標(biāo)題: Titlebook: Messenger RNA Therapeutics; Stefan Jurga,Jan Barciszewski Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive licen [打印本頁] 作者: 我要黑暗 時間: 2025-3-21 17:00
書目名稱Messenger RNA Therapeutics影響因子(影響力)
作者: chronicle 時間: 2025-3-21 20:29 作者: 定點(diǎn) 時間: 2025-3-22 02:16
Messenger RNA Therapeutics: Start of a New Era in Medicine,ses of RNA-based therapeutics. Among these, mRNA-based therapy is centered on producing proteins within the cells to supplant deficient or abnormal proteins and in vaccination to a target pathogen. The potential of mRNA therapeutics is evident from the two major mRNA vaccines approved for COVID-19: 作者: 鞏固 時間: 2025-3-22 08:11
Hospital-Based RNA Therapeutics,e mRNA is essentially biological software, therapeutic RNA constructs can be rapidly developed. The generation of small batches of clinical-grade mRNA to support IND applications and first-in-man clinical trials, as well as personalized mRNA therapeutics delivered at the point-of-care, is feasible a作者: meretricious 時間: 2025-3-22 08:55 作者: 與野獸博斗者 時間: 2025-3-22 14:11
SARS-COV-2 and Other mRNA Vaccines, for the prevention of SARS-COV-2 disease following unprecedented speed of development through to emergency use licensure in around three hundred days from virus sequence availability. Case studies of three SARS-COV-2 mRNA vaccines for which field clinical efficacy data are available are examined an作者: Hirsutism 時間: 2025-3-22 17:09 作者: Peculate 時間: 2025-3-23 00:37
Synthetic mRNA Gene Therapies and Hepatotropic Non-viral Vectors for the Treatment of Chronic HBV Ience of HBV-associated liver cancer and cirrhosis. Currently, there is no cure for chronic HBV infection, and novel therapeutic approaches, including gene editing and epigenome engineering, are being investigated. Although promising, the liver-specific delivery, expression and safety profile of thes作者: infarct 時間: 2025-3-23 04:44
,Preparation of Synthetic mRNAs—Overview and Considerations,afe. The central advantage of the successful use of synthetic mRNA as a vaccine hinge on being able to rapidly manufacture the mRNA molecules. The synthetic mRNA is prepared in vitro via a cell-free enzymatic process. The aim of this chapter is to provide an overview of the enzymatic mRNA synthesis 作者: Respond 時間: 2025-3-23 06:45
In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of Twenty-First Century:an efficient delivery system, the host cell ribosomes will be recruited to translate and produce the corresponding desired proteins. Nowadays, about 20?years after the first report as for the use of IVT-mRNA, this technology has all the spotlight on it, due to the recently produced vaccines against 作者: 高興一回 時間: 2025-3-23 12:33 作者: Audiometry 時間: 2025-3-23 17:19
Adjuvants, the Elephant in the Room for RNA Vaccines,rly understood. Although the attractiveness of mRNA as an immunogen has been recognized already more than thirty years ago, it wasn’t until the current COVID-19 crisis that its full potential was shown. From a fringe approach, it has now become a leading technology in vaccine development which will 作者: 嚴(yán)峻考驗(yàn) 時間: 2025-3-23 20:35 作者: 偉大 時間: 2025-3-24 02:15 作者: GROVE 時間: 2025-3-24 04:40
RNA/Polymer-Based Supramolecular Approaches for mRNA Delivery, a therapeutic modality, mRNA still has issues of poor bioavailability, showing rapid enzymatic degradation in physiological environments and inducing uncontrollable inflammatory responses. Chemical modification of mRNA is a prevalent approach to these issues and effectively reduces mRNA immunogenic作者: 易受騙 時間: 2025-3-24 07:02
Delivery Vehicles for Self-amplifying RNA,y into the cytosol. This amplification results in high protein expression from a relatively low dose of saRNA (~100-fold lower than mRNA). The rapid, cost-effective, cell-free manufacturing, low dosage requirement, and acceptable safety profile have drawn spotlight on saRNA, which has recently enter作者: 遺傳學(xué) 時間: 2025-3-24 11:38 作者: HARP 時間: 2025-3-24 14:51 作者: 切割 時間: 2025-3-24 21:36
Nonsequential Pre-mRNA Splicing: From Basic Understanding to Impacts on Splice-Manipulating Therapies. The development of antisense oligonucleotides (AOs) to harness the splicing process and manipulate it to treat various inherited and acquired diseases has been boosted by its flexibility and customisation capability. As the amount of research in this space increases, certain aspects need to be c作者: 不幸的人 時間: 2025-3-25 01:14
gical insights into diseases pathogenesis and therapeutic intervention. Herein, we introduce a quantitative strategy utilizing isobaric stable isotope-labeling techniques combined with two-dimensional liquid chromatography–tandem mass spectrometry (2D-LC–MS/MS) for large-scale, deep quantitative pro作者: photopsia 時間: 2025-3-25 04:00
Randall A. Meyer,Sara Trabulo,Julie A. Douthwaite,Jose Luis Santosapplications. Method development is driven by the need to establish new—and validate current—protein biomarkers of high-to-low abundance for clinical utility. In this chapter, we describe a methodology involving two-dimensional (2D) reversed-phase liquid chromatography (RPLC), operated under alkalin作者: Mobile 時間: 2025-3-25 09:49
Nicholas Jacksonby an ensemble of atoms. More useful is the power spectrum, which is attributed to fluctuations of the field amplitudes and gives variations in the field intensity as a function of frequency. As demonstrated in the previous chapter, the calculation of the power spectrum requires the knowledge of the作者: 空洞 時間: 2025-3-25 14:25
Saloni Jain,Abhilash J. George,Vasu Sharma,Gagandeep Singh,Vandana Gupta free fields, but are generated by sources such as atoms or molecules. We now turn more specifically to the subject of spectroscopy with signal fields produced by single multilevel atoms radiating due to the interaction with the ordinary vacuum and irradiated by quasi-resonant fields. The study of s作者: 人工制品 時間: 2025-3-25 19:45
Tulsi Ram Damase,Roman Sukhovershin,Min Zhang,Daniel L. Kiss,John P. Cookeconventional order for which the usual condensed matter methods like the Landau paradigm or the free fermion framework break down. Concepts and tools in quantum information science such as entanglement, quantum circuits, and the tensor network representation prove to be highly useful in studying suc作者: 男生如果明白 時間: 2025-3-25 21:48
A. C. Matin,Alexis Forterreof long-range quantum entanglement and the discovery of related mathematical theories (such as tensor category theory), a systematic understanding of all gapped states in any dimensions is emerging, which include topological orders and SPT orders. However, our understanding of highly entangled gaple作者: 樂意 時間: 2025-3-26 03:28 作者: 錫箔紙 時間: 2025-3-26 04:28 作者: IRS 時間: 2025-3-26 10:35
Dylan Kairuz,Prashika Singh,Tiffany Smith,Patrick Arbuthnot,Abdullah Ely,Kristie Bloomace in mind, we introduce the concept of locality. It is naturally associated with the spatial geometry of the system, where the most natural interaction between degrees of freedom are those “l(fā)ocal” ones, for instance nearest neighbor interactions. We discuss the effect of locality on the ground-sta作者: 欄桿 時間: 2025-3-26 12:58
Siu-Hong Chan,Bijoyita Royconventional order for which the usual condensed matter methods like the Landau paradigm or the free fermion framework break down. Concepts and tools in quantum information science such as entanglement, quantum circuits, and the tensor network representation prove to be highly useful in studying suc作者: 機(jī)構(gòu) 時間: 2025-3-26 19:58
A. N. Miliotou,I. S. Pappas,I. S. Vizirianakis,L. C. Papadopouloung information, there is a need for the development and application of high-throughput real time PCR genotyping and gene expression methods that significantly broaden the current screening capabilities. Thermo Fisher Scientific (USA) has released a platform (QuantStudio? 12K Flex system coupled with作者: invert 時間: 2025-3-26 21:52
Melike Ongun,Abhijeet Girish Lokras,Camilla Foged,Aneesh Thakuroduced during PCR amplification, resulting from the differences associated with length polymorphism and the varying number of copies of the rRNA operon among fungal species, the lack of specificity of the primers targeting the different regions of the rRNA operon, or their insufficient coverage of t作者: investigate 時間: 2025-3-27 03:57 作者: incisive 時間: 2025-3-27 05:57 作者: 向外供接觸 時間: 2025-3-27 12:10
Maria L. Guevara,Francesca Persano,Stefano Persano executing and not the software as a monolithic system. In computer software systems, it is the functionality that fails. Some functionalities may be virtually failure free while other functionalities will collapse with certainty whenever they are executed. The focus of this paper is on the notion t作者: 有效 時間: 2025-3-27 15:17
Eger Boonstra,Satoshi Uchida,Horacio Cabral executing and not the software as a monolithic system. In computer software systems, it is the functionality that fails. Some functionalities may be virtually failure free while other functionalities will collapse with certainty whenever they are executed. The focus of this paper is on the notion t作者: 嘲笑 時間: 2025-3-27 21:44 作者: 奇怪 時間: 2025-3-28 00:47 作者: acrophobia 時間: 2025-3-28 05:29
https://doi.org/10.1007/978-3-031-08415-7mRNA therapeutics; RNA vaccines; SARS-CoV-2; Lipid nanoparticles; Adjuvants; Cancer Immunotherapy; Self-am作者: Indelible 時間: 2025-3-28 06:28
Stefan Jurga,Jan BarciszewskiFocuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics.Discusses the strengths and key challenges of this emerging class of drugs.Provides a state-of-the-art overview 作者: GUMP 時間: 2025-3-28 14:20
RNA Technologieshttp://image.papertrans.cn/m/image/631097.jpg作者: Coordinate 時間: 2025-3-28 18:17 作者: phlegm 時間: 2025-3-28 21:23 作者: preservative 時間: 2025-3-29 01:37
Hospital-Based RNA Therapeutics, to support IND applications and first-in-man clinical trials, as well as personalized mRNA therapeutics delivered at the point-of-care, is feasible at a modest scale of cGMP manufacturing. Advances in mRNA manufacturing science and innovations in mRNA biology are increasing the scope of mRNA clinical applications.作者: VICT 時間: 2025-3-29 06:06
SARS-COV-2 and Other mRNA Vaccines, from virus sequence availability. Case studies of three SARS-COV-2 mRNA vaccines for which field clinical efficacy data are available are examined and related to mRNA/LNP attributes where possible. The status of other SARS-COV-2 and non-SARS-COV-2 mRNA vaccines in clinical development and select future prospective innovations are reviewed.作者: Iatrogenic 時間: 2025-3-29 10:56
,Preparation of Synthetic mRNAs—Overview and Considerations,thetic mRNA is prepared in vitro via a cell-free enzymatic process. The aim of this chapter is to provide an overview of the enzymatic mRNA synthesis process and discuss the enzymatic components involved in the workflow. Furthermore, critical parameters that need to be considered for characterization of the synthetic mRNAs are also discussed.作者: 暫時過來 時間: 2025-3-29 15:16
Nuclear Export of mRNAs with Disease Pathogenesis and Therapeutic Implications,teins in different cellular compartments. In this chapter, we describe how gene expression is controlled at the level of mRNA export from nucleus to the cytoplasm with implications for disease pathogenesis and therapeutic development.作者: 無禮回復(fù) 時間: 2025-3-29 16:02
2197-9731 merging class of drugs.Provides a state-of-the-art overview This book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs.?In the past 30 years, extensive research and technological dev作者: 被詛咒的人 時間: 2025-3-29 21:32
Messenger RNA Therapeutics: Start of a New Era in Medicine,hetic mRNA platforms, production, purification; strategies to increase the stability and reduce the immunogenicity of therapeutic mRNA molecules; delivery methods of these mRNAs in vivo; and their applications, safety, and efficacy.作者: Throttle 時間: 2025-3-30 03:55
Nonsequential Pre-mRNA Splicing: From Basic Understanding to Impacts on Splice-Manipulating Therapio study intron removal order and the occasions that they are best suited. Finally, we discuss how nonsequential splicing could facilitate or impede the development of splice-manipulating AOs and aspects to consider when analysing AO effectiveness.作者: Mercurial 時間: 2025-3-30 04:02
Advances in mRNA Delivery and Clinical Applications, vitro transcription (IVT), and, especially, delivery technology, the therapeutic mRNA got immense popularity. In this chapter, we described the latest advances in mRNA delivery systems as well as tried to figure out the development trend of delivery platforms and also summarized the applications of mRNA therapeutics.作者: 隼鷹 時間: 2025-3-30 11:35 作者: archetype 時間: 2025-3-30 15:30 作者: 易于出錯 時間: 2025-3-30 18:22
Nicholas Jacksonry fields, i.e., fields whose properties are independent of the origin of time. Under this condition, all the two-time correlation functions will involve components that depend on the time arguments only through their difference. Also, we shall follow the definition?(.) of the power spectrum, which 作者: Inkling 時間: 2025-3-30 23:19
Saloni Jain,Abhilash J. George,Vasu Sharma,Gagandeep Singh,Vandana Guptaitting of the atomic energy levels, transition frequencies between the levels, and their populations. Here, we shall focus on a different aspect of atomic spectroscopy, which utilizes optical spectra to tackle the problem of quantum fluctuations, their control and effect on the radiative properties 作者: 本土 時間: 2025-3-31 04:41
Tulsi Ram Damase,Roman Sukhovershin,Min Zhang,Daniel L. Kiss,John P. Cookestrongly interacting systems, the topological order, and shows how it can essentially be defined and characterized in terms of entanglement.? Part IV shows that the key entanglement structure of topological states can be captured using the tensor network representation, which provides a powerful too作者: bourgeois 時間: 2025-3-31 05:48 作者: anachronistic 時間: 2025-3-31 11:02
Nicholas Jacksonstrongly interacting systems, the topological order, and shows how it can essentially be defined and characterized in terms of entanglement.? Part IV shows that the key entanglement structure of topological states can be captured using the tensor network representation, which provides a powerful too作者: Pander 時間: 2025-3-31 14:41 作者: 不要嚴(yán)酷 時間: 2025-3-31 19:48
Dylan Kairuz,Prashika Singh,Tiffany Smith,Patrick Arbuthnot,Abdullah Ely,Kristie Bloome also discuss a special kind of local Hamiltonians, called the frustration-free Hamiltonians, where the ground state is also ground states of all the local interaction terms. However, to determine whether a Hamiltonian is frustration-free is in general hard.作者: menopause 時間: 2025-4-1 00:37
Siu-Hong Chan,Bijoyita Roystrongly interacting systems, the topological order, and shows how it can essentially be defined and characterized in terms of entanglement.? Part IV shows that the key entanglement structure of topological states can be captured using the tensor network representation, which provides a powerful too作者: Consensus 時間: 2025-4-1 05:02 作者: 盡管 時間: 2025-4-1 07:38 作者: 加花粗鄙人 時間: 2025-4-1 13:32 作者: epinephrine 時間: 2025-4-1 15:03
Bo Hu,Abid Hussain,Qing Liu,Yuhua Weng,Yuanyu Huangthese efforts, and indicate how they can be used to construct a discipline of measuring and evaluating how well processes can be expected to deliver specific knowledge about software product qualities. We look towards the gradual, but eventual, establishment of an orderly discipline of software qual
