標(biāo)題: Titlebook: High Performance Computing for Drug Discovery and Biomedicine; Alexander Heifetz Book 2024 The Editor(s) (if applicable) and The Author(s) [打印本頁] 作者: GUAFF 時間: 2025-3-21 17:38
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書目名稱High Performance Computing for Drug Discovery and Biomedicine被引頻次學(xué)科排名
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書目名稱High Performance Computing for Drug Discovery and Biomedicine讀者反饋
書目名稱High Performance Computing for Drug Discovery and Biomedicine讀者反饋學(xué)科排名
作者: 承認(rèn) 時間: 2025-3-22 00:18 作者: Gene408 時間: 2025-3-22 03:10
Ivan Pribec,Stephan Hachinger,Mohamad Hayek,Gavin J. Pringle,Helmut Brüchle,Ferdinand Jamitzky,Geralg elderly..In the final setup a Wizard of Oz prototype was used, being participants interviewed at their homes and characterized based on International Classification of Functioning, Disability and Health (ICF). A decision matrix was implemented, enabling to find the best trade-off between elderly’s profile and recognition method.作者: FEAS 時間: 2025-3-22 04:37 作者: 陳腐的人 時間: 2025-3-22 10:23
Bayesian Optimization in Drug Discovery,ement it. This explanation aims to be accessible to people involved in drug discovery projects. A strong emphasis is made on the solutions to deal with the specific constraints of drug discovery. Finally, a large set of practical applications of BO is highlighted.作者: 要控制 時間: 2025-3-22 15:49
The Future of Drug Development with Quantum Computing,cific drug discovery challenges, including protein folding, molecular docking, AI?/ML-based optimization, and novel modalities for small molecules and RNA secondary structures. Consequently, we will discuss the latest QC landscape’s opportunities and challenges.作者: 松軟 時間: 2025-3-22 20:46
Computational Biomedicine (CompBioMed) Centre of Excellence: Selected Key Achievements, training to foster a culture of HPC among biomedical practitioners, our free service to port and tune biomedical applications to HPC, providing future supercomputers access to surgery, and bringing FDA-endorsed credibility to biomedical simulations.作者: 中子 時間: 2025-3-23 00:57
A Blood Flow Modeling Framework for Stroke Treatments,ter. Among them, we propose an algorithm for imposing pressure boundary conditions. We show how to use the method developed by Walsh et al. (Comput Geosci 35(6):1186–1193, 2009) to simulate the permeability law of any porous medium. Finally, we illustrate the features of the framework through a thrombolysis model.作者: 成份 時間: 2025-3-23 01:24
1064-3745 expertsThis volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The first section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, nat作者: 熄滅 時間: 2025-3-23 05:39 作者: 混亂生活 時間: 2025-3-23 23:15 作者: 多余 時間: 2025-3-24 03:41
Knowledge Graphs and Their Applications in Drug Discovery,onsidered when constructing biomedical knowledge graphs, examine recent advances in mining such systems to gain insights for drug discovery, and identify potential future areas for further development.作者: oxidant 時間: 2025-3-24 06:41
Book 2024 section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (F作者: crockery 時間: 2025-3-24 11:41
xtremities because they aren’t able to take the TV control with their hands, thus collaborating with inclusion and digital accessibility. To get this purpose, a Brain Computer Interface BCI helmet was used, its allows the brain-machine interaction using non-invasive electroencephalography signals wi作者: 配偶 時間: 2025-3-24 16:13 作者: gustation 時間: 2025-3-24 20:00 作者: Excitotoxin 時間: 2025-3-25 00:04
Gavin J. Pringlen and Communication Technologies (ICT) with the aim of improving their self-care and health care empowerment for active aging. Most of the analyzed studies are focused on monitoring and assistance of older adults, meanwhile there are a minority of studies focused on rehabilitation. The most used ICT作者: Salivary-Gland 時間: 2025-3-25 04:54 作者: 雇傭兵 時間: 2025-3-25 07:30
Lionel Colliandre,Christophe Mullerystem. Nevertheless, the specificities of mobile devices are creating numerous and significant challenges in the field of usability and user experience (UX). In addition, the evaluation of applications of the TV ecosystem should not be restricted to the measurement of its instrumental qualities typi作者: Irksome 時間: 2025-3-25 14:59 作者: 心神不寧 時間: 2025-3-25 18:22
Bhushan Bonde,Pratik Patil,Bhaskar Choubeyystem. Nevertheless, the specificities of mobile devices are creating numerous and significant challenges in the field of usability and user experience (UX). In addition, the evaluation of applications of the TV ecosystem should not be restricted to the measurement of its instrumental qualities typi作者: 繼而發(fā)生 時間: 2025-3-26 00:02
Bhushan Bondestry. The proposal arises from the perception that, in the same proportion that the audiovisual production is being created in digital formats, it is expected the preservation of such information to be based on appropriate techniques and technologies also digital. It is similarly considered that the作者: 常到 時間: 2025-3-26 00:21 作者: 吹牛者 時間: 2025-3-26 07:49
J. Charles G. Jeynes,Tim James,Matthew Corney Nevertheless, despite the continuous growth of the number of available contents, it is hard to find those which can be useful for a specific educational purpose. In order to provide a solution to this issue, in this paper we propose a model of a semantic Recommender System for educational iDTV prog作者: Feature 時間: 2025-3-26 09:32 作者: 抑制 時間: 2025-3-26 15:10
Martin Kotev,Constantino Diaz Gonzalez NLU to perform in an accurate way, it must be trained to correctly understand a wide scope of users’ intentions and give (correct) answers. The interaction context must also be considered, meaning that optimizing a NLI system for the TV domain, with a conversational dynamic close to that of humans,作者: 運動吧 時間: 2025-3-26 20:25 作者: 允許 時間: 2025-3-26 22:19
Jazmin Aguado-Sierra,Renee Brigham,Apollo K. Baron,Paula Dominguez Gomez,Guillaume Houzeaux,Jose M. t fully exploited and each application scenario, such as digital television and smart rooms, uses different computing devices that increase dependence on foreign suppliers, increase production or marketing costs and cannot be reused in other similar scenarios, nor to expand their possibilities and l作者: 膽小鬼 時間: 2025-3-27 02:32
Zainab Altai,Erica Montefiori,Xinshan Liive TV, jAUTI 2021, held in Sangolqui, Ecuador, during December 2–3, 2021..The 9 full papers included in this book were carefully reviewed and selected from 25 submissions. They were organized in topical sections as follows: ?Usability and UX; interaction techniques and accesibility; and technologie作者: 蚊子 時間: 2025-3-27 05:47 作者: 調(diào)整 時間: 2025-3-27 12:16 作者: 寄生蟲 時間: 2025-3-27 15:18
Ivan Pribec,Stephan Hachinger,Mohamad Hayek,Gavin J. Pringle,Helmut Brüchle,Ferdinand Jamitzky,Geralowing viewers to enjoy a truly personalized TV experience. However, usability and efficiency of recognition methods depend upon users’ cognitive and psychomotor characteristics, scenario even more complex when elderly viewers are at stake, since they present a great variety of combinations of those 作者: Ovulation 時間: 2025-3-27 21:26
Alexander Heifetzfications to adapt to these changes. After applying different research methodologies the results indicate that in order to be able to make such adjustment features and meet the demands of end users one needs an optimum level of accessibility and usability in such a workflow with information. As a po作者: 運動性 時間: 2025-3-28 01:24 作者: intrigue 時間: 2025-3-28 04:53 作者: Demonstrate 時間: 2025-3-28 09:09 作者: placebo 時間: 2025-3-28 11:07 作者: FIR 時間: 2025-3-28 15:49 作者: saturated-fat 時間: 2025-3-28 22:37
Automated Virtual Screening, identification to lead optimization. The overall aim of these computational methods is to obtain a more efficient discovery process, by reducing the number of “wet” experiments required to produce therapeutics that have higher probability of succeeding in clinical development and subsequently benef作者: cauda-equina 時間: 2025-3-29 00:00 作者: LUMEN 時間: 2025-3-29 03:45
Edge, Fog, and Cloud Against Disease: The Potential of High-Performance Cloud Computing for Pharma ance, resource management, and running costs. The rapid growth in computing hardware has made it possible to provide cost-effective, robust, secure, and scalable alternatives to the on-premise (on-prem) HPC via Cloud, Fog, and Edge computing. It has enabled recent state-of-the-art machine learning (作者: MUTED 時間: 2025-3-29 10:52
Knowledge Graphs and Their Applications in Drug Discovery,applications in drug discovery, including democratizing access to biomedical data, contextualizing or visualizing that data, and generating novel insights through the application of machine learning approaches. Knowledge graphs put data into context and therefore offer the opportunity to generate ex作者: Dedication 時間: 2025-3-29 15:27
Natural Language Processing for Drug Discovery Knowledge Graphs: Promises and Pitfalls,e many heterogeneous data sources in a format that facilitates discovering connections. The utility of KGs has been exemplified in areas such as drug repurposing, with insights made through manual exploration and modeling of the data. In this chapter, we discuss promises and pitfalls of using natura作者: ACME 時間: 2025-3-29 17:10 作者: GRAZE 時間: 2025-3-29 23:39 作者: ANT 時間: 2025-3-30 01:53
High-Throughput Structure-Based Drug Design (HT-SBDD) Using Drug Docking, Fragment Molecular OrbitaD aims to offer a computational replacement to traditional high-throughput screening (HTS) methods of drug discovery. This “virtual screening” technique utilizes the structural data of a target protein in conjunction with large databases of potential drug candidates and then applies a range of diffe作者: Nostalgia 時間: 2025-3-30 06:00
HPC Framework for Performing in Silico Trials Using a 3D Virtual Human Cardiac Population as Means nerate a platform to perform human cardiac in-silico clinical trials as means to assess the pro-arrhythmic risk after the administrations of one or combination of two potentially arrhythmic drugs. The drugs assessed in this study were hydroxychloroquine and azithromycin. The framework employs electr作者: 集中營 時間: 2025-3-30 08:57
Effect of Muscle Forces on Femur During Level Walking Using a Virtual Population of Older Women,mobility and quality of life. In the past, muscles and bones are often studied separately using generic or scaled information that are not personal-specific, nor are they representative of the large variations seen in the elderly population. Consequently, the mechanical interaction between the aged 作者: GLIDE 時間: 2025-3-30 13:09 作者: Silent-Ischemia 時間: 2025-3-30 16:35
A Blood Flow Modeling Framework for Stroke Treatments,emodynamics conditions to impose on a numerical model or how to simulate porous media, which ineluctably need to be addressed in strokes. We propose a validated open-source, flexible, and publicly available lattice-Boltzmann numerical framework for such problems and present its features in this chap作者: 制度 時間: 2025-3-30 22:41 作者: CHAR 時間: 2025-3-31 02:54 作者: emission 時間: 2025-3-31 08:41 作者: expire 時間: 2025-3-31 11:51 作者: photophobia 時間: 2025-3-31 15:39 作者: 地牢 時間: 2025-3-31 19:13 作者: Kindle 時間: 2025-4-1 00:09 作者: modifier 時間: 2025-4-1 05:31
High Performance Computing for Drug Discovery and Biomedicine作者: 堅毅 時間: 2025-4-1 07:00
Book 2024gth from CT data, and many more subjects. Written?for the highly successful?.Methods inMolecular Biology?.series, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step and readily reproducible modeling protocols, and tips on troubleshootin作者: conduct 時間: 2025-4-1 14:11 作者: prosthesis 時間: 2025-4-1 17:32
Introduction to High-Performance Computing,emory systems, distributed memory systems, and hybrid systems and the different programming models used in HPC, including message passing, shared memory, and data parallelism. Finally, the chapter discusses significant challenges and future directions in supercomputing. Overall, this chapter provide作者: 損壞 時間: 2025-4-1 19:25
In Silico Clinical Trials: Is It Possible?,d established precedence use cases in key applications, which is currently impeded by a shattered collection of tools and practices. In order to address these key challenges, efforts to establish best practice workflows need to be undertaken and new collaborative M&S tools devised, and an attempt to作者: 弄臟 時間: 2025-4-2 00:24
Automated Virtual Screening,rtual databases of predicted reaction products, to identify molecules that would exert a particular biochemical response. This initial stage of the discovery process is very important since the subsequent stages will use the initial chemical motifs that have been found at the hit finding stage, and 作者: 致敬 時間: 2025-4-2 05:12
Edge, Fog, and Cloud Against Disease: The Potential of High-Performance Cloud Computing for Pharma aradigm shift landscape to?microservices driven application programming (API) and message parsing interface (MPI)-based scientific computing across the distributed, high-available infrastructure. This is coupled?with agile?DevOps, and good coding practices, low code and no-code application developme作者: Inordinate 時間: 2025-4-2 08:14 作者: acolyte 時間: 2025-4-2 13:33
Alchemical Free Energy Workflows for the Computation of Protein-Ligand Binding Affinities,g algorithms or enhanced sampling methods. Some workflows can accommodate more than one molecular dynamics (MD) engine and use external libraries for tasks. Differences between workflows can present advantages for different use cases, however a lack of interoperability of the workflows’ components h
