標(biāo)題: Titlebook: Heat Shock Proteins in Cancer; Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Book 2007 Springer Science+Business Media B.V. 2007 Anti [打印本頁] 作者: 浮標(biāo) 時間: 2025-3-21 19:02
書目名稱Heat Shock Proteins in Cancer影響因子(影響力)
書目名稱Heat Shock Proteins in Cancer影響因子(影響力)學(xué)科排名
書目名稱Heat Shock Proteins in Cancer網(wǎng)絡(luò)公開度
書目名稱Heat Shock Proteins in Cancer網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Heat Shock Proteins in Cancer被引頻次
書目名稱Heat Shock Proteins in Cancer被引頻次學(xué)科排名
書目名稱Heat Shock Proteins in Cancer年度引用
書目名稱Heat Shock Proteins in Cancer年度引用學(xué)科排名
書目名稱Heat Shock Proteins in Cancer讀者反饋
書目名稱Heat Shock Proteins in Cancer讀者反饋學(xué)科排名
作者: 容易懂得 時間: 2025-3-22 00:08 作者: insomnia 時間: 2025-3-22 02:00
J.L. Holmes,S.Y. Sharp,P. Workmandementia. The classification can briefly be stated as follows I. Early onset FAD with mean age of onset before 50 years; II. Late onset FAD with mean age of onset after 60 years; III. Intermediate/variable onset FAD; IV. Familial dementia with atypical Alzheimer changes; V. FAD without multigeneration involvement.作者: exigent 時間: 2025-3-22 07:31 作者: 蠟燭 時間: 2025-3-22 10:12 作者: 削減 時間: 2025-3-22 15:54 作者: 行為 時間: 2025-3-22 19:42 作者: 后來 時間: 2025-3-23 00:19
Stuart K. Calderwood,Michael Y. Sherman,Daniel R. First book to comprehensively cover heat shock proteins in cancer -- an area of high interest.Detailed discussion of the role of hsp90 in cancer therapy and drug development.Heat shock proteins both a作者: Provenance 時間: 2025-3-23 02:54
Heat Shock Proteinshttp://image.papertrans.cn/h/image/425012.jpg作者: CAMEO 時間: 2025-3-23 08:55
The Hsp90 Chaperone Machinery Acts at Protein Folding Clefts to Regulate Both Signaling Protein Fun proteins that are involved in the genesis and progression of cancer, such as p53, RAF, ERBB2, AKT, and CDK4. The multiple effects of Hsp90 on signaling proteins issue from the focal interaction of the multichaperone machinery with protein folding clefts in natively folded proteins. Clefts in the cl作者: stratum-corneum 時間: 2025-3-23 13:18 作者: 禮節(jié) 時間: 2025-3-23 14:48 作者: 河流 時間: 2025-3-23 21:37
,Anti-apoptotic, Tumorigenic and Metastatic Potential of Hsp27 (HspB1) and αB-crystallin (HspB5): Em share dynamic phosphorylation and oligomeric properties suggesting that different functional forms of these proteins exist. Elevated levels of expression of these sHsps counteract both necrotic and apoptotic cell deaths induced by various stimuli including heat shock, oxidative stress, inflammatory作者: 原告 時間: 2025-3-24 02:15 作者: BOGUS 時間: 2025-3-24 04:26 作者: STALL 時間: 2025-3-24 07:11 作者: 發(fā)酵 時間: 2025-3-24 12:59
Involvement of Heat Shock Proteins in Protection of Tumor Cells from Genotoxic Stresses,lly relevant doses induce apoptosis mostly in lymphoid cells, while in epithelial tumors they evoke different type of response, mainly senescence and mitotic catastrophe, which leads to loss of clonogenic potential of cells. Here we review old and new data showing that upregulation of Hsp27 or Hsp70作者: VOK 時間: 2025-3-24 17:33
Hsp70 in Tumors: Friend or Foe?,p70 promotes growth and survival of tumor cells by engaging misfolded or aggregated proteins and proteins involved in cell proliferation. As such, it endows tumor cells with stress resistance. However, Hsp70 can also promote tumor immunity by stimulating innate immune mechanisms and enhancing cross-作者: optional 時間: 2025-3-24 22:47 作者: jet-lag 時間: 2025-3-25 03:09
Heat Shock Protein 90: The Cancer Chaperone, signaling proteins, as well as multiple mutated, chimeric, and/or over-expressed signaling proteins, that promote cancer cell growth and/or survival. Hsp90 inhibitors are unique in that, although they are directed towards a specific molecular target, they simultaneously inhibit multiple cellular si作者: 自愛 時間: 2025-3-25 03:34
Targeting Hsp90 Function to Treat Cancer: Much More to Be Learned,ver, Hsp90 is unique because it is not required for the biogenesis of most polypeptides. Instead, it oversees a surprisingly diverse network of conformationally labile client substrates that regulate signaling pathways and gene expression. Many of the processes modulated by Hsp90 are dysregulated in作者: HAIL 時間: 2025-3-25 07:41 作者: concentrate 時間: 2025-3-25 11:52 作者: myocardium 時間: 2025-3-25 16:52
Cdc37 and protein kinase folding,in protein kinase folding is dependent on direct interaction between the chaperone and the N-lobe of the kinase catalytic domain. In addition, Cdc37 can inhibit the ATPase activity of Hsp90 that is thought to promote assembly of the kinase client with both chaperone proteins. Treatment of cells with作者: CLOUT 時間: 2025-3-25 22:23 作者: canvass 時間: 2025-3-26 00:31
y. Moreover, target validation studies indicate BACE1 to be a high priority anti-amyloid therapeutic target for the treatment of AD. However, inhibition of BACE1 activity may not be completely free of mechanism-based consequences related to possible roles of BACE1-dependent APP/AICD signaling in cog作者: 高度表 時間: 2025-3-26 05:52
William B. Pratt,Yoshihiro Morishima,Yoichi Osawa) and one late-onset risk-factor (.), strong evidence exists suggesting the presence of additional AD genes for both forms of the disease. The hunt for these genes is aggravated by several factors that generally complicate the identification of complex disease genes: locus and/or allelic heterogenei作者: majestic 時間: 2025-3-26 09:26
Daniel R. Ciocca,Mariel A. Fanelli,F. Dario Cuello-Carrión,Stuart K. Calderwoodears. Exact register parallelism is emerging as a common structural motif for amyloid fibrils and may also represent a key organizing principle for amyloid oligomers. Also, characterization of the interactions of A. with transition metals has opened up a new vista of potential pathogenic interaction作者: VAN 時間: 2025-3-26 13:23 作者: 提名 時間: 2025-3-26 16:48
Andre-Patrick Arrigo) and one late-onset risk-factor (.), strong evidence exists suggesting the presence of additional AD genes for both forms of the disease. The hunt for these genes is aggravated by several factors that generally complicate the identification of complex disease genes: locus and/or allelic heterogenei作者: Supplement 時間: 2025-3-26 23:43 作者: beta-carotene 時間: 2025-3-27 02:09 作者: Cupidity 時間: 2025-3-27 06:59
Custer C. Deocaris,Sunil C. Kaul,Renu WadhwaPP and the related APLP1 and APLP2 members. The importance of APP in AD clearly lies in its role as precursor to the A. peptide that plays a central role in the amyloid hypothesis. However, APP has a number of additional biological activities, some of which impact neuronal development and function. 作者: 高談闊論 時間: 2025-3-27 10:17 作者: 只有 時間: 2025-3-27 14:25 作者: legitimate 時間: 2025-3-27 18:14 作者: 規(guī)范要多 時間: 2025-3-27 22:01
M. Brunet,C. Didelot,S. Subramaniam,A.L. Rérole,A. de Thonel,C. Garridoof researchers who?challenge it. The current “defect” of the . is that its supporters see their ultimate proof in the clinical success of clearing amyloid beta from the brain of affected individuals. However, so far, removal of the peptide did not result in a convincing clinical benefit or breakthro作者: Bravado 時間: 2025-3-28 03:14
Len Neckers years are demented and therefore dementia also explains a part of cognitive variability. The question is whether the different factors for dementia (such as ApoE4, external atrophy parameter of the cranial computer tomography [cCT], education, sex or serum zinc level) influence the relation between作者: overture 時間: 2025-3-28 08:51
Luke Whitesell,Catherine A. McLellane sole change. In dementia of Alzheimer’s type white matter disease in the nature of a selective incomplete white matter infarction was found in around 60% of cases. It was regarded as being most likely due to regional hypoperfusion of the white matter and might therefore be prevented, halted or eve作者: Felicitous 時間: 2025-3-28 12:25 作者: 拍翅 時間: 2025-3-28 17:27
J.L. Holmes,S.Y. Sharp,P. Workmandementia. The classification can briefly be stated as follows I. Early onset FAD with mean age of onset before 50 years; II. Late onset FAD with mean age of onset after 60 years; III. Intermediate/variable onset FAD; IV. Familial dementia with atypical Alzheimer changes; V. FAD without multigenerati作者: 時間等 時間: 2025-3-28 22:07 作者: Obstacle 時間: 2025-3-29 00:05
Stuart K. Calderwood,Daniel R. Ciocca,Phillip J. Gray,Nava Zaarur,Stan Lepchammer,Michael Y. Shermanry of the disease that bears his name. At present that disease remains poorly understood and even less well treated. However, the speed with which new insights into its characteristic clinical and pathological findings now arise gives us optimism that afflicted patients will, someday soon, be better作者: 無能的人 時間: 2025-3-29 04:06 作者: GOUGE 時間: 2025-3-29 10:54 作者: Herd-Immunity 時間: 2025-3-29 14:53 作者: 典型 時間: 2025-3-29 18:54
1877-1246 ncer therapy and drug development.Heat shock proteins both a.Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. Howev作者: 贊美者 時間: 2025-3-29 21:30 作者: 閃光東本 時間: 2025-3-30 02:46 作者: heartburn 時間: 2025-3-30 07:02 作者: Pruritus 時間: 2025-3-30 11:58
Role of Heat Shock Protein Hsp25/27 in~the~Metastatic Spread of Cancer Cells,tumors become resistant to most therapies, and the disease is almost incurable. Therefore, therapeutic interventions designed to inhibit metastatic spread of cancer cells are critical. This chapter will briefly cover recent advances in the study of tumor metastasis and the important role played by heat shock protein 25/27作者: 向宇宙 時間: 2025-3-30 13:36
Implications of Heat Shock Proteins in Carcinogenesis and Cancer Progression,egulation or down-regulation of specific Hsp. This can explain the variations in Hsp expression found in pre-neoplastic and neoplastic human tumors in different tissues and organs. These variations have important clinical consequences in cancer progression, and the exploitation of such knowledge may improve anticancer treatment strategies作者: 敲詐 時間: 2025-3-30 19:59 作者: 尊敬 時間: 2025-3-30 22:27 作者: 啪心兒跳動 時間: 2025-3-31 01:59 作者: 物質(zhì) 時間: 2025-3-31 06:59 作者: corpuscle 時間: 2025-3-31 10:43
Custer C. Deocaris,Sunil C. Kaul,Renu WadhwaGrowing evidence suggests that perturbations of some of these activities may also contribute to AD pathogenesis and neurodegeneration. As such, it will be important to continue to investigate the normal function of APP.作者: CBC471 時間: 2025-3-31 16:30 作者: 無可爭辯 時間: 2025-3-31 18:36
s involved directly in memory formation, as well as for evaluating to what extent A. peptide associated synaptic abnormalities are reversible following reductions of BACE1 activity. Finally, studies summarized in this review emphasize the pivotal roles that BACE1 plays in both health and disease, fi作者: Bridle 時間: 2025-4-1 00:19
William B. Pratt,Yoshihiro Morishima,Yoichi Osawaupdated meta-analyses) should enable us to disentangle the genetics of AD and other complex diseases. Eventually, the insights gained from such studies will lead to a better understanding of the pathophysiological mechanisms leading to neurodegeneration. This knowledge will lay the foundation to dev作者: Sarcoma 時間: 2025-4-1 05:42 作者: GREG 時間: 2025-4-1 06:57 作者: vanquish 時間: 2025-4-1 10:10
Cornelia O’Callaghan-Sunol,Vladimir L. Gabaiother forms of dementia, and tau pathology correlates better with neurodegeneration and progression than does Aβ pathology. A variety of therapeutic agents are advancing through the pipeline, many targeting Aβ and tau. New symptomatic treatments are still needed for those who have already progressed作者: Ingest 時間: 2025-4-1 17:58
