作者: 要素 時間: 2025-3-21 20:52 作者: Sciatica 時間: 2025-3-22 01:52 作者: Polydipsia 時間: 2025-3-22 08:38 作者: LEER 時間: 2025-3-22 11:06
Epidermal Melanocytes: Regulation of Their Survival, Proliferation, and Function in Human Skin,iscuss the significance of paracrine and autocrine factors and their signaling pathways in modulating the survival, proliferation, and function of melanocytes, constitutively, and in response to solar ultraviolet radiation (UV), a major environmental stressor and etiological factor for skin cancers,作者: 表示向下 時間: 2025-3-22 13:42
Melanoma Genetics and Genomics,r the formation of melanoma. The first pathway involves relatively young individuals with large numbers of nevi and who develop melanomas on locations (e.g., trunk) that are intermittently UV exposed. This pathway is further corroborated by the fact that . mutations, which frequently occur in nevi, 作者: chandel 時間: 2025-3-22 17:38 作者: Baffle 時間: 2025-3-23 00:51 作者: 翅膀拍動 時間: 2025-3-23 01:41
,Cell–Cell and Cell–Matrix Contacts in Melanoma and the Tumor Microenvironment,their ligands; (4) loss of anchorage to the basement membrane due to altered expression of cell–matrix adhesion molecules; (5) increased expression of metalloproteinases..Melanoma depends on, interacts with and reacts to its stroma, including extracellular matrix, growth factors, cytokines, fibrobla作者: 鐵砧 時間: 2025-3-23 05:40 作者: 生命 時間: 2025-3-23 11:01
Immunotherapy of Melanoma: A New Era,metastatic disease..In the adjuvant setting, vaccines have performed remarkably poorly. In a number of trials multiple vaccinations seemed even associated with worse outcome. A similar boost to vaccine development, also in the adjuvant setting, may depend on combinations with innovative immunomodula作者: 核心 時間: 2025-3-23 17:06 作者: 廣口瓶 時間: 2025-3-23 20:23
Satoru Yokoyama,David E. Fisherto make their assessment practices more systematic, want to have assessment devices readily available, and want to expand their assessment practices with the most up-to-date approaches.978-0-306-46582-6978-0-306-47628-0Series ISSN 1869-2281 Series E-ISSN 1869-229X 作者: muster 時間: 2025-3-24 00:21 作者: LOPE 時間: 2025-3-24 05:26
Eric Lau,Ze’ev A. Ronaito make their assessment practices more systematic, want to have assessment devices readily available, and want to expand their assessment practices with the most up-to-date approaches.978-0-306-46582-6978-0-306-47628-0Series ISSN 1869-2281 Series E-ISSN 1869-229X 作者: florid 時間: 2025-3-24 10:04
Paola Zigrino,Cornelia Mauchto make their assessment practices more systematic, want to have assessment devices readily available, and want to expand their assessment practices with the most up-to-date approaches.978-0-306-46582-6978-0-306-47628-0Series ISSN 1869-2281 Series E-ISSN 1869-229X 作者: 填料 時間: 2025-3-24 14:15 作者: dictator 時間: 2025-3-24 18:37
Jürgen Eberle,Lothar F. Feckerto make their assessment practices more systematic, want to have assessment devices readily available, and want to expand their assessment practices with the most up-to-date approaches.978-0-306-46582-6978-0-306-47628-0Series ISSN 1869-2281 Series E-ISSN 1869-229X 作者: 詳細(xì)目錄 時間: 2025-3-24 20:00
Helen Rizos,Lyndee L. Scurrto make their assessment practices more systematic, want to have assessment devices readily available, and want to expand their assessment practices with the most up-to-date approaches.978-0-306-46582-6978-0-306-47628-0Series ISSN 1869-2281 Series E-ISSN 1869-229X 作者: debouch 時間: 2025-3-25 00:54
Tobias Schatton,Markus H. Frankto make their assessment practices more systematic, want to have assessment devices readily available, and want to expand their assessment practices with the most up-to-date approaches.978-0-306-46582-6978-0-306-47628-0Series ISSN 1869-2281 Series E-ISSN 1869-229X 作者: Thyroiditis 時間: 2025-3-25 06:54
Luigi Strizzi,Katharine M. Hardy,Elisabeth A. Seftor,Naira V. Margaryan,Dawn A. Kirschmann,Gina T. Kto make their assessment practices more systematic, want to have assessment devices readily available, and want to expand their assessment practices with the most up-to-date approaches.978-0-306-46582-6978-0-306-47628-0Series ISSN 1869-2281 Series E-ISSN 1869-229X 作者: glucagon 時間: 2025-3-25 07:30
Gao Zhang,Meenhard Herlynto make their assessment practices more systematic, want to have assessment devices readily available, and want to expand their assessment practices with the most up-to-date approaches.978-0-306-46582-6978-0-306-47628-0Series ISSN 1869-2281 Series E-ISSN 1869-229X 作者: 憤憤不平 時間: 2025-3-25 14:58 作者: reception 時間: 2025-3-25 16:17
Keith T. Flahertyto make their assessment practices more systematic, want to have assessment devices readily available, and want to expand their assessment practices with the most up-to-date approaches.978-0-306-46582-6978-0-306-47628-0Series ISSN 1869-2281 Series E-ISSN 1869-229X 作者: 有角 時間: 2025-3-25 21:31
contribute to this knowledge. Summarizing the newest data and presenting upcoming research areas in the field, the book will be of great interest to basic researchers and physicians working in the important fields of melanoma, cancer research, therapy and dermatology.978-3-7091-0371-5作者: 戰(zhàn)勝 時間: 2025-3-26 03:42
of worksheets and handouts included in the book can be reproduced or fine-tuned to fit age and ability levels...Featured topics include:...Emotion dysregulation as a risk factor for mental disorders, including978-1-4419-4477-1978-0-387-73851-2作者: –吃 時間: 2025-3-26 06:00
Anja Bosserhoff,Luigi Strizzi of worksheets and handouts included in the book can be reproduced or fine-tuned to fit age and ability levels...Featured topics include:...Emotion dysregulation as a risk factor for mental disorders, including978-1-4419-4477-1978-0-387-73851-2作者: indemnify 時間: 2025-3-26 10:40
Zalfa A. Abdel-Malek,Viki B. Swope of worksheets and handouts included in the book can be reproduced or fine-tuned to fit age and ability levels...Featured topics include:...Emotion dysregulation as a risk factor for mental disorders, including978-1-4419-4477-1978-0-387-73851-2作者: 易怒 時間: 2025-3-26 13:51
Springer-Verlag/Wien 2011作者: 急性 時間: 2025-3-26 19:49 作者: 心痛 時間: 2025-3-27 00:37 作者: 諷刺滑稽戲劇 時間: 2025-3-27 02:26 作者: 梯田 時間: 2025-3-27 07:12
Regulation of Apoptosis in Melanoma Cells: Targets for Therapeutic Strategies,resent suitable targets. Extrinsic (death receptor-mediated) and intrinsic (mitochondria-mediated) proapoptotic pathways have been described, and the better understanding how proapoptotic pathways are blocked in melanoma may provide a basis for the development of new therapeutic strategies.作者: 不確定 時間: 2025-3-27 11:39
Introduction,me risk for developing melanoma in the US has increased from approximately 1 in 1,500 during the 1930s to its present risk of approximately 1 in 60 (Giblin and Thomas 2007). The American Cancer Society’s recent cancer report estimates that 68,130 new cases of melanoma will be diagnosed and 8,700 dea作者: conjunctiva 時間: 2025-3-27 14:34 作者: TIGER 時間: 2025-3-27 19:53
Melanoma Epidemiology,ffer by age and sex as well as geographic location. Light pigmentation and multiple nevi are critical risk factors for the development of melanoma as are family history and intermittent sun exposure. Tanning lamp exposure has been clearly identified as adverse risk for melanoma and other environment作者: terazosin 時間: 2025-3-27 22:59 作者: Chemotherapy 時間: 2025-3-28 04:47 作者: 疼死我了 時間: 2025-3-28 08:50 作者: Ccu106 時間: 2025-3-28 11:46
Altered Signal Transduction Pathways in Melanoma, and protein kinases, transcription factors, and other regulatory proteins. Naturally, this is the most important component in control of any cellular process, and therefore it is not surprising that it is often deregulated in cancer. Melanoma is in fact a paradigm for rewired signaling, since most 作者: Dysarthria 時間: 2025-3-28 17:33
Proteases in Melanoma,quires a series of proteolytic events that modify not only the pericellular environment but also host-tumor communication..A variety of proteolytic enzymes, produced either by the tumor cells themselves or by the “tumor-activated” stroma, has been implicated in the pathogenesis of cancer including m作者: 我怕被刺穿 時間: 2025-3-28 18:51
,Cell–Cell and Cell–Matrix Contacts in Melanoma and the Tumor Microenvironment, multiple contacts with keratinocytes, which in turn control melanocyte growth and expression of cell surface receptors. Most melanomas arise within the epidermis (melanoma in situ) and then invade across the basement membrane. These melanoma cells escape from control by keratinocytes through five m作者: Afflict 時間: 2025-3-29 01:31
Regulation of Apoptosis in Melanoma Cells: Targets for Therapeutic Strategies,resent suitable targets. Extrinsic (death receptor-mediated) and intrinsic (mitochondria-mediated) proapoptotic pathways have been described, and the better understanding how proapoptotic pathways are blocked in melanoma may provide a basis for the development of new therapeutic strategies.作者: 分離 時間: 2025-3-29 06:22 作者: nocturnal 時間: 2025-3-29 07:54 作者: PAC 時間: 2025-3-29 14:11
Lessons from Embryogenesis,like characteristics. As the molecular signaling pathways underlying tumor cell plasticity become more transparent, our understanding of how to suppress this elusive phenotype will be enhanced. Indeed, we are making progress in identifying critical embryonic pathways, such as the Nodal signaling pat作者: medieval 時間: 2025-3-29 15:46
Tumor Microenvironment for Melanoma Cells,cell types is localized in the physiological environment. Melanoma cells actively interact with the tumor microenvironment in a bidirectional manner by orchestrating the normal cells. Human epidermal melanocytes can readily be isolated and used as a paradigm to -understand initiation and development作者: 笨拙的你 時間: 2025-3-29 20:52 作者: troponins 時間: 2025-3-30 02:54
New Therapeutic Approaches in Signaling,. For decades the melanoma field has lagged behind others in achieving significant alteration in the natural history of metastatic disease with conventional cytotoxic chemotherapy. Even immunotherapy, a treatment standard both in the metastatic and adjuvant setting, fails to benefit more than a smal作者: acrimony 時間: 2025-3-30 04:17
Immunotherapy of Melanoma: A New Era,of therapeutic vaccines in patients with metastatic melanoma, novel ways of modulating the immune system by monoclonal antibodies have changed the landscape. For the first time a clinically important and statistically significant impact on survival by a systemic therapy in advanced metastatic melano作者: ethnology 時間: 2025-3-30 08:50 作者: 辯論 時間: 2025-3-30 15:55 作者: scotoma 時間: 2025-3-30 18:44
Zalfa A. Abdel-Malek,Viki B. Swopen in school-aged children.Is written for practitioners, the .Most children master emotion regulation skills during their early childhood, though, increasingly, many enter school with mild or serious deficits that may not be addressed effectively or early enough. .Practitioner’s Guide to Emotion Regu作者: exacerbate 時間: 2025-3-30 22:16
Marianne Berwickat may not be addressed effectively or early enough. .Practitioner’s Guide to Emotion Regulation in School-Aged Children. presents in-depth background and practical information on the subject to enable school professionals to craft interventions that are developmentally appropriate, relevant, and ti作者: observatory 時間: 2025-3-31 04:01 作者: 2否定 時間: 2025-3-31 07:00
Satoru Yokoyama,David E. Fisherce and severity of anxiety and related disorders.Includes suDespite the high prevalence (as many as one in four) and severe impairment often associated with anxiety disorders, people who suffer are often undiagnosed, and may fail to receive appropriate treatment. The purpose of this volume is to pro作者: placebo 時間: 2025-3-31 10:33
Daniel W. Mueller,Anja Bosserhoffce and severity of anxiety and related disorders.Includes suDespite the high prevalence (as many as one in four) and severe impairment often associated with anxiety disorders, people who suffer are often undiagnosed, and may fail to receive appropriate treatment. The purpose of this volume is to pro作者: boisterous 時間: 2025-3-31 14:59
Eric Lau,Ze’ev A. Ronaice and severity of anxiety and related disorders.Includes suDespite the high prevalence (as many as one in four) and severe impairment often associated with anxiety disorders, people who suffer are often undiagnosed, and may fail to receive appropriate treatment. The purpose of this volume is to pro作者: Acclaim 時間: 2025-3-31 20:48
Paola Zigrino,Cornelia Mauchce and severity of anxiety and related disorders.Includes suDespite the high prevalence (as many as one in four) and severe impairment often associated with anxiety disorders, people who suffer are often undiagnosed, and may fail to receive appropriate treatment. The purpose of this volume is to pro作者: Biofeedback 時間: 2025-3-31 23:12 作者: endoscopy 時間: 2025-4-1 03:09
