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標(biāo)題: Titlebook: Hypoxia in Cancer: Significance and Impact on Cancer Therapy; Sukhes Mukherjee,Jagat Rakesh Kanwar Book 2023 The Editor(s) (if applicable) [打印本頁]

作者: NK871    時(shí)間: 2025-3-21 16:25
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作者: 樹上結(jié)蜜糖    時(shí)間: 2025-3-21 21:19

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CRISPR/Cas9-Editing-Based Modeling of Tumor Hypoxia,pact. The effectiveness of new HIF-1 inhibitors is being sought after, and their effectiveness as anticancer therapies is being investigated. The HIF-1 transcription factor complex binds to hypoxia-responsive element (HRE) sequences found in the promoters of target genes to mediate the expression of
作者: LIMIT    時(shí)間: 2025-3-22 22:36
Tumor-on-a-Chip: Microfluidic Models of Hypoxic Tumor Microenvironment,therapeutic, and screening. ToC microdevices, in particular, are competent for microscopic analysis of the interplay between tumors, immune, and cells in the TME, which are not amendable with simple tissue cultures or animal models. The difficulties in developing ToC tech for the next generation are
作者: NAUT    時(shí)間: 2025-3-23 02:22
Imaging the Hypoxic Tumor Microenvironment in Cancer Models,s, a number of molecular imaging systems have been progressed for hypoxia diagnostics in patients; these include invasive procedures like the use of oxygen polarographic electrode which measures tissue oxygen and phosphorescence quenching, noninvasive techniques such as magnetic resonance imaging (M
作者: 懶惰民族    時(shí)間: 2025-3-23 07:38
Hypoxia-Targeting Drugs as New Cancer Chemotherapy Agents: Molecular Insights,he resistance to therapy. This has inspired cancer researchers to investigate the signal molecules for tumor hypoxia as potential molecular targets for cancer therapeutics. This chapter will overview various signaling pathways for hypoxia, its role in tumor proliferation, differentiation, progress i
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作者: 摘要    時(shí)間: 2025-3-23 16:59
technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.978-981-99-0315-3978-981-99-0313-9
作者: synovial-joint    時(shí)間: 2025-3-23 19:26
Book 2023ival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.
作者: Morose    時(shí)間: 2025-3-24 00:48
https://doi.org/10.1007/978-3-658-18250-2to suit the neoplastic cell’s survival. Metastasis—one of the most feared outcomes of neoplasm—has almost all of its steps upregulated or controlled by hypoxia and HIF. Hypoxia is also responsible for drug resistance to various chemotherapeutic agents by different mechanisms. This makes it harder to
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作者: 興奮過度    時(shí)間: 2025-3-24 08:07
https://doi.org/10.1007/978-3-663-12884-7on is a hallmark of various tumor forms, although their precise tumorigenic roles are still unknown. Patients‘ cancer type-specific piRNA signatures differ from one another. The malignancy renal cell carcinoma, defined by constitutive activation of hypoxia-related signaling brought on by a common mu
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Wie macht man Karriere in der Wissenschaftnscript (hTR), and an increase in telomerase gene expression is linked to the growth of cancers. Therefore, it is conceivable that elements of the tumor’s environment and the signaling pathways involved in tumor growth may have an impact on the regulation of the telomerase gene. Recent research has
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作者: 背心    時(shí)間: 2025-3-25 18:29
https://doi.org/10.1007/978-3-662-63175-1p care improve cancer patients’ survival rates and life expectancy in countries with advanced systems..A variety of factors are involved in cancer progression in the human body. One of the significant factors is a low level of oxygen or hypoxia in the tumor; the pancreatic tumor with 0.3% O. is the
作者: onlooker    時(shí)間: 2025-3-25 22:20
Hypoxia in Cancer: Significance and Impact on Cancer Therapy
作者: 使顯得不重要    時(shí)間: 2025-3-26 00:35

作者: 駭人    時(shí)間: 2025-3-26 06:54
Book 2023sistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding t
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作者: Vulnerable    時(shí)間: 2025-3-27 02:21
,Was f?rdert moralisches Verhalten?,ling networks, including PI3K and MAPK pathways. We have discussed how hypoxia regulates progression of various cancers, including breast, ovarian, cervical, and prostate, and their metastasis, angiogenesis, and drug resistance for better understanding of the implications of hypoxia in cancer therapy.
作者: subordinate    時(shí)間: 2025-3-27 07:50
https://doi.org/10.1007/978-3-662-29467-3any researchers. In cancer therapeutics, different approaches like viral vectors, artificial biomolecules, locked nucleic acid, antisense anti-miR oligonucleotides, miRNA antagomirs, and miRNA sponges are being tried to revert the expression of miRNA back to its physiological state.
作者: Ethics    時(shí)間: 2025-3-27 13:08
https://doi.org/10.1007/978-3-662-50385-0d O. carriers. Cancer cells prefer aerobic glycolysis to oxidative phosphorylation, which leads to a buildup of reducing agents and enzymes. In comparison to other first-row metals on the periodic table, cobalt(III) complexes are kinetically inert and exhibit much slower rates of ligand substitution processes.
作者: 褪色    時(shí)間: 2025-3-27 15:31
Hypoxia and Its Biological Implications for Cancer Therapy,ling networks, including PI3K and MAPK pathways. We have discussed how hypoxia regulates progression of various cancers, including breast, ovarian, cervical, and prostate, and their metastasis, angiogenesis, and drug resistance for better understanding of the implications of hypoxia in cancer therapy.
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https://doi.org/10.1007/978-3-531-19128-7hanisms and factors contributing to the modulation of oncogene-induced senescence. This chapter reviews the previous and recent data that contribute to the understanding of the fundamentals of cellular senescence as well as the mechanisms of hypoxia-induced modulation of OIS.
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作者: 允許    時(shí)間: 2025-3-28 14:50
Role of Hypoxia and Reactive Oxygen Species in Cancer Biology,h also is associated with oxygen. This chapter will discuss the crucial role of hypoxia and ROS in cancer initiation and progression. Besides, this chapter also will provide a comprehensive overview, focusing on the contribution of hypoxia and ROS in cancer biology. This chapter also summarizes the updated information on hypoxia and ROS.
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作者: 朋黨派系    時(shí)間: 2025-3-29 07:46
Hypoxia and Its Biological Implications for Cancer Therapy,mon characteristic feature of solid tumors, is caused by structural and functional modifications in microvasculature. Hypoxia-inducible factor-1 (HIF-1) is the principal regulator of physiological adaptations to hypoxia that activates the expression of battery of target genes, leading to the develop
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作者: FLINT    時(shí)間: 2025-3-29 18:34
Role of Hypoxia and Reactive Oxygen Species in Cancer Biology,es like cancer. The critical roles of hypoxia and reactive oxygen species (ROS) on human health have been investigated comprehensively over the years. Numerous scientific evidence from various laboratory and clinical investigations points toward the role of hypoxia in cancer. Besides, ROS also plays
作者: 沒血色    時(shí)間: 2025-3-29 21:45
Hypoxic Tumor Microenvironment: Driver for Cancer Progression,ical steps of tumor progression ranging from angiogenesis, lymphangiogenesis to metastasis and resistance to cancer therapies. It is regulated by a family of transcription factor HIF-1α, which is a master regulator controlling a wide variety of genes involved in cancer progression. In recent years,
作者: 危險(xiǎn)    時(shí)間: 2025-3-30 02:19
Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression,s induced via replicative exhaustion due to telomere shortening, in preneoplastic cells it emerges as a cellular failsafe program provoked by oncogenic activation and serves as an initial barrier constraining the malignant progression. Regulation of senescence is influenced by various intrinsic and
作者: 緯度    時(shí)間: 2025-3-30 07:23
Hypoxia-Regulated Gene Expression and Metastasis,he condition of insufficient oxygen supply at the tissue level. Commonly hypoxia is known as a characteristic feature of solid tumors playing an important role in supporting tumor progression and metastasis by promoting various processes such as angiogenesis or epithelial to mesenchymal transition (
作者: 西瓜    時(shí)間: 2025-3-30 10:43
MicroRNA Signatures of Tumor Hypoxia,expression of miRNAs in different types of tumors in response to hypoxic conditions. The hypoxic microenvironment favors the selection of cancer stem-like cells that show features like indefinite self-renewal, chromosomal abnormalities, highly dysregulated differentiation, and tumor development. The
作者: START    時(shí)間: 2025-3-30 14:03
piRNA-Based Cancer Therapy in Hypoxic Tumor,hows that additional factors may affect how the tumors react to hypoxia. Hypoxia is frequently found in solid tumors and is known to influence aggressive tumor activity, chemotherapy resistance, and radiation resistance, all of which lead to a bad prognosis for the cancer patient. PIWI-interacting R
作者: 忍受    時(shí)間: 2025-3-30 19:07
Hypoxia and the Metastatic Cascade,p process with several intercellular interactions. In this process, a metastatic cell overcomes many barriers and adapts to the changing microenvironment. Our understanding of motility, invasion and epithelial to mesenchymal transition has led to the identification of targetable signalling networks
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作者: jagged    時(shí)間: 2025-3-31 11:57
CRISPR/Cas9-Editing-Based Modeling of Tumor Hypoxia, exhibit tumor hypoxia, primarily caused by an insufficient and diverse vascular network. Hypoxia, brought on by inadequate blood flow and oxygen supply in tumors, reduces the sensitivity of tumor cells to anticancer therapy. The major cellular stressor, hypoxia, influences various molecular pathway
作者: CRACK    時(shí)間: 2025-3-31 14:14
Tumor-on-a-Chip: Microfluidic Models of Hypoxic Tumor Microenvironment,apy, one requires a superior cognizance of the tumor microenvironment (TME) including more sophisticated means to screen potential anticancer therapies. Hypoxia or low blood oxygen is a critical component of the TME and is significantly linked to tumor immune response, angiogenesis, metabolism, and
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