標題: Titlebook: Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection; Alexzander A.A. Asea,Ian R. Brown Book [打印本頁] 作者: corrode 時間: 2025-3-21 19:05
書目名稱Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection影響因子(影響力)
書目名稱Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection影響因子(影響力)學科排名
書目名稱Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection網(wǎng)絡公開度
書目名稱Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection網(wǎng)絡公開度學科排名
書目名稱Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection被引頻次
書目名稱Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection被引頻次學科排名
書目名稱Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection年度引用
書目名稱Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection年度引用學科排名
書目名稱Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection讀者反饋
書目名稱Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection讀者反饋學科排名
作者: 馬賽克 時間: 2025-3-21 20:37
Chaperones and Polyglutamine Expansion Disordersquality control. Hence, dysfunctional cellular protein quality control presents a very basic and fundamental problem of protein misfolding and therefore of polyglutamine toxicity. Thus, the elucidation of the interplay between polyglutamine expansion proteins and molecular chaperones contributes pro作者: 蛤肉 時間: 2025-3-22 03:39 作者: BABY 時間: 2025-3-22 06:31 作者: 惰性女人 時間: 2025-3-22 10:26 作者: 犬儒主義者 時間: 2025-3-22 14:31
Heat Shock Proteins Hsp70 and Hsp27 and Neural Cellular Protectionntaining cell homeostasis..Experimentally, the induction of Hsp27 and Hsp70 in neurons and glia is usually through stress, or altered gene expression. If levels of Hsp27 or Hsp70 can be increased to higher levels by drug or supplement administration, increased levels of Hsps may be a therapy for neu作者: Dungeon 時間: 2025-3-22 19:48
Molecular Chaperones and Protection in Animal and Cellular Models of Ischemic Strokeolved. Despite a great deal of study, much remains to be learned about the multifaceted effects of Hsps in cerebral ischemia. The endogenous stress response remains a model of cell protection with promise for the development of novel therapies for ischemic brain injury作者: cajole 時間: 2025-3-23 01:01
Strategies for Conferring Neuroprotection and Countering the High Threshold for Induction of the Stralso contribute to constitutive and stress-induced regulation of heat shock genes and are potential therapeutic targets. Another approach is to screen chemical libraries using a test system that expresses motor neuronal properties, with positive hits being validated .. The most effective therapies w作者: Scleroderma 時間: 2025-3-23 03:05 作者: pulmonary-edema 時間: 2025-3-23 09:23 作者: 庇護 時間: 2025-3-23 13:22
Extracellular Chaperones and Amyloidsic proteins/peptides. However, it also appears possible that in the presence of a high molar excess of misfolded protein, such as might occur during disease, the limited amounts of ECs available may actually exacerabate pathology. Further advances in understanding of the mechanisms that control extr作者: 發(fā)牢騷 時間: 2025-3-23 16:45 作者: 預定 時間: 2025-3-23 20:44 作者: cuticle 時間: 2025-3-24 02:10
spectrometer to scan brain tissue slices with high spatial resolution, analyzing 50 μm cell layers. The lipid spectra obtained for each pixel are transformed to color-coded intensity maps of hundreds of lipid species included those within a single tissue slice.作者: 刻苦讀書 時間: 2025-3-24 04:19 作者: 富足女人 時間: 2025-3-24 07:30 作者: 禍害隱伏 時間: 2025-3-24 11:57
Chaperones and Polyglutamine Expansion Disordersty and leads to the dysfunction and ultimately to the demise of neurons in affected individuals. The molecular basis for polyglutamine toxicity is unclear and the number and complexity of documented cellular pathways involved in polyglutamine expansion disorders is daunting. However, the use of effe作者: 歸功于 時間: 2025-3-24 18:37 作者: 和音 時間: 2025-3-24 21:36
Cellular and Molecular Mechanisms Underlying Parkinson’s Disease: The Role of Molecular Chaperonesic proteins cause cell death in various brain regions and accumulate in intraneuronal inclusion bodies. In Parkinson’s disease (PD), Lewy bodies (LBs) containing the small acidic protein, α-synuclein, are found at autopsy making α-synuclein a candidate for the toxic protein in PD and other synuclein作者: 發(fā)芽 時間: 2025-3-25 00:56
Heat Shock Proteins as Therapeutic Targets in Amyotrophic Lateral Sclerosism and spinal cord, resulting in paralysis and death within 1–5 years of diagnosis. Although the precise etiology of ALS remains elusive, approximately 20% of cases are known to be familial and of these approximately 10%–20% are due to mutations in the ubiquitously expressed human Cu/Zn superoxide di作者: NUL 時間: 2025-3-25 05:13 作者: Modicum 時間: 2025-3-25 08:44 作者: 復習 時間: 2025-3-25 12:40 作者: BAIT 時間: 2025-3-25 17:41 作者: 清洗 時間: 2025-3-25 21:48 作者: fiction 時間: 2025-3-26 01:04 作者: flaggy 時間: 2025-3-26 06:21
Use of Viral Gene Delivery Systems to Investigate the Neuroprotective Roles of Hsp70 and Hsp40 Prote70, hsp40 and hsj1a) gene function in neurons. Ad vectors are particularly well suited to in vitro studies and we demonstrate that the overexpression of Hsp70 and Hsp40 in primary hippocampal neurons increased luciferase activity following a denaturing stress. Furthermore, the Ad mediated expression作者: 浪蕩子 時間: 2025-3-26 10:32 作者: Thymus 時間: 2025-3-26 14:56
Release of Heat Shock Proteins and their Effects When in the Extracellular Space in the Nervous Systells, especially those of the nervous system. Preventing the loss of neurons is a more parsimonious approach to treatment of injury and disease than is replacement because of the difficulty in reconstructing the complex architecture of the nervous system, the basis for its function storage of inform作者: Tonometry 時間: 2025-3-26 18:47
Silencing of Metastasis-associated Gene 1 (Mta1) Stimulates Hsp70 Cellular Release and Neurite extene nucleosome remodeling histone deacetylase complex (NuRD complex). In addition, MTA is associated with metastatic cancer tissues such as breast, gastric and esophageal carcinoma. In several human metastatic breast cell lines the expression level of MTA is highly upregulated; however, little is know作者: 過份艷麗 時間: 2025-3-26 22:58
Extracellular Chaperones and Amyloids as protein deposition diseases, many of these affect the brain and the central nervous system. In many cases the amyloid deposits are extracellular and are found associated with newly identified abundant extracellular chaperones (ECs). Evidence is discussed which suggests an important regulatory ro作者: Harridan 時間: 2025-3-27 01:38
to be characterized by the early onset of important disturbances of instrumental functions. Moreover, atypical presentations, which are characterized by the progressive disruption of one instrumental function (visual or linguistic), appear to be more frequent in younger subjects. This pattern is li作者: Detonate 時間: 2025-3-27 09:14 作者: incubus 時間: 2025-3-27 11:44 作者: 羊欄 時間: 2025-3-27 17:20
Jordi Magrané,Henry W. Querfurthfor a quick cure from choline or lecithin precursor administration, inspired by the success of levodopa in Parkinson’s disease, quickly faded when put to the test. Nonetheless, the cholinergic hypothesis of memory dysfunction in AD was valid, and eventually it led to the introduction of AChEI drugs 作者: 洞穴 時間: 2025-3-27 20:55
Pamela J. Mcleanfor a quick cure from choline or lecithin precursor administration, inspired by the success of levodopa in Parkinson’s disease, quickly faded when put to the test. Nonetheless, the cholinergic hypothesis of memory dysfunction in AD was valid, and eventually it led to the introduction of AChEI drugs 作者: 他很靈活 時間: 2025-3-27 22:37 作者: COW 時間: 2025-3-28 02:13 作者: 安心地散步 時間: 2025-3-28 09:04 作者: GRACE 時間: 2025-3-28 11:57 作者: 陰險 時間: 2025-3-28 18:28
nefit from further investigations. The most significant benefit to the person, the family, and to society would be a breakthrough in our understanding of a disease process that is at present not treatable and not preventable—a disease that is as malignant in its own way as cancer.作者: 耕種 時間: 2025-3-28 22:24 作者: pulmonary-edema 時間: 2025-3-29 01:16 作者: 暫時過來 時間: 2025-3-29 04:46
Heather D. Durhamnefit from further investigations. The most significant benefit to the person, the family, and to society would be a breakthrough in our understanding of a disease process that is at present not treatable and not preventable—a disease that is as malignant in its own way as cancer.作者: Acclaim 時間: 2025-3-29 09:52 作者: 笨拙的你 時間: 2025-3-29 11:49 作者: 愛國者 時間: 2025-3-29 18:50 作者: 侵略者 時間: 2025-3-29 21:30 作者: 初學者 時間: 2025-3-30 03:01
N. K. Singh,Preethi Rao,Alexzander Aseaes and functional states in both healthy and diseased brains. To exploit fully the technologies available for such studies, one must extract and isolate pure nuclei from unfixed postmortem tissue while preserving the molecules to be interrogated. Currently, nuclei are necessary substitutes for indiv作者: Debrief 時間: 2025-3-30 06:55
Mark R. Wilson,Justin J. Yerbury,Stephen Poond procedure is provided to improve the ultrastructural quality of the samples, using aldehyde fixatives followed by immunoperoxidase staining of allograft inflammatory factor 1 (AIF1, also known as IBA1), a marker of myeloid cells, and cluster of differentiation . (CD68), a marker of phagolysosomal 作者: micronized 時間: 2025-3-30 11:57
ltiplicity of lipid complex species present in the human brain. This, in combination with quantitative studies carried out in plasma samples, helps to identify disease biomarkers including for Alzheimer’s disease (AD). Mass spectrometry imaging (MSI) is particularly powerful for the anatomical local作者: 萬神殿 時間: 2025-3-30 13:23 作者: 脖子 時間: 2025-3-30 19:47 作者: 地名表 時間: 2025-3-30 21:19 作者: Lucubrate 時間: 2025-3-31 01:18 作者: 受傷 時間: 2025-3-31 07:00
