標(biāo)題: Titlebook: In Silico Methods for Predicting Drug Toxicity; Emilio Benfenati Book 2016 Springer Science+Business Media New York 2016 Pharmaceutical mo [打印本頁] 作者: 難受 時(shí)間: 2025-3-21 17:31
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作者: Neuropeptides 時(shí)間: 2025-3-21 23:00
In Silico 3D Modeling of Binding Activitiesr homology modeling of receptors have been reliably used in pharmacological research and development for decades. Molecular docking methodologies are helpful for revealing facets of activation and inactivation, thus improving mechanistic understanding and predicting molecular ligand binding activity作者: 賠償 時(shí)間: 2025-3-22 03:29
Modeling Pharmacokineticsescriptions of xenobiotics’ absorption, distribution, metabolism, and excretion processes. They model the body as a set of homogeneous compartments representing organs, and their parameters refer to anatomical, physiological, biochemical, and physicochemical entities. They offer a quantitative mecha作者: abnegate 時(shí)間: 2025-3-22 07:49 作者: POWER 時(shí)間: 2025-3-22 12:28
In Silico Prediction of Chemically Induced Mutagenicity: How to Use QSAR Models and Interpret Their AR models that can predict Ames genotoxicity are freely available for download from the Internet and they can provide relevant information for the toxicological profiling of chemicals. Indeed, they can be straightforwardly used for predicting the presence or absence of genotoxic hazards associated w作者: Ordeal 時(shí)間: 2025-3-22 13:27
In Silico Methods for Carcinogenicity Assessmentative predictive models, ranging from short-term biological assays (e.g. mutagenicity tests) to theoretical models, have been attempted in this field. Theoretical approaches such as (Q)SAR are highly desirable for identifying carcinogens, since they actively promote the replacement, reduction, and r作者: Intruder 時(shí)間: 2025-3-22 19:32 作者: 姑姑在炫耀 時(shí)間: 2025-3-22 22:09 作者: 舊式步槍 時(shí)間: 2025-3-23 03:58
In Silico Models for Repeated-Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Leve is the determination of the no observed adverse effect level (NOAEL) and the lowest observed adverse effect level (LOAEL). NOAEL is important since it serves to calculate the maximum recommended starting dose (MRSD) which is the safe starting dose for clinical studies in human beings. Since in vivo作者: Blemish 時(shí)間: 2025-3-23 08:37
In Silico Models for Acute Systemic Toxicityvailability of structure-based computational models that are available and potentially useful in the assessment of acute systemic toxicity. The most recently published literature models for acute systemic toxicity are also discussed, and perspectives for future developments in this field are offered作者: 高興一回 時(shí)間: 2025-3-23 13:39
In Silico Models for Hepatotoxicitycal system and our ability to emulate that in a predictive capacity. We give an overview of the published modeling approaches in this area to date and discuss their design, strengths, and weaknesses. It is interesting to note the shift during the period of this review in the direction of evidenced-b作者: 統(tǒng)治人類 時(shí)間: 2025-3-23 14:49
In Silico Models for Ecotoxicity of Pharmaceuticalsls into the environment are industries, hospitals, or direct disposal of unwanted or expired drugs made by the patient. The most important and distinct features of pharmaceuticals are that they are deliberately designed to have an explicit mode of action and designed to exert an effect on humans and作者: Cacophonous 時(shí)間: 2025-3-23 20:40 作者: Mhc-Molecule 時(shí)間: 2025-3-23 22:48 作者: Banquet 時(shí)間: 2025-3-24 04:02
A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms omechanisms of action is a crucial strategy. In this chapter, we describe a systems biology approach that incorporates analyses of hepatotoxicant data for 33 compounds from three different sources: a chemical structure similarity analysis based on the 3D Tanimoto coefficient, a chemical structure-bas作者: intangibility 時(shí)間: 2025-3-24 06:33
In Silico Study of In Vitro GPCR Assays by QSAR Modelingays. One goal is to prioritize chemicals for more detailed analyses based on activity in assays that target molecular initiating events (MIEs) of adverse outcome pathways (AOPs). However, the chemical space of interest for environmental exposure is much wider than ToxCast’s chemical library. In sili作者: Cryptic 時(shí)間: 2025-3-24 13:16 作者: 連接 時(shí)間: 2025-3-24 17:00 作者: 滲入 時(shí)間: 2025-3-24 20:30 作者: FRONT 時(shí)間: 2025-3-25 00:19 作者: FILLY 時(shí)間: 2025-3-25 07:00
Frederic Y. Bois,Céline Brochotesses a specific clinical problem.Focuses on clinical care o.The current medical literature contains ample text addressing the topics of trauma and critical care. However, there are few texts existing that specifically address the common surgical problems encountered by practicing acute care surgeon作者: Gossamer 時(shí)間: 2025-3-25 11:02
Jayeeta Ghosh,Michael S. Lawless,Marvin Waldman,Vijay Gombar,Robert Fraczkiewiczesses a specific clinical problem.Focuses on clinical care o.The current medical literature contains ample text addressing the topics of trauma and critical care. However, there are few texts existing that specifically address the common surgical problems encountered by practicing acute care surgeon作者: Narcissist 時(shí)間: 2025-3-25 15:12 作者: Magnitude 時(shí)間: 2025-3-25 18:32 作者: Femish 時(shí)間: 2025-3-25 23:00
Azadi Golbamaki,Emilio Benfenati, emergency department (ED), or intensive care unit (ICU) for a wide variety of indications. Regardless of location or indication, vascular access procedures are not innocuous and procedural success traditionally has relied on knowledge of anatomy and familiarity of the procedure. In a prospective s作者: 打谷工具 時(shí)間: 2025-3-26 02:09
Martin Smie?ko,Angelo Vedanient will benefit; choose poorly and your patient may suffer. Ultimately, the management of any critically ill patient returns to a single, central question: “What is making my patient unstable?” Unfortunately, this very question is one of the most difficult to answer. In part, it is a difficult ques作者: coalition 時(shí)間: 2025-3-26 07:10
Marco Marzo,Alessandra Roncaglioni,Sunil Kulkarni,Tara S. Barton-Maclaren,Emilio Benfenatins in the diagnosis and management of this common and potentially complex clinical problem (Solomkin et al., Clin Infect Dis Off Publ Infect Dis Soc Am 50:133–164, 2010). The management of patients with intra-abdominal infections consumes considerable hospital resources and spans multiple areas of t作者: 毀壞 時(shí)間: 2025-3-26 10:14
Fabiola Pizzo,Emilio Benfenati titrated to laboratory and clinical parameters. Phases of resuscitation occur in the pre-hospital environment, emergency room, operating room, interventional radiology suite, and intensive care unit (ICU) where multiple health care providers and physicians influence patient outcome by their attenti作者: 立即 時(shí)間: 2025-3-26 15:57 作者: 激勵(lì) 時(shí)間: 2025-3-26 17:07
Mark Hewitt,Katarzyna Przybylak physical pions as a spectroscopic tool to investigate nuclear states, which is little more than an extension of Van de Graaff physics to a new particle and to less preciseness. With a few exceptions (mainly photopions and radiative π-capture) this is not a great challenge to our imagination and it 作者: exceptional 時(shí)間: 2025-3-26 22:46
Kunal Roy,Supratik Kar physical pions as a spectroscopic tool to investigate nuclear states, which is little more than an extension of Van de Graaff physics to a new particle and to less preciseness. With a few exceptions (mainly photopions and radiative π-capture) this is not a great challenge to our imagination and it 作者: 欄桿 時(shí)間: 2025-3-27 01:24
Serena Manganelli,Emilio Benfenatintre in Alberta, Canada from August 21 through September 1, 1978. The present volume contains the text of 25 lectures and seminars given at the Institute and illustrates the directions that nuclear physicists are taking in the evolution toward a unified picture of low, medium and high energy phenome作者: 緩解 時(shí)間: 2025-3-27 07:06 作者: Neutropenia 時(shí)間: 2025-3-27 10:21
Mathieu Vinken Street, window-shopping for a new pair of gloves.. As she moved through the growing evening crowd, she was approached by a Metropolitan Police Officer, Police Constable Bowden Endacott, and told to her great dismay that she had been seen soliciting men for the purposes of prostitution, to their ann作者: Phonophobia 時(shí)間: 2025-3-27 14:39 作者: SLING 時(shí)間: 2025-3-27 21:27 作者: 小母馬 時(shí)間: 2025-3-28 01:33
In Silico Models for Hepatotoxicity discuss their design, strengths, and weaknesses. It is interesting to note the shift during the period of this review in the direction of evidenced-based approaches including structural alerts and pharmacophore models. Proposals on how best to utilize the data emerging from modeling studies are also discussed.作者: 厚臉皮 時(shí)間: 2025-3-28 03:24 作者: 使?jié)M足 時(shí)間: 2025-3-28 07:12 作者: ESO 時(shí)間: 2025-3-28 13:30
1064-3745 ontains key notes and implementation advice from the experts.This detailed volume explores in silico methods forpharmaceutical toxicity by combiningthe theoretical advanced research with the practical application of the tools.Beginning with a section covering sophisticated models addressing the bind作者: BLUSH 時(shí)間: 2025-3-28 18:11
In Silico 3D Modeling of Binding Activitiesever, only applicable for chemical hazard identification situations where the specific target receptor for a given chemical is known and the crystal structure/homology model of the receptor is available.作者: cortex 時(shí)間: 2025-3-28 22:36 作者: Ceremony 時(shí)間: 2025-3-29 01:07
In Silico Models for Repeated-Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Levelimitations since they do not refer to a single end point but to several different effects and the doses used in experimental studies strongly influence the final results. Few attempts to model NOAEL and LOAEL have been reported. The available database and models for the prediction of NOAEL and LOAEL are reviewed here.作者: GOAT 時(shí)間: 2025-3-29 03:22 作者: expunge 時(shí)間: 2025-3-29 08:43
Modeling ADMETpossible in drug discovery. Here, we describe in detail how ADMET models can be developed and applied using a commercially available package, ADMET Predictor? 7.2 (ADMET Predictor v7.2. Simulations Plus, Inc., Lancaster, CA, USA).作者: SAGE 時(shí)間: 2025-3-29 15:14
Adverse Outcome Pathways as Tools to Assess Drug-Induced Toxicitynumber of purposes pertinent to safety assessment of drugs, in particular the establishment of quantitative structure-activity relationships, the development of novel in vitro toxicity screening tests, and the elaboration of prioritization strategies.作者: 獸皮 時(shí)間: 2025-3-29 16:51
Book 2016on of the tools.Beginning with a section covering sophisticated models addressing the bindingto receptors, pharmacokinetics and adsorption, metabolism, distribution, andexcretion, the book continues with chapters delving into models for specifictoxicological and ecotoxicological endpoints, as well a作者: molest 時(shí)間: 2025-3-29 21:08
1064-3745 fers the advantage of incorporating data and knowledge fromdifferent fields, such as chemistry, biology, -omics, and pharmacology, toachieve goals in this vital area of research..978-1-4939-8093-2978-1-4939-3609-0Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: EXALT 時(shí)間: 2025-3-30 02:49
QSAR Methods,plied to chemical design, to computational toxicology, and to drug discovery. We discuss how the experimental practice in biological science is moving more and more toward modeling and simulation. Such virtual experiments confirm hypotheses, provide data for regulation, and help in designing new che作者: 不在灌木叢中 時(shí)間: 2025-3-30 07:20
In Silico Model for Developmental Toxicity: How to Use QSAR Models and Interpret Their Resultsxamples illustrating an approach to combine human-based rules and statistical methods to support the prediction of developmental toxicity; we also discuss assumptions and uncertainties of the methodology.作者: 殘廢的火焰 時(shí)間: 2025-3-30 12:15
In Silico Models for Ecotoxicity of Pharmaceuticals in silico methods to provide quick information about the risk assessment and fate properties of pharmaceuticals as well as their ecological and indirect human health effects. This chapter aims to offer information regarding occurrence of pharmaceuticals in the environment, their persistence, enviro作者: offense 時(shí)間: 2025-3-30 15:21 作者: 粗俗人 時(shí)間: 2025-3-30 19:25
In Silico Study of In Vitro GPCR Assays by QSAR Modeling lists. The specific aim of the current work was to build QSAR models for 18 G-protein-coupled receptor (GPCR) assays, part of the aminergic family. Two QSAR modeling strategies were adopted: classification models were developed to separate chemicals into active/non-active classes, and then regressi作者: Range-Of-Motion 時(shí)間: 2025-3-31 00:21
e of palliative care. .Authored by respected experts in the field and illustrated throughout with detailed photographs, .Common Problems in Acute Care Surgery. is of great value to resident surgeons in training, fellows, and practicing surgeons in acute care surgery..978-1-4939-0236-1978-1-4614-6123-4
