作者: strdulate 時(shí)間: 2025-3-21 23:09
The Early Clinical Development of Indacaterol,elopment of indacaterol confirmed preclinical data characterizing indacaterol as a long-acting β.-agonist with a sustained 24 h duration of bronchodilation, thus suitable for once-daily dosing, a rapid onset of action and a favourable safety profile over a range of dosages and delivery modes, both in asthma and COPD patients of various severities.作者: 洞穴 時(shí)間: 2025-3-22 02:04
Current Pharmacotherapy for COPD, a role limited to the severe and very severe patient with frequent exacerbations. Recent evidence suggests that maintenance antibiotic therapy may be additive to the effect of bronchodilators in reducing exacerbation frequency. The choice of agents may be based primarily on individual response, cost, side-effect profile, and availability.作者: 咽下 時(shí)間: 2025-3-22 07:38
The Preclinical Pharmacology of Indacaterol,o systems as well as a large cohort of COPD patients, no association could be demonstrated between β.-adrenoceptor polymorphisms and indacaterol response. In conclusion, the preclinical profile of indacaterol suggests that this compound has a duration of action compatible with once-daily dosing in human, together with a fast onset of action.作者: 五行打油詩(shī) 時(shí)間: 2025-3-22 09:59 作者: nocturia 時(shí)間: 2025-3-22 13:45
2296-6056 cotherapy of COPD.Includes supplementary material: .Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, 作者: Wallow 時(shí)間: 2025-3-22 20:27
Indacaterol978-3-0348-0709-8Series ISSN 2296-6056 Series E-ISSN 2296-6064 作者: pulse-pressure 時(shí)間: 2025-3-22 22:43
https://doi.org/10.1007/978-3-0348-0709-8Asthma; Beta-2-Agonists; Bronchitis; Bronchodilatator; Lung function作者: Affiliation 時(shí)間: 2025-3-23 04:12
Alexandre TrifilieffSummarizes preclinical and clinical data.A valuable source of information for scientists and clinicians.Contemporary monograph on the pharmacotherapy of COPD.Includes supplementary material: 作者: 開(kāi)始沒(méi)有 時(shí)間: 2025-3-23 07:55 作者: 缺陷 時(shí)間: 2025-3-23 10:13 作者: 睨視 時(shí)間: 2025-3-23 17:29
The Preclinical Pharmacology of Indacaterol,various in vitro systems, indacaterol is close to a full agonist at the human β.-adrenoceptor with nanomolar potency. In isolated superfused human and guinea pig trachea, indacaterol has a fast onset of and a long duration of action. In the conscious guinea pig, when given intratracheally as a dry p作者: 有害處 時(shí)間: 2025-3-23 21:45 作者: 正式演說(shuō) 時(shí)間: 2025-3-24 02:06 作者: 多骨 時(shí)間: 2025-3-24 02:44
INHANCE: An Adaptive Confirmatory Study with Dose Selection at Interim,istical issues that must be considered when planning an adaptive design, for example, controlling the Type I error rate, prespecifying the adaptation criteria, and setting up well-organised procedures to maintain data confidentiality at interim analyses. The number of adaptations should be limited, 作者: 整頓 時(shí)間: 2025-3-24 08:06 作者: 暗語(yǔ) 時(shí)間: 2025-3-24 14:09 作者: 正式演說(shuō) 時(shí)間: 2025-3-24 17:41 作者: extemporaneous 時(shí)間: 2025-3-24 22:20 作者: adhesive 時(shí)間: 2025-3-24 23:42
of the truth. When evaluating the success of a cosmetic not medically indicated surgery our target should be to satisfy the subjective expectations of our customer. Such a subjective goal does not necessarily coincide with a visual acuity (VA) of 20/20 or decimally described VA of 1.0. Many social,作者: Pericarditis 時(shí)間: 2025-3-25 05:28
James F. Donohue,Matthew C. Miles,Jill A. Oharbone, an osteotomy is created and tension stress is applied via a distraction device, daily as to separate the edges of the bone, in effect mimicking natural growth. Over time, the gap is advanced daily at a rate of 1 mm per day for mature skeletons and 2 mm per day for young children and infants. T作者: 占線 時(shí)間: 2025-3-25 07:30 作者: 加花粗鄙人 時(shí)間: 2025-3-25 15:04 作者: 機(jī)構(gòu) 時(shí)間: 2025-3-25 17:41
Jutta Beier,Kai M. Beehft lip and palate deformities requires a thorough consideration of the complexities of the anatomical deformity and a balance between intervention and growth. Complications can occur in the management of the cleft patients due to lack of understanding of surgical principles and improper techniques. 作者: MIR 時(shí)間: 2025-3-25 23:05 作者: 表皮 時(shí)間: 2025-3-26 02:01
Ronald Dahlbtedly encounter patients with certain psychological disorders at a much higher frequency than many of their colleagues. At its most superficial level, the underlying goal of any cosmetic surgery procedure is to provide some sort of psychological benefit to the patient from the completion of the pro作者: GRATE 時(shí)間: 2025-3-26 04:42 作者: mettlesome 時(shí)間: 2025-3-26 11:33
David Young,Lee Wood,Dilraj Singh,Juergen Dederichsdecades. Cosmetic, excisional, and reconstructive pro- dures are being performed by primary care physicians and a variety of specialists in different disciplines, such as dermatology, plastic surgery, ophthalmology, and otolaryngology. As the number of cutaneous surgery procedures rises, so will the作者: 火花 時(shí)間: 2025-3-26 16:37 作者: mitten 時(shí)間: 2025-3-26 20:36
Book 2014 setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD..作者: 防御 時(shí)間: 2025-3-26 21:10 作者: probate 時(shí)間: 2025-3-27 01:15
James F. Donohue,Matthew C. Miles,Jill A. OharO techniques were basic, including the use of external distraction devices, based on developments in orthopedics. This early literature is replete with reports of how to control the vector as it was recognized that during the distraction process, the local muscle pull can affect the vector of the di作者: myopia 時(shí)間: 2025-3-27 05:21
Alexandre Trifilieff,Steven J. Charlton,Robin A. Fairhurstor the osteosynthesis of craniofacial trauma..Therefore, this chapter discusses and explains the pros versus cons of elective metal OM removal and gives an overview about potential long-term systemic side effects of titanium like corrosion if left in situ for ever.作者: craven 時(shí)間: 2025-3-27 12:05 作者: 明智的人 時(shí)間: 2025-3-27 16:52 作者: Fraudulent 時(shí)間: 2025-3-27 19:36
David Lawrence,Frank Bretz,Stuart PocockO techniques were basic, including the use of external distraction devices, based on developments in orthopedics. This early literature is replete with reports of how to control the vector as it was recognized that during the distraction process, the local muscle pull can affect the vector of the di作者: 玩忽職守 時(shí)間: 2025-3-27 23:26 作者: Integrate 時(shí)間: 2025-3-28 04:13
Donald A. Mahlerorming cosmetic procedures should have a working knowledge of the presentation, etiology, and treatment options for many of the common diseases that may be encountered. With this knowledge the cosmetic surgeon will also be able to aid in the identification of patients in need of counseling or psychi作者: preservative 時(shí)間: 2025-3-28 07:44
Peter J. Barnesat will enable the pr- ticing physician to formulate a preoperative strategy to prevent complications before they occur and to properly diagnose and manage complications when they arise in order to provide a better service to the patient. This book is divided into three sections: acute surgical comp作者: stressors 時(shí)間: 2025-3-28 10:44
2296-6056 f the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD..978-3-0348-0709-8Series ISSN 2296-6056 Series E-ISSN 2296-6064 作者: 凈禮 時(shí)間: 2025-3-28 16:05
David Young,Lee Wood,Dilraj Singh,Juergen Dederichse they occur and to properly diagnose and manage complications when they arise in order to provide a better service to the patient. This book is divided into three sections: acute surgical comp978-1-4419-2510-7978-0-387-73152-0作者: 思想 時(shí)間: 2025-3-28 21:52 作者: Dri727 時(shí)間: 2025-3-28 23:23 作者: MINT 時(shí)間: 2025-3-29 05:27
Phase III Clinical Efficacy of Indacaterol: Patient-Centered Outcomes,significant improvements in health status, as measured by the St. George’s Respiratory Questionnaire, relative to placebo therapy. In two of three randomized trials, the differences in the St. George’s Respiratory Questionnaire between indacaterol and placebo achieved the minimal important differenc
