標(biāo)題: Titlebook: Mapping Genetic Interactions; Franco Joseph Vizeacoumar,Andrew Freywald Book 2021 The Editor(s) (if applicable) and The Author(s), under e [打印本頁] 作者: 聲音會爆炸 時間: 2025-3-21 19:05
書目名稱Mapping Genetic Interactions影響因子(影響力)
作者: 不朽中國 時間: 2025-3-21 21:35 作者: CORE 時間: 2025-3-22 01:05 作者: Bucket 時間: 2025-3-22 06:27 作者: 詢問 時間: 2025-3-22 09:10
Book 2021ncer cells. Chapters guide readers through genetic interactions in model organisms, RNA interference, CRISPR/Cas9 based genome editing technologies, drug-gene interactions, mapping chemical genetic interactions, synergistic drug-gene relations, single cell sequencing, gene expression profiling, and 作者: 萬花筒 時間: 2025-3-22 15:26 作者: 代理人 時間: 2025-3-22 20:15 作者: 全能 時間: 2025-3-22 22:21
Machine Learning to Identify Gene Interactions from High-Throughput Mutant Crossesres of single gene mutants to identify gene interactions in double mutants. Here we present how machine learning models that consider the characteristics of the phenotypic data improve on the classical multiplicative model. Importantly, machine learning improves the selection of cutoff values to identify gene interactions from phenotypic scores.作者: 懶惰民族 時間: 2025-3-23 03:18 作者: Condense 時間: 2025-3-23 07:58 作者: 亂砍 時間: 2025-3-23 10:56
Chemical–Genetic Interactions as a Means to Characterize Drug Synergy the most important studies in this field. The concept of chemical genetics interactions derives from classical studies of synthetic lethality and functional genomics. These techniques have recently graduated from the research lab to the clinic, and a better understanding of the basic principles can help accelerate this translation.作者: 形容詞詞尾 時間: 2025-3-23 17:47 作者: Barter 時間: 2025-3-23 19:16
orse plasma. When the plasma clotted, it formed a solid surface into which the heart cells explanted. Left unattended, these cells died within several days. By regularly feeding the grow- ing cells with aqueous extracts of whole chick embryos and periodically sub- dividing them, Carrel was able to m作者: 預(yù)感 時間: 2025-3-23 23:34
Alla Gagarinova,Ali Hosseinnia,Mohan Babut and postharvest handling account for a majority (>50%) of the production cost, researchers developed innovative technologies to reduce the harvest cost and lower the fruit postharvest handling fee. An innovative apple harvest and infield sorting (HIS) machine was developed by combining harvest pla作者: 逃避責(zé)任 時間: 2025-3-24 04:35 作者: innate 時間: 2025-3-24 09:57
Juan-Carlos A. Padilla,Ashley Chin,Dhara Patel,Xiaofeng Wang,Philippe Jolivet,Eric Lécuyern plant cells and whole plant growth.Covers all levels of pl.Chemical reactions and interactions between molecules are commonly considered the basis of life, and thus the biochemical nature of cells and organisms is relatively well recognized. Research conducted in recent years, however, increasingl作者: ALIEN 時間: 2025-3-24 14:26 作者: Prostatism 時間: 2025-3-24 18:38 作者: 純樸 時間: 2025-3-24 18:59 作者: FUSE 時間: 2025-3-25 00:13 作者: 使迷惑 時間: 2025-3-25 04:07 作者: 惰性女人 時間: 2025-3-25 09:17 作者: 音樂學(xué)者 時間: 2025-3-25 15:20 作者: SUE 時間: 2025-3-25 16:18 作者: 王得到 時間: 2025-3-25 22:31 作者: EVICT 時間: 2025-3-26 00:08 作者: 燈絲 時間: 2025-3-26 07:31
Evan M. Kerek,Christopher R. Cromwell,Basil P. Hubbardn plant cells and whole plant growth.Covers all levels of pl.Chemical reactions and interactions between molecules are commonly considered the basis of life, and thus the biochemical nature of cells and organisms is relatively well recognized. Research conducted in recent years, however, increasingl作者: 水土 時間: 2025-3-26 08:36 作者: Curmudgeon 時間: 2025-3-26 14:11
n plant cells and whole plant growth.Covers all levels of pl.Chemical reactions and interactions between molecules are commonly considered the basis of life, and thus the biochemical nature of cells and organisms is relatively well recognized. Research conducted in recent years, however, increasingl作者: 一瞥 時間: 2025-3-26 20:22 作者: 離開真充足 時間: 2025-3-26 23:10 作者: 裝飾 時間: 2025-3-27 02:26
Systematic High-Content Screening of Fluorescently Tagged Yeast Double Mutant StrainsThis approach can be used to map genetic interactions by monitoring one or more subcellular fluorescent markers of interest. In this case, changes in the morphology or abundance of a subcellular compartment, pathway or bioprocess are monitored in the background of a systematic array of yeast double 作者: immunity 時間: 2025-3-27 08:54 作者: 殺子女者 時間: 2025-3-27 10:24
RNA Interference (RNAi) Screening in Cultured , Cellsmediated depletion of gene products represents a powerful means of elucidating gene function, as it allows one to systematically probe the phenotypic effects resulting from the functional loss of specific targets. The relative ease of use of RNAi technologies in cultured cells has allowed the design作者: 懸崖 時間: 2025-3-27 16:51 作者: chisel 時間: 2025-3-27 19:34
Identification of Synthetic Lethal Interactions Using High-Throughput, Arrayed CRISPR/Cas9-Based Plaof the best strategies to selectively eliminate cancer cells. Some of the most successful approaches to identify synthetic lethal interactions (SLIs) were largely dependent on pooled screening formats that require heavy validation in order to mitigate false positives. Here, we describe a high-throug作者: 確認(rèn) 時間: 2025-3-28 00:28
Exploring Candidate Human Synthetic Lethal Interactions Through siRNA and Quantitative Imaging-Basedtargets for the development of innovative cancer therapeutic strategies. Despite recent technological advancements including CRISPR/Cas9 approaches, the systematic assessment of all pairwise gene interactions in humans (~ 200 million pairs) remains an unmet goal. Thus, hypothesis-driven approaches, 作者: Ancillary 時間: 2025-3-28 05:00
Mapping Genetic Interactions in Human Cancer Cells Using a One-Step tRNA-CRISPR Systemped a new one-step tRNA-CRISPR method called TCGI (tRNA-CRISPR for genetic interactions) which generates high-efficiency, barcode-free, and scalable pairwise CRISPR libraries to identify genetic interactions in mammalian cells. Here we describe this method in detail regarding the construction of the作者: 鴕鳥 時間: 2025-3-28 07:08
In Vivo Genome-Wide Pooled RNAi Screens in Cancer Cells to Identify Determinants of Chemotherapy/Druo the nature of the selection process involved in screens, RNAi screens are also very useful for identifying genes involved in drug responses. The information gained from these screens could be used to predict a cancer patient’s response to a specific drug (i.e., precision medicine) or identify anti作者: 偶然 時間: 2025-3-28 11:13 作者: largesse 時間: 2025-3-28 18:02
Machine Learning to Identify Gene Interactions from High-Throughput Mutant Crossess. Detecting gene interactions in even small microbial genomes relies on measuring growth phenotypes in thousands of crossed strains followed by statistical analysis to compare single and double mutants. The preferred computational approach is to use a multiplicative model that factors phenotype sco作者: gratify 時間: 2025-3-28 21:33 作者: 晚來的提名 時間: 2025-3-29 02:00
Chemical–Genetic Interactions as a Means to Characterize Drug Synergy, gene–environment interactions, and more recently, into the mechanism of action of human therapeutics. The success of these studies relies, in part, on?the ability to quantify the combined effects of multifactorial biological interactions. In this review, we explore the history and rationale behind作者: averse 時間: 2025-3-29 05:22 作者: 一瞥 時間: 2025-3-29 09:31 作者: TOM 時間: 2025-3-29 12:04
https://doi.org/10.1007/978-1-0716-1740-3lower eukaryotes; synthetic genetic array (SGA); ; D; melanogaster; C; elegans; CRISPR作者: finale 時間: 2025-3-29 15:52 作者: reptile 時間: 2025-3-29 23:14 作者: 解脫 時間: 2025-3-30 03:37
lial cells in vivo to determine the role of transmembrane potential in the transduction of fluid mechanical forces generated by blood flow to a biochemical response. Depolarizing all of the cells within the vascular system by injecting potassium chloride into the animal‘s bloodstream clearly is not an option,978-3-662-03422-4978-3-662-03420-0作者: Minatory 時間: 2025-3-30 04:59
lial cells in vivo to determine the role of transmembrane potential in the transduction of fluid mechanical forces generated by blood flow to a biochemical response. Depolarizing all of the cells within the vascular system by injecting potassium chloride into the animal‘s bloodstream clearly is not an option,978-3-662-03422-4978-3-662-03420-0作者: SKIFF 時間: 2025-3-30 09:46
Alla Gagarinova,Ali Hosseinnia,Mohan Babu the processing apple incidences ranging from 5 to 15%, the annual benefits by adopting the HIS would range from $13,500 to $78,400 for the machine price between $100,000 and $160,000. With the same price range, benefits of adopting the HIS machine for a processing apple orchard with processing appl作者: acquisition 時間: 2025-3-30 13:03
John A. Calarcoto them. The mechanical aspects of plant responses to stresses are also presented. Finally, all these aspects are placed in an evolutionary context..978-3-642-26902-8978-3-642-19091-9Series ISSN 1867-9048 Series E-ISSN 1867-9056 作者: aristocracy 時間: 2025-3-30 18:29
Juan-Carlos A. Padilla,Ashley Chin,Dhara Patel,Xiaofeng Wang,Philippe Jolivet,Eric Lécuyerto them. The mechanical aspects of plant responses to stresses are also presented. Finally, all these aspects are placed in an evolutionary context..978-3-642-26902-8978-3-642-19091-9Series ISSN 1867-9048 Series E-ISSN 1867-9056 作者: 束縛 時間: 2025-3-30 22:39
