標(biāo)題: Titlebook: Ion Channels as Targets in Drug Discovery; Gary Stephens,Edward Stevens Book 2024 The Editor(s) (if applicable) and The Author(s), under e [打印本頁(yè)] 作者: 拐杖 時(shí)間: 2025-3-21 19:09
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作者: 火海 時(shí)間: 2025-3-21 21:06
Conservation of Ligand Binding Between Voltage-Gated Sodium and T-Type Calcium Channels,Na.1) and calcium (Ca.3) channels. When the cell membrane is moderately depolarized, these channels allow the rapid influx of their respective ions – Na. and Ca.. Na.1 and Ca.3 channels are structurally related, and their expression overlaps in various excitable tissues, such as muscles and neurons.作者: 彩色 時(shí)間: 2025-3-22 01:50 作者: TEN 時(shí)間: 2025-3-22 04:59
Voltage-Gated Sodium Channels as Drug Targets in Epilepsy-Related Sodium Channelopathies,ts in the genes encoding the brain-expressed VGSCs have been identified in patients with severe epilepsy syndromes making clear that proper VGSC activity is required for normal neurological development and function. Given this central role in determining neuronal physiology, VGSCs are one of the mos作者: 個(gè)人長(zhǎng)篇演說 時(shí)間: 2025-3-22 10:46 作者: 折磨 時(shí)間: 2025-3-22 15:48
The Contribution of Genetic Sequencing Information to the Identification and Functional Characterize mutation causes the disease (monogenic diseases) and where the mutation is more subtly associated with the disease and changes the likelihood of a patient developing the disease (polygenic diseases)..In this review, we describe examples of monogenic diseases where both gain and loss of channel fun作者: 雄偉 時(shí)間: 2025-3-22 20:27
The Voltage-Gated Potassium Channel Kv2.1 as a Multicellular Drug Target,rofiles makes them interesting drug targets. The K.2.1 channel, encoded by the . gene, has a multitude of physiological roles from setting neuronal firing frequency to influencing viral replication. Here we look at the biophysical fingerprint of the K.2.1 channel and its role in a variety of unique 作者: 尖 時(shí)間: 2025-3-22 23:41
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Targeted Therapeutics for Cystic Fibrosiuse of the disease, pathogenic variants in the ATP-binding cassette transporter cystic fibrosis transmembrane conductance regulator (CFTR). Here, we selectively review understanding of CFTR function as an ATP-gated anion channel, its physiological role in epithelia and the molecular mechanisms of CF作者: BOOST 時(shí)間: 2025-3-23 04:31
Validation of TMEM16A Modulation as a Therapeutic Approach for the Treatment of Cystic Fibrosis: Thulation of these channels as a therapeutic approach for the treatment of muco-obstructive respiratory diseases, including cystic fibrosis. However, the recent literature is paradoxical with some investigators suggesting that inhibition of TMEM16A is the correct approach, while others advocate increa作者: compel 時(shí)間: 2025-3-23 08:53
Targeting Acid-Sensing Ion Channels in Disease,-sensing ion channels (ASICs) are exquisitely sensitive to decreases in pH and activated by protons. The expression and function of ASICs is enhanced under conditions of ischemia, inflammation, and trauma. Here, we will focus on this family of ion channels whose main role appears to be the detection作者: saphenous-vein 時(shí)間: 2025-3-23 11:52 作者: 無(wú)政府主義者 時(shí)間: 2025-3-23 15:36 作者: Colonnade 時(shí)間: 2025-3-23 20:25
Purinergic P2X Receptors as Therapeutic Targets,cal subunits (homomeric) or from a combination of subunits (heteromeric) and display different biophysical and pharmacological properties. This chapter provides an overview of the P.X family and their roles in various disease states as documented over the last 20?years. We highlight the potential of作者: 撫育 時(shí)間: 2025-3-23 22:26
Immune Cell Ion Channels as Therapeutic Targets, network of cellular and tissue barriers, soluble extracellular regulatory and effector molecules, and various tissue resident or highly mobile cell types, the system can be divided into the innate and adaptive immune system. Conceptually the innate system can be considered a pre-programmed response作者: COWER 時(shí)間: 2025-3-24 06:02
Ion Channel Tools and Therapeutics from Venoms and Toxins,f as magical, now we are understanding their true power and utility in drug discovery. A diverse range of venoms and toxins have been used to decipher the properties of ion channels and as a result hold a key functional place as positive controls in many assays. Such control toxins include tetrodoto作者: Aprope 時(shí)間: 2025-3-24 07:55
Rocio K. Finol-Urdaneta,Jeffrey R. McArthur,David J. Adams Lernen, Bildung und Erziehung fachunabh?ngig behandelt werden. Das Projekt . hat zum Ziel, den Ertrag dieses Studienteils, n?mlich das bildungswissenschaftliche Wissen von angehenden Lehrkr?ften nach dem Studium, empirisch zu erfassen und seine Bedeutung für den Einstieg in die Berufspraxis zu ermi作者: 浪費(fèi)物質(zhì) 時(shí)間: 2025-3-24 11:08 作者: filial 時(shí)間: 2025-3-24 17:38
Eric R. Wengert,Raquel M. Miralles,Manoj K. Patelnd sehr stabil, beeintr?chtigen schulische Leistungen und stellen für Lehrkr?ft e eine gro?e Herausforderung dar. Der vorliegende Beitrag beschreibt zwei Kooperationsprojekte (Universit?t zu K?ln Düsseldorf: Charlotte Hanisch, Uniklinik K?ln: Manfred D?pfner), die evidenzbasierte Strategien zum Umga作者: 手術(shù)刀 時(shí)間: 2025-3-24 21:40 作者: Radiation 時(shí)間: 2025-3-25 00:35 作者: machination 時(shí)間: 2025-3-25 06:19 作者: SIT 時(shí)間: 2025-3-25 11:23
Diana-Florentina Veselu,Han-I Yeh,Mayuree Rodrat,Jacob D. Bradbury,Yanira Manzanares Fornies,Hongyu zu gew?hrleisten und die Reak- tionsprodukte frei von unerwünschten Begleitstoffen zu halten, wird bei allen Handelsformen auf einen hohen Reinheitsgrad und gro?es Reaktions- verm?gen des Kalkes geachtet. Vor allem die chemische Industrie mu? be- sonderen Wert darauf legen, da? die Eigenschaften de作者: 關(guān)節(jié)炎 時(shí)間: 2025-3-25 14:31
Leanne Stokes,Stefan Bidula,Ronald Sluyteren praktischen Einsatz vorbereitet. Funktionalit?t, Stabilit?t und Verfügbarkeit haben ein nahezu akzeptables Ma? erreicht. Sinnvolle Anwendungsgebiete und Verwendungsm?glichkeiten sind ausreichend bekannt. Vor diesem Hintergrund wiegt es besonders schwer, da? die zugeh?rigen Entwicklungsverfahren f作者: Distribution 時(shí)間: 2025-3-25 18:01 作者: Commonplace 時(shí)間: 2025-3-25 23:44 作者: Consensus 時(shí)間: 2025-3-26 02:18 作者: Handedness 時(shí)間: 2025-3-26 07:51 作者: interlude 時(shí)間: 2025-3-26 08:44 作者: 水土 時(shí)間: 2025-3-26 13:55
978-3-031-52199-7The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl作者: 割讓 時(shí)間: 2025-3-26 20:40 作者: obstinate 時(shí)間: 2025-3-26 23:23 作者: MODE 時(shí)間: 2025-3-27 03:48
Validation of TMEM16A Modulation as a Therapeutic Approach for the Treatment of Cystic Fibrosis: Thdeliver benefit. In this chapter we describe the discovery of a novel tool compound (ET002663), which effectively potentiates the activity of TMEM16A, and the studies undertaken to validate the concept of enhancing TMEM16A activity as a novel approach for the treatment of cystic fibrosis.作者: hankering 時(shí)間: 2025-3-27 09:03 作者: SOW 時(shí)間: 2025-3-27 11:22 作者: 小卷發(fā) 時(shí)間: 2025-3-27 16:12
Voltage-Gated Sodium Channels as Drug Targets in Epilepsy-Related Sodium Channelopathies,targeting VGSCs in the treatment of epilepsy-related sodium (Na) channelopathies. Notwithstanding significant technical hurdles, modulators of VGSCs are likely to remain a mainstay in the treatment of epilepsy-related channelopathies and epilepsy more generally.作者: 小教堂 時(shí)間: 2025-3-27 19:43
Therapeutic Targeting of Potassium Channels,onsequently, K. channels are validated drug targets for many of these disorders. The aim of the present chapter is to provide an overview of the therapeutic targeting of K. channels, paying attention to new developments in the field.作者: FILTH 時(shí)間: 2025-3-28 01:44 作者: Phonophobia 時(shí)間: 2025-3-28 02:13 作者: 辮子帶來(lái)幫助 時(shí)間: 2025-3-28 08:04 作者: 滲透 時(shí)間: 2025-3-28 14:00 作者: 共棲 時(shí)間: 2025-3-28 15:30
Rocio K. Finol-Urdaneta,Jeffrey R. McArthur,David J. Adamsgliederten L?ngsschnitt-Erhebung sowie flankierende Validierungsstudien. Unsere Studienergebnisse zeigen, dass zwar theoretisch ein Konsens über die im bildungswissenschaftlichen Studienteil zu behandelnden Inhalte besteht, jedoch das universit?re Studienangebot sowie die individuelle Nutzung seiten作者: laxative 時(shí)間: 2025-3-28 22:03 作者: 愉快么 時(shí)間: 2025-3-29 01:06 作者: 溫順 時(shí)間: 2025-3-29 05:36
Nikita Gamper,Dongyang Huang,Jinlong Qi,Lilong Dong,Hailin Zhangserungen in Aufmerksamkeit und Regelverhalten durch die P?dagogen-zentrierte Intervention ergaben, schien die Kind-zentrierte Intervention keine weitergehenden Effekte zu erzielen. Es wird diskutiert, inwieweit Forschungsmethodik und Rahmenbedingungen des offenen Ganztags zu geringeren Effektst?rken作者: 符合你規(guī)定 時(shí)間: 2025-3-29 09:56
Alistair Mathie,Samuel R. Bourne,Rachel Forfar,Walter E. Perfect,Emma L. Vealewohl für Merkmale der Lehramtsstudierenden (kognitive F?higkeiten) als auch für Merkmale der Schülerinnen und Schüler gefunden werden. Es konnten reziproke Effekte von Schülerleistung und -motivation auf die Lehrkrafteinsch?tzung von Motivation und Leistung der Schülerinnen und Schüler aufgedeckt we作者: Gorilla 時(shí)間: 2025-3-29 13:32 作者: GRIN 時(shí)間: 2025-3-29 17:01 作者: 獎(jiǎng)牌 時(shí)間: 2025-3-29 21:44 作者: 杠桿 時(shí)間: 2025-3-30 00:56 作者: CHANT 時(shí)間: 2025-3-30 04:20 作者: Defense 時(shí)間: 2025-3-30 11:25 作者: 嘴唇可修剪 時(shí)間: 2025-3-30 16:21 作者: 貪婪的人 時(shí)間: 2025-3-30 18:58 作者: 光亮 時(shí)間: 2025-3-31 00:42
Ion Channels as Targets in Drug Discovery: Outlook and Perspectives, dominated ion channel drugs but also newer “biologic” agents, such as peptides and larger antibodies. Alongside this, new technological advances, including in drug engineering strategies, structural biology, and related computational modelling techniques, are now starting to make significant contri作者: Factorable 時(shí)間: 2025-3-31 02:57
,The Presynaptic α2δ Protein Family and Their Therapeutic Potential,, have been administered particularly in the treatment of neuropathic pain conditions, epilepsy, and restless leg syndrome. Extensive efforts have been and are being made to understand the structure and functions of α.δ proteins and how they interact with synaptic proteins. This is ultimately helpin作者: PANIC 時(shí)間: 2025-3-31 05:49
The Contribution of Genetic Sequencing Information to the Identification and Functional Characteriznal genomic information is extremely useful in its own right for patients that are identified as having the mutations, it also has wider implications, when particular K2P channels have a role in physiological processes underlying disease states. As such, modifying the activity of the channels associ作者: excrete 時(shí)間: 2025-3-31 12:46 作者: 有特色 時(shí)間: 2025-3-31 13:35 作者: 流浪者 時(shí)間: 2025-3-31 17:44
Nicotinic Receptors of the Neuronal and Non-neuronal Cholinergic Systems as Therapeutic Targets: Opderstanding nAChR function and regulation, the translation of promising preclinical candidates to new therapeutics has been almost totally disappointing. After surveying the diversity of the nAChR family and the opportunities that they present for drug discovery, factors that have limited the succes
