作者: STERN 時間: 2025-3-21 21:20
Alessandro Peri,Dario Norello,Benedetta Fibbi, that include a molecular symmetry parameter (b), are included. An expression for the activation hardness in terms of the activation potential energy function and b for the molecular system under study are derived. A qualitative proof of the principle of maximum hardness (PMH) is shown. The procedu作者: 表被動 時間: 2025-3-22 01:16
Fabio Luiz Fernandes-Rosa, a non-IgG binding scaffold, in a specific . strain to obtain high yields of protein carrying both a thiol and an azide group. We provide straightforward protocols for strain-promoted azide–alkyne cycloaddition (SPAAC) and thiol–maleimide conjugation, and furthermore compare these conjugation chemi作者: 剛毅 時間: 2025-3-22 07:43
Sheerazed Boulkroun,Maria-Christina Zennaroded coil and a more hydrophobic, collapsed state that is smaller in volume. The differences in the polymer steric properties serve to block or allow ligand access to the binding site. The control of polymer molecular weight is a particularly important design parameter for these molecular gates.作者: Choreography 時間: 2025-3-22 11:51 作者: 歡呼 時間: 2025-3-22 16:34
Dario De Alcubierre,Emilia Sbardella,Andrea M. Isidoriically coupled with DNA in a DNA MTase-catalyzed reaction. By attaching interesting reporter groups to a suitable position of .-adenosylaziridine a large variety of new synthetic cofactors are obtained for sequence-specific labeling of DNA. This method is illustrated by coupling primary amino groups作者: terazosin 時間: 2025-3-22 17:03
2510-1927 be faced with the management of endocrine diseases responsible of salt and water imbalance. ..The book is part of the SpringerReference program, which provides access to ‘living editions’ that are constantly updated using a dynamic, peer-review publishing process..978-3-030-44628-4作者: inculpate 時間: 2025-3-22 22:00
Silvia Graciela Ruginsk,Lucila Leico Kagohara Elias,José Antunes-Rodrigues,André Souza Mecawi作者: Palpate 時間: 2025-3-23 03:23 作者: 盡管 時間: 2025-3-23 07:12 作者: 精密 時間: 2025-3-23 11:26 作者: 協(xié)議 時間: 2025-3-23 15:57
Sonir Roberto Rauber Antonini,Thais Milioni Lucianore advanced considerations of key topics. The book is a dynamic document. All the code shown can be executed on a local computer, and readers are able to reproduce every computation, figure, and table..978-0-387-77239-4978-0-387-77240-0Series ISSN 2197-5736 Series E-ISSN 2197-5744 作者: 偶然 時間: 2025-3-23 18:07 作者: 謊言 時間: 2025-3-23 23:53 作者: outset 時間: 2025-3-24 02:31
Physiology of Vasopressin Secretion,erts its multiple effects by binding to its receptors, classified in different subtypes depending on tissue expression, function, and second messengers. Disorders in AVP synthesis or action can lead to clinical syndromes characterized by water and electrolyte imbalance.作者: Glower 時間: 2025-3-24 09:44 作者: 貪心 時間: 2025-3-24 12:09
Familial Hyperkalemic Hypertension (FHHt),t in vitro and in vivo studies have demonstrated that NCC is stimulated by a signaling pathway activated by WNK1 and WNK4, which are themselves targeted for proteosomal degradation by the Cul3-KLHL3 complex..Therefore, the study of this very rare and easily treatable syndrome has led to the discover作者: 不規(guī)則 時間: 2025-3-24 15:20 作者: 隱藏 時間: 2025-3-24 21:17
Syndrome of Inappropriate Antidiuresis, early postoperative period following transsphenoidal surgery. However, the diagnosis and therapy of this potentially life-threatening disorder are still a challenge and require a multidisciplinary approach.作者: 注意 時間: 2025-3-25 01:24 作者: catagen 時間: 2025-3-25 04:58 作者: obsolete 時間: 2025-3-25 11:06
Apparent Mineralocorticoid Excess,ys low aldosterone levels in the presence of a high serum or urinary cortisol/cortisone (F/E) ratio. NC-AME is mainly related to partial 11βHSD2 deficiency associated with genetic variations and epigenetic modifications (first hit) and potential additive actions of endogenous or exogenous inhibitors作者: 殺人 時間: 2025-3-25 11:46 作者: 謙虛的人 時間: 2025-3-25 17:00 作者: UNT 時間: 2025-3-25 22:26 作者: interior 時間: 2025-3-26 00:18
Hydrosaline Alterations in Cushing Disease, increased mortality in patients with Cushing’s syndrome: therefore, treatment must be initiated early and primarily involves the resolution of hypercortisolism through surgery and eventually cortisol-lowering medical therapy; if the regression of hypertension is not achieved, adjuvant antihypertens作者: 鋸齒狀 時間: 2025-3-26 05:52
Living reference work 20220th editionspects. It covers various topics in the endocrine control of salt and water homeostasis, such as neuroendocrine determinants of water balance, adrenal hormone biosynthesis, hormonal function in target renal cells, and dysfunction of hormonal target effectors in the kidney. It also ?features an updat作者: NADIR 時間: 2025-3-26 10:28 作者: Phagocytes 時間: 2025-3-26 13:23
Electrolyte Disturbance in Congenital Adrenal Hyperplasia Due to 21-OH Deficiency,herapeutic management. This chapter will summarize mechanisms of sodium and water reabsorption, particularly the aldosterone-mineralocorticoid receptor signaling pathway, its expression and regulation in neonates, and the impact of a complete 21-hydroxylase deficiency.作者: pulmonary-edema 時間: 2025-3-26 18:12
2510-1927 inical management, including new diagnostic and therapeutic This book provides an overview of endocrine diseases associated with alterations of salt metabolism, with a focus on clinical and pathophysiological aspects. It covers various topics in the endocrine control of salt and water homeostasis, s作者: fabricate 時間: 2025-3-27 00:58 作者: 譏笑 時間: 2025-3-27 05:10 作者: 射手座 時間: 2025-3-27 06:37 作者: 向下 時間: 2025-3-27 11:38
Neuroendocrine Regulation of Hydrosaline Metabolism,rosaline metabolism, focusing on the major neural and endocrine systems implicated in the control of water and sodium balance. This chapter will bring the readers the new advances on the understanding of how our body controls extracellular fluid volume and osmolality, initiating with the sensory aff作者: capillaries 時間: 2025-3-27 16:32
Physiology of Vasopressin Secretion, and then transported to the neurohypophysis, where it is released in the bloodstream. Alterations in plasma osmolality represent the main input affecting AVP secretion, yet many other physiological and pathophysiological conditions can intervene in modulating its levels, as hypovolemia and hypotens作者: HILAR 時間: 2025-3-27 21:43 作者: inspired 時間: 2025-3-27 22:11 作者: 神化怪物 時間: 2025-3-28 05:47
Diabetes Insipidus: Novel Diagnostic Approaches, polydipsia. The polyuria-polydipsia syndrome includes four major entities: central DI (CDI), gestational DI (GDI), nephrogenic DI (NDI), and primary polydipsia (PP). It is essential to differentiate accurately CDI from the other forms, because a wrong diagnosis can have fatal consequences. Clinical作者: 橫截,橫斷 時間: 2025-3-28 06:39 作者: CHANT 時間: 2025-3-28 13:20 作者: 燒烤 時間: 2025-3-28 15:40
Approach to Hyponatremia According to the Clinical Setting,the consequence of a relative excess of water compared to total body sodium, which can be reduced, normal or even increased. Because of its frequency and different causes, hyponatremia can be observed in virtually all possible clinical scenarios, encompassing medical as well as surgery specialties. 作者: Expediency 時間: 2025-3-28 20:55
Electrolyte Disturbance in Congenital Adrenal Hyperplasia Due to 21-OH Deficiency,um homeostasis, particularly in the neonatal period. The pathophysiology of this impaired sodium balance is still poorly investigated as well as its therapeutic management. This chapter will summarize mechanisms of sodium and water reabsorption, particularly the aldosterone-mineralocorticoid recepto作者: jungle 時間: 2025-3-29 02:05
Rare Forms of Congenital Adrenal Hyperplasia Affecting Electrolyte Homeostasis, deficiency. However, rare forms of CAH, representing around 5% of cases, are attributed to five other enzymatic defects that disrupt steroidogenesis and impact electrolyte homeostasis..Enzymatic defects can occur at various stages of the steroidogenesis pathway, leading to impaired conversion of ch作者: 小平面 時間: 2025-3-29 04:03
Apparent Mineralocorticoid Excess,ow-renin levels allowed the identification of two different clinical entities: aldosterone-mediated mineralocorticoid receptor (MR) activation and cortisol-mediated MR activation. The spectrum of cortisol-mediated MR activation includes the classic apparent mineralocorticoid excess?(AME) to milder (作者: 傻瓜 時間: 2025-3-29 08:59
Mineralocorticoid Resistance,imulating sodium reabsorption in the distal nephron. Pseudohypoaldosteronism type 1 (PHA1) is a rare disease characterized by salt loss in the neonatal period secondary to a target organ resistance to mineralocorticoid action. Patients exhibit salt wasting in the neonatal period with failure to thri作者: 花費(fèi) 時間: 2025-3-29 12:07
Primary Aldosteronism,enal hyperplasia. Over the past 15?years, major advances have been made in our understanding of the disease with the identification of somatic and germline mutations responsible for the development of APA and of familial form of hyperaldosteronism. These mutations affect essentially ionic channels a作者: 引起痛苦 時間: 2025-3-29 18:27
MR and Aldosterone: From Hydro-Saline Metabolism to Metabolic Diseases,phron. In the last 10 years, a number of preclinical studies has shown that MR is expressed also in extra-renal tissues such as heart, adipose tissue and vasculature, providing strong evidence that dysregulated extra-renal MR activation contributes to the development of hypertension, obesity, insuli作者: Apraxia 時間: 2025-3-29 22:36 作者: Overstate 時間: 2025-3-30 03:37
Emanuele Ferrante,Júlia Ferreira de Carvalhon of fossil fuel resources, global energy crisis and growing concerns about environmental pollutants. Among them, the green biocomposites totally based on plants, which consist of lignocellulosic fibers as reinforcement agents and biopolymers as matrices, have many beneficial advantages in a wide ra作者: 配置 時間: 2025-3-30 06:54 作者: 先兆 時間: 2025-3-30 08:42
Alessandro Peri,Dario Norello,Benedetta Fibbichange its electron density distribution, namely the molecular hardness (.). Its evolution along a given reaction coordinate is examined in order to better understand the chemical reactivity of the system of interest. In this work, compounds that are often used as prototypes to study their linkage i作者: excursion 時間: 2025-3-30 13:47
L. Martinerie website offering color figures and solutions to exercises.I.Bioconductor software has become a standard tool for the analysis and comprehension of data from high-throughput genomics experiments. Its application spans a broad field of technologies used in contemporary molecular biology. In this volu作者: ASSAY 時間: 2025-3-30 18:09 作者: 影響帶來 時間: 2025-3-31 00:25
Cristian A. Carvajal,Alejandra Tapia-Castillo,Thomas Uslar,Carlos E. Fardella website offering color figures and solutions to exercises.I.Bioconductor software has become a standard tool for the analysis and comprehension of data from high-throughput genomics experiments. Its application spans a broad field of technologies used in contemporary molecular biology. In this volu作者: 蛙鳴聲 時間: 2025-3-31 02:42
Fabio Luiz Fernandes-Rosamolecules for cell killing, or half-life extension modules for optimized pharmacokinetics. Although many conjugation strategies are straightforward to apply, most of them do not enable site-specific and orthogonal conjugation, and do not yield a defined stoichiometry. Moreover, techniques offering t
