標(biāo)題: Titlebook: Lessons from Animal Diabetes VI; 75th Anniversary of Eleazar Shafrir Book 1996 Birkh?user Boston 1996 Diabetes.Diabetes mellitus.genetics. [打印本頁] 作者: 詭計 時間: 2025-3-21 20:08
書目名稱Lessons from Animal Diabetes VI影響因子(影響力)
書目名稱Lessons from Animal Diabetes VI影響因子(影響力)學(xué)科排名
書目名稱Lessons from Animal Diabetes VI網(wǎng)絡(luò)公開度
書目名稱Lessons from Animal Diabetes VI網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Lessons from Animal Diabetes VI被引頻次
書目名稱Lessons from Animal Diabetes VI被引頻次學(xué)科排名
書目名稱Lessons from Animal Diabetes VI年度引用
書目名稱Lessons from Animal Diabetes VI年度引用學(xué)科排名
書目名稱Lessons from Animal Diabetes VI讀者反饋
書目名稱Lessons from Animal Diabetes VI讀者反饋學(xué)科排名
作者: 小口啜飲 時間: 2025-3-21 21:18
Beverly E. Faulkner-Jones,Michelle B. French,Robert S. Schmidli,Susan Williamson,David S. Cram,Margonment Approaches: The Computer as a Multi-role Mediator in Teaching/Learning Physics 5 E. Balzano, P. Guidoni, M. Moretti, E. Sassi, G. Sgueglia Practical Work Aid: Knowledge Representation in a Model Based AI System 21 J. Courtois Simultaneous Processing of Different Problem Aspects in Expert Probl作者: 青少年 時間: 2025-3-22 02:59
Hiroshi Ikegami,Susumu Makino,Toshio OgiharaA more critical perspective reveals that Anderson lays emphasis on procedural learning, completely neglecting cognitive processes. The weak points of White and Frederiksen’s approach consist in the fact that knowledge acquisition processes are not described in psychological terms, but rather in phys作者: Forehead-Lift 時間: 2025-3-22 06:51
Beate Kuttler,Silke Lucke,Lutz Vogt,Ingrid Kl?ting,Tibor Diamanstein,Hans-Jürgen HahnA more critical perspective reveals that Anderson lays emphasis on procedural learning, completely neglecting cognitive processes. The weak points of White and Frederiksen’s approach consist in the fact that knowledge acquisition processes are not described in psychological terms, but rather in phys作者: 虛假 時間: 2025-3-22 09:14
Toshiaki Hanafusa,Koji Tomita,Hiromu Nakajima,Chisa Nakagawa,Jun-Ichiro Miyagawa,Masamichi Kuwajima,A more critical perspective reveals that Anderson lays emphasis on procedural learning, completely neglecting cognitive processes. The weak points of White and Frederiksen’s approach consist in the fact that knowledge acquisition processes are not described in psychological terms, but rather in phys作者: 易改變 時間: 2025-3-22 15:25 作者: fertilizer 時間: 2025-3-22 17:54 作者: 整潔 時間: 2025-3-23 00:30 作者: 新義 時間: 2025-3-23 05:16
C. Bruce Verchere Ph.D.,David A. D’Alessio,Steven E. Kahnre applied to the images in order to enhance image qualities. After that, the corrosion part is detected and the percentage of the corrosion area in the entire image is measured. The proposed system has the potential to be implemented for the autonomous correction detection with the image enhancemen作者: 不愿 時間: 2025-3-23 07:43
Mitsuo Itakura MD, PhD,Maki Moritani,Katsuhiko Yoshimoto,Chikara Hashimoto,Satoshi Otsuka,Toshiaki Sre applied to the images in order to enhance image qualities. After that, the corrosion part is detected and the percentage of the corrosion area in the entire image is measured. The proposed system has the potential to be implemented for the autonomous correction detection with the image enhancemen作者: ALTER 時間: 2025-3-23 10:09
Mitsuo Itakura M.D., Ph.D.,Setsuko II,Mika Ohta,Takashi Yamaokare applied to the images in order to enhance image qualities. After that, the corrosion part is detected and the percentage of the corrosion area in the entire image is measured. The proposed system has the potential to be implemented for the autonomous correction detection with the image enhancemen作者: antiquated 時間: 2025-3-23 15:08
S. Lee Marbán,Jesse Rothf the formation of life. In addition to the planned missions to Mars and Europa, there are extensive efforts to search for life outside the solar system. Rapid advances in the detection of extrasolar planets, outlined in Chap. 3, are expected to lead to the discovery of Earth-like planets in the nea作者: RAG 時間: 2025-3-23 19:11
Kazuya Kawano,Tsukasa Hirashima,Shigehito Mori,Takashi Natori the stage on which life made its appearance. Another way to learn about planets is to conduct detailed search programs, which recently have become very successful, although they have not yet found an Earth-like planet. These planet search methods are discussed in Chap. 3 and the question of what co作者: 功多汁水 時間: 2025-3-24 01:05 作者: extemporaneous 時間: 2025-3-24 02:22 作者: CRUC 時間: 2025-3-24 08:42 作者: 我要沮喪 時間: 2025-3-24 11:03 作者: 嘮叨 時間: 2025-3-24 17:36 作者: 不要嚴(yán)酷 時間: 2025-3-24 20:46
Consequences of human IAPP expression in transgenic mice in which non-amyloidogenic IAPP is produced, such as rats and mice, islet amyloid deposits are not observed. However, it appears that production of amyloidogenic IAPP is in itself insufficient for islet amyloid formation to occur, since dog IAPP contains the necessary amyloidogenic sequence, yet am作者: medium 時間: 2025-3-25 02:32 作者: 喃喃訴苦 時間: 2025-3-25 05:15
Diabetes in the Chinese hamstert. Due to the unusually small number of chromosomes, Chinese hamster cells are convenient for chromosomal studies. The development of immortal cell lines has made this even easier. During the last decade in several hundred studies cell lines developed from nondiabetic Chinese hamster lung fibroblast作者: echnic 時間: 2025-3-25 10:27 作者: 模范 時間: 2025-3-25 12:33 作者: 收藏品 時間: 2025-3-25 16:41
Masakazu Hattori,Eiji Yamato,Eisaku Matsumoto,Naoto Itoh,Tetsushi Toyonaga,Maria Petruzzelli,Masahirtive of research directions that will be carried out in the future. There are four main issues running through the papers presented in this book: ? knowledge ab978-3-642-64608-9978-3-642-60927-5Series ISSN 0258-1248 作者: harbinger 時間: 2025-3-25 21:30 作者: 縱欲 時間: 2025-3-26 02:01
Overview: 978-1-4612-8658-5978-1-4612-4112-6作者: Derogate 時間: 2025-3-26 05:49 作者: Largess 時間: 2025-3-26 08:34
https://doi.org/10.1007/978-1-4612-4112-6Diabetes; Diabetes mellitus; genetics; homeostasis; insulin; metabolism; therapy作者: 密切關(guān)系 時間: 2025-3-26 15:06
tion of the intersection of effective schools and effective .Effective educational leadership, while highly contextualized, is more and more recognized as a crucial input and process variable that determines to a very large extent the outcomes for educational organizations. This book pulls together 作者: FEMUR 時間: 2025-3-26 19:50
Beverly E. Faulkner-Jones,Michelle B. French,Robert S. Schmidli,Susan Williamson,David S. Cram,Margo total of 31 researchers from Europe (France, Germany, Greece, Italy, Portugal, and the U. K. ), the U. S. A. , and Japan worked together. This proceedings volume contains most of the contributions to the workshop. The papers show clearly the main directions of research in intelligent learning envir作者: ALIBI 時間: 2025-3-26 23:21
Hiroshi Ikegami,Susumu Makino,Toshio Ogiharaintelligent tutoring systems is discussed with regard to cognitive approaches. Anderson’s approach provides a conceptual basis for analyzing knowledge acquisition processes with regard to cognitive skills. Within the framework of this approach Anderson models problem-solving behaviour and knowledge 作者: 記憶法 時間: 2025-3-27 02:10
Antje Faust,Rainer Kleemann,Helga Rothe,Hubert Kolb2, 1990. A total of 31 researchers from Europe (France, Germany, Greece, Italy, Portugal, and the U. K. ), the U. S. A. , and Japan worked together. This proceedings volume contains most of the contributions to the workshop. The papers show clearly the main directions of research in intelligent lear作者: 媒介 時間: 2025-3-27 07:30 作者: 細(xì)胞膜 時間: 2025-3-27 11:56
Toshiaki Hanafusa,Koji Tomita,Hiromu Nakajima,Chisa Nakagawa,Jun-Ichiro Miyagawa,Masamichi Kuwajima,intelligent tutoring systems is discussed with regard to cognitive approaches. Anderson’s approach provides a conceptual basis for analyzing knowledge acquisition processes with regard to cognitive skills. Within the framework of this approach Anderson models problem-solving behaviour and knowledge 作者: 有危險 時間: 2025-3-27 13:44
Masakazu Hattori,Eiji Yamato,Eisaku Matsumoto,Naoto Itoh,Tetsushi Toyonaga,Maria Petruzzelli,Masahir the case of geometry", held in Grenoble, France, November 13-16, 1989. The main aim of the workshop was to foster exchanges among researchers who were concerned with the design of intelligent learning environments for geometry. The problem of student modelling was chosen as a central theme of the w作者: 難解 時間: 2025-3-27 19:06
Hiroshi Okamotohe need for formal systems can be examinated here. The different types of models: ‘models by physicists’ based upon laws built from observation and measures or ‘models by mathematicians’ based upon geometrical descriptions needing the choice of representations can be presented. The roles of a model 作者: 帶來的感覺 時間: 2025-3-27 23:04
Sigurd Lenzen,Markus Tiedge,Anne J?rns,Rex Mundaywith proper medication, a patient can lead a better life. This imparts the importance for early detection of this disease. In this paper, our aim is to process hand-drawn images such as spiral, wave, cube, and triangle shapes drawn by the patients using deep learning architectures. For computer-base作者: amyloid 時間: 2025-3-28 06:10 作者: interlude 時間: 2025-3-28 09:07 作者: 發(fā)起 時間: 2025-3-28 12:56
Mitsuo Itakura MD, PhD,Maki Moritani,Katsuhiko Yoshimoto,Chikara Hashimoto,Satoshi Otsuka,Toshiaki Sgh inspection cost. Visual inspection for pressure vessels can be done by an Unmanned Aerial Vehicle (UAV) with the sensing module. Image enhancement techniques and image processing techniques are vital in the UAV inspection of pressure vessels. However, there are several issues to be overcome in th作者: pessimism 時間: 2025-3-28 18:39
Mitsuo Itakura M.D., Ph.D.,Setsuko II,Mika Ohta,Takashi Yamaokagh inspection cost. Visual inspection for pressure vessels can be done by an Unmanned Aerial Vehicle (UAV) with the sensing module. Image enhancement techniques and image processing techniques are vital in the UAV inspection of pressure vessels. However, there are several issues to be overcome in th作者: Salivary-Gland 時間: 2025-3-28 20:42 作者: Infirm 時間: 2025-3-28 22:59 作者: 迫擊炮 時間: 2025-3-29 06:03
Stephen C. Blair,Ian D. Caterson,Gregory J. Cooneyhere (see Chaps. 5 and 6). A more direct approach is to search for favorable conditions and traces of life on other celestial bodies, both in the solar system and beyond. Clearly, there is little chance of encountering nonhuman intelligent beings in the solar system. But there could well be primitiv作者: 玉米棒子 時間: 2025-3-29 08:15
Barbara J. Frankel consequence of stellar evolution, the present cosmic abundances of chemical elements came about. Planets do not form independently; rather, their generation is an inevitable byproduct of star formation. This is because the gravitational collapse of large amounts of gas and dust from the interstella作者: 都相信我的話 時間: 2025-3-29 14:42 作者: 前兆 時間: 2025-3-29 17:46
Expression of glutamic acid decarboxylase (GAD) and its role as an autoantigen in insulin-dependent models of human IDDM, the non-obese diabetic (NOD) mouse and the Bio-Breeding (BB) rat.. Similar pathogenic mechanisms are thought to result in human IDDM.. In all three species, autoimmune B-cell destruction appears to be a highly selective process, with relative sparing of the other islet cell typ作者: prostatitis 時間: 2025-3-29 22:30
Molecular genetics of insulin-dependent diabetes mellitus: Analysis of congenic strains individuals. Both in animal models and humans, major genetic susceptibility to IDDM has been mapped to the major histocompatibility complex (MHC). In addition, recent genome screening has mapped non-MHC susceptibility genes to chromosomal segments in the mouse and human genomes. For most loci, howe作者: calumniate 時間: 2025-3-30 02:35
Role of macrophages and cytokines in B-cell deathor cells of autoimmunity, or as effector cells of B-cell destruction. In the spontaneously diabetic NOD mouse, macrophages and dendritic cells are the first cells infiltrating at perivascular and peri-insular regions in early insulitis beginning at the age of 3 wk.. These cells start to invade the i作者: 使困惑 時間: 2025-3-30 07:54
Immunotherapy of insulin-dependent diabetes mellitus: Tolerance after short-term anti—;IL-2 receptorted. and occurs in all mammals.. Investigations of animal strains predominantly used in diabetes research, the NOD mouse and the BB rat, demonstrated that the acute onset of hyperglycemia is the final result of a chronic preclinical phase (prediabetes). Already during prediabetes and definitely at t作者: AND 時間: 2025-3-30 08:14 作者: JOT 時間: 2025-3-30 15:18 作者: BALK 時間: 2025-3-30 18:38
Okamoto model for B-cell damage: Recent advanceshysiological and pathological significance of NAD. and poly (ADP-ribose) in pancreatic B-cells are discussed. In the second part, a novel metabolite of NAD., cyclic ADP-ribose, a second messenger for insulin secretion in B-cells, is described. Then, the synthesis and degradation of cyclic ADP-ribose作者: zonules 時間: 2025-3-30 22:22
Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alled to the property of the substance to stain the skin a characteristic red color.. Twenty years later, the German chemists, W?hler and Liebig, studied uric acid oxidation in detail and obtained the same compound, which they named ., apparently from conflation of the words . and ... The early history作者: 離開可分裂 時間: 2025-3-31 04:00
Role of glucokinase in regulation of insulin secretion: Lessons from transgenic micew pancreatic B-cells to sense and respond to physiological changes in blood glucose. Glucose-induced insulin secretion requires the metabolism of glucose in B-cells,. and the phosphorylation of glucose to glucose-6-phosphate, which determines the rate of glycolysis, is considered the major glucose-s作者: 復(fù)習(xí) 時間: 2025-3-31 05:11 作者: overhaul 時間: 2025-3-31 09:54
Immunostimulatory versus immunosuppressive roles of IL-10 in IDDM: Analysis with IL-10—Producing tra. The models of human IDDM, non-obese diabetic (NOD) mice and Bio Breeding (BB) rats, have provided a large amount of information on the pathogenesis of IDDM. In these animal models, immune cells, which include helper T (CD4.) and cytotoxic T (CD8.) lymphocytes, B-lymphocytes, and macrophages, infil作者: MEN 時間: 2025-3-31 14:12 作者: 不近人情 時間: 2025-3-31 18:15
Transgenic hyperinsulinemia: A mouse model of insulin resistance and glucose intolerance without obe primary metabolic abnormality initiating this disease process remains elusive, in spite of extensive study of the human condition and multiple animal models.. Most of these models share several features with human type II diabetes, including glucose intolerance associated with hyperinsulinemia, ins作者: Ointment 時間: 2025-4-1 01:09
Spontaneously diabetic rat “OLETF” as a model for NIDDM in humans Charles River Canada (St. Constant, Quebec, Canada) in 1982. A strain of rats was developed by selective breeding from this rat and designated OLETF (Otsuka Long-Evans Tokushima Fatty). The OLETF line has been maintained since then by brother-sister mating at the Tokushima Research Institute, Otsuk作者: 吊胃口 時間: 2025-4-1 03:23
Glucose and lipid metabolism in the gold thioglucose injected mouse model of diabesity During toxicology studies, it was noted by Brecher and Waxier. that a single i.p. or s.c. injection of GTG induced a syndrome of hyperphagia and obesity in mice. This observation was subsequently confirmed by Marshall and colleagues,. who reported that GTG induced bilateral necrosis of the ventrome作者: 剛開始 時間: 2025-4-1 07:18
Diabetes in the Chinese hamstertment of pneumonia at the Peking Medical College Hospital in 1919 because laboratory mice were not available.. The Chinese or “striped-back” hamster is recognized by the black stripe that runs down the middle of the otherwise yellowish-brown fur on its back. The hamster is also known for its low chr作者: chronicle 時間: 2025-4-1 11:32
Studies on the pathogenesis of NIDDM in the GK (Goto-Kakizaki) ratsues.. It is still a matter of debate as to which of these defects is primary. However, impaired insulin secretion seems to be a prerequisite for the development of NIDDM.. When the B-cells fail to secrete enough insulin to compensate for insulin resistance, hyperglycemia develops. In contrast, subj作者: 充足 時間: 2025-4-1 15:54
Role of immune and non-immune aspects of genetics in different expressions of diabetes in db/db micedevelopment of novel treatment and prevention strategies. Additional contribution derived from investigation of spontaneous and induced forms of diabetes resembling human IDDM and NIDDM, two entities distinguished by their pathogenic background and their clinical presentation. Among the animal model作者: alcoholism 時間: 2025-4-1 21:46
Inositols—Potential roles in insulin action and in diabetes: Evidence from insulin-resistant nonhuma first identified in cardiac muscle by Scherer in 1850. It is a component of membrane phospholipids, and the function of these membrane phosphoinositides may prove to be important to the action of insulin, as discussed later. Myoinositol, a cyclitol, is the most common of the nine isomers of hexahyd
