標題: Titlebook: Jak-Stat Signaling : From Basics to Disease; Thomas Decker,Mathias Müller Book 2012 Springer-Verlag Wien 2012 Cell Differentiation.Hematop [打印本頁] 作者: cherub 時間: 2025-3-21 17:08
書目名稱Jak-Stat Signaling : From Basics to Disease影響因子(影響力)
書目名稱Jak-Stat Signaling : From Basics to Disease影響因子(影響力)學科排名
書目名稱Jak-Stat Signaling : From Basics to Disease網(wǎng)絡公開度
書目名稱Jak-Stat Signaling : From Basics to Disease網(wǎng)絡公開度學科排名
書目名稱Jak-Stat Signaling : From Basics to Disease被引頻次
書目名稱Jak-Stat Signaling : From Basics to Disease被引頻次學科排名
書目名稱Jak-Stat Signaling : From Basics to Disease年度引用
書目名稱Jak-Stat Signaling : From Basics to Disease年度引用學科排名
書目名稱Jak-Stat Signaling : From Basics to Disease讀者反饋
書目名稱Jak-Stat Signaling : From Basics to Disease讀者反饋學科排名
作者: craving 時間: 2025-3-21 23:11 作者: 表示問 時間: 2025-3-22 01:39
JAK/STAT Signaling and Invertebrate Immune Responses,d topics include the components of JAK/STAT signaling and their role in humoral, cellular and mucosal immunity. Finally, we summarize recent developments on the role of JAK/STAT signaling in the maintenance of homeostasis in response to intestinal challenge.作者: Androgen 時間: 2025-3-22 06:07
STAT1 and STAT3 Transcription Factors in Inflammation-associated Colon Cancer,ors and signaling networks that are implicated in these heterotypic tumor-stroma interactions and modulate preconditions of tumor formation such as chronic inflammation. Here, tumor-promoting and tumor-adverse effects of cytokine-activated transcription factors STAT1 and STAT3 in inflammatory cells and colorectal cancer cells are discussed.作者: SMART 時間: 2025-3-22 09:33 作者: ALT 時間: 2025-3-22 13:39 作者: SHOCK 時間: 2025-3-22 19:15
Self-association of STAT Proteins from Monomers to Paracrystals,ed STATs from inactivation. Thus, the central event in cytokine signaling – STAT tyrosine phosphorylation – does not initiate STAT dimerization. Rather, STAT activation regulates the partitioning between different dimer conformations and triggers polymerization of the activated dimers.作者: HAWK 時間: 2025-3-22 23:33 作者: CRUMB 時間: 2025-3-23 04:59 作者: aplomb 時間: 2025-3-23 06:10 作者: Perennial長期的 時間: 2025-3-23 11:17 作者: FAZE 時間: 2025-3-23 15:45 作者: Intersect 時間: 2025-3-23 20:05 作者: 桉樹 時間: 2025-3-24 00:26 作者: inquisitive 時間: 2025-3-24 04:42
Universal and Specific Functions of STAT3 in Solid Tumours,s. Moreover, STAT3 was recently shown to play unexpected roles in regulating cell metabolism and mitochondrial activity via both transcriptional and non-transcriptional mechanisms. Here, we review the main knowledge about the role of STAT3 in solid tumours, with a particular focus on breast cancer and our recent work with mouse models.作者: ANA 時間: 2025-3-24 08:56 作者: 露天歷史劇 時間: 2025-3-24 13:39
The Continuing Fascination with Jaks and Stats: An Introduction,ge Stark were fascinated by the fact that gene transcription could be induced within minutes after treating cells with type I interferons (IFN-I). The speed with which a signal generated by the plasma membrane–associated IFN-I receptor travelled to nuclear target genes suggested few intermediate ste作者: Exonerate 時間: 2025-3-24 18:06
Regulation of JAKs: Insights Gleaned from the Functional Protein Domains, 15 years until a first crystal structure of a Janus kinase domain was described and by today the structures of all four kinase domains have been explored. In this chapter we discuss the effects of the different JAK domains on the activity, trafficking and localisation of JAKs that were reported in 作者: troponins 時間: 2025-3-24 19:26 作者: 馬賽克 時間: 2025-3-24 23:53 作者: SEEK 時間: 2025-3-25 04:18 作者: Minuet 時間: 2025-3-25 11:17 作者: 揭穿真相 時間: 2025-3-25 13:56
Evolution of Jak and Stat Proteins,the signaling pathway in general. We then oppose the simply structured pathway in . to the more complex situation in mammals. Furthermore, we compare the Jak-Stat system between mammals and teleost fishes. Finally, we move to the less well investigated roles of Stats in the worm . and the slime mold作者: 描繪 時間: 2025-3-25 18:28 作者: absolve 時間: 2025-3-25 22:32
JAK/STAT Signaling and Invertebrate Immune Responses,n the model organism .. However, we tentatively cover available information on JAK/STAT signaling in other invertebrates, including mosquitoes. Covered topics include the components of JAK/STAT signaling and their role in humoral, cellular and mucosal immunity. Finally, we summarize recent developme作者: 公社 時間: 2025-3-26 01:22
Stat5 as a Hematopoietic Master Regulator for Differentiation and Neoplasia Development,ions of Stat5a and Stat5b genes to the generation of hematopoietic cells and to their malignant transformation are subject of the following review. Absence of Stat5 proteins causes lymphopenia and Stat5 was recognized to be indispensable for the development of B-, T- and NK-cells. The few peripheral作者: jealousy 時間: 2025-3-26 07:50
Regulation of Dendritic Cell Development by STATs, activating adaptive immune cell types. Delineating the molecular control of DC development will provide important information about the generation of natural immunity as well as approaches to regulate DCs in clinical settings. DCs are generated from hematopoietic stem cells through specialized prog作者: BALE 時間: 2025-3-26 09:27
STAT Transcription Factors: Controlling All Aspects of NK Cell Biology,l decades NK cells have been portrayed as first line defense against virally infected and malignant cells. But recent reports unraveled far more diverse properties of NK cells, e.g. their involvement in reproductive immunology and in mucosal defense of pathogens in the gut, and especially their abil作者: Tidious 時間: 2025-3-26 14:21
Function of JAKs and STATs in Lymphocytes: Bench to Bedside,ammalian genome, each with unique functions in immune cells. Consistent with studies in mice, genetic evidence in humans has strongly linked the JAK/STAT pathway to primary immunodeficiencies, infection, autoimmunity and cancers. The following chapter will discuss the key role played by JAKs and STA作者: 撫慰 時間: 2025-3-26 19:54
The Role of Janus Kinases in Hematopoietic Malignancies,activity causes various hematological phenotypes associated with overproduction of terminally differentiated cells and/or blastic transformation. Here we review the somatic mutations in the Janus family kinases and the associated hematological phenotypes.作者: 刀鋒 時間: 2025-3-26 23:00
Activation of Janus Kinases During Tumorigenesis,or mammalian development, and conventional knockout models in mice show that the absence of just one of these two kinases causes prenatal and postnatal lethality. Recent studies using JAK2 conditional knockout mice show that this tyrosine kinase plays key roles in mammary gland development, fertilit作者: Occipital-Lobe 時間: 2025-3-27 01:52 作者: ellagic-acid 時間: 2025-3-27 08:03
Universal and Specific Functions of STAT3 in Solid Tumours,ressive disease and bad prognosis. Persistent STAT3 activity, to which tumours often become addicted, is mostly due to the aberrant activation of pro-oncogenic/pro-inflammatory signals that can trigger its phosphorylation, such as oncogenes, growth factor receptors and cytokines. Among STAT3-mediate作者: dissent 時間: 2025-3-27 10:42 作者: 不溶解 時間: 2025-3-27 15:50
Crosstalk with the Jak-STAT Pathway in Inflammation,omes of Jak-STAT signaling are modulated by signaling crosstalk with heterologous signaling pathways. Conversely, Jak-STAT signaling regulates cell responses to multiple cytokines and inflammatory factors. Emerging evidence suggests that on balance Jak-STAT signaling is pathogenic in chronic inflamm作者: 辭職 時間: 2025-3-27 18:24 作者: arterioles 時間: 2025-3-27 22:05
Thomas Decker,Mathias Müller research is focused primarily on the conveyor idlers load determination by numerical simulation of the contact between the conveyor belt and idlers. A nonlinear theory of the finite element method is applied, taking into account the effects of large displacements and the contact problems. The basic作者: Accrue 時間: 2025-3-28 04:36 作者: exorbitant 時間: 2025-3-28 10:06
Mark A. Dawson,Andrew J. Bannister research is focused primarily on the conveyor idlers load determination by numerical simulation of the contact between the conveyor belt and idlers. A nonlinear theory of the finite element method is applied, taking into account the effects of large displacements and the contact problems. The basic作者: Notorious 時間: 2025-3-28 11:38
Amanda M. Jamieson,Matthias Farlik,Thomas Decker under fire conditions.Provides the theoretical and practica.This book presents the comprehensive results of experimental and numerical investigations of glass fa?ade breakage behavior under fire conditions. First of all, full-scale frame and point-supported glass fa?ades, incorporating single, doub作者: comely 時間: 2025-3-28 15:21
Daniel J. Gough,Pravin Sehgal,David E. Levyrst of all, full-scale frame and point-supported glass fa?ades, incorporating single, double and coated glazing, were tested under pool fire conductions. The results determined the effects of different glass frames, types of glass, and thermal shocks on breakage behavior. Small-scale tests, using th作者: 微枝末節(jié) 時間: 2025-3-28 21:27 作者: reject 時間: 2025-3-29 00:34 作者: 單調(diào)女 時間: 2025-3-29 04:02 作者: 補充 時間: 2025-3-29 08:20
Harini Nivarthi,Katrin Friedbichler,Richard Moriggl1992. The objective of the workshop was to bring together a select group of theoreticians and experimental biologists to present the latest results in the area of biological pattern formation and to foster interactiqn across dis- plines. The workshop was divided into 5 main areas: (i) limb developme作者: 泛濫 時間: 2025-3-29 14:41
Haiyan S. Li,Stephanie S. Watowichly because of the lack of a good observational guidance. One major conceptual problem in massive star formation arises from the radiation pressure they exert on the surrounding dust and gas, which could be strong enough to halt further accretion and impose a limit to the mass of a star. Radiation hy作者: orient 時間: 2025-3-29 17:15
Eva Maria Putz,Eva Zebedin,Veronika Sexld a hydrodynamic model in order to study dark matter halos of galaxies. The theoretical general idea is to start with the Einstein–Hilbert Lagrangian in which we have added a complex scalar field minimally coupled to the geometry. Then, by making variations of the corresponding action we come up wit作者: Absenteeism 時間: 2025-3-29 22:30
Alejandro Villarino,Xiang-Ping Yang,Kiyoshi Hirahara,Yuka Kanno,John J. O’ Shea,Arian Laurencely because of the lack of a good observational guidance. One major conceptual problem in massive star formation arises from the radiation pressure they exert on the surrounding dust and gas, which could be strong enough to halt further accretion and impose a limit to the mass of a star. Radiation hy作者: Indolent 時間: 2025-3-30 00:25
Damla Olcaydu,Robert Kralovicsterials. However, it has two undesirable properties, namely: low tensile strength and large brittleness that cause the collapse to occur shortly after the formation of the first crack. To improve these two negative properties and to achieve a partial substitute of conventional reinforcement, an addi作者: fidelity 時間: 2025-3-30 06:36
Jeffrey W. Schmidt,Kay-Uwe Wagnerterials. However, it has two undesirable properties, namely: low tensile strength and large brittleness that cause the collapse to occur shortly after the formation of the first crack. To improve these two negative properties and to achieve a partial substitute of conventional reinforcement, an addi作者: LIKEN 時間: 2025-3-30 12:12 作者: 整潔 時間: 2025-3-30 15:10 作者: 我正派 時間: 2025-3-30 19:51
Maria M. Caffarel,Christine J. Watsonc targets and evaluating new pharmacological interventions. The in vivo animal models are generated to replicate the pathological, neurobehavioral, and electrophysiological characteristics observed in TLE patients. There are different types of models based on their method of induction of epileptic s作者: 外科醫(yī)生 時間: 2025-3-30 23:38
Lionel B. Ivashkivventional MES test, seizures are induced by applying an electrical stimulus of high intensity and high frequency for a short duration, which evokes tonic seizures that are manifested by a rigid extension of the hindlimbs. The subcutaneous (s.c.) PTZ test is in turn employed to produce clonic seizure作者: Intruder 時間: 2025-3-31 01:53
Book 2012on describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues..作者: 改正 時間: 2025-3-31 08:12
Kriti Gaur,Willis X. Liver economy, behavioral finance, economic and non-economic factors determining the behavior of household members, consumer preferences, social campaigns, and neuromarketing. International case studies are also offered. .978-3-030-30253-5978-3-030-30251-1Series ISSN 2198-7246 Series E-ISSN 2198-7254 作者: confederacy 時間: 2025-3-31 10:24
The Continuing Fascination with Jaks and Stats: An Introduction,ways stimulated by, respectively, the IFN, erythropoietin and growth hormone receptors (Argetsinger et al. 1993; Velazquez et al. 1992; Witthuhn et al. 1993). The same kinases had previously emerged from screens for novel pTKs, conducted in the labs of John Krolewski and Andrew Wilks and named Janus作者: averse 時間: 2025-3-31 13:41
Nuclear Functions of the Janus Kinases,y altering gene expression by changing the structure and function of chromatin. In this chapter we review nuclear functions of the Janus kinases with an emphasis on the emerging evidence that these tyrosine kinases have a critical role as chromatin modifying enzymes.作者: Migratory 時間: 2025-3-31 17:47
Stat5 as a Hematopoietic Master Regulator for Differentiation and Neoplasia Development,, where it regulates expression of genes controlling cell survival and cell cycle progression. Expression of Stat5 in hematopoietic neoplasms was both found to be elevated at the mRNA and protein level. Interestingly, higher Stat5 levels were linked with tyrosine kinase inhibitor drug resistance.作者: tackle 時間: 2025-3-31 21:42
Activation of Janus Kinases During Tumorigenesis,de the epigenetic silencing of negative regulators of JAKs as well as an aberrant autocrine stimulation of growth factors such as PRL, EPO, and IL-6. In addition to the canonical pathway through Signal Transducers and Activators of Transcription (STATs), JAKs are an integral part of a crosstalk with作者: Priapism 時間: 2025-4-1 02:54 作者: 嬰兒 時間: 2025-4-1 09:57 作者: Myocarditis 時間: 2025-4-1 10:26 作者: saturated-fat 時間: 2025-4-1 15:48
Thomas Decker,Mathias Müllerty of the presented approach to the modelling of the considered problem. The axial load on the wing (side) idlers is generated only during the partial loading of the conveyor. It has considerably high intensity only until the conveyor belt touches the horizontal idler. Applying the gradually increas作者: Precursor 時間: 2025-4-1 20:37
Claude Haan,Daniela Ungureanu,Tuija Pekkala,Olli Silvennoinen,Serge Haanlues on conversion fraction (α) during pyrolysis. It was found that identified variations of E. with α arise from the different chemical structures among cellulose, hemicelluloses and lignin in tested samples that may affect on their effective activation energies.
