標(biāo)題: Titlebook: Huntington’s Disease; Sophie V. Precious,Anne E. Rosser,Stephen B. Dunne Book 2018 Springer Science+Business Media, LLC, part of Springer [打印本頁(yè)] 作者: BULB 時(shí)間: 2025-3-21 16:41
書(shū)目名稱(chēng)Huntington’s Disease影響因子(影響力)
作者: BARK 時(shí)間: 2025-3-21 20:47 作者: Biomarker 時(shí)間: 2025-3-22 02:55 作者: 輕打 時(shí)間: 2025-3-22 06:36
Cellular Models: HD Patient-Derived Pluripotent Stem Cells,ene. Traditionally, HD cellular models consisted of either patient cells not affected by disease or rodent neurons expressing expanded polyQ repeats in HTT. As these models can be limited in their disease manifestation or proper genetic context, respectively, human HD pluripotent stem cells (PSCs) a作者: 經(jīng)典 時(shí)間: 2025-3-22 10:15 作者: 實(shí)現(xiàn) 時(shí)間: 2025-3-22 15:38 作者: Modicum 時(shí)間: 2025-3-22 17:04 作者: regale 時(shí)間: 2025-3-22 23:05
,Automated Operant Assessments of Huntington’s Disease Mouse Models,the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operan作者: 思考 時(shí)間: 2025-3-23 02:21
,Neurophysiological Assessment of Huntington’s Disease Model Mice, fatal neurological disorder caused by an expansion of CAG repeats in the . gene. Changes in neuronal activity often precede the behavioral manifestations of HD, therefore, understanding the electrophysiology of HD is critical for identifying potential prodromal markers and therapeutic targets. This作者: Fillet,Filet 時(shí)間: 2025-3-23 06:33
,Murine Models of Huntington’s Disease for Evaluating Therapeutics,typically present later on in life, although juvenile cases do exist. The identification of the disease-causing mutation, a CAG triplet repeat expansion in the HTT gene, in 1993 generated numerous investigations into the cellular and molecular pathways underlying the disorder. HD mouse models have p作者: 鬧劇 時(shí)間: 2025-3-23 10:44 作者: 有危險(xiǎn) 時(shí)間: 2025-3-23 17:45 作者: 匍匐 時(shí)間: 2025-3-23 21:10
,Minipigs as a Large-Brained Animal Model for Huntington’s Disease: From Behavior and Imaging to Gen. Challenges in the development of, for example, gene therapy, such as delivery, distribution, and persistence of virus vectors or oligo sense nucleotides, can be explored in large brains and organisms approaching human size. We here introduce the transgenic Libechov minipig as a large animal model 作者: 生命 時(shí)間: 2025-3-24 00:06 作者: capsule 時(shí)間: 2025-3-24 04:47
,In Vivo Multidimensional Brain Imaging in Huntington’s Disease Animal Models,tingtin protein. This mutation induces the expression of a polyglutamine stretch in the mutated protein resulting in the modification of various biological properties of the wild-type protein and the progressive appearance of motor, cognitive, and psychiatric disorders that are typically associated 作者: Incise 時(shí)間: 2025-3-24 06:36
,Magnetic Resonance Imaging in Huntington’s Disease,ulation of radio waves and static field gradients, MRI uses the principle of nuclear magnetic resonance to produce images with high spatial resolution, appropriate for the investigation of brain structure and function.作者: 友好 時(shí)間: 2025-3-24 11:49 作者: CHASE 時(shí)間: 2025-3-24 18:02
,Assessing and Modulating Kynurenine Pathway Dynamics in Huntington’s Disease: Focus on Kynurenine 3. Several novel genetic and pharmacological tools have recently been developed to modulate key regulatory steps in the KP such as the reaction catalyzed by the enzyme kynurenine 3-monooxygenase (KMO). This insight has offered new options for exploring the mechanistic link between this metabolic path作者: Emg827 時(shí)間: 2025-3-24 22:26
,Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington’s Disease, with mitochondria in a deleterious manner. As the central hub of the cell, not only mitochondrial bioenergetics is affected but there is also diminished mitochondrial membrane potential (Δ..) and altered production of reactive oxygen species (ROS). Restoration of mitochondrial function has proven t作者: 預(yù)定 時(shí)間: 2025-3-25 00:18
Mariah J. Lelos,Stephen B. Dunnettnd consists of two lists (alphabetical by compounds), one for Curie and one for Neel temperatures. Where different values appeared in the literature for a single compound, all are listed with sepa- rate references given for each. There is no attempt at critical evaluation, which, except for a few we作者: Anecdote 時(shí)間: 2025-3-25 04:26
A. J. MortonMay 1972 and consists of two lists (alphabetical by compounds), one for Curie and one for Neel temperatures. Where different values appeared in the literature for a single compound, all are listed with sepa- rate references given for each. There is no attempt at critical evaluation, which, except fo作者: nerve-sparing 時(shí)間: 2025-3-25 07:54 作者: AFFIX 時(shí)間: 2025-3-25 15:22 作者: mortuary 時(shí)間: 2025-3-25 16:18 作者: 做事過(guò)頭 時(shí)間: 2025-3-25 20:36
Sarah Gregory,Rachael I. Scahill,Geraint Rees,Sarah Tabrizily, are usually considered as distinct subjects, many of the underlying fundamental principles, scientific achievements, and practical applications have common features. Following the evolvment of the initial principles and techniques during the closing decade of the last century, microwave engineer作者: GROUP 時(shí)間: 2025-3-26 01:19
Filipe B. Rodrigues,Lauren M. Byrne,Edward J. Wildly, are usually considered as distinct subjects, many of the underlying fundamental principles, scientific achievements, and practical applications have common features. Following the evolvment of the initial principles and techniques during the closing decade of the last century, microwave engineer作者: prostate-gland 時(shí)間: 2025-3-26 05:45
Korrapati V. Sathyasaikumar,Carlo Breda,Robert Schwarcz,Flaviano Giorginily, are usually considered as distinct subjects, many of the underlying fundamental principles, scientific achievements, and practical applications have common features. Following the evolvment of the initial principles and techniques during the closing decade of the last century, microwave engineer作者: 借喻 時(shí)間: 2025-3-26 12:02
I. Luísa Ferreira,Catarina Carmo,Luana Naia,Sandra I. Mota,A. Cristina Regoually considered as distinct subjects, many of the underlying fundamental principles, scientific achievements, and practical applications have common features. Following the evolvment of the initial principles and techniques during the closing decade of the last century, microwave engineering has lo作者: 褪色 時(shí)間: 2025-3-26 15:00 作者: 支柱 時(shí)間: 2025-3-26 19:55
,Automated Operant Assessments of Huntington’s Disease Mouse Models,hermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental therapeutics. We here present an overview of the most commonly used operant behavioral tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of HD.作者: Parley 時(shí)間: 2025-3-26 21:13
,Murine Models of Huntington’s Disease for Evaluating Therapeutics,reviewed in this chapter. As new interventions and therapeutic approaches are evaluated and implemented, genetic mouse models will continue to be used with the hope of developing effective treatments for HD.作者: ADOPT 時(shí)間: 2025-3-27 05:02 作者: 豐滿(mǎn)中國(guó) 時(shí)間: 2025-3-27 09:06 作者: Freeze 時(shí)間: 2025-3-27 10:46
1064-3745 actical insights from experts in the fieldThis detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by und作者: ureter 時(shí)間: 2025-3-27 14:54
,Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington’s Disease,mitochondrial calcium handling, and levels of mitochondrial ROS. Here we focus on biological samples derived from HD . control cells and/or animal models, namely functional isolated brain mitochondria, an ex vivo animal model, and cultured cells, including cell lines and primary neural cultures, as in vitro models.作者: 不來(lái) 時(shí)間: 2025-3-27 21:35
,Mouse Models of Huntington’s Disease, disorder. Here we review the transgenic, knock-in mice commonly used to model HD, as well those that have been generated to study specific disease mechanisms. We then provide a brief overview of the importance of standardizing the use of HD mice and describe brief protocols used for genotyping the mouse models used within the Bates Laboratory.作者: 小丑 時(shí)間: 2025-3-28 01:49 作者: 收藏品 時(shí)間: 2025-3-28 05:31
,Stereological Methods to Quantify Cell Loss in the Huntington’s Disease Human Brain,ternative when tissue availability is limited. Both methods use systematic random sampling (SRS) techniques to account for the inhomogeneous nature of biological tissue. Here we describe the criteria for a successful and accurate stereological study, using human brain tissue.作者: 脆弱么 時(shí)間: 2025-3-28 07:22 作者: pester 時(shí)間: 2025-3-28 12:33 作者: Ingrained 時(shí)間: 2025-3-28 17:11 作者: 倒轉(zhuǎn) 時(shí)間: 2025-3-28 20:47
,Assessing and Modulating Kynurenine Pathway Dynamics in Huntington’s Disease: Focus on Kynurenine 3way and HD, and provided novel opportunities for the development of candidate drug-like compounds. Here, we present an overview of the field, focusing on some novel approaches for interrogating the pathway experimentally.作者: glamor 時(shí)間: 2025-3-29 00:01 作者: indicate 時(shí)間: 2025-3-29 03:58 作者: SYN 時(shí)間: 2025-3-29 07:52
Sophie V. Precious,Anne E. Rosser,Stephen B. DunneIncludes cutting-edge techniques for the study of Huntington‘s Disease.Provides clear details essential for reproducible results.Contains practical insights from experts in the field作者: breadth 時(shí)間: 2025-3-29 11:25
Methods in Molecular Biologyhttp://image.papertrans.cn/h/image/429997.jpg作者: 線(xiàn) 時(shí)間: 2025-3-29 17:17 作者: 輕推 時(shí)間: 2025-3-29 20:02
Huntington’s Disease978-1-4939-7825-0Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: Oversee 時(shí)間: 2025-3-30 02:31
Mariah J. Lelos,Stephen B. Dunnette do they appear as brief comments in the body of the lists. In order to include the most recent data, and to eliminate the delay involved in recomposition of the lists, an addendum is provided. While this requires the perusal of two lists rather than one, it does ensure that the compilation represe作者: 命令變成大炮 時(shí)間: 2025-3-30 07:31
A. J. Morton literature do they appear as brief comments in the body of the lists. In order to include the most recent data, and to eliminate the delay involved in recomposition of the lists, an addendum is provided. While this requires the perusal of two lists rather than one, it does ensure that the compilation represe978-1-4684-1396-0作者: POWER 時(shí)間: 2025-3-30 09:31
Ralf Reilmann,Verena Schuldenzucker literature do they appear as brief comments in the body of the lists. In order to include the most recent data, and to eliminate the delay involved in recomposition of the lists, an addendum is provided. While this requires the perusal of two lists rather than one, it does ensure that the compilation represe978-1-4684-1396-0作者: BAIT 時(shí)間: 2025-3-30 14:52 作者: 寄生蟲(chóng) 時(shí)間: 2025-3-30 18:20
Julien Flament,Philippe Hantraye,Julien Valette literature do they appear as brief comments in the body of the lists. In order to include the most recent data, and to eliminate the delay involved in recomposition of the lists, an addendum is provided. While this requires the perusal of two lists rather than one, it does ensure that the compilation represe978-1-4684-1396-0作者: 嬰兒 時(shí)間: 2025-3-30 21:29 作者: MURAL 時(shí)間: 2025-3-31 01:15 作者: 貿(mào)易 時(shí)間: 2025-3-31 07:43 作者: STANT 時(shí)間: 2025-3-31 13:00
I. Luísa Ferreira,Catarina Carmo,Luana Naia,Sandra I. Mota,A. Cristina Regove treatment of these two fields, division being made by subject matter rather than by the artificial distinctions of frequency and/or wavelength ranges. However, a full text on the combined subjects would be very large and unwieldy and, thus, this Bibliography is presented in the hope that it will 作者: jocular 時(shí)間: 2025-3-31 17:26
Book 2018itative and invaluable, .Huntington’s Disease.?aims to help scientists to significantly extend the breadth and quality of research in laboratories dedicated to mastering and controlling this devastating human condition..作者: Lacerate 時(shí)間: 2025-3-31 21:29 作者: 緯度 時(shí)間: 2025-3-31 21:56
