作者: comely 時(shí)間: 2025-3-21 20:48 作者: STYX 時(shí)間: 2025-3-22 01:04 作者: INCH 時(shí)間: 2025-3-22 05:51 作者: 適宜 時(shí)間: 2025-3-22 09:22
Kunihiko Gekkoo issues of life and death. More recently, however, the newer area of Nursing Ethics has attracted attention. It is the task of this paper to explore the extent to which Nursing Ethics represents a distinct subject of study.作者: commute 時(shí)間: 2025-3-22 13:51
Mike P. Williamsono issues of life and death. More recently, however, the newer area of Nursing Ethics has attracted attention. It is the task of this paper to explore the extent to which Nursing Ethics represents a distinct subject of study.作者: 颶風(fēng) 時(shí)間: 2025-3-22 20:09 作者: 貧窮地活 時(shí)間: 2025-3-22 23:53 作者: 遺傳 時(shí)間: 2025-3-23 04:10 作者: 執(zhí) 時(shí)間: 2025-3-23 07:34
Fumio HirataModern nursing began with the revolutionary changes introduced by Florence Nightingale in the middle of the nineteenth century. At the time, virtually all nurses were women and all doctors were men. Like women in general, nurses were typically thought of as the helpmates of men — dependent functionaries who aided doctors in their work.作者: Brittle 時(shí)間: 2025-3-23 10:01
This chapter presents an introduction to the book. It starts with on overview of the value and limits the use of informetric indicators in research assessment, and presents a short history of the field. It continues with the book’s main assumptions, scope and structure. Finally, it clarifies the terminology used in the book.作者: oncologist 時(shí)間: 2025-3-23 16:50
978-94-024-0225-4Springer Science+Business Media Dordrecht 2015作者: Flustered 時(shí)間: 2025-3-23 19:35
High Pressure Bioscience978-94-017-9918-8Series ISSN 0306-0225 Series E-ISSN 2542-8810 作者: DUCE 時(shí)間: 2025-3-24 00:18
Early Days of Pressure Denaturation Studies of Proteins0?atm within 30?min by Bridgman (J Biol Chem 19:511–512, 1914), and Kiyama and Yanagimoto (Rev Phys Chem Jpn 21:41–43, 1951) confirmed that the coagulation occurs above 3,880?kg?cm.. Grant et al. (Science 94:616, 1941) and Suzuki and Kitamura (Abstracts of 30th annual meeting of Japanese Biochemical作者: reflection 時(shí)間: 2025-3-24 05:37
Protein Denaturation on ,-, Axes – Thermodynamics and Analysisrrect function, study of their structural changes attracted great interest in the past decades. The three dimensional structure of proteins is influenced by several factors including temperature, pH, presence of chaotropic and cosmotropic agents, or presence of denaturants. Although pressure is an e作者: dowagers-hump 時(shí)間: 2025-3-24 08:03 作者: 預(yù)知 時(shí)間: 2025-3-24 13:27
Why and How Does Pressure Unfold Proteins?14). Since that time a large and recently increasing number of studies of pressure effects on protein stability have been published, yet the mechanism for the action of pressure on proteins remains subject to considerable debate. This review will present an overview from this author’s perspective of作者: 共和國 時(shí)間: 2025-3-24 18:03 作者: ANA 時(shí)間: 2025-3-24 22:12
Pressure-Dependent Conformation and Fluctuation in Folded Protein Moleculesthe range of fluctuations at ambient pressure. The largest changes are around cavities and buried water molecules. Sheets distort much more than helices. Hydrogen bonds compress about 0.012???kbar., although there is a wide range, including some hydrogen bonds that lengthen. In the presence of ligan作者: amyloid 時(shí)間: 2025-3-25 02:27 作者: ARK 時(shí)間: 2025-3-25 05:23
Pressure Effects on the Intermolecular Interaction Potential of Condensed Protein Solutionsgregation, crystallization, and the phase behavior of proteins in general. Here, we report on a combined small-angle X-ray scattering and liquid-state theoretical approach to study dense lysozyme solutions as a function of temperature and pressure, but also in the presence of salts and osmolytes of 作者: COW 時(shí)間: 2025-3-25 09:30
High Pressure NMR Methods for Characterizing Functional Substates of Proteins In addition, these states can be characterized by their thermodynamic parameters, the free enthalpies at ambient pressure, the partial molar volumes, and the partial molar compressibility that can be obtained from the analysis of the high pressure NMR data. Two main types of states of proteins exis作者: 懸掛 時(shí)間: 2025-3-25 14:03
High-Pressure NMR Spectroscopy Reveals Functional Sub-states of Ubiquitin and Ubiquitin-Like Proteinstate N. and a locally disordered state I – between the basic folded state N. and totally unfolded U state. The high-energy states are conserved among ubiquitin-like post-translational modifiers, ubiquitin, NEDD8, and SUMO-2, showing the E1-E2-E3 cascade reaction. It is quite intriguing that structu作者: 谷類 時(shí)間: 2025-3-25 18:43
Functional Sub-states by High-pressure Macromolecular Crystallographyreover, within the context of high-pressure adaptation of deep-sea organisms, it allows to decipher the molecular determinants of piezophily. To provide an accurate description of structural changes produced by pressure in a macromolecular system, developments have been made to adapt macromolecular 作者: 鬧劇 時(shí)間: 2025-3-25 20:35 作者: COMMA 時(shí)間: 2025-3-26 03:17
Exploring the Protein Folding Pathway with High-Pressure NMR: Steady-State and Kinetics Studiesd in biophysical chemistry for over 50 years. Although a great deal of progress has been made in recent years towards this goal, a number of important questions remain. These include characterizing the structural, thermodynamic and dynamic properties of the barriers between conformational states on 作者: 未成熟 時(shí)間: 2025-3-26 08:12
Basic Equations in Statics and Kinetics of Protein Polymerization and the Mechanism of the Formationive characterization of the protein fibrillation reaction with respect to volumetric parameters is necessary to elucidate mechanisms of amyloid fibrillation in molecular terms such as protein cavity and hydration. Here we discuss, firstly, basic equations in statics and kinetics of protein polymeriz作者: Generosity 時(shí)間: 2025-3-26 09:39 作者: Soliloquy 時(shí)間: 2025-3-26 13:31 作者: AV-node 時(shí)間: 2025-3-26 19:35 作者: maladorit 時(shí)間: 2025-3-26 22:36 作者: 多節(jié) 時(shí)間: 2025-3-27 03:32 作者: 領(lǐng)導(dǎo)權(quán) 時(shí)間: 2025-3-27 07:43 作者: Fecal-Impaction 時(shí)間: 2025-3-27 13:31
Catherine A. Royer for intelligence and good judgment., and professional role responsibilities are those minimum responsibilities which all practitioners acquire upon entry into a profession. Some are attached to all professions: for example, obligations to respect client autonomy, maintain confidentiality, be truthf作者: 禮節(jié) 時(shí)間: 2025-3-27 16:50 作者: 使成波狀 時(shí)間: 2025-3-27 21:22 作者: 侵害 時(shí)間: 2025-3-27 22:45 作者: Ceramic 時(shí)間: 2025-3-28 04:18 作者: NEG 時(shí)間: 2025-3-28 07:58
ndex, full text downloads and altmetrics..Discusses a series.This book presents an introduction to the field of applied evaluative informetrics, dealing with the use of bibliometric or informetric indicators in research assessment. It sketches the field’s history, recent achievements, and its potent作者: 漂亮才會(huì)豪華 時(shí)間: 2025-3-28 13:44
Hans Robert Kalbitzeres of alternative approaches, indicating their pros and cons. The proposals relate to: measurement of communication effectiveness; new indicators of multi-dimensional research output and impact; the definition and application of minimum performance standards; academic policies towards the world univ作者: 笨拙的你 時(shí)間: 2025-3-28 14:45
Ryo Kitaharahe scientific literature as a network of scientific papers, and introduces important informetric concepts, including ‘research front’ and ‘immediacy effect’. Next, the chapter shows how his pioneering work on modelling the relational structure of subject space evolved into the creation of a series o作者: 會(huì)犯錯(cuò)誤 時(shí)間: 2025-3-28 19:04
Anne-Claire Dhaussy,Eric Girardnts an overview of major theoretical concepts and distinctions. The chapter continues with distinguishing four domains of intellectual activity in research assessment, namely the domains of policy, evaluation, analytics and data collection. It clarifies the relationships between these domains. Final作者: 天然熱噴泉 時(shí)間: 2025-3-29 01:14 作者: motor-unit 時(shí)間: 2025-3-29 05:41 作者: 邊緣 時(shí)間: 2025-3-29 09:42
Hideki Tachibanaower and memory requirements), the selection of operators and their parameters is a complex problem in itself, and the complex nature of the EA search space. This chapter considers potential solutions to these issues based on hardware approaches and parallel processing techniques. It also reviews so作者: Instantaneous 時(shí)間: 2025-3-29 11:58
Jerson L. Silva,Shana P. C. Barroso,Ygara S. Mendes,Carlos H. Dumard,Patricia S. Santos,Andre M. O. yle operators of crossover, selection, and mutation. One important variation was developed by John Koza (Koza, 1992), termed Genetic Programming (GP). GP is distinctive in seeking to automate the generation of complete computer programs and adopts a tree-based representation scheme to allow the enco作者: 慟哭 時(shí)間: 2025-3-29 18:22 作者: 合群 時(shí)間: 2025-3-29 23:19
Protein Denaturation on ,-, Axes – Thermodynamics and Analysisanges, while the protein was under pressure..Recently a number of proteins were studied under pressure, and complete pressure-temperature phase diagrams were determined for several of them. This review summarizes the thermodynamic background of the typical elliptic .-. phase diagram, its limitations作者: BROTH 時(shí)間: 2025-3-30 02:30 作者: 盡責(zé) 時(shí)間: 2025-3-30 07:20 作者: palette 時(shí)間: 2025-3-30 12:01
