標(biāo)題: Titlebook: High Throughput Screening; Methods and Protocol William P. Janzen Book 20021st edition Springer Science+Business Media New York 2002 [打印本頁] 作者: 自由才謹(jǐn)慎 時間: 2025-3-21 16:08
書目名稱High Throughput Screening影響因子(影響力)
作者: Allergic 時間: 2025-3-21 23:14 作者: 性冷淡 時間: 2025-3-22 02:53
al methods and a thoeretical linear models course..Applied Regression Analysis. emphasizes the concepts and the analysis of data sets. It provides a review of t978-1-4757-7155-8978-0-387-22753-5Series ISSN 1431-875X Series E-ISSN 2197-4136 作者: 激怒某人 時間: 2025-3-22 05:16 作者: 宴會 時間: 2025-3-22 10:48 作者: 薄荷醇 時間: 2025-3-22 15:15 作者: installment 時間: 2025-3-22 18:27
Introduction to Screening Automation,Cartesian robots had three degrees of freedom (XYZ) and were usually mounted in an XYZ frame. Cylindrical robots had four degrees of freedom: rotation at the base and wrist, elevation, and lateral movement, thus defining a workspace similar to a cylinder. Articulating robots added yet another (fifth作者: 神圣在玷污 時間: 2025-3-23 00:08
al for achieving optimal benefits from a least squares analysis. This book builds on the fundamentals of statistical methods and provides appropriate concepts that will allow a scientist to use least squares as an effective research tool..Applied Regression Analysis. is aimed at the scientist who wi作者: 提名 時間: 2025-3-23 03:34 作者: 猛然一拉 時間: 2025-3-23 07:59 作者: craven 時間: 2025-3-23 13:08
,Homogeneous Techniques for Monitoring Receptor–Ligand Interactions,-surface receptors (.). The initial studies relied on laborious, vacuum-filtration techniques that are cumbersome and difficult to automate. Despite these limitations, filtration-based radioligand binding assays were adequate to probe the kinetics of receptor-ligand interactions and to screen small 作者: 厚顏 時間: 2025-3-23 15:59
Comparison of SPA, FRET, and FP for Kinase Assays,lecule libraries and natural products (.–.). Many of high throughput kinase assays have been developed in 96-, 384-, and 1536-well formats using these technologies (.–.). Development of these technologies allow one to quickly large synthetic compound or natural product libraries in a very short peri作者: 注意到 時間: 2025-3-23 18:07 作者: 騎師 時間: 2025-3-24 01:03
Cellular Assays in HTS,y in the 1940s, 1950s, and 1960s (.). However, cellular assays also represent one of the most dynamic areas of innovation in high-throughput screening (HTS). The driver of this innovation is the demand for more leads from more complex targets. Genomics discovery efforts have generated many potential作者: 呼吸 時間: 2025-3-24 04:29
Compound Library Management,d screening technologies are a response to the need of more and better quality compounds in the industry pipelines. But these inmense collections (from several hundred thousands to several millions of compounds) pose a tremendous logistical problem to be overcome in order to harvest all their tre-me作者: 責(zé)問 時間: 2025-3-24 07:23
Natural Products or Not? How to Screen for Natural Products in the Emerging HTS Paradigm, in the world are natural products or their derivatives (.). Roughly 60% of the antitumor and anti-infective agents that are available commercially or were in latestage clinical development from 1989–1995 are of natural products origin (.,.).作者: 想象 時間: 2025-3-24 10:54
Introduction to Screening Automation, 1) small scale servo-driven robotic devices; 2) the personal computer; and 3) the microplate. The word “robot” is derived from the Czechoslovakian word Robota, which is translated into English as servant, slave, or laborer. The Robot Institute of America (RIA) defines a robot as a “reprogrammable m作者: Soliloquy 時間: 2025-3-24 18:00
Unit Automation in High Throughput Screening,omation is best implemented only to the extent that operations are standardized, i.e., if you standardize individual assay steps (or unit operations) they can be readily (and effectively) automated (.). If entire assay formats could be standardized, then it would make sense to automate the entire as作者: 開始從未 時間: 2025-3-24 20:10
Management and Maintenance of High Throughput Screening Systems,apidly and in the most cost effective manner possible. The most reliable way this can be achieved is by rigorous attention to the quality of the assays themselves, the quality of the compounds used, as well as the quality and condition of the equipment used. To effectively reach this goal all of the作者: 不吉祥的女人 時間: 2025-3-25 00:02
1064-3745 diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wish had been available when they started in HTS, these expert seasoned authors illuminate the HTS process with richly detailed tutoria作者: 華而不實 時間: 2025-3-25 03:56
Comparison of SPA, FRET, and FP for Kinase Assays,od of time with high sensitivity, accuracy, and reproducibility. Therefore, development of these new technologies has significantly accelerated the process of discovering drug leads for kinases. In this chapter, I will summarize and compare a number of technologies for development of homogeneous, high-throughput kinase assays.作者: 使無效 時間: 2025-3-25 07:45 作者: Mindfulness 時間: 2025-3-25 12:37
Management and Maintenance of High Throughput Screening Systems,labs is constantly increasing, the requirements for its continued maintenance are problems faced in all laboratories. An additional process that requires constant maintenance, but that is often forgotten, is management of personnel within the screening environment. This is, however, also an integral part of the efficient screening process.作者: 并排上下 時間: 2025-3-25 19:11
Book 20021st editiond in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wish had been available when they started in HTS, these expert seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, t作者: 人類 時間: 2025-3-25 22:06
Book 20021st editionements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge.作者: CHOKE 時間: 2025-3-26 02:58 作者: 滔滔不絕地說 時間: 2025-3-26 06:25
Cellular Assays in HTS, approaches have also been driven by the need to address complex, multi-component target classes that may not be feasible in biochemical assays. Finally, the increasingly combative intellectual property playing field, and the need to accelerate the drug discovery process have driven innovations in cell-based screening methodologies.作者: 最低點 時間: 2025-3-26 10:54
Design and Implementation of High Throughput Screening Assays,ing numbers of chemical compounds being produced through high-throughput chemistry initiatives. Many large companies study 100 targets or more each year, and in order to progress these targets, lead compounds must be found. Increasingly, pharmaceutical companies are relying on HTS as the primary engine driving lead discovery.作者: Congestion 時間: 2025-3-26 14:36
,Homogeneous Techniques for Monitoring Receptor–Ligand Interactions,hese limitations, filtration-based radioligand binding assays were adequate to probe the kinetics of receptor-ligand interactions and to screen small libraries of compounds in search of receptor-binding antagonists. A number of reviews are available that described this methodology in detail (.,.).作者: Exclaim 時間: 2025-3-26 19:13 作者: alcohol-abuse 時間: 2025-3-26 21:57
High Throughput Screening978-1-59259-180-0Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: 要求比…更好 時間: 2025-3-27 01:43
Compound Library Management: ,The Automated Liquid Sample Bank (ALSB) is a key component of our strategy to increase drug-discovery productivity and to reduce manning requirements wherever possible.作者: 小卒 時間: 2025-3-27 05:58 作者: 千篇一律 時間: 2025-3-27 12:16
Natural Products or Not? How to Screen for Natural Products in the Emerging HTS Paradigm, in the world are natural products or their derivatives (.). Roughly 60% of the antitumor and anti-infective agents that are available commercially or were in latestage clinical development from 1989–1995 are of natural products origin (.,.).作者: aphasia 時間: 2025-3-27 13:45
William P. JanzenIncludes supplementary material: 作者: 外向者 時間: 2025-3-27 17:57
Methods in Molecular Biologyhttp://image.papertrans.cn/h/image/426534.jpg作者: Mast-Cell 時間: 2025-3-27 22:19
Information Ergonomics: Expediting Maintenance Workflow Using Mixed Realityypes that describe both the physical space and the actions within it. Technicians rely on documentation, collaboration with local and remote technicians, and their own research to address the challenges they face. While job aids such as manuals, build sheets, online tutorials, and contact with more 作者: neoplasm 時間: 2025-3-28 03:59
Primary Charge Separation in the Reaction Centers of Rhodobacter Sphaeroides: Evidence for a Sequentemely rapid on the time-scale of picoseconds. A series of recent experiments gave the following picture of this charge transfer process (data taken for reaction centers from Rhodobacter (Rb.) sphae-roides /1–4/): After excitation of the lowest excited singlet state of the primary electron donor (a “作者: 粗魯?shù)娜?nbsp; 時間: 2025-3-28 09:28
Die Mehrgenerationenperspektive und das Genogrammsamen Prozessen beschrieben. Die klinischen Manifestationen dieser Prozesse werden in ihrer familiendiagnostischen Relevanz ebenso erl?utert wie die Bedeutung der verschiedenen Generationen füreinander. Schlie?lich wird das Genogramm als Instrument zur dynamischen Exploration des mehrgenerationalen 作者: 鼓掌 時間: 2025-3-28 10:46
Empfehlungen zur Gestaltung effektiver Finanzkommunikation mit Finanzanalysten,ten, wie Bilanzkennzahlen, G&V oder Cashflow Statement, analysieren. Zur Bewertung von Unternehmen müssen auch eine Vielzahl von Aspekten interpretiert werden, z.B. Forschungsvorhaben, Patente und Strategien, die sich für gew?hnlich unter ?Non-financials“ subsumieren lassen..Der Finanzanalyse kommt 作者: Extort 時間: 2025-3-28 15:48 作者: 抒情短詩 時間: 2025-3-28 21:32 作者: 笨重 時間: 2025-3-29 00:25
https://doi.org/10.1007/978-1-4842-9306-5ers are grouped into competitive divisions depending on their age and skill. The most highly skilled players play at the AAA level. I classified each AAA registrant as either a First Half birth (meaning the player was born in one of the first six months of the year) or a Second Half birth (the last six months of the year).作者: moratorium 時間: 2025-3-29 04:16
Two Planets, One Species: Does a Mission to Mars Alter the Balance in Favour of Human Enhancement?ed timescales for the development of these genetic enhancements and the ethical questions raised by the possibility of speciation. Cooperation among spacefaring nations in this context and the development of norms for the use of such technologies is desirable.作者: 可行 時間: 2025-3-29 11:03
An Introduction to Fluid Mechanics flexible learning. Then, a more extended global workspace emerges that affords subjective conscious experiences that can be stored in working memory. The chapter ends with a summary of Integrated Information Theory and Global Workspace Theory and shows how the current approach frames and interrelat作者: jaundiced 時間: 2025-3-29 14:57
Shailendra Kumar,Amit Kumartion has to be supplied to specify the decision problem. Usually a notation ν of M, i.e. a surjective function ν : W(∑)→M, is given. Also a numbering ν : ?→M could be used. W.l.g. we consider the case of a notation here. By Theorem 1.8.9 both approaches yield the same decidability results.作者: cruise 時間: 2025-3-29 18:58
Silicon Mitigates the Effects of Calcium, Magnesium, and Sulfur in Plants,f the effect of the joint supply of Ca and Si in plants, its potential effects in terms of absorption, accumulation, and physiological and structural processes, plus its benefits for men, regarding the biofortification of the edible parts of plants, and their future prospects. We also carried out a 作者: FLIC 時間: 2025-3-29 20:43 作者: abreast 時間: 2025-3-30 03:47 作者: 改革運動 時間: 2025-3-30 06:06
S. Kasperques is being used for purification of water and out of that adsorption is found to be the most affordable and fast technique. In recent years, nanotechnology has played an important role in water purification and decontamination. Nanomaterials (NMs) have proved to be a very good adsorbent for the r作者: Adulate 時間: 2025-3-30 08:35
