAMPsiology and pathophysiology. In this chapter, we review some of the evidence in support of compartmentalisation of cAMP/PKA signalling, and we summarise recent findings indicating that distinct pools of cAMP, under the control of different phosphodiesterases, have opposing effects on cardiac myocyte作者: 稱贊 時間: 2025-3-23 09:42 作者: 上腭 時間: 2025-3-23 15:46 作者: patriot 時間: 2025-3-23 18:40
Computational Modeling of Cyclic Nucleotide Signaling Mechanisms in Cardiac Myocytesinear and intertwined reaction networks. By precisely defining and quantifying biochemical reactions involved, data-driven and integrative modeling bridge causal gaps across spatiotemporal scale, from the characteristics of individual molecular components to the collective responses of the entire si作者: HATCH 時間: 2025-3-23 23:56 作者: BLANC 時間: 2025-3-24 03:10 作者: 僵硬 時間: 2025-3-24 08:24
The Control of Sub-plasma Membrane Calcium Signalling by the Plasma Membrane Calcium ATPase Pump PMCiew techniques developed for the study of calcium levels local to PMCA4, the protein interaction and signalling complexes formed and regulated by the pump and the physiological implications of these in the heart and vascular systems.作者: Reservation 時間: 2025-3-24 14:22
2509-7830 cular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology.?.978-3-319-85430-4978-3-319-54579-0Series ISSN 2509-7830 Series E-ISSN 2509-7849 作者: Morbid 時間: 2025-3-24 16:41
A. M. Gómez,T. R. R. Mesquita,J. J. Mercadier,J. L. álvarez,J. P. Benitahonment. Today, not only the large companies, but also the medium companies are quickly learning that a highly integrated EIS is more and more a required element of doing business. Businesses all over the wor978-1-4899-7919-3978-0-387-76312-5Series ISSN 1868-4238 Series E-ISSN 1868-422X 作者: Memorial 時間: 2025-3-24 21:42 作者: 具體 時間: 2025-3-25 01:52 作者: 繁榮地區(qū) 時間: 2025-3-25 06:01 作者: 大約冬季 時間: 2025-3-25 08:15
Katharina Schrade,Enno Klussmann process included workshops, cyclic refinements of the instrument, pretests and the framework evaluation within 30 critical infrastructure organizations. The framework was found to be particularly useful as learning and benchmarking tool capable of highlighting weaknesses, strengths, and gaps in rel作者: 不易燃 時間: 2025-3-25 14:55
Alessandra Ghigo,Flora Pirozzi,Mingchuan Li,Emilio Hirschper proposes a hybrid genetic algorithm and a data support-based initialization method that addresses the problem. Experiments show that the approach result in significant reduction in total data management cost and the algorithm is with good performance.作者: circumvent 時間: 2025-3-25 18:31
Ibrahim Bedioune,Pierre Bobin,Jér?me Leroy,Rodolphe Fischmeister,Grégoire Vandecasteeleper proposes a hybrid genetic algorithm and a data support-based initialization method that addresses the problem. Experiments show that the approach result in significant reduction in total data management cost and the algorithm is with good performance.作者: 發(fā)源 時間: 2025-3-25 21:26
Anna Zoccarato,Manuela Zaccoloper proposes a hybrid genetic algorithm and a data support-based initialization method that addresses the problem. Experiments show that the approach result in significant reduction in total data management cost and the algorithm is with good performance.作者: 喚醒 時間: 2025-3-26 03:57 作者: Firefly 時間: 2025-3-26 05:55
Lauren Wills,Bracy A. Fertig,George S. Baillietegories dependence, a number of functional brand posts are dependent on the number of experiential brand posts and a number of sales promotion posts are dependent on the number of functional brand posts. Implications: Improve targeted advertising, carefully watch what types of post publish on socia作者: investigate 時間: 2025-3-26 09:25
Claire Y. Zhaoed models since used systems are usually distributed and involving several organizations which can have different definitions for a given role. This framework manages the consistency between already allowed data access rights and potential given rights to a given business stakeholder according to bu作者: RAFF 時間: 2025-3-26 13:06 作者: 常到 時間: 2025-3-26 18:35 作者: lattice 時間: 2025-3-27 00:06 作者: 群島 時間: 2025-3-27 04:06
Alexey V. Glukhov,Anamika Bhargava,Julia Gorelikn of domain knowledge graphs requires more domain related data. In this paper, encyclopedia data and the financial report data are used to extract domain terms and relations. And then a domain knowledge graph for quantitative trading is constructed to realize the automatic generation of quantitative作者: 誘使 時間: 2025-3-27 05:42
Karin P. Hammer,Lars S. Maierta. In turn, this will help the farmer to prepare them to give water and on the other hand it will be helpful to use appropriate ground water and also it can be used for predict energy utilization. In this research Multiple linear regression algorithm is used for this prediction. Data from the irrig作者: RAGE 時間: 2025-3-27 09:42
Nicholas Stafford,Ludwig Neyses,Delvac Oceandyta. In turn, this will help the farmer to prepare them to give water and on the other hand it will be helpful to use appropriate ground water and also it can be used for predict energy utilization. In this research Multiple linear regression algorithm is used for this prediction. Data from the irrig作者: Classify 時間: 2025-3-27 15:02 作者: 冥想后 時間: 2025-3-27 19:58 作者: 夾死提手勢 時間: 2025-3-27 23:38 作者: Pepsin 時間: 2025-3-28 02:22
Pharmacological Approaches for Delineating Functions of AKAP-Based Signalling Complexes and Finding The interacting partners can comprise all proteins of canonical cAMP signalling: protein kinase A (PKA), PKA substrates, adenylyl cyclases, phosphodiesterases (PDEs) and protein phosphatases. AKAPs are central for compartmentalising these components and thus for achieving specificity of cAMP signal作者: 是剝皮 時間: 2025-3-28 08:41
Chatting Second Messengers: PIP3 and cAMPe to activation of G protein-coupled receptors (GPCRs) by a wide array of hormones and neurotransmitters. Although these small molecules engage distinct and seemingly unrelated downstream signal transducers, a growing body of evidence points to a strict cooperation of cAMP and PIP3 cascades in the c作者: 山羊 時間: 2025-3-28 10:26
Cyclic Nucleotide Phosphodiesterases and Compartmentation in Normal and Diseased Heart highly diverse class of enzymes encoded by 21 genes encompasses 11 families which are not only responsible for the termination of cyclic nucleotide signalling, but are also involved in the generation of dynamic microdomains of cAMP and cGMP controlling specific cell functions in response to various作者: 貪婪的人 時間: 2025-3-28 17:39 作者: hermetic 時間: 2025-3-28 22:21
Subcellular Targeting of PDE4 in Cardiac Myocytes and Generation of Signaling Compartmentstion. Conversely, much less was known about the PDE4 family of proteins expression and function in the heart. Indeed, PDE4-selective inhibitors were developed with the rationale that they would retain the beneficial properties of a nonselective inhibitor but would be devoid of cardiac effects. Yet i作者: 慌張 時間: 2025-3-28 23:17
Cardiac cAMP Microdomains and Their Modulation Using Disruptor Peptidesm the 11 families are selectively expressed and targeted in cellular microdomains, with each isoform’s function underpinned by its location, affinity/specificity of its cyclic nucleotide substrate, and ability to be modified by posttranslational modifications. The best way to define the function of 作者: 放大 時間: 2025-3-29 04:17 作者: 無聊的人 時間: 2025-3-29 10:59
Signalling Microdomains: The Beta-3 Adrenergic Receptor/NOS Signalosomerface receptors. This is achieved by spatial confinement of receptors and effectors in specific membrane locales, such as caveolae, but also by receptor translocation to particular plasma membrane locations upon ligand stimuli, cellular stress or pathophysiologic conditions, thereby changing downstr作者: BLINK 時間: 2025-3-29 13:59 作者: 大漩渦 時間: 2025-3-29 15:36 作者: 武器 時間: 2025-3-29 22:20
Distribution and Regulation of L-Type Ca2+ Channels in Cardiomyocyte MicrodomainsExcitation of the cellular membrane results in opening of the voltage-gated L-type Ca. channels, which allow a small amount of Ca. to enter the cell. This triggers the release of a much greater amount of Ca. from the intracellular Ca. store, the sarcoplasmic reticulum, and gives rise to the systolic作者: 不來 時間: 2025-3-30 02:45 作者: 辮子帶來幫助 時間: 2025-3-30 07:15 作者: coddle 時間: 2025-3-30 10:29 作者: 切掉 時間: 2025-3-30 13:09
Nadja I. Bork,Viacheslav O. Nikolaev context of cyber-security of organizations operating within critical infrastructure sectors. A design science approach was applied to establish a framework artifact that consists of the four dimensions “Security Ambition”, “Security Process”, “Resilience” and “Business Value”. These dimensions were作者: Pulmonary-Veins 時間: 2025-3-30 18:18 作者: 鄙視讀作 時間: 2025-3-30 23:14 作者: CHOIR 時間: 2025-3-31 01:21 作者: 他很靈活 時間: 2025-3-31 05:56 作者: Astigmatism 時間: 2025-3-31 10:35 作者: 墻壁 時間: 2025-3-31 14:52 作者: 助記 時間: 2025-3-31 20:31
Marco Contial data. Among imposed constraints, we find that while a disclosure occurs on user’s personal data, the burden of proof is now in the charge of business owners. In this context, data access has to be managed according to what is mentioned in Terms of Service and logged in a way to prove the occurren作者: 逢迎白雪 時間: 2025-3-31 23:27
