標(biāo)題: Titlebook: Information management; The evaluation of in Leslie Willcocks Book 1994 Leslie Willcocks 1994 Information Technology (IT).information manag [打印本頁] 作者: 老鼠系領(lǐng)帶 時(shí)間: 2025-3-21 19:13
書目名稱Information management影響因子(影響力)
作者: 浪費(fèi)時(shí)間 時(shí)間: 2025-3-21 23:11
Beyond return on investment top 200 companies provided data on how they carried out IT investment appraisal, in particular how they managed, or more usually ignored, the intangible benefits. This adds to the picture on evaluation practice developed in Chapters 2 and 3 of this book.作者: indignant 時(shí)間: 2025-3-22 01:18 作者: Liberate 時(shí)間: 2025-3-22 06:13 作者: CODE 時(shí)間: 2025-3-22 11:03 作者: 細(xì)頸瓶 時(shí)間: 2025-3-22 15:19
rse of the past 30 years. The text does not attempt to give a complete and meticulous account of the work accomplished in many other laboratories; in that sense it is not a review of the field in a conventional sense. Since the author is also one of the editors of this series of . on DNA methylation作者: intellect 時(shí)間: 2025-3-22 20:02
Leslie Willcockswn to act as hotspots formutations due to the high rate of spontaneous deamination of this base to thymine, resulting in a G/T mismatch. This will be fixed as a C→T transition after replication if not repaired by the base excision repair (BER) pathway or specific repair enzymes dedicated to this pur作者: REP 時(shí)間: 2025-3-22 23:42 作者: 啞劇 時(shí)間: 2025-3-23 02:17 作者: anarchist 時(shí)間: 2025-3-23 07:12
Leslie Willcocks,Stephanie Lester our understanding of epigenetic regulation in the fruit fly .. In the past, DNA methylation research has primarily utilized mammalian model systems. However, several recent landmark discoveries have been made in other organisms. For example, the interaction between DNA methylation and histone methy作者: Patrimony 時(shí)間: 2025-3-23 12:07
A methylation patterns produced through their de novo-type DNA methylation activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l), which is a member of the Dnmt3 family but does not possess DNA methylation activity, was reported to be indispensable for globa作者: misshapen 時(shí)間: 2025-3-23 15:14
John Wardique and selective manner. Here, we review various aspects of MTase engineering, both methodological and conceptual, and also discuss future directions and challenges. Bacterial MTases that are part of restriction/modification (R/M) systems offer a convenient way for the selection of large gene libr作者: Landlocked 時(shí)間: 2025-3-23 21:53 作者: PSA-velocity 時(shí)間: 2025-3-24 00:36
Malcolm Iliffly specific genotyping by minisequencing single-base extension with the advantages of a microarray format that allows highly multiplexed and parallel analysis of any custom selected SNPs..Cyclic minisequencing reactions with fluorescently labeled dideoxynucleotides (ddNTPs) are performed in solution作者: 陪審團(tuán)每個(gè)人 時(shí)間: 2025-3-24 04:00 作者: 壓艙物 時(shí)間: 2025-3-24 07:05
oss-hybridizations). One goal of temperature optimization is to minimize the contribution of mismatch species; however, achieving this goal may come at the expense of obtaining equilibrium reaction conditions. We employ two-component thermodynamic and kinetic models to study the trade-offs involved 作者: Exploit 時(shí)間: 2025-3-24 11:36
Tom Coleman,Mark Jamiesonnuclear DNA of several kinetoplastid parasites. Within these organisms, base J is formed in two putative steps, which include the initial recognition and hydroxylation of a specific thymine by J-binding proteins (JBP1 and JBP2) and the subsequent glycosylation by a glucosyltransferase (GT). Since th作者: 情節(jié)劇 時(shí)間: 2025-3-24 15:20 作者: G-spot 時(shí)間: 2025-3-24 21:26 作者: Graphite 時(shí)間: 2025-3-25 02:12 作者: 同步信息 時(shí)間: 2025-3-25 05:00
Veronica Symons attracted widespread attention in many related fields. Therefore, creating highly effective, selective, and easy-operating detection methods for these important natural existing DNA modifications is important not only to understand the fundamentals of physiological regulation, but also serve as the作者: facilitate 時(shí)間: 2025-3-25 09:17 作者: ANN 時(shí)間: 2025-3-25 12:25 作者: 殺人 時(shí)間: 2025-3-25 16:35
Why companies invest in information technologydo they support strategic business goals and effectively target the use of . (IT), as well as maximizing short- and long-term returns? Finally, what proposals might be developed for the purpose of optimizing the way in which such decisions are made?作者: reject 時(shí)間: 2025-3-25 20:15
Evaluating the feasibility of information systems investments: recent UK evidence and new approaches period from early 1990, have served to place IT issues above the parapet in most organizations, perhaps irretrievably. IT expenditure across private and public sectors in the United Kingdom exceeded ￡15 billion in 1992. In companies this represented a national average of 1.5% of turnover; in the pu作者: dandruff 時(shí)間: 2025-3-26 01:00
A portfolio approach to evaluating information systems investments and setting prioritiesorganization’s funds. While application software may for ‘legal’ reasons be written off as an expense item, it is in reality not a consumable item whose benefits accrue in the year it is purchased. It is an investment whose benefits accrue over time. Technology is normally treated as a capital item,作者: forestry 時(shí)間: 2025-3-26 07:24 作者: 祖?zhèn)髫?cái)產(chǎn) 時(shí)間: 2025-3-26 10:12
The real value of strategy formulation for information technologyhis can make to corporate effectiveness. It looks at the place of IT in the broader context of an information management strategy and the interaction of the related components of a well formulated strategy. It considers the role that some analytical techniques can play in its development. Prescripti作者: Conserve 時(shí)間: 2025-3-26 12:43 作者: TIA742 時(shí)間: 2025-3-26 18:02 作者: 不能仁慈 時(shí)間: 2025-3-26 23:52
Information economics: a practical approach to valuing information systems This has received attention elsewhere in the book, notably in Chapters 3 and 4. The objective here will be to suggest how the IE approach can be operationalized. Two case studies will be used to show and assess the learning points from the IE approach in practice. Information economics was devised 作者: tooth-decay 時(shí)間: 2025-3-27 02:49 作者: callous 時(shí)間: 2025-3-27 06:23
Risk and information systems: developing the analysiscross the information systems portfolio. Peters in Chapter 5 showed how business risks could be identified and information systems use could be related to minimization of those risks. Wiseman described the usefulness of the information economics approach for risk identification, and elements of both作者: offense 時(shí)間: 2025-3-27 11:53
Responsibility for IT: a grey area of management realize, often through bitter experience, that treating IT project proposals as one-off investment decisions is not the way to achieve solid business benefits for their companies and positive financial returns for their shareholders (Hochstrasser and Griffiths, 1990). For IT to provide benefits to 作者: epicardium 時(shí)間: 2025-3-27 17:42 作者: Heretical 時(shí)間: 2025-3-27 19:36
Justifying IT investmentsifying IT investment has been developed that concentrates on critical success factors, on risk assessment, on business performance indicators, and on strategic alignment while offering at the same time a mechanism to monitor and evaluate the investment over time.作者: 大吃大喝 時(shí)間: 2025-3-27 23:22 作者: eucalyptus 時(shí)間: 2025-3-28 05:35 作者: 預(yù)兆好 時(shí)間: 2025-3-28 07:00 作者: 招人嫉妒 時(shí)間: 2025-3-28 11:28 作者: giggle 時(shí)間: 2025-3-28 16:11
The real value of strategy formulation for information technologyof the related components of a well formulated strategy. It considers the role that some analytical techniques can play in its development. Prescriptive ideas are presented for ensuring success in the evaluation, formulation and the implementation of the strategy and the use of a Portakabin type approach to application projects.作者: eustachian-tube 時(shí)間: 2025-3-28 21:04
Introduction: of capital importancend oil refining and processing sectors; by 1993 the computer and electronics sector may well constitute the largest single US industry. On some predictions, by the year 2000 the whole IT industry will account for some 10% of world economic activity — a doubling of the 1990 figure (Cane, 1992; Heath and Swinden, 1992).作者: 寬敞 時(shí)間: 2025-3-29 02:15
Assessing the value of strategic information technology investmentsgain a competitive advantage includes investments by such firms as American Airlines, American Hospital Supply Corporation, Avis, Bank America, Citicorp, Digital Equipment Corporation, and General Electric (Cash and Konsynski, 1985; Ives and Learmonth, 1984; Porter and Millar, 1985; Strassmann, 1988; Wiseman, 1985).作者: orient 時(shí)間: 2025-3-29 04:28
Evaluation of information systems investments: towards multiple perspectives is now software on the market to help in assessment of computing facilities. Yet as other contributors to this book demonstrate, there is no commonly accepted framework or methodology for information systems (IS) evaluation.作者: 臭名昭著 時(shí)間: 2025-3-29 10:03
actice, a survey was undertaken in 1990 of 80 American, British, Australian and New Zealand companies. A one-page survey form was used that provided 15 possible 1ST investment criteria, a means of indicating whether they are used or not, the percentage of projects to which each criterion is applied,作者: 糾纏 時(shí)間: 2025-3-29 11:39
DNA methylation, we focused mainly on the human genome. The following topics in DNA methylation will be treated in detail: (1) The de novo methylation of integrated foreign genomes; (2) the long-term gene silencing effect of sequence-specific promoter methylation and its reversal; (3) the propertie作者: 補(bǔ)助 時(shí)間: 2025-3-29 15:48
Leslie Willcocks such as p53 and the retinoblastoma protein, causing cancer. We also examine the specific repair enzymes involved, namely the endonuclease Vsr in . and two members of the uracil DNA glycosylase (UDG) superfamily in mammals, TDG and MBD4. Repair brings its own problems, since it will require remethyl作者: Acupressure 時(shí)間: 2025-3-29 19:53
ted. Cytosine DNA methylation in plants is more rich and diverse compared with animals. It is carried out by the families of specific enzymes that belong to at least three classes of DNA methyltransferases. Open reading frames (ORF) for adenine DNA methyltransferases are found in plant and animal ge作者: 吹氣 時(shí)間: 2025-3-30 01:02
C. James Bacon exhibit cancer-associated hypomethylation. However, one of these repeated sequences (NBL2) displayed predominant increases in methylation in some ovarian carcinomas and Wilms tumors and decreases in others. Furthermore, decreases and increases in CpG methylation can be interspersed within a small s作者: Alopecia-Areata 時(shí)間: 2025-3-30 06:56
Leslie Willcocks,Stephanie Lesterchapter, we will focus on three aspects that represent the complexity of epigenetic gene regulation. (1) We will discuss the available data about the DNA methylation system, (2) we will illuminate the interaction between DNA methylation and chromatin regulation, and (3) we will provide an overview o作者: 草率男 時(shí)間: 2025-3-30 09:17
that methylates CpG sites. Dnmt1 contains an N-terminal independently folded domain (NTD) that interacts with a variety of regulatory factors, a replication foci-targeting sequence (RFTS) domain that recognizes the histone H3K9me3 mark and H3 ubiquitylation, a CXXC domain that recognizes unmodified
