作者: GLUT 時(shí)間: 2025-3-22 00:16
Physiological Functions and Regulation of TRPC ChannelsPC channels generates distinct intracellular Ca. signals that regulate downstream signaling events and consequent cell functions. This requires localization of TRPC channels in specific plasma membrane microdomains and precise regulation of channel function which is coordinated by various scaffolding, trafficking, and regulatory proteins.作者: 掃興 時(shí)間: 2025-3-22 03:27 作者: DEBT 時(shí)間: 2025-3-22 05:33
0171-2004 s special cell sensors.Current findings in this field are cr?In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single作者: 深淵 時(shí)間: 2025-3-22 09:21
TRP Channels and Thermosensationrole as thermosensors in the somatosensory system and to understand the basis of their high thermal sensitivity. In this chapter, I provide a brief critical overview of current knowledge on the role of TRP channels in thermosensing and on the thermodynamic and molecular basis of their steep temperature dependence.作者: Neuralgia 時(shí)間: 2025-3-22 13:05
High-Resolution Views of TRPV1 and Their Implications for the TRP Channel Superfamilybinding sites, and conformational changes related to channel pore gating. We also discuss some of the structures’ implications for the TRP channel family and a few of the many questions still left unanswered.作者: elucidate 時(shí)間: 2025-3-22 18:18
Evolutionarily Conserved, Multitasking TRP Channels: Lessons from Worms and Fliesing proteins, and second, many functions and modes of activation of these channels are evolutionarily conserved, including some that were formerly thought to be unique to invertebrates, such as phototransduction. Thus, worms and flies offer the potential to decipher roles for mammalian TRPs, which would otherwise not be suspected.作者: buoyant 時(shí)間: 2025-3-22 21:44
Structural Biology of TRP Channelsength structures of different TRP channel subfamilies, such as building homology models. Finally, we close by summarizing the outlook of the “holy grail” of understanding in atomic detail the diverse functions of TRP channels.作者: capsule 時(shí)間: 2025-3-23 03:07
Book 2014gy of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Recep作者: 不再流行 時(shí)間: 2025-3-23 08:41
TRPs and Pain expression patterns, electrophysiological properties and the effects of channel deletion in transgenic animal models have produced a great deal of evidence linking these channels to transduction of noxious stimuli as well as signalling within the pain system.作者: GIBE 時(shí)間: 2025-3-23 11:53
TRP Channels in Reproductive (Neuro)Endocrinology at different levels of the reproductive pathway. Still, our understanding of TRP channel involvement in (neuro)endocrinology is quite limited. Due to their mechanism of activation and complex regulation, these channels are however ideally suited to be part of the transduction machinery of hormone-secreting cells.作者: Lipoma 時(shí)間: 2025-3-23 16:12
Phosphoinositide Regulation of TRP Channelssphate [PI(4,5)P. or PIP.] acts as a positive cofactor, similarly to many other ion channels. In several cases, however, PI(4,5)P. inhibits TRP channel activity, sometimes even concurrently with the activating effect. This chapter will provide a comprehensive overview of the literature on regulation of TRP channels by membrane phosphoinositides.作者: 圣歌 時(shí)間: 2025-3-23 18:48 作者: MILL 時(shí)間: 2025-3-23 23:18 作者: 慢慢沖刷 時(shí)間: 2025-3-24 04:07
Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/m/image/622044.jpg作者: 瘙癢 時(shí)間: 2025-3-24 08:14 作者: Enliven 時(shí)間: 2025-3-24 12:54
978-3-319-35878-9Springer International Publishing Switzerland 2014作者: 共和國(guó) 時(shí)間: 2025-3-24 17:18
Mammalian Transient Receptor Potential (TRP) Cation Channels978-3-319-05161-1Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: Inculcate 時(shí)間: 2025-3-24 21:37
ustand durch ein ?u?eres magnetisches Feld auch ge?ndert. Die dabei hervorgerufenen ?nderungen in der Orientierung beim Mikroaufbau der Materie führt zu elastischen und nichtelastischen Ver?nderungen. Letztere treten als Verluste in Erscheinung, die wesentlich bestimmte Anwendungen begrenzen. Gleich作者: BADGE 時(shí)間: 2025-3-25 00:20
Thomas Voetskompakten Wicklungen ist die übertragene Leistung durch die Streuinduktivit?t begrenzt. Ein Unterkapitel zeigt M?glichkeiten auf, wie die Gr??e der Streuinduktivit?t beeinflusst werden kann. Schwingkreise in der Leistungselektronik nutzen magnetische Energiespeicher und stellen selbst Systeme h?here作者: 枯燥 時(shí)間: 2025-3-25 04:14
Tim D. Planturchaus als biedermeierliche Ausnüchterungskur gegenüber der als mesmeristische Tmnkenheit empfundenen vorg?ngigen Emphase zu verstehen. Und indem sie sich im Sinne einer alle Beunruhigung stillstellenden Vereindeutigung auf die Seite ph?nomenologischer Reduktionen schlagen, greifen sie, der Kreis s作者: explicit 時(shí)間: 2025-3-25 08:27
Shunichi Shimizu,Nobuaki Takahashi,Yasuo Morie Kontinuit?t gegenüber, mit der der Mesmerismus in seinem dichterischen Werk figuriert. Bereits in dem unmittelbar nach Abschlu? seines Studiums konzipierten Erstling ?Hollin’s Liebeleben“ von 1802 wird an ihm die Befindlichkeit des Titelhelden exemplifiziert. Auch in der 1810 erschienenen ?Gr?fin 作者: 刪除 時(shí)間: 2025-3-25 15:22
Roger C. Hardienkten eines zu dem Ringe koncentrischen Kreises denselben Werth. Auch in einem langen und geraden Stabmagnet ist H überall konstant, wenn wir von der N?he der Enden absehen. Ob nun aber H sich konstant verh?lt oder nicht, es ist immer in jedem Punkte dem Werth und der Richtung nach bestimmt; dasselb作者: glucagon 時(shí)間: 2025-3-25 17:54 作者: 失望昨天 時(shí)間: 2025-3-25 23:40 作者: aphasia 時(shí)間: 2025-3-26 01:58 作者: Accede 時(shí)間: 2025-3-26 04:33 作者: 疲憊的老馬 時(shí)間: 2025-3-26 08:54
Flavia Carla Meotti,Edinéia Lemos de Andrade,Jo?o B. Calixtoeigt. Durch Zus?tze von Chrom wird nach P. . gem?? Abb. 270 der Curiepunkt herabgesetzt und seine Abh?ngigkeit vom Nickelgehalt vermindert. Auf die Verwendung solcher Legierungen mit Zus?tzen von Cr und Si weisen L. R. . und H. W. . und M. . hin. Genaue Angaben über die Zusammensetzung liegen jedoch作者: abnegate 時(shí)間: 2025-3-26 13:45 作者: cringe 時(shí)間: 2025-3-26 20:32
TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmitters)y H.O. via modification of cysteine (Cys) free sulfhydryl groups. Nitric oxide (NO), a vasoactive gaseous molecule, regulates TRP channels directly via Cys S-nitrosylation or indirectly via cyclic GMP (cGMP)/protein kinase G (PKG)-dependent phosphorylation. Anoxia induced by O.-glucose deprivation a作者: 假裝是我 時(shí)間: 2025-3-27 00:38
Photosensitive TRPsG protein-coupled phospholipase C (PLCβ4) cascade. Although still debated, recent evidence indicates the channels can be activated by a combination of PIP. depletion and protons released by the PLC reaction. PIP. depletion may act mechanically as membrane area is reduced by cleavage of PIP.’s bulky 作者: 明智的人 時(shí)間: 2025-3-27 01:28
TRPs in Taste and Chemesthesis In many sensory fibers and epithelial cells lining the oronasal cavity, TRPA1 is also co-expressed with TRPV1. As with TRPV1, TRPA1 transduces a wide variety of irritants and, in combination with TRPV1, assures that there is a broad response to noxious chemical stimuli. Other TRP channels, includin作者: Salivary-Gland 時(shí)間: 2025-3-27 08:21
TRPs in Olfactiontory system but that other TRP channel subtypes such as TRPC1, TRPC4, TRPC6, TRPM4, and TRPM5 could also play important functional roles in mammalian olfaction. Here, I review such findings and discuss future areas for investigation.作者: CANDY 時(shí)間: 2025-3-27 13:27
The TRPCs–STIM1–Orai Interactionific and non-overlapping physiological functions of Ca. influx mediated by the two channel types, and argue that the TRPC channels should be the preferred therapeutic target to control the toxic effect of excess Ca. influx.作者: Herpetologist 時(shí)間: 2025-3-27 17:35
The TRPC Family of TRP Channels: Roles Inferred (Mostly) from Knockout Mice and Relationship to ORAI containing channels, a plethora of studies have shown TRPCs to be important both in physiologic systems as well as in pathophysiologic phenomena. Particularly important in defining roles of TRPCs, have been studies with mice with targeted disruption of their genes, i.e., with TRPC KO mice. In this 作者: 按時(shí)間順序 時(shí)間: 2025-3-27 19:29
TRPs: Modulation by Drug-Like Compounds only underwent a preliminary validation. For some TRP channels, reliable low molecular weight inhibitors are not yet available. Hence, further efforts need to be undertaken in order to explore the physiological impact and possible therapeutic potential of TRP channel targeting with drug-like compou作者: 巫婆 時(shí)間: 2025-3-28 00:39
TRP Modulation by Natural Compoundsn order to find new drug classes to treat different disorders. Indeed, the transient receptor potential (TRP) proteins are targets for several natural compounds, and antagonists of TRPs have been synthesised based on the knowledge of naturally derived products. In this context, this chapter focuses 作者: Ancillary 時(shí)間: 2025-3-28 05:22 作者: Collar 時(shí)間: 2025-3-28 10:17 作者: MEN 時(shí)間: 2025-3-28 11:38 作者: 極肥胖 時(shí)間: 2025-3-28 17:01 作者: Lumbar-Stenosis 時(shí)間: 2025-3-28 22:34 作者: 單片眼鏡 時(shí)間: 2025-3-29 02:26 作者: 防止 時(shí)間: 2025-3-29 03:46 作者: 永久 時(shí)間: 2025-3-29 09:39 作者: Conduit 時(shí)間: 2025-3-29 12:13 作者: enmesh 時(shí)間: 2025-3-29 18:38 作者: nutrition 時(shí)間: 2025-3-29 20:39
Ute A. Hellmich,Rachelle Gaudetert. Zur schon l?nger verwendeten optischen Spektroskopie und R?ntgenbeugungsmethode sind die Massenspektrometrie, die Mikrowellenspektroskopie, die Elektronenspinresonanz, die Gaschromatographie, die Dünnschichtchromatographie, die Ultrazentrifugentechnik, die Isotopentechnik und schlie?lich auch d作者: 無(wú)情 時(shí)間: 2025-3-30 03:31 作者: 有限 時(shí)間: 2025-3-30 06:41
Flavia Carla Meotti,Edinéia Lemos de Andrade,Jo?o B. Calixtofen mit stark temperaturabh?ngiger Magnetisierung angebracht. Es müssen dies Werkstoffe sein, deren Curiepunkt etwa bei der Gebrauchstemperatur, im allgemeinen also bei Raumtemperatur, liegt. Es werden hierfür Legierungen mit etwa 70% Ni und 30% Cu, deren Curiepunkt bei etwa 80° liegt, oder mit 30% 作者: 過(guò)份 時(shí)間: 2025-3-30 10:40
TRP Channels and Thermosensationor heating. Based on this characteristic feature, these so-called “thermoTRPs” have been widely studied with the aim to elucidate their potential key role as thermosensors in the somatosensory system and to understand the basis of their high thermal sensitivity. In this chapter, I provide a brief cr作者: prostatitis 時(shí)間: 2025-3-30 14:01 作者: enumaerate 時(shí)間: 2025-3-30 19:48
TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmitters) from outside and inside the cell. Upon chemical or physical stimulation of cells, TRP channels transduce electrical and/or Ca. signals via their cation channel activities. These functional features of TRP channels allow the body to react and adapt to different forms of environmental changes. Indeed作者: 車(chē)床 時(shí)間: 2025-3-31 00:44 作者: pacific 時(shí)間: 2025-3-31 02:22
TRPs in Taste and Chemesthesisemical stimuli, giving rise to sensations of taste, irritation, warmth, coolness, and pungency. Specifically, TRPM5 acts downstream of taste receptors in the taste transduction pathway. TRPM5 channels convert taste-evoked intracellular Ca. release into membrane depolarization to trigger taste transm作者: 切割 時(shí)間: 2025-3-31 05:34
TRPs and Pain and can become chronic and debilitating. A demand for more effective treatments to deal with this highly prevalent problem requires a better understanding of the underlying mechanisms. TRP channels are associated with numerous sensory functions across a wide range of species. Investigation into the作者: 彈藥 時(shí)間: 2025-3-31 12:51
TRPs in Hearingceed Brownian motion. Attempts to molecularly identify these auditory transduction channels have put the focus on TRPs in ears. In ., hearing has been shown to involve TRPA, TRPC, TRPN, and TRPV subfamily members, with candidate auditory transduction channels including NOMPC (=TRPN1) and the TRPVs N作者: 脾氣暴躁的人 時(shí)間: 2025-3-31 16:40 作者: CHOP 時(shí)間: 2025-3-31 19:03 作者: Extort 時(shí)間: 2025-3-31 22:50
Structural Biology of TRP Channelsre determination. We review recent progress towards a structural understanding of TRP channels and the techniques used to that end. We discuss available low-resolution structures from electron microscopy (EM), X-ray crystallography, and nuclear magnetic resonance (NMR) and review the resulting insig作者: Figate 時(shí)間: 2025-4-1 02:39 作者: Conflagration 時(shí)間: 2025-4-1 07:25 作者: Customary 時(shí)間: 2025-4-1 10:39
The TRPCs–STIM1–Orai Interaction membrane, the store-operated Ca. channels (SOCs). The two known SOCs are the Orai and TRPC channels. The SOC-dependent Ca. influx mediates and sustains virtually all Ca.-dependent regulatory functions. The signal that transmits the Ca. content of the ER stores to the plasma membrane is the ER resid作者: arboretum 時(shí)間: 2025-4-1 16:26
The TRPC Family of TRP Channels: Roles Inferred (Mostly) from Knockout Mice and Relationship to ORAIy excitable or non-excitable, Ca. enters through channels that are activated downstream of phosphoinositide mobilization (activation of phospholipase C, PLC) and through channels that are activated secondary to depletion of internal stores. Depletion of internal stores activates plasma membrane chan作者: initiate 時(shí)間: 2025-4-1 22:23
