標(biāo)題: Titlebook: Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development; Avraham Yacobi (Director),Jerome P. Sk [打印本頁(yè)] 作者: Stimulant 時(shí)間: 2025-3-21 19:27
書目名稱Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development影響因子(影響力)
書目名稱Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development影響因子(影響力)學(xué)科排名
書目名稱Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development網(wǎng)絡(luò)公開度
書目名稱Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development被引頻次
書目名稱Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development被引頻次學(xué)科排名
書目名稱Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development年度引用
書目名稱Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development年度引用學(xué)科排名
書目名稱Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development讀者反饋
書目名稱Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development讀者反饋學(xué)科排名
作者: 并排上下 時(shí)間: 2025-3-21 21:05
The Case for Preclinical Pharmacodynamicst of relevant variables such as pharmacologically active metabolites, pharmacodynamic drug interactions and effects of genetics and underlying diseases. Available (though limited) information indicates that drug concentrations required to produce a defined intensity of pharmacologic action are quite作者: 易怒 時(shí)間: 2025-3-22 01:44 作者: Grievance 時(shí)間: 2025-3-22 06:35
Pharmacokinetics and Drug Metabolism in Animal Studies (ADME, Protein Binding, Mass Balance, Animal at drug, and should be initiated very early in the drug development program. These studies are of primary importance for the planning and design of animal toxicity studies, and for the selection of the appropriate animal model for purposes of estimating a safe clinical dose. Examples of the usefulne作者: 偽書 時(shí)間: 2025-3-22 11:11
Nonclinical Considerations: Disposition of Drugs data. Recommendations will be offered regarding the conduct of studies relating the advantages of using the same species, route of administration, and frequency of administration, where possible, as that proposed for pharmacologic and toxicologic testing. The period of dosing should be representati作者: 外形 時(shí)間: 2025-3-22 14:32 作者: 浸軟 時(shí)間: 2025-3-22 21:00
Use of Pharmacokinetics and Pharmacodynamics in Preclinical Studies to Guide Dosage Escalation Scheminical testing and Phase I clinical trials. Recent experiences with very lengthy Phase I trials for at least 8 drugs have provided particular impetus for the project. The specific concept was that dose-limiting toxicity is predicted by drug concentrations in plasma, and that the quantitative relatio作者: 舊石器時(shí)代 時(shí)間: 2025-3-22 22:09
Use of Toxicokinetic Principles in Drug Development: Bridging Preclinical and Clinical Studiessuring blood levels, the concept of comparing safe/toxic blood concentrations in animals to those in man has not been fully realized. Furthermore, in many cases, the frequency of dosing in animal safety studies may not match with that proposed for use in man. Many examples exist demonstrating that t作者: 挑剔為人 時(shí)間: 2025-3-23 01:44
Preclinical Pharmacodynamics of Central Nervous System Active Agentsarmacological properties of new psychotropic drugs. In this chapter a new approach is proposed for this type of investigations, which allows additional quantitative pharmacodynamic information (i.e. potency, intrinsic efficacy, rate of biophase equilibration) to be derived.作者: travail 時(shí)間: 2025-3-23 09:17 作者: 致敬 時(shí)間: 2025-3-24 00:45
The Role of Pharmacokinetics in the Drug Development Processparameters, listed in order of importance, are: 1) clearance, 2) effective concentrations, 3) extent of availability, 4) fraction of the available dose excreted unchanged, 5) the blood/plasma concentration ratio, 6) half-life, 7) toxic concentrations, 8) protein binding, 9) volume of distribution, a作者: Endemic 時(shí)間: 2025-3-24 03:07 作者: indemnify 時(shí)間: 2025-3-24 07:22
Pharmacoepidemiology, Population Pharmacokinetics and New Drug Developments well into the post-marketing period. The responsibility of regulators, scientists, physicians, and the pharmaceutical industry to pursue knowledge about drug safety and efficacy extends well beyond the time when sufficient information is available to suggest that a drug is safe and efficacious, an作者: 來這真柔軟 時(shí)間: 2025-3-24 10:43 作者: faucet 時(shí)間: 2025-3-24 18:05 作者: Incorruptible 時(shí)間: 2025-3-24 20:19
Pharmacokinetic and Pharmacodynamic Modeling Applied to Anesthetic Drugsntravenous hypnotics and opioids. The measurement of drug effect for each of these classes differs in complexity and resolution. Many concepts of drug pharmacokinetic and pharmacodynamic modeling have been developed with anesthetic drugs. This has occurred because the drug effects are generally prof作者: Infant 時(shí)間: 2025-3-25 00:26 作者: chapel 時(shí)間: 2025-3-25 04:04 作者: cinder 時(shí)間: 2025-3-25 08:41
https://doi.org/10.1007/978-1-4757-1520-0drug; drug development; kinetics; metabolism; pharmaceutical; pharmacodynamics; pharmacokinetics; pharmacol作者: Legend 時(shí)間: 2025-3-25 12:12
http://image.papertrans.cn/i/image/468872.jpg作者: NIL 時(shí)間: 2025-3-25 19:35
978-1-4757-1522-4Springer Science+Business Media New York 1993作者: onlooker 時(shí)間: 2025-3-25 23:53 作者: 創(chuàng)新 時(shí)間: 2025-3-26 02:35 作者: 男生戴手銬 時(shí)間: 2025-3-26 05:00
Preclinical Pharmacodynamics of Antihypertensiveso identify therapeutic entities with: increased efficacy, decreased toxicity, increased ease and convenience of administration, an improved profile on metabolic, hemodynamic and cellular parameters, and defined and unique mechanisms of action.作者: 頂點(diǎn) 時(shí)間: 2025-3-26 12:31 作者: 擴(kuò)音器 時(shí)間: 2025-3-26 13:05
Asoke Mukherjee,Conrad Chen,Lucy Jean,Claude B. Coutinho作者: 使?jié)M足 時(shí)間: 2025-3-26 19:15 作者: 生意行為 時(shí)間: 2025-3-26 23:39 作者: COM 時(shí)間: 2025-3-27 03:02 作者: ORBIT 時(shí)間: 2025-3-27 05:19
Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development作者: 對(duì)待 時(shí)間: 2025-3-27 10:03
Avraham Yacobi (Director),Jerome P. Skelly (Deputy作者: 使長(zhǎng)胖 時(shí)間: 2025-3-27 13:54 作者: Consequence 時(shí)間: 2025-3-27 20:29 作者: 北京人起源 時(shí)間: 2025-3-28 01:50 作者: Engaging 時(shí)間: 2025-3-28 03:15
Use of Pharmacokinetics and Pharmacodynamics in Preclinical Studies to Guide Dosage Escalation Schem–24 months. Overall, there is now a substantial collection of data which demonstrates that coordination with preclinical pharmacology and toxicology studies can save both time and resources in early clinical trials without a loss of safety.作者: Afflict 時(shí)間: 2025-3-28 06:35
Use of Toxicokinetic Principles in Drug Development: Bridging Preclinical and Clinical Studiesationship between safe dosages, pharmacologic-toxicologic activities, and blood levels can guide in selecting early dosages for initial administration to man and in subsequent dosing escalation strategy.作者: 門閂 時(shí)間: 2025-3-28 13:06
Preclinical Pharmacodynamics of Anxiolytics: Effects of Chronic Benzodiazepine Administrationbserved during chronic administration, suggesting the presence of a “withdrawal” syndrome. Administration of carbamazepine after lorazepam discontinuation attenuated the behavioral and neurochemical withdrawal effects. Studies to determine the cellular mechanisms of these receptor alterations indica作者: 鋼盔 時(shí)間: 2025-3-28 16:03 作者: 夾死提手勢(shì) 時(shí)間: 2025-3-28 22:48
Assessment of Pharmacokinetic Drug Interactions in Clinical Drug Developmenthips of the chemical classes or metabolic pathways. A “Check-list” approach is often followed. More and more frequently, these studies serve several purposes including molecular modification to produce new compounds without the potential for interaction, and competitive marketing. One major issue, s作者: 上釉彩 時(shí)間: 2025-3-28 23:13
Pharmacokinetics and Drug Metabolism in Animal Studies (ADME, Protein Binding, Mass Balance, Animal imal toxicity studies, and for the selection of the appropriate animal model for purposes of estimating a safe clinical dose. Examples of the usefulness of nonclinical pharmacokinetic data for explaining toxicity which occurred, while allowing clinical trials to continue, are presented.作者: cinder 時(shí)間: 2025-3-29 06:19
Use of Acute Toxicity Data in the Design and Interpretation of Subchronic and Chronic Toxicity Studiical for acute, subchronic and chronic dosing in the same species (rat). The importance and usefulness of careful considerations of toxicokinetic and toxicodynamic data obtained in acute experiments for the design of subchronic and chronic toxicity studies is discussed.作者: 燒瓶 時(shí)間: 2025-3-29 09:48 作者: LAVA 時(shí)間: 2025-3-29 12:59 作者: cyanosis 時(shí)間: 2025-3-29 17:16
Guidelines for Development of a New Diuretic Agentticular nephron site allows prediction of the degree of natriuresis that will occur and also the concomitant excretion of other electrolytes which may impact on adverse effects (e.g., potassium or magnesium).作者: Latency 時(shí)間: 2025-3-29 21:06 作者: BLINK 時(shí)間: 2025-3-30 00:29
Preclinical Pharmacodynamics of Anti-Inflammatory Drugsnely for the evaluation of AI agents and includes some suggestions as to how one might approach the development of newer models that may help identify novel AI drugs with varying mechanisms of therapeutic action.作者: Forsake 時(shí)間: 2025-3-30 05:15
Pharmacoepidemiology, Population Pharmacokinetics and New Drug Developmente events requiring at best a change in labeling; and at worst removal from the market at great cost, in terms of credibility and dollars, to both FDA and the pharmaceutical industry (FDA Drug Review, 1990).作者: Spinal-Fusion 時(shí)間: 2025-3-30 09:06 作者: Synapse 時(shí)間: 2025-3-30 14:26
Shruti Jain,Jitendra Virmanients of the plans were financed essentially through state-to-state loans or project credits from other governments or supranational institutions. Domestically, the financial structure involved the allocation of credit and foreign exchange according to the priorities of the plans. In this setting, fi作者: CUR 時(shí)間: 2025-3-30 18:21
Kevin Mintzs Fachgebiet mit besonders gravierendem Wandel heraus. Insbesondere werden bei einer Supply Chain gro?e Verbesserungspotenziale vermutet. Hartmut Werner zeigt in seinem Lehrbuch konkrete Wege zur Aussch?pfung dieser Optimierungsm?glichkeiten auf. Dazu werden die Grundlagen des Supply Chain Managemen作者: Amenable 時(shí)間: 2025-3-31 00:26
Edward Neather,Mike Ounsworthno condotto negli ultimi anni, affronta i principali temi connessi alla valutazione delle funzioni adattive nelle forme spastiche della PCI (la definizione e le sue modifiche negli ultimi decenni, i nuovi orientamenti classificativi, l’eziopatogenesi, le correlazioni anatomo-funzionali, la semeiotic作者: BANAL 時(shí)間: 2025-3-31 00:52
Personalising Learning through Prerequisite Structures Derived from Concept Mapsnowledge, learning progress, learning goal, and possibly further characteristics. For creating personalised learning paths and efficiently uncovering the knowledge or competence level of a learner, prerequisite structures on learning objects and assessment problems, or on skills underlying those ent作者: critic 時(shí)間: 2025-3-31 07:31
The Urban Life Cycle in the Italian Demographic Winter. An Analysis on Metropolitan Citiesh interaction allowed spreading of new ideas, solutions, applications. The traditional, spontaneous, way of spreading of innovation has recently left the pace to more structured systems. To-date, innovation is part of structured and prepared business models in enterprises, and it is very often roote作者: 路標(biāo) 時(shí)間: 2025-3-31 10:01
Herbig-Haro Objects in the Orion Nebula Regioninfrared and is probably the result of Rayleigh-Taylor instabilities in shocked material moving into the near side of the giant molecular cloud OMC-1. The South System is associated with source(s) within the Trapezium cluster, with the shocked HH objects occuring where jets from pre-main sequence st作者: 腐爛 時(shí)間: 2025-3-31 16:36 作者: Mawkish 時(shí)間: 2025-3-31 18:21
Economic Performance of Six Economies of Central and Eastern Europe,r half of the decade (see Table 8.33.1). Germany’s share, as the leading economy of the European Union, doubled during the whole period, while the advanced economies of the European Union came to hold 75 percent of aggregate exports by 1999. Overall, the restructuring of the economy was catalyzed by作者: 天然熱噴泉 時(shí)間: 2025-3-31 22:41
xciting new medical treatment concepts and numerous surgical.This well-illustrated book presents the latest diagnostic concepts and management techniques in the rapidly expanding subspecialty of pediatric oculofacial plastic surgery. Covering all aspects of the field and taking into account numerous作者: 使厭惡 時(shí)間: 2025-4-1 04:35 作者: fallible 時(shí)間: 2025-4-1 09:23
,Bolivia: “Social Control” as the Fourth State Power 1994–2015,ility and high authorisation. Over time, the process of up-scaling the ideals of indigenous community participation from the local to the national scale converted the relationship into one of antagonism, while dissolving the articulation between different circuits of representation that aimed to overcome the domination of electoral representation.作者: MONY 時(shí)間: 2025-4-1 12:26
https://doi.org/10.1007/978-3-531-90425-2so revealed that agricultural expenditure had positive statistical significant impact on agricultural GDP growth at 1% probability in both short run and long run with coefficients of 0.02270 and 0.003055, respectively. Inflation (0.890787), public investment (0.004469) and private investment (0.0044作者: anus928 時(shí)間: 2025-4-1 17:28 作者: 輕率看法 時(shí)間: 2025-4-1 20:19 作者: 黑豹 時(shí)間: 2025-4-2 00:09 作者: AVANT 時(shí)間: 2025-4-2 04:33
Lumped Mass Models of Gantry Cranes, does not reflect the deflections within the individual parts of the crane but only considers their rigid body movements and results in a lumped mass model (LMM). Both the overhead and container cranes, shown in Figs.?. and ., respectively, lie within the category of gantry cranes. In developing the作者: quiet-sleep 時(shí)間: 2025-4-2 09:13 作者: corn732 時(shí)間: 2025-4-2 14:23
