標(biāo)題: Titlebook: Mathematical and Statistical Methods for Genetic Analysis; Kenneth Lange Textbook 2002Latest edition Springer Science+Business Media New Y [打印本頁] 作者: False-Negative 時間: 2025-3-21 18:59
書目名稱Mathematical and Statistical Methods for Genetic Analysis影響因子(影響力)
書目名稱Mathematical and Statistical Methods for Genetic Analysis影響因子(影響力)學(xué)科排名
書目名稱Mathematical and Statistical Methods for Genetic Analysis網(wǎng)絡(luò)公開度
書目名稱Mathematical and Statistical Methods for Genetic Analysis網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Mathematical and Statistical Methods for Genetic Analysis被引頻次
書目名稱Mathematical and Statistical Methods for Genetic Analysis被引頻次學(xué)科排名
書目名稱Mathematical and Statistical Methods for Genetic Analysis年度引用
書目名稱Mathematical and Statistical Methods for Genetic Analysis年度引用學(xué)科排名
書目名稱Mathematical and Statistical Methods for Genetic Analysis讀者反饋
書目名稱Mathematical and Statistical Methods for Genetic Analysis讀者反饋學(xué)科排名
作者: 滴注 時間: 2025-3-21 23:07
Diffusion Processes, a deterministic framework, these models also raise the mathematical bar. The current chapter surveys the theory at an elementary level, stressing intuition rather than rigor. Readers with the time and mathematical background should follow up this brief account by delving into serious presentations of the mathematics [1, 2, 7, 8].作者: 刀鋒 時間: 2025-3-22 02:38 作者: 愛得痛了 時間: 2025-3-22 07:34 作者: Inkling 時間: 2025-3-22 09:15
Computation of Mendelian Likelihoods,of the story. Evaluation of pedigree likelihoods remains a subject sorely in need of further theoretical improvement. Linkage calculations alone are among the most demanding computational tasks in modern biology.作者: Mercurial 時間: 2025-3-22 13:46 作者: penance 時間: 2025-3-22 18:49 作者: Confidential 時間: 2025-3-23 00:58 作者: CUB 時間: 2025-3-23 03:34
Counting Methods and the EM Algorithm,ted by Dempster et al. [5, 12]. Our initial example retraces some of the steps in the long march from concrete problems to an abstract algorithm applicable to an astonishing variety of statistical models.作者: 反省 時間: 2025-3-23 07:21
,Newton’s Method and Scoring, have much to offer in small to moderate-sized problems. For those uncomfortable with pulling prior distributions out of thin air, . procedures can be an appealing compromise between classical and Bayesian methods. This chapter illustrates some of these well-known themes in the context of allele frequency estimation and linkage analysis.作者: interior 時間: 2025-3-23 12:32
Genetic Identity Coefficients,ric autosomal locus and depend only on the relevant pedigree connecting two relatives and not on any phenotypes observed in the pedigree. In Chapter 6 we will investigate the applications of identity coefficients. Readers desiring motivation for the combinatorial problems attacked here may want to glance at Chapter 6 first.作者: 無可非議 時間: 2025-3-23 13:53
Descent Graph Methods, productive alternatives use elementary graph theory. The Lander-Green-Kruglyak algorithm alluded to in Chapter 7 exploits gene flow graphs and works well on small pedigrees. For large pedigrees, it is helpful to combine the graph theory perspective with stochastic methods of numerical integration [12, 23, 24, 32, 39, 40, 42].作者: 大炮 時間: 2025-3-23 19:44
Radiation Hybrid Mapping,ophisticated and successful versions raise many fascinating statistical problems. We will first discuss the mathematically simpler case of haploid radiation hybrids. Once this case is thoroughly digested, we will turn to the mathematically subtler case of polyploid radiation hybrids.作者: 宮殿般 時間: 2025-3-24 01:49 作者: Ingrained 時間: 2025-3-24 04:19 作者: Biomarker 時間: 2025-3-24 10:04
Counting Methods and the EM Algorithm,dels, geneticists by and large rely on maximum likelihood estimators rather than on competing estimators derived from minimax, invariance, robustness, or Bayesian principles. A host of methods exists for numerically computing maximum likelihood estimates. Some of the most appealing involve simple co作者: 賄賂 時間: 2025-3-24 13:45
,Newton’s Method and Scoring,owever, the trade-offs of programming ease, numerical stability, and speed of convergence are complex, and statistical geneticists should be fluent in a variety of numerical optimization techniques for finding maximum likelihood estimates. Outside the realm of maximum likelihood, Bayesian procedures作者: 犬儒主義者 時間: 2025-3-24 17:35
Hypothesis Testing and Categorical Data,ests or likelihood ratio tests based on large sample theory. Although one could easily dismiss this conservatism as undue reverence for Karl Pearson and R. A. Fisher, it is grounded in the humble reality of geneticists’ inability to describe precise alternative hypotheses and to impose convincing pr作者: 取消 時間: 2025-3-24 21:11
Genetic Identity Coefficients,reeding of a single individual and the degree of relatedness of a pair of relatives. Since the degree of inbreeding of a single individual can be summarized by the relationship between his or her parents, we will focus on identity coefficients for relative pairs. These coefficients pertain to a gene作者: idiopathic 時間: 2025-3-25 00:27 作者: 成份 時間: 2025-3-25 05:21
Computation of Mendelian Likelihoods,vestigate efficient algorithms for likelihood computation on pedigree data, placing particular stress on the pioneering algorithm of Elston and Stewart 8. It is no accident that their research coincided with the introduction of modern computing. To analyze human pedigree data is tedious, if not impo作者: 熱心 時間: 2025-3-25 11:21 作者: Feigned 時間: 2025-3-25 13:43
Molecular Phylogeny,olecular genetics [17, 22, 23]. It is now relatively simple to sequence genes and to compare the results from several contemporary taxa. In the current chapter we will assume that the chore of aligning the DNA sequences from these taxa has been successfully accomplished. The taxa are then arranged i作者: 確保 時間: 2025-3-25 19:01
Radiation Hybrid Mapping,e of the irradiated cells by hybridization to rodent cells, and analyzing the hybrid cells for surviving fragments of a particular human chromosome. For various technical reasons, radiation hybrid mapping languished for nearly a decade and a half until revived by Cox et al. [10]. The current, more s作者: 愛花花兒憤怒 時間: 2025-3-25 20:21
Models of Recombination,ter pairs then perfectly align to form a bundle of four chromatids. Crossing-over occurs at points along the bundle known as .. At each ., one sister chromatid from each pair is randomly selected and cut at the crossover point. The cell then rejoins the partial paternal chromatid above the cut to th作者: 反對 時間: 2025-3-26 03:35
Sequence Analysis,minate the evolutionary history of the new gene and the structure and function of its derived protein. Indeed, it is fair to say that sequence comparison is the single most useful application of the burgeoning genetic databases. Cross species comparisons are being done on a massive scale to identify作者: KIN 時間: 2025-3-26 08:02
Poisson Approximation,a sum of weakly dependent Bernoulli random variables. In contrast to many asymptotic methods, this approximation carries with it explicit error bounds. Let .. be a Bernoulli random variable with success probability ., where α ranges over some finite index set ..作者: 聚集 時間: 2025-3-26 12:24 作者: 先行 時間: 2025-3-26 16:02 作者: 歌劇等 時間: 2025-3-26 18:15
Kenneth Langeed in Southern Russia, it has a historically large Jewish population in its demographic structure. A ravine on the outskirts of the city—Zmievskaya Balka—is the largest Holocaust site in post-Soviet Russia. The reconstruction of Holocaust history during the second occupation of Rostov-on-Don based m作者: 使糾纏 時間: 2025-3-26 22:32
Kenneth Langeimes against Jews—using the judicial proceedings before the Bulgarian People’s Courts as a lens on the relationships between Jews and gentiles during the war, as well as in its immediate aftermath. Set up in the fall of 1944, Chamber 7 of the People’s Courts was the first jurisdiction exclusively de作者: HUMID 時間: 2025-3-27 03:37
Kenneth Lange the Second World War.?Historians, sociologists, and anthropologists adopt comparative perspectives on those who now lived in ‘cleansed’ borderlands. Its contributors explore local subjectivities of social change through the concept of ‘No Neighbors’ Lands’: How does it feel to wear the dress of you作者: 深淵 時間: 2025-3-27 08:00 作者: ONYM 時間: 2025-3-27 12:56
Kenneth Langeting over when it comes to food concerns ethical claims. Eat this. Avoid that. Why? Because that is what you should do. For the environment! Because animals feel pain, too! Support local businesses! Food justice! There is no reason to be daunted by the subject of ethics, or ., a term I generally pre作者: 不知疲倦 時間: 2025-3-27 16:50 作者: 狗舍 時間: 2025-3-27 20:13 作者: Commemorate 時間: 2025-3-27 22:41
Kenneth Langepractical action.Provides a sound basis to promote sustainab.The problems related to the process of industrialisation such as biodiversity depletion, climate change and a worsening of health and living conditions, especially but not only in developing countries, intensify. Therefore, there is an inc作者: Explosive 時間: 2025-3-28 03:29 作者: 滋養(yǎng) 時間: 2025-3-28 10:20 作者: 配偶 時間: 2025-3-28 11:30 作者: BRAND 時間: 2025-3-28 17:08 作者: Cleave 時間: 2025-3-28 19:28 作者: Lasting 時間: 2025-3-29 02:33 作者: dissolution 時間: 2025-3-29 06:47 作者: Biomarker 時間: 2025-3-29 09:50
Applications of Identity Coefficients,prediction involving just two relatives. This setting is artificial because practical genetic counseling usually takes into account information on a whole pedigree rather than information on just a single relative. We will revisit the question of genetic counseling when we explore algorithms for computing pedigree likelihoods.作者: 抗原 時間: 2025-3-29 13:01
Poisson Approximation,a sum of weakly dependent Bernoulli random variables. In contrast to many asymptotic methods, this approximation carries with it explicit error bounds. Let .. be a Bernoulli random variable with success probability ., where α ranges over some finite index set ..作者: 讓步 時間: 2025-3-29 18:24 作者: 公豬 時間: 2025-3-29 21:16 作者: Tartar 時間: 2025-3-30 01:35
Kenneth Langeows for a better understanding and fosters knowledge about it..Concretely, the defined targets are:.Eradicate extreme poverty for all people everywhere, currently measured as people living on less than $1.25 a 978-3-319-95714-2Series ISSN 2523-7403 Series E-ISSN 2523-7411 作者: degradation 時間: 2025-3-30 04:29 作者: Canopy 時間: 2025-3-30 10:45
Mathematical and Statistical Methods for Genetic Analysis作者: 裹住 時間: 2025-3-30 13:50
Kenneth Langeg a further obstacle to the study and remembrance of certain groups of victims, including their names and fates throughout the Soviet period. The generalization of all victims as civilians has caused memory conflicts in modern Russia at the level of the activity of Jewish communities, local historia作者: 凹處 時間: 2025-3-30 18:42 作者: defibrillator 時間: 2025-3-30 23:16
Kenneth Langeitized and turned into venues for brutal financial extraction. She also shows how in the final months of the war the dense web of personal connections permeating Bulgarian society hindered the ability of the prosecutors to prove the guilt and ensure the conviction of the defendants. Ultimately, the 作者: 外貌 時間: 2025-3-31 01:13
Kenneth Lange multi-religious,?.experienced.?postwar reconstruction, attempted to?.come to terms.?with what had happened, and negotiated?.remembrance...Chapter 7 and 13 are available open access under a Creative Commons Attribution 4.0 International License via?link.springer.com..
