作者: Assault 時間: 2025-3-21 21:23
978-3-319-84287-5Springer International Publishing AG 2017作者: Compassionate 時間: 2025-3-22 02:38
Leucine-Rich Repeat Kinase 2 (LRRK2)978-3-319-49969-7Series ISSN 2190-5215 Series E-ISSN 2190-5223 作者: compassion 時間: 2025-3-22 05:37
Hardy J. RideoutThorough overview of the current state of knowledge on LRRK2.Discussed the links between LRRK2 mutations and Parkinson‘s Disease.Explores what we know about the normal function of LRRK2.Includes suppl作者: 推延 時間: 2025-3-22 12:39
Advances in Neurobiologyhttp://image.papertrans.cn/l/image/585293.jpg作者: 借喻 時間: 2025-3-22 16:13 作者: 誘導 時間: 2025-3-22 19:55
Clinical Features of , Carriers with Parkinson’s Diseaseciated with PD, the most common of which is the Gly2019Ser mutation. In the following review, we summarize the demographics and motor and non-motor symptoms of . carriers with PD, as well as symptoms in non-manifesting carriers. The clinical features of .-associated PD are often indistinguishable fr作者: 脾氣暴躁的人 時間: 2025-3-22 23:07
LRRK2 Phosphorylationnson’s disease. LRRK2 is a large multi-domain protein with a functional GTPase and kinase domain. The signal transduction pathways in which LRRK2 is dysfunctional in the disease state are only now being resolved, but we do know that LRRK2 is, itself, a substrate of multiple kinases and phosphatases 作者: deceive 時間: 2025-3-23 03:10
Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicityto the ROCO superfamily of proteins, characterized by a Ras-of-complex (Roc) GTPase domain in tandem with a C-terminal-of-Roc (COR) domain. LRRK2 also contains a protein kinase domain adjacent to the Roc-COR tandem domain in addition to multiple repeat domains. Disease-causing familial mutations clu作者: 專橫 時間: 2025-3-23 08:54
LRRK2 and Autophagyd as autophagy. In this chapter, the evidence linking LRRK2 to autophagy will be examined, along with how regulation of autophagy and lysosomal pathways may provide a nexus between the physiological function of this protein and the different diseases with which it has been associated. Data from cell作者: Nebulizer 時間: 2025-3-23 13:30 作者: nonplus 時間: 2025-3-23 17:03 作者: 百靈鳥 時間: 2025-3-23 18:55 作者: champaign 時間: 2025-3-24 00:20
Models of LRRK2-Associated Parkinson’s Diseaset genetic risk factors in sporadic PD. The LRRK2 protein contains a GTPase and a kinase domain and several protein-protein interaction domains. Both in vitro and in vivo assays in different model systems have provided tremendous insights into the molecular mechanisms underlying LRRK2-induced dopamin作者: Graves’-disease 時間: 2025-3-24 03:04
LRRK2 and the “LRRKtosome” at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relativ kinase 2 (LRRK2), including its kinase and GTPase activities, its protein interactors and subcellular localization, and its expression in the CNS and peripheral tissues. However, the mechanism(s) by which expression of mutant forms of LRRK2 lead to the death of dopaminergic neurons of the ventral m作者: 低三下四之人 時間: 2025-3-24 10:02 作者: 抗原 時間: 2025-3-24 12:17
Mechanisms of Mutant LRRK2 Neurodegenerationms by which mutations can be linked to neurodegeneration are not fully defined. Here I will argue that mechanism in this context encompasses a variety of levels of information. Mutations or alterations in gene expression at a genetic level are one set of mechanisms that are reflected at the biochemi作者: 接觸 時間: 2025-3-24 16:27 作者: insipid 時間: 2025-3-24 21:42 作者: 得體 時間: 2025-3-24 23:53 作者: Sinus-Rhythm 時間: 2025-3-25 05:56
Edoardo Monfrini,Alessio Di Fonzorrently only few compilers available that support this standard. Therefore, we have implemented a stand-alone library according to the standard that can be compiled with standard C compilers. The library is available as open source and written in plain C, thus can be used in various target architect作者: Habituate 時間: 2025-3-25 09:53 作者: 我不重要 時間: 2025-3-25 15:19
rrently only few compilers available that support this standard. Therefore, we have implemented a stand-alone library according to the standard that can be compiled with standard C compilers. The library is available as open source and written in plain C, thus can be used in various target architect作者: lethal 時間: 2025-3-25 19:29
R. Jeremy Nicholsure. The DECOS architecture guides system engineers in the development of complex embedded real-time systems by providing a framework for integrating multiple application systems within a single distributed computer system. This integration is supported by a model-based development process which ena作者: fiscal 時間: 2025-3-25 22:47
An Phu Tran Nguyen,Darren J. Moorerrently only few compilers available that support this standard. Therefore, we have implemented a stand-alone library according to the standard that can be compiled with standard C compilers. The library is available as open source and written in plain C, thus can be used in various target architect作者: Thyroxine 時間: 2025-3-26 03:14 作者: 榨取 時間: 2025-3-26 05:23
Laura Civiero,Isabella Russo,Luigi Bubacco,Elisa Greggios. When ontologies are distributed, the problem of finding related concepts between them arises. This problem is undertaken by a process which defines rules to relate relevant parts of different ontologies, called “Ontology Alignment.” In literature, most of the methodologies proposed to reach the o作者: 不能平靜 時間: 2025-3-26 12:19
Nicolas L. Dzamkosight, it can provide high rewards and increases in quality of product, services and decisions. Intelligence can be defined as an ability to acquire knowledge as well as having wisdom to apply knowledge and skills in the right way. It is also defined as an ability to respond quickly, flexibly and by作者: Coma704 時間: 2025-3-26 15:42
Jean-Marc Taymanssight, it can provide high rewards and increases in quality of product, services and decisions. Intelligence can be defined as an ability to acquire knowledge as well as having wisdom to apply knowledge and skills in the right way. It is also defined as an ability to respond quickly, flexibly and by作者: 休戰(zhàn) 時間: 2025-3-26 19:47 作者: 討厭 時間: 2025-3-26 23:43 作者: 粗野 時間: 2025-3-27 04:38 作者: 凝視 時間: 2025-3-27 06:41 作者: 過渡時期 時間: 2025-3-27 11:33 作者: Antioxidant 時間: 2025-3-27 15:11 作者: nutrients 時間: 2025-3-27 21:12
le agent simulation.Includes supplementary material: E-commerce has passed through a number of stages in the minds of most readers of the daily press. Initially it was the province of the specialist and considered almost irrelevant to the needs and activities of everyday life - companies looking for作者: Fresco 時間: 2025-3-28 00:02 作者: indigenous 時間: 2025-3-28 05:33
Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicityss attention. The GTPase domain has been shown to play an important role in regulating kinase activity, in dimerization, and in mediating the neurotoxic effects of LRRK2. Accordingly, the GTPase domain has emerged as a potential therapeutic target for inhibiting the pathogenic effects of LRRK2 mutat作者: 不透氣 時間: 2025-3-28 09:42
LRRK2 and the “LRRKtosome” at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relativ LRRK2 is comparatively quite low in ventral midbrain dopaminergic neurons, the possibility exists that non-cell autonomous signaling also contributes to the loss of these neurons. In this chapter, we will discuss the different neuronal death pathways that may be activated by mutant forms of LRRK2, 作者: 辭職 時間: 2025-3-28 13:26 作者: 過份艷麗 時間: 2025-3-28 16:00
Jo?o Paulo Lima Dahertonishing changes which a global economy has brought with it are reflected in the changes to the way we do business which are increasingly synonymous with e-commerce. Indeed, the term e-commerce itself i978-3-642-05811-0978-3-540-40003-5Series ISSN 1434-9922 Series E-ISSN 1860-0808 作者: 牽連 時間: 2025-3-28 22:30 作者: 一窩小鳥 時間: 2025-3-29 02:07
tonishing changes which a global economy has brought with it are reflected in the changes to the way we do business which are increasingly synonymous with e-commerce. Indeed, the term e-commerce itself i978-3-642-05811-0978-3-540-40003-5Series ISSN 1434-9922 Series E-ISSN 1860-0808 作者: NICE 時間: 2025-3-29 04:53
2190-5215 ent state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.978-3-319-84287-5978-3-319-49969-7Series ISSN 2190-5215 Series E-ISSN 2190-5223 作者: Aerate 時間: 2025-3-29 08:49 作者: Morose 時間: 2025-3-29 11:34 作者: mechanism 時間: 2025-3-29 17:46 作者: 健談的人 時間: 2025-3-29 23:36
