標(biāo)題: Titlebook: Hydrology and Its Discontents; Contemplations on th John T. Van Stan II,Jack Simmons Book 2024 The Editor(s) (if applicable) and The Author [打印本頁(yè)] 作者: Motion 時(shí)間: 2025-3-21 17:44
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作者: ARM 時(shí)間: 2025-3-21 20:15 作者: alabaster 時(shí)間: 2025-3-22 01:46 作者: 藐視 時(shí)間: 2025-3-22 04:41 作者: deface 時(shí)間: 2025-3-22 11:08
John T. Van Stan II,Jack Simmonsrnobyl. These considerations, however, were not the reason for writing this book although it is hoped that it will also be helpful in this respect. The interaction of radiation with biological systems is such an interesting research objective that to my mind no special justification is needed to pur作者: modish 時(shí)間: 2025-3-22 13:53 作者: Infusion 時(shí)間: 2025-3-22 17:22
John T. Van Stan II,Jack Simmons, the initial biogical receptors for the hydrocarbons have been identified as the microsomal mixed-function oxygenases. The polycyclic aromatic hydrocarbons are initially oxygenated by this enzyme system and the metabolites formed can be further oxygenated by the same mixed-function oxygenases. Othe作者: 磨碎 時(shí)間: 2025-3-23 01:04 作者: 繼而發(fā)生 時(shí)間: 2025-3-23 04:18
John T. Van Stan II,Jack Simmonsanemia and leukemia. It has been our aim to study the link between the metabolism of benzene and the mechanism by which it produces bone marrow toxicity (Snyder et al., 1967, 1977, 1982). The mixed function oxidases, a family of hemoprotein cytochrome P-450 enzymes located in the smooth endoplasmic 作者: 冷淡一切 時(shí)間: 2025-3-23 06:54 作者: adj憂郁的 時(shí)間: 2025-3-23 12:49 作者: 難管 時(shí)間: 2025-3-23 14:07
John T. Van Stan II,Jack Simmonsnd saturation of enzymatic activation and detoxification processes and of DNA repair affect the relationship between dose and steady-state DNA adduct level; (ii) The fixation of DNA adducts in the form of mutations is accelerated by stimulation of the cell division, for instance due to regenerative 作者: PUT 時(shí)間: 2025-3-23 18:16
John T. Van Stan II,Jack Simmonstry is replete with exam- ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive作者: 僵硬 時(shí)間: 2025-3-23 22:18
John T. Van Stan II,Jack Simmonsgermander (.) was traditionally used as a folk medicine for its for and antiseptic properties. In 1991, germander consumed to treat obesity, caused an epidemic of cytolytic hepatitis. Thirty cases of hepatotoxicity were first reported including cases with positive rechallengge. For these patients, a作者: sterilization 時(shí)間: 2025-3-24 02:21
John T. Van Stan II,Jack Simmons test systems providing the metabolic activation of styrene. Styrene is converted to styrene-7,8-oxide as catalyzed by cytochrome P-450 cored enzyme complex. Styrene-7,8-oxide is mutagenic in prokaryotic and eukaryotic test systems without metabolic activation. It reacts with nucleic acid bases, esp作者: legitimate 時(shí)間: 2025-3-24 08:14 作者: cogent 時(shí)間: 2025-3-24 12:40
approaches. One approach, stemming from thermodynamic considerations, led Lipmann (1941) to postulate that amino acids had to be activated before they could be polymerized. Subsequently, Hoagland .. (1957) discovered the formation of high-energy anhydride bonds between ATP and the carboxyl groups of作者: Exposition 時(shí)間: 2025-3-24 14:58
,The “Water Problem”,ndards. Instead of designing experiments for the sheer pursuit of knowledge, scientists are compelled to maximize their likelihood of securing money and attention, to fit the demands of society as described in the solicitations of governmental funding agencies or to fit the topics trending in corpor作者: Affable 時(shí)間: 2025-3-24 19:18
Tensions from the Start: Tales of the First Hydrologist and His Civilization,itten record from the time, a time marked by Plato’s writings about Socrates. Thus, as a group, they are often called the “pre-Socratics.” Among the pre-Socratics, modern hydrologists have developed a particular affinity for Heraclitus, who lived around 500?BCE. One of his . includes the phrase “Pan作者: LUCY 時(shí)間: 2025-3-25 02:46 作者: Meditate 時(shí)間: 2025-3-25 05:47 作者: onlooker 時(shí)間: 2025-3-25 10:09
,Limits in Language: Which “Water” Do You Mean?,ies of aquatic and terrestrial life. Water was not merely a physical entity but a dynamic, life-sustaining element that was experienced viscerally. However, with the advent of written language, we now rarely read water in its natural form. This intimate connection with the “l(fā)anguage” of water embodi作者: linear 時(shí)間: 2025-3-25 14:11
Hydrology by the Numbers and for the Numbers,poses multiple difficulties, e.g.: complex water phenomena are hard to predict, and they are difficult to communicate effectively and efficiently. Thus, we use reductionism to simplify the complex phenomena we encounter into manageable ideas. When done well, it overcomes these difficulties (and many作者: 禍害隱伏 時(shí)間: 2025-3-25 16:35
Are Hydrologists Wading Through Ideas, Instead of Water?, concepts and ideas (often called the “ideal” or “metaphysical” realm). In using models to estimate or predict water-related phenomena, water scientists, decision-makers, stakeholders, etc., wade into this ideal realm. It is crucial to recognize that these models are idealized representations of wat作者: 酷熱 時(shí)間: 2025-3-25 23:43
,An “Umbrella Perspective” of Water: The Hermeneutics of Hydrology,g that view. A “view of water” can come in many forms: empirical measurements, model outputs, an intuition or thought, or a personal observation. We piece together each of these views of water, what Hans-Georg Gadamer called “finite presentations,” to form and test the theory. But we must occasional作者: extrovert 時(shí)間: 2025-3-26 01:06
When Water Bows to Market Demands, So May Its Science,ated as the “water–diamond paradox” by Adam Smith, and partially explored by Karl Marx at the start of his critique of political economy. Humanity, the self-proclaimed “calculating animal,” has been setting values, measuring, and determining prices for millennia. Yet, one might ask without seeming a作者: 破裂 時(shí)間: 2025-3-26 06:39 作者: 恩惠 時(shí)間: 2025-3-26 11:55 作者: 發(fā)誓放棄 時(shí)間: 2025-3-26 15:11 作者: 拍下盜公款 時(shí)間: 2025-3-26 19:57 作者: Enrage 時(shí)間: 2025-3-26 21:56 作者: Negligible 時(shí)間: 2025-3-27 04:08
y. Consequently, this book explores compelling and inescapable tensions that resist tidy universal resolution, such as: the language of water science, including its mathematical reductions (i.e., models); the e978-3-031-49770-4978-3-031-49768-1作者: 蕨類 時(shí)間: 2025-3-27 06:25 作者: 其他 時(shí)間: 2025-3-27 10:11
Tensions from the Start: Tales of the First Hydrologist and His Civilization,ng in a paradoxical tone.?Given this tone, one may not be surprised to hear that Heraclitus was often called, “The Dark One.” He did not appear to favor the systematic use of empirical results to form reductionist theories that will, “tell us how the world is; he wants to show us. He creates little 作者: Dappled 時(shí)間: 2025-3-27 15:09 作者: 預(yù)知 時(shí)間: 2025-3-27 19:03 作者: 掙扎 時(shí)間: 2025-3-27 22:29
,Limits in Language: Which “Water” Do You Mean?, that bear little resemblance to the water we experience in daily life—and are undeniably drier. This evolution of hydrological jargon and professional discourse represents the other end of our paradox: the abstract, symbolic understanding of water.作者: GRUEL 時(shí)間: 2025-3-28 04:41
,Neocolonial Hydrology: How “Authentic” Are Today’s Human–Water Interactions?,of varying cultural interactions with water. Here, we introduce the concept of “neocolonial hydrology,” a term we use to describe the standardized water knowledge propagated by an international scientific community in collaboration with governments and corporations. This often manifests as norms imp作者: Magnificent 時(shí)間: 2025-3-28 07:45 作者: Addictive 時(shí)間: 2025-3-28 10:25 作者: Osteons 時(shí)間: 2025-3-28 16:46 作者: Culpable 時(shí)間: 2025-3-28 22:08
John T. Van Stan II,Jack Simmonsknow that propositions about the histology must be somehow translatable into propositions about the function. The picture, neuron—axonal branching—endfeet—other neurons, suggests combinatorial schemes but leads to defeatism because of the sheer complexity of the histology analyzed this way. A more u作者: motor-unit 時(shí)間: 2025-3-29 01:50 作者: 女歌星 時(shí)間: 2025-3-29 05:56
John T. Van Stan II,Jack Simmonsof biological organization. It starts with the absorption in essential atoms and molecules and ends with the development of cancer and genetic hazards to future generations. The structure of the book reflects this. Beginning with physical and chemical fundamentals, it then turns to a description of 作者: 不可磨滅 時(shí)間: 2025-3-29 08:59 作者: Outshine 時(shí)間: 2025-3-29 12:16 作者: 偏離 時(shí)間: 2025-3-29 19:01
John T. Van Stan II,Jack Simmonsis, and pathways for true detoxication of these chemicals. The work of R. T. Williams, beginning in the late 1920s and early 1930s, marked the first concerted effort to understand the biotransformation of foreign chemicals in animals. He investigated the metabolic pathway of numerous compounds in a 作者: Mendacious 時(shí)間: 2025-3-29 19:58
John T. Van Stan II,Jack Simmons postulated to be generated from an “iron-catalyzed cytochrome P-450-dependent Haber Weiss reaction.” Gorsky and Coon (1984) have demonstrated that the pathway by which benzene is metabolized is directly related to the concentration utilized in the . reaction, i.e. with very low concentrations the r作者: Ovulation 時(shí)間: 2025-3-30 01:00
John T. Van Stan II,Jack Simmonsich would permit careful investigation of their mechanism. It is probable that if enough different types of animals were tried, an animal model could be developed, but it might take many thousands of different species before one was found that would have a reaction similar to the rare individual hum作者: esoteric 時(shí)間: 2025-3-30 04:46 作者: 引起 時(shí)間: 2025-3-30 11:30
John T. Van Stan II,Jack Simmonshe curve is the maximum observed (formaldehyde). In contrast to animal experiments, epidemiological data in humans rarely show a significant deviation from linearity. The discrepancy might be explained by the fact that a large number of genes contribute to the overall sensitivity of an individual an作者: 沒有希望 時(shí)間: 2025-3-30 15:13 作者: 牛的細(xì)微差別 時(shí)間: 2025-3-30 17:33 作者: ethereal 時(shí)間: 2025-3-30 23:58
John T. Van Stan II,Jack Simmonside in cultured human blood cells..Although also an arene oxide, styrene-3,4-oxide, has been suggested in the biotransformation of styrene, the evidence so far supports the view that the vinyl group oxidation and oxirane formation plays a predominant role in the genotoxicity of styrene.作者: PACK 時(shí)間: 2025-3-31 02:58
John T. Van Stan II,Jack Simmonseic acids could not form highly specific templates for binding the side chains of the amino acids. Nucleic acids lack both the charges required to bind amino acids and the hydrophobic cavities necessary for interaction with the aliphatic amino acids. Moreover, Crick noted that a particular sequence 作者: 推崇 時(shí)間: 2025-3-31 06:58
eic acids could not form highly specific templates for binding the side chains of the amino acids. Nucleic acids lack both the charges required to bind amino acids and the hydrophobic cavities necessary for interaction with the aliphatic amino acids. Moreover, Crick noted that a particular sequence
