作者: 健談的人 時間: 2025-3-21 20:47 作者: Small-Intestine 時間: 2025-3-22 00:25 作者: 下級 時間: 2025-3-22 07:47
International Collaboration for Lynch Syndrome,lished in 2005. This society was always the center of the physician, surgeon, researcher, geneticist, genetic counselor, etc. involved in this field and established clinical criteria and central database with collection of causative gene alterations for clinical use. It also supported multiple inter作者: 世俗 時間: 2025-3-22 12:24 作者: PLUMP 時間: 2025-3-22 13:53 作者: Headstrong 時間: 2025-3-22 17:37 作者: HERE 時間: 2025-3-22 22:54 作者: 群居動物 時間: 2025-3-23 01:31 作者: 虛構(gòu)的東西 時間: 2025-3-23 07:26 作者: 薄荷醇 時間: 2025-3-23 13:41 作者: 一罵死割除 時間: 2025-3-23 15:02
Tatsuro Yamaguchi (BO), components of BO, the decisive role of BO in service, manufacturing, and hybrid operations, what has changed pre- and post-global disruption regarding the behavioural aspect of operations, and implications for operational leadership, with particular reference to sub-Saharan Africa.作者: BOAST 時間: 2025-3-23 19:14
Takeshi Nagasakanctionally equivalent combinations of drivers or conditions that led to high-performing networks at community level which were different from the combinations leading to a poor level of community-level performance. The findings also carry practical implications for managing UNESCO sites.作者: Annotate 時間: 2025-3-23 23:05 作者: 全能 時間: 2025-3-24 02:22
Nagahide Matsubaramonstrate that it is not simply prejudiced attitudes themselves that are potentially malleable, but people’s understanding of what constitutes prejudice in the first place. Recognition of this is particularly important in social-change efforts when there is lack of consensual agreement over what is 作者: 墻壁 時間: 2025-3-24 06:52
Kazuo Tamuraarchers, and practitioners interested in supply chain management, leadership, and resilience. It contributes to the existing literature on these topics and provides practical insights for improving supply chain978-3-031-32363-8978-3-031-32364-5Series ISSN 2191-530X Series E-ISSN 2191-5318 作者: BIPED 時間: 2025-3-24 12:02
Hideyuki Ishida,Keiichiro Ishibashi,Kensuke Kumamoto作者: 灰心喪氣 時間: 2025-3-24 16:42 作者: FIR 時間: 2025-3-24 20:13
https://doi.org/10.1007/978-981-15-6891-6Colorectal cancer; Colorectal neoplasms; Gynecological malignancies; Urological malignancies; Multiple-g作者: Muffle 時間: 2025-3-25 02:43
Naohiro TomitaProvides a comprehensive review of Lynch syndrome.Offers essential insights into a new phase in the management of Lynch syndrome.Describes the genetic and epigenetic basis of Lynch syndrome作者: 果核 時間: 2025-3-25 06:37
http://image.papertrans.cn/l/image/589234.jpg作者: NADIR 時間: 2025-3-25 11:26
Surveillance Colonoscopy for Lynch Syndrome Affected Individuals,ex gastric cancer, and duodenal cancer, and also to surveillance of the relatives who have the same pathogenic variant of Lynch syndrome proband. In this paper, we introduce recent guidelines and reports from multicenter study in addition to an outline of the risk of gastrointestinal cancer in individuals with Lynch syndrome.作者: OPINE 時間: 2025-3-25 12:24
Clinical Features of Lynch Syndrome,gastric cancer. The risk of developing LS-associated tumors may vary greatly depending on the population, gender of the carrier, and mismatch repair gene mutated. In this chapter, we discuss the clinical features of LS.作者: Ingenuity 時間: 2025-3-25 16:28
Lynch Syndrome-Associated Urological Malignancies,, highlighting the importance of medical and family history of UTUC patients. Several studies have suggested that Lynch patients may have an increased risk of development of bladder and prostate cancer; however, this potential association may need further investigations because of the high incidence of those cancers in general population.作者: orient 時間: 2025-3-25 23:30
Immunotherapy for Lynch Syndrome Patients,nction of antitumor T lymphocytes, the treatment of such dMMR-associated recurrent/metastatic cancers has drastically changed. This chapter aims to review some of the many advances in immunotherapy for Lynch syndrome patients with advanced cancers.作者: 分開如此和諧 時間: 2025-3-26 00:49
Immunohistochemistry for Mismatch Repair Proteins,cognized for a correct evaluation to be made. This chapter discusses the backgrounds and practical issues regarding the use of immunohistochemistry for MMR proteins in the screening process for Lynch syndrome.作者: STRIA 時間: 2025-3-26 04:35
Genetic Analysis for Lynch Syndrome,ssay. Although it is still difficult to detect some complex variants such as large insertion, inversion, complex rearrangement, and so on, these technologies will give more chances to diagnose with Lynch syndrome.作者: arterioles 時間: 2025-3-26 08:49
Screening for Lynch Syndrome,proteins is similar to that of microsatellite instability; however, immunohistochemistry is more readily available and helps to direct gene testing. The universal genetic testing is reported from some groups; however, it is still premature to generalize the universal genetic testing as a screening test for Lynch syndrome.作者: 表示問 時間: 2025-3-26 14:26 作者: 向外供接觸 時間: 2025-3-26 18:19 作者: 摘要記錄 時間: 2025-3-26 23:56 作者: Jacket 時間: 2025-3-27 02:32
Chemoprevention for Lynch Syndrome-Associated Malignancies,associated CRC yielded promising results for future clinical use. In this chapter, we introduce cancer chemoprevention and focus on the current status and future prospects of chemoprevention for LS-associated malignancies.作者: 撤退 時間: 2025-3-27 07:56 作者: flaunt 時間: 2025-3-27 12:12 作者: BROW 時間: 2025-3-27 14:00
Clinical Features of Lynch Syndrome, than 100,000 individuals in Japan carry LS variants. This autosomal dominant disease is mainly caused by germline variants of mismatch repair genes (., ., ., .) or .. Individuals with LS tend to develop with various types of tumors at a young age, such as colorectal cancer, endometrial cancer, and 作者: CAMEO 時間: 2025-3-27 20:19
Pathology of Lynch Syndrome-Associated Tumors,ined by immunohistochemistry, and loss of the proteins can be recognized visually, the carcinoma lesions arising in Lynch syndrome have some characteristic histological features in hematoxylin-eosin (H&E) staining. Most of the Lynch syndrome carcinomas are Microsatellite Instability-High (MSI-High),作者: vitrectomy 時間: 2025-3-28 01:44 作者: 心神不寧 時間: 2025-3-28 04:58 作者: Fecundity 時間: 2025-3-28 08:37 作者: 腐爛 時間: 2025-3-28 11:40
Lynch Syndrome-Associated Urological Malignancies,n increased risk of development of upper tract urothelial carcinomas (UTUC) in Lynch syndrome and in fact, upper tract urothelial carcinoma has been found to be the third most common Lynch-associated malignancy. Interestingly, universal screening of UTUC exhibited that 5% of UTUC is Lynch-associated作者: Incise 時間: 2025-3-28 16:26
Screening for Lynch Syndrome,as clinical screening testing using family history and cancer history. Since these screening testings do not detect all colorectal cancer with microsatellite instability, the universal tumor screening for Lynch syndrome using microsatellite instability testing or immunohistochemistry of mismatch rep作者: irradicable 時間: 2025-3-28 18:55
Surveillance Colonoscopy for Lynch Syndrome Affected Individuals,ous colorectal cancer in the residual colon and/or rectum after surgery. The same responsibility applies to another Lynch syndrome-associated cancer, ex gastric cancer, and duodenal cancer, and also to surveillance of the relatives who have the same pathogenic variant of Lynch syndrome proband. In t作者: Hyperlipidemia 時間: 2025-3-28 23:45
Surgical Approach for Colorectal Cancer in Patients with Lynch Syndrome,cancer (CRC) is a hallmark of the syndrome, and the cumulative risk of CRC ranges from 10 to 46% by 70 years old, depending on the gene affected. Moreover, despite the high cumulative risk of subsequent CRC (metachronous CRC) after the first CRC is managed with surgery, the optimal surgical treatmen作者: 有效 時間: 2025-3-29 03:53 作者: 人工制品 時間: 2025-3-29 09:46
Chemoprevention for Lynch Syndrome-Associated Malignancies,y thought. The development of next-generation sequencing gene panel testing will diagnose more patients; thus, the number of Lynch syndrome (LS) patients may increase in the future. As a result, we must perform CRC screening and target preventive measures to younger individuals. In addition to diet 作者: 正常 時間: 2025-3-29 15:14
International Collaboration for Lynch Syndrome, due to the insignificant manifestation of the disease compared to other hereditary CRCs such as FAP, which typically develops thousands of polyps in a large intestine and simply identified by colonoscopy. International collaboration is always essential in understanding of the etiology and the clini作者: 1FAWN 時間: 2025-3-29 16:01
Kazuo Tamuraformation from the manufacturing industry.Proposes a leaders.This book presents a novel approach for studying the impact of leadership styles on supply chain resilience using a combination of transactional and transformational leadership. The book consists of two main sections: The first introduces 作者: 破譯密碼 時間: 2025-3-29 22:07 作者: acquisition 時間: 2025-3-30 02:57
Harumi Saeki,Okio Hinornal and external customers (Krajewski et al. 2016, .. 11th ed. Pearson Education Limited; Moscoso and Lago 2017, .. McGraw Hill Education). The transformation of inputs into outputs in terms of products and services requires the intervention of human beings, and the effective coordination of the hu作者: 瘙癢 時間: 2025-3-30 05:46
Shigeki SekineHendijani, .(3), 12–30, 2019; Moscoso and Lago, ., McGraw Hill Education, 2017; Donohue et al., .(1), 191–202, 2020). It emphasises the significant role human beings play in operations management. Amongst all the inputs required for any operations architecture, the human being is the only one that c作者: MANIA 時間: 2025-3-30 09:22 作者: 白楊 時間: 2025-3-30 12:57
Wataru Yamagami,Daisuke AokiHendijani, .(3), 12–30, 2019; Moscoso and Lago, ., McGraw Hill Education, 2017; Donohue et al., .(1), 191–202, 2020). It emphasises the significant role human beings play in operations management. Amongst all the inputs required for any operations architecture, the human being is the only one that c
