作者: 嚴(yán)厲譴責(zé) 時(shí)間: 2025-3-21 20:26 作者: CRUMB 時(shí)間: 2025-3-22 01:47
http://image.papertrans.cn/m/image/631591.jpg作者: guzzle 時(shí)間: 2025-3-22 07:28
978-3-7091-1669-2Springer-Verlag/Wien 2011作者: AVOID 時(shí)間: 2025-3-22 08:43
,Platinum(II) Intercalating Complexes Based on 2,2′:6′,2″-Terpyridine, caused considerable interest in other platinum complexes, particularly metallointercalators as it is believed these complexes could display a different spectrum of anticancer activity due to their different mode of binding [2].作者: Incommensurate 時(shí)間: 2025-3-22 13:18
Introduction to Nuclear Magnetic Resonance,range of applications in various fields of research [1,2]. Of all the analytical techniques in chemistry, NMR has been proven to be superior and extremely useful for the characterisation of complex mixtures, biomolecular structures and dynamics, molecular interactions and aggregations.作者: BIBLE 時(shí)間: 2025-3-22 20:16 作者: 討人喜歡 時(shí)間: 2025-3-23 00:22
Target Biological Structures: The Cell, Organelles, DNA and RNA,potential targets for therapeutics. Water, inorganic ions and a large array of relatively small organic molecules (e.g., sugars, vitamins and fatty acids) account for approximately 80% of living matter, with water being the most abundant. Macromolecules such as proteins, polysaccharides, ribonucleic作者: 光明正大 時(shí)間: 2025-3-23 03:22
Ruthenium Polypyridyl Metallointercalators,rea of research, at the junction between biology and chemistry, is a challenge, as the fundamental principles by which DNA discriminates are not well understood. Investigating the biological functions of DNA necessitates probing interactions at the molecular level. As a result, there have been exten作者: 茁壯成長(zhǎng) 時(shí)間: 2025-3-23 08:14
The Synthesis of Platinum(II) Intercalators,essential to gain some understanding of the mechanisms of drug action, and to determine which structural characteristics influence the pharmacological properties. Of particular interest are the interactions between anticancer agents and DNA, as DNA is considered to be the major cellular target for a作者: MORPH 時(shí)間: 2025-3-23 13:13 作者: 多余 時(shí)間: 2025-3-23 14:07
Introduction to Nuclear Magnetic Resonance,range of applications in various fields of research [1,2]. Of all the analytical techniques in chemistry, NMR has been proven to be superior and extremely useful for the characterisation of complex mixtures, biomolecular structures and dynamics, molecular interactions and aggregations.作者: oracle 時(shí)間: 2025-3-23 21:34
,NMR Studies of Metallointercalator–DNA Interactions,ordén [3] and Barton [4] to the point that it is now a central theme in bio-inorganic chemistry. While there has been considerable interest in metal complexes that bind nucleic acids, the interaction of metallointercalators with DNA and RNA has received the most attention [5, 6]. Square-planar plati作者: PIZZA 時(shí)間: 2025-3-23 23:20 作者: 結(jié)合 時(shí)間: 2025-3-24 05:14
Mass Spectrometric Studies of Non-Covalent Binding Interactions Between Metallointercalators and DNpplications for molecules that can accomplish this task with high affinity and selectivity. As a result many workers have used a wide variety of experimental techniques, several of which are discussed in other chapters of this book, to unravel the details of the precise intermolecular interactions i作者: obscurity 時(shí)間: 2025-3-24 08:39
Investigating Binding Interactions Using Linear Dichroism and Circular Dichroism,hether a putative metallointercalator does indeed bind to DNA intercalatively. In general, we require two pieces of evidence from completely different techniques that strongly suggest intercalation before we can conclude with any confidence that we do have a metallointercalator. The purpose of this 作者: 勤勉 時(shí)間: 2025-3-24 13:00
Applications of Fluorescence Spectroscopy and Confocal Microscopy,racellular localisation of novel metallointercalators. Fluorescence is the property whereby some atoms or molecules absorb UV or visible light and then re-emit it at longer wavelengths after a brief interval, termed the fluorescence lifetime.作者: archenemy 時(shí)間: 2025-3-24 15:26 作者: anaphylaxis 時(shí)間: 2025-3-24 19:18 作者: FRONT 時(shí)間: 2025-3-24 23:38
Investigating the Biological Significance of Metallointercalators with cDNA Microarrays,c blueprint of all living things. All the information required for the development, operation and maintenance of cells is contained in a sequence of adenine (A), thymine (T), cytosine (C) and guanine (G) bases, where adenine is paired with thymine and cytosine is paired with guanine [1]. The DNA seq作者: Confirm 時(shí)間: 2025-3-25 05:25
Cytotoxicity Testing: Cell Experiments,eening for cytotoxic activity is still a standard tool in the search for new anticancer agents, especially if the mode of action of a substance is not yet known. A wide variety of cell culture methods with unique end-points are available for testing the anticancer potential of a substance. Each has 作者: defendant 時(shí)間: 2025-3-25 09:51 作者: 減去 時(shí)間: 2025-3-25 12:56
Animal Testing,ntries all around the world [1]. Application of a new drug for admission to the market is supported by preclinical and clinical data, both including the determination of pharmacodynamics, toxicity, antitumour activity, therapeutic index, etc. As preclinical studies are associated with high cost, opt作者: amnesia 時(shí)間: 2025-3-25 17:21
outh Africa and abroad (e.g. Andersen & Collins, 2007; Mama, 1995). However, the ways in which these subject positions influence narratives involving oppression or historical trauma remain fluid, dynamic and open to interpretation (McEwan, 2003; Russell, 2008; Theidon, 2007). This chapter explores t作者: inconceivable 時(shí)間: 2025-3-25 22:26
Marcelis van Holst,Maxine P. Grant,Janice Aldrich-Wrights under the old apartheid order’ because ‘traumatic experiences from the past will constantly attempt to re-inscribe themselves (often in masked form) in the present, if they are not acknowledged, interrogated and addressed’ (Apartheid Archive Project, 2010). To that end, my role as a researcher par作者: Acquired 時(shí)間: 2025-3-26 03:31
Nikita Orkey,Paul Wormell,Janice Aldrich-Wrighttion in the construction of the archive itself. Although narratives have and will continue to be collected through various channels, one of the primary means of submission is a Web-based portal. Thus far, many of the contributions have been offered by the research team and their associates, and to a作者: 斗志 時(shí)間: 2025-3-26 08:11 作者: CHOP 時(shí)間: 2025-3-26 10:59 作者: Sarcoma 時(shí)間: 2025-3-26 14:46 作者: Optic-Disk 時(shí)間: 2025-3-26 17:59 作者: 尊嚴(yán) 時(shí)間: 2025-3-26 22:58
Gang Zheng,Anwen M. Krause-Heuer,William S. Price they almost universally realize that citizen approval is a kind of political capital, which can be enhanced or squandered. Approval ratings are a running tally of how citizens view their elected leaders. A number of political actors carefully watch ratings to judge the range of possibility in polit作者: dapper 時(shí)間: 2025-3-27 01:54 作者: 蒼白 時(shí)間: 2025-3-27 07:00
Alison Rodger,Per Lincolnnce of recognising the racialised nature of this environment.Thisis the first academic monograph to focus exclusively on issues of race,ethnicity, whiteness and multiculture at the English seaside. The book callsfor acknowledgement of the racialised nature of this environment, and proposesthat its d作者: 譏諷 時(shí)間: 2025-3-27 10:49 作者: 平躺 時(shí)間: 2025-3-27 15:10 作者: Esalate 時(shí)間: 2025-3-27 20:08
Nichola C. Garbettnce of recognising the racialised nature of this environment.Thisis the first academic monograph to focus exclusively on issues of race,ethnicity, whiteness and multiculture at the English seaside. The book callsfor acknowledgement of the racialised nature of this environment, and proposesthat its d作者: 抗生素 時(shí)間: 2025-3-27 23:33 作者: 終端 時(shí)間: 2025-3-28 04:36
Renate Grünert,Aron Westendorf,Magdalena Buczkowska,Mareike H?nsch,Sybil Grüunert,Patrick J. Bednarsthey happened in real time, through the words of those who participated, allowing the reader to understand and recognize the unvarnished truth. As a means of education and learning, it is innately valuable. Speaking of race and racism, it allows us to underscore our values and principles of social j作者: 大漩渦 時(shí)間: 2025-3-28 09:39
Albert Bolhuis,Adair D. Richardsthey happened in real time, through the words of those who participated, allowing the reader to understand and recognize the unvarnished truth. As a means of education and learning, it is innately valuable. Speaking of race and racism, it allows us to underscore our values and principles of social j作者: Promotion 時(shí)間: 2025-3-28 12:19
Johnny Moretto,Bruno Chauffert,Florence Bouyerf race and cross-racial interaction..This book uses an histoStorytelling is one of the oldest, yet most provocative human art forms. It allows us to learn through the illustration and presentation of events as they happened in real time, through the words of those who participated, allowing the read作者: 依法逮捕 時(shí)間: 2025-3-28 15:32 作者: Anticoagulants 時(shí)間: 2025-3-28 20:19 作者: Processes 時(shí)間: 2025-3-29 02:56
Investigating the Biological Significance of Metallointercalators with cDNA Microarrays,uence is made usable by transcription of the nucleotide sequence into single stranded messenger RNA (mRNA).. This means that the four member nucleic acid base code sequence is converted into a 22 member amino acid code [2].作者: 預(yù)兆好 時(shí)間: 2025-3-29 03:50 作者: Keratectomy 時(shí)間: 2025-3-29 11:19 作者: ESPY 時(shí)間: 2025-3-29 13:16 作者: 多骨 時(shí)間: 2025-3-29 16:44
Target Biological Structures: The Cell, Organelles, DNA and RNA,les which are vital for cellular function are imported into the cell by a variety of mechanisms but unlike smaller molecules, macromolecules are assembled within the cell itself. Drugs are usually designed to target cellular macromolecules, as they perform very specific roles in the metabolic processes.作者: insolence 時(shí)間: 2025-3-29 21:52 作者: 解開(kāi) 時(shí)間: 2025-3-30 00:45 作者: 表示向下 時(shí)間: 2025-3-30 05:18 作者: conscribe 時(shí)間: 2025-3-30 08:53
The Synthesis of Platinum(II) Intercalators, properties. Of particular interest are the interactions between anticancer agents and DNA, as DNA is considered to be the major cellular target for a large number of compounds that are effective in the treatment of various types of cancers [1–11].作者: 取回 時(shí)間: 2025-3-30 16:20
Pulsed Gradient Spin-Echo NMR, pulsed gradient spin-echo (PGSE) NMR has become a method of choice for the study of molecular dynamics and structural details of biological systems [1, 2]; in combination with magnetic resonance imaging (MRI), it allows (localised) . diffusion measurements.作者: 纖細(xì) 時(shí)間: 2025-3-30 17:25 作者: Muscularis 時(shí)間: 2025-3-30 22:26 作者: CHIDE 時(shí)間: 2025-3-31 02:39 作者: 抗原 時(shí)間: 2025-3-31 08:42 作者: 使痛苦 時(shí)間: 2025-3-31 10:21
llustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery. .978-3-7091-1669-2978-3-211-99079-7作者: anus928 時(shí)間: 2025-3-31 14:29
Alison Rodger,Per Lincolnetical insight and empirical fieldwork, the book disruptsdominant thinking that fixes ontologically minority ethnic bodies to urbanspaces, and overcomes their erasure and silencing from the seaside landscapesof the popular imagination..978-1-349-68655-1978-1-137-45012-8作者: Dendritic-Cells 時(shí)間: 2025-3-31 18:32
