標題: Titlebook: High-Throughput Screening Assays in Toxicology; Hao Zhu,Menghang Xia Book 2016 Springer Science+Business Media New York 2016 Chemical toxi [打印本頁] 作者: 新石器時代 時間: 2025-3-21 17:43
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書目名稱High-Throughput Screening Assays in Toxicology讀者反饋
書目名稱High-Throughput Screening Assays in Toxicology讀者反饋學科排名
作者: 支形吊燈 時間: 2025-3-21 21:18
Cell-Based Assay for Identifying the Modulators of Antioxidant Response Element Signaling Pathway a cell-based ARE assay in a quantitative high-throughput screening (qHTS) format to test a large collection of compounds that induce nuclear factor erythroid 2-related factor (Nrf2)/ARE signaling. The assay is described through cell handling, assay preparation, and instrument usage.作者: 使害怕 時間: 2025-3-22 04:00 作者: bronchodilator 時間: 2025-3-22 08:18
Correction of Microplate Data from High-Throughput Screeningped into three categories: run-wise (temporal, multiple plates), plate-wise (background pattern, single plate), and well-wise (single well). In this chapter, we describe a systematic solution for identifying and correcting such errors and noises, mainly basing on pattern recognition and digital signal processing technologies.作者: 彎曲道理 時間: 2025-3-22 11:51
1064-3745 ts.Contains key notes and implementation advice from the expThis book focuses on recently developed High Throughput Screening (HTS) assay protocols, many involved in the ToxCast and/or Tox21 initiatives, and the relevant HTS data analysis techniques. Divided into three sections, in vitro assays, in 作者: 舉止粗野的人 時間: 2025-3-22 13:23
Monitoring Ligand-Activated Protein–Protein Interactions Using Bioluminescent Resonance Energy Transtion system in live cells. Here we review the construction of BRET fusion proteins, describe the BRET methodology, and outline strategies to overcome obstacles that may arise. Furthermore, we describe the advantage of BRET over other resonance energy transfer methods for monitoring protein–protein interactions.作者: vanquish 時間: 2025-3-22 20:01
Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 Cellsironmental chemicals. The DMSO-treated HuH-7 model is also a suitable tool for investigating hepatotoxicity. This chapter describes a detailed methodology for developing DMSO-treated HuH-7 cells, which are subsequently used for CYP3A4 inhibition and hepatotoxicity studies.作者: 正面 時間: 2025-3-22 22:21 作者: Kernel 時間: 2025-3-23 05:18 作者: 悅耳 時間: 2025-3-23 08:14 作者: Cognizance 時間: 2025-3-23 09:50 作者: FIG 時間: 2025-3-23 17:43
CurveP Method for Rendering High-Throughput Screening Dose-Response Data into Digital Fingerprintscan be a part of HTS data analysis or can be used as input for a broad spectrum of computational applications, such as Quantitative Structure-Activity Relationship (QSAR) modeling, computational toxicology, bio- and cheminformatics.作者: 很像弓] 時間: 2025-3-23 19:20 作者: homocysteine 時間: 2025-3-23 22:25 作者: cataract 時間: 2025-3-24 02:20
High-Throughput and High-Content Micronucleus Assay in CHO-K1 Cellsfragment of chromosome can lead to formation of micronuclei (MNi). The in vitro micronucleus assay can be conducted using nuclear dyes with high-content imaging platforms. This chapter describes the cytochalasin block method of measuring micronuclei in CHO-K1 cell lines.作者: 被告 時間: 2025-3-24 09:24
Hao Zhu,Menghang XiaIncludes cutting-edge methods and protocols for HTS assays to examine toxicity.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the exp作者: OMIT 時間: 2025-3-24 12:54 作者: Pandemic 時間: 2025-3-24 17:11
978-1-4939-8171-7Springer Science+Business Media New York 2016作者: fiscal 時間: 2025-3-24 21:42 作者: 迎合 時間: 2025-3-24 23:32
https://doi.org/10.1007/978-1-4939-6346-1Chemical toxicity testing; HTS assays; Computational techniques; In vitro and In vivo; Toxicology assess作者: enterprise 時間: 2025-3-25 05:30
Book 2016ng new HTS techniques into standardized chemical toxicity assessment tools in order to advance modern toxicology research to a new era where HTS techniques can partially replace the prevailing animal models..作者: hardheaded 時間: 2025-3-25 10:18 作者: 不能平靜 時間: 2025-3-25 12:26
Caitlin Lynch,Jinghua Zhao,Hongbing Wang,Menghang Xiaeoretischen Begründung des vorliegenden Untersuchungsgegenstandes Ans?tze der Arbeitswissenschaft, insbesondere der Arbeitszeitforschung, ausgew?hlte verhaltenswissenschaftliche Theorien, die Informations?konomie und die Erfolgstheorie, insbesondere die Markterfolgstheorie herangezogen. Einen überbl作者: Alopecia-Areata 時間: 2025-3-25 17:25 作者: 閑聊 時間: 2025-3-25 21:01 作者: 套索 時間: 2025-3-26 03:17
Yitong Liutrieben der Metall-/Elektro- und Chemieindustrie, dem Einzelhandel und Verwaltungen im ?ffentlichen Dienst Handlungsm?glichkeiten sucht, die langfristig zur L?sung dieser Aufgaben führen. Der Beitrag beschreibt den Aufbau und die Strukturen des Projekts ZEITREICH und zeigt auf, welche Schritte n?tig作者: Pedagogy 時間: 2025-3-26 06:58 作者: Evolve 時間: 2025-3-26 08:44
Yuhong Wang,Ruili Huangatorische und soziale Gestaltungsma?nahmen in die überlegungen miteinzubeziehen, wobei das System Produktion sowohl im technisch-betriebswirtschaftlichen als auch im organisatorischen und sozialen Bereich Zielkonflikten unterliegt. Für eine optimale, marktgerechte Gestaltung von Produktionsstrukture作者: 微粒 時間: 2025-3-26 16:08
Alexander Sedykh Milderung der Arbeitsmarktprobleme wird Arbeitszeitverkürzung in der Bundesrepublik erst seit dem Entstehen hoher Arbeitslosigkeit Mitte der siebziger Jahre diskutiert. Die gegenw?rtig erhobenen Forderungen nach Einführung der 35-Stunden-Woche und/oder Vorverlegung des Rentenalters sind haupts?chli作者: MURAL 時間: 2025-3-26 19:04 作者: 蒸發(fā) 時間: 2025-3-26 22:39 作者: Cloudburst 時間: 2025-3-27 03:54
1064-3745 ology. serves as a valuable reference resource for translating new HTS techniques into standardized chemical toxicity assessment tools in order to advance modern toxicology research to a new era where HTS techniques can partially replace the prevailing animal models..978-1-4939-8171-7978-1-4939-6346-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: Dorsal-Kyphosis 時間: 2025-3-27 07:39
Srilatha Sakamuru,Matias S. Attene-Ramos,Menghang Xia作者: misshapen 時間: 2025-3-27 13:13
Using β-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Si Using a quantitative high-throughput screening (qHTS) approach, we are able to screen large chemical libraries to profile potential small molecule modulators of the HIF-1 signaling pathway in a 1536-well format. This chapter describes two orthogonal cell based assays; one utilizing a β-lactamase re作者: 現(xiàn)暈光 時間: 2025-3-27 16:40 作者: exophthalmos 時間: 2025-3-27 18:48
Better, Faster, Cheaper: Getting the Most Out of High-Throughput Screening with Zebrafishafish, with its well-documented advantages over many animal models, is now emerging as a true biosensor of chemical activity. Herein, we draw on nearly a decade of experience developing high-throughput toxicology screens in the developmental zebrafish to summarize the best practices in fulfilling th作者: 返老還童 時間: 2025-3-28 00:24 作者: LAVE 時間: 2025-3-28 03:09 作者: 貧窮地活 時間: 2025-3-28 08:13
Using β-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Sies or those with inadequate oxygen concentrations, activation of the HIF-1 transcription factor allows for subsequent activation of target gene expression implicated in cell survival. As a result, cells proliferate through formation of new blood vessels and expansion of vascular systems, providing n作者: 愛得痛了 時間: 2025-3-28 13:07 作者: padding 時間: 2025-3-28 15:22
Transactivation and Coactivator Recruitment Assays for Measuring Farnesoid X Receptor ActivityXR signaling can be used as therapeutic candidates or identified as potentially hazardous compounds depending on exposure doses and health states. Therefore, there is an increasing need for high-throughput screening assays of FXR activity to profile large numbers of environmental chemicals and drugs作者: 賄賂 時間: 2025-3-28 22:03 作者: 牽索 時間: 2025-3-29 00:11
Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 Cellsn hepatoma HuH-7 cells develop into a differentiated in vitro model resembling primary human hepatocytes after a 2-week dimethyl sulfoxide (DMSO) treatment. DMSO-treated HuH-7 cells express elevated cytochrome P450 3A4 (CYP3A4) enzyme gene expression and activity compared to untreated HuH-7 cells. T作者: 輕浮思想 時間: 2025-3-29 04:32
Determination of Histone H2AX Phosphorylation in DT40 Cellsd blocked replication forks induce the phosphorylation of H2AX at serine 139 (γH2AX), and accumulate γH2AX which can then be detected as foci. The detection of γH2AX foci by immunostaining with antibodies that recognize γH2AX is an indicator of DSBs presence. This chapter describes the measurement o作者: 修剪過的樹籬 時間: 2025-3-29 08:27 作者: 狗窩 時間: 2025-3-29 13:21 作者: jagged 時間: 2025-3-29 19:11
Fast Functional Germline and Epigenetic Assays in the Nematode ,y of their genome are therefore of utmost importance for the health of organisms and survival of species. Many features of mammalian germ cells, including their long development span and difficulty of access, present challenges for their study in the context of toxicity assays. In light of these bar作者: 偶像 時間: 2025-3-29 21:50 作者: cacophony 時間: 2025-3-30 02:12
Correction of Microplate Data from High-Throughput Screeningand cost-effective manner. The errors and noises in the microplate-formatted data from HTS have unique characteristics, and they can be generally grouped into three categories: run-wise (temporal, multiple plates), plate-wise (background pattern, single plate), and well-wise (single well). In this c作者: 事物的方面 時間: 2025-3-30 06:30
CurveP Method for Rendering High-Throughput Screening Dose-Response Data into Digital Fingerprintsta normalization, additional parsing is often needed to account for incomplete read outs or various artifacts that arise from signal interferences..CurveP is a heuristic, user-tunable, curve-cleaning algorithm that attempts to find a minimum set of corrections, which would give a monotonic dose–resp作者: GEAR 時間: 2025-3-30 11:43 作者: 1分開 時間: 2025-3-30 13:16 作者: forbid 時間: 2025-3-30 17:46 作者: Exclaim 時間: 2025-3-31 00:24
Caitlin Lynch,Jinghua Zhao,Hongbing Wang,Menghang Xiatlichen Dienst auf die Mitarbeiterzufriedenheit der Krankenhaus?rzte und die Hospital Performance Outcomes bislang noch nicht existent. Aus diesem Grund werden sowohl die bestehenden Erkenntnisse aus dem Krankenhausbereich als auch weitere Erkl?rungsans?tze, die sich in verwandten Bereichen bew?hrt 作者: 不真 時間: 2025-3-31 02:09 作者: Foregery 時間: 2025-3-31 06:56 作者: Desert 時間: 2025-3-31 10:19 作者: 燈泡 時間: 2025-3-31 13:56 作者: 責怪 時間: 2025-3-31 17:46 作者: ONYM 時間: 2025-3-31 21:42 作者: Fibrillation 時間: 2025-4-1 03:09
