標(biāo)題: Titlebook: Handbook of Antimicrobial Resistance; Matthias Gotte,Albert Berghuis,Donald Sheppard Living reference work 20200th edition [打印本頁(yè)] 作者: hydroxyapatite 時(shí)間: 2025-3-21 20:00
書目名稱Handbook of Antimicrobial Resistance影響因子(影響力)
書目名稱Handbook of Antimicrobial Resistance影響因子(影響力)學(xué)科排名
書目名稱Handbook of Antimicrobial Resistance網(wǎng)絡(luò)公開(kāi)度
書目名稱Handbook of Antimicrobial Resistance網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書目名稱Handbook of Antimicrobial Resistance被引頻次
書目名稱Handbook of Antimicrobial Resistance被引頻次學(xué)科排名
書目名稱Handbook of Antimicrobial Resistance年度引用
書目名稱Handbook of Antimicrobial Resistance年度引用學(xué)科排名
書目名稱Handbook of Antimicrobial Resistance讀者反饋
書目名稱Handbook of Antimicrobial Resistance讀者反饋學(xué)科排名
作者: audiologist 時(shí)間: 2025-3-21 21:53
https://doi.org/10.1007/978-3-319-70371-8) and varicella-zoster virus (VZV) infections. The modest activity of ACV against human cytomegalovirus (HCMV) has prompted the development of another nucleoside analogue, ganciclovir (GCV), for the management of systemic and organ-specific HCMV diseases. Second-line agents such as the pyrophosphate作者: 兇殘 時(shí)間: 2025-3-22 00:42 作者: 民間傳說(shuō) 時(shí)間: 2025-3-22 08:39 作者: analogous 時(shí)間: 2025-3-22 11:56
The Jet: Fluid in Motion and More Vorticity,o vaccine available yet, the control of these parasites relies solely on chemotherapy. Low-cost antimony-derived compounds remain the primary antileishmanial treatment in most developing countries. Increasing drug resistance towards these molecules has forced the use of alternative therapies in high作者: 享樂(lè)主義者 時(shí)間: 2025-3-22 15:02
https://doi.org/10.1007/978-981-13-0155-1rbidity and mortality in many parts of the world. In 2012, 8.6 million people became sick with tuberculosis, and 1.3 million died from this curable disease (World Health Organization 2013a). While the majority of cases are caused by strains susceptible to all antituberculosis antibiotics, drug resis作者: Indebted 時(shí)間: 2025-3-22 18:29 作者: Foment 時(shí)間: 2025-3-23 00:20 作者: APEX 時(shí)間: 2025-3-23 04:18
The Vulnerability of the Human Worldfic HIV protease inhibitors (PIs), based on thorough understanding of the structure of HIV protease and its substrate, serves as a prime example of structure-based drug design. The introduction of first-generation PIs marked the start of combination antiretroviral therapy. However, low bioavailabili作者: botany 時(shí)間: 2025-3-23 07:10
Neurotoxicity of Polychlorinated Biphenylstive in multiple randomized, placebo-controlled clinical trials throughout the world. Preexposure prophylaxis trials have included over 20,000 men and women at risk for HIV infection through sexual or intravenous exposure. A consistent finding is that drug exposure is essential for PrEP efficacy. In作者: 舊病復(fù)發(fā) 時(shí)間: 2025-3-23 13:22
https://doi.org/10.1057/9781137292148 is unique among HIV antiretrovirals as it encompasses drugs that target the different stages of the HIV entry cascade. There are currently 2 FDA-approved drugs in this class, the chemokine receptor-5 (CCR5) antagonist maraviroc (MVC) and the fusion inhibitor enfuvirtide (T-20). Attachment inhibitor作者: multiply 時(shí)間: 2025-3-23 15:09 作者: 嬰兒 時(shí)間: 2025-3-23 19:18 作者: 令人發(fā)膩 時(shí)間: 2025-3-23 22:16
Kevin Buterbaugh,Richard FultonV infection, allowing for viral elimination in the majority of treated patients. The first two drugs to be approved for the treatment of HCV genotype 1 infection were the HCV NS3/4A protease inhibitors telaprevir and boceprevir. However, their administration in combination with pegylated interferon 作者: 動(dòng)作謎 時(shí)間: 2025-3-24 05:46
Food Security and Agriculture Sector, features of RNA viral quasispecies such as internal interactions within mutant spectra and the effect of population size and bottleneck events as they affect the frequency of inhibitor-escape mutants. Genetic barriers to resistance and fitness cost of specific amino acid substitutions involved in r作者: dissolution 時(shí)間: 2025-3-24 09:44 作者: 拔出 時(shí)間: 2025-3-24 14:37 作者: recede 時(shí)間: 2025-3-24 18:00 作者: 微塵 時(shí)間: 2025-3-24 19:50 作者: FOR 時(shí)間: 2025-3-24 23:35 作者: 我要沮喪 時(shí)間: 2025-3-25 04:20 作者: 燒瓶 時(shí)間: 2025-3-25 10:25
Antiviral Drug Resistance in Herpesviruses,) and varicella-zoster virus (VZV) infections. The modest activity of ACV against human cytomegalovirus (HCMV) has prompted the development of another nucleoside analogue, ganciclovir (GCV), for the management of systemic and organ-specific HCMV diseases. Second-line agents such as the pyrophosphate作者: GEM 時(shí)間: 2025-3-25 13:32
Azole Resistance in ,: Mechanisms, Route of Resistance Selection, and Clinical Implications,rophytic mold .. However, acquired azole resistance in . is an emerging problem that compromises the clinical efficacy of azole antifungals. Several mutations in the cyp51A gene of . affect the activity of all mold-active antifungal azoles. These mutations result in the complete loss of activity of 作者: 取之不竭 時(shí)間: 2025-3-25 18:36 作者: 要素 時(shí)間: 2025-3-25 20:06
Drug Resistance in ,,o vaccine available yet, the control of these parasites relies solely on chemotherapy. Low-cost antimony-derived compounds remain the primary antileishmanial treatment in most developing countries. Increasing drug resistance towards these molecules has forced the use of alternative therapies in high作者: 毗鄰 時(shí)間: 2025-3-26 03:47 作者: NUDGE 時(shí)間: 2025-3-26 05:03
HBV Therapy and the Problem of Drug Resistance,e risk of liver disease progression, including cirrhosis, hepatic failure, and hepatocellular carcinoma. Nucleos(t)ide analogue monotherapy is commonly used as first-line therapy, and most patients will require long-term antiviral therapy. As for all direct-acting antiviral agents, the emergence of 作者: 含鐵 時(shí)間: 2025-3-26 09:48
HIV Drug Resistance in Mothers and Infants Following Use of Antiretrovirals to Prevent Mother-to-Chection in the plasma is standard of care for prevention of mother-to-child transmission of HIV (.). In many resource-limited communities, financial and infrastructure limitations preclude ART for pregnancy. Instead, abbreviated PMTCT regimens of short-term antiretrovirals (.) (mono- or dual therapy)作者: IOTA 時(shí)間: 2025-3-26 13:55
HIV Protease Inhibitor Resistance,fic HIV protease inhibitors (PIs), based on thorough understanding of the structure of HIV protease and its substrate, serves as a prime example of structure-based drug design. The introduction of first-generation PIs marked the start of combination antiretroviral therapy. However, low bioavailabili作者: cushion 時(shí)間: 2025-3-26 20:08
HIV-1 Drug Resistance in Preexposure Prophylaxis Trials,tive in multiple randomized, placebo-controlled clinical trials throughout the world. Preexposure prophylaxis trials have included over 20,000 men and women at risk for HIV infection through sexual or intravenous exposure. A consistent finding is that drug exposure is essential for PrEP efficacy. In作者: 泥土謙卑 時(shí)間: 2025-3-26 22:11 作者: 謙虛的人 時(shí)間: 2025-3-27 01:22 作者: 墻壁 時(shí)間: 2025-3-27 07:26
Microevolution of Antifungal Drug Resistance,ng invasive fungal infections. Fungal infections are on the rise with the increasing populations of individuals with impaired immune function who are most vulnerable to the opportunistic pathogens. Most antifungal drugs target the distinct composition of the fungal cell membrane (azoles and polyenes作者: 嬰兒 時(shí)間: 2025-3-27 12:40
Protease Inhibitor Resistance,V infection, allowing for viral elimination in the majority of treated patients. The first two drugs to be approved for the treatment of HCV genotype 1 infection were the HCV NS3/4A protease inhibitors telaprevir and boceprevir. However, their administration in combination with pegylated interferon 作者: 招人嫉妒 時(shí)間: 2025-3-27 16:39
Quasispecies and Drug Resistance, features of RNA viral quasispecies such as internal interactions within mutant spectra and the effect of population size and bottleneck events as they affect the frequency of inhibitor-escape mutants. Genetic barriers to resistance and fitness cost of specific amino acid substitutions involved in r作者: 橡子 時(shí)間: 2025-3-27 17:55 作者: 油氈 時(shí)間: 2025-3-27 23:47
Strategies for Circumventing Bacterial Resistance Mechanisms,mised but is now found both in and out the boundaries of the hospital. Preserving the efficacy of the antibacterials we have, in order to secure the time needed to discover and develop new antibacterials, will require abrupt change: in the way antibacterials are dispensed and disposed, in the criter作者: Interferons 時(shí)間: 2025-3-28 03:20
Substrate-Envelope-Guided Design of Drugs with a High Barrier to the Evolution of Resistance,he selective pressure of therapy. Antiviral drug targets especially have a high mutational plasticity due to the diverse genetic viral population. An ideal antiviral inhibitor should be robust against these quasispecies. Fortunately, a therapeutic target can be evolutionarily constrained by the biol作者: 揮舞 時(shí)間: 2025-3-28 10:16 作者: 下垂 時(shí)間: 2025-3-28 13:20
The Ins and Outs of Azole Antifungal Drug Resistance: Molecular Mechanisms of Transport,e, currently a serious problem in antifungal therapy. Azole antifungal drugs, many of which are approved for clinical use, are relatively inexpensive, share similar chemical structures, and are effective against most fungal species. Azoles target a crucial enzyme in the ergosterol biosynthesis pathw作者: 含糊其辭 時(shí)間: 2025-3-28 17:17 作者: Surgeon 時(shí)間: 2025-3-28 21:21 作者: 連系 時(shí)間: 2025-3-28 23:18 作者: 邪惡的你 時(shí)間: 2025-3-29 05:52 作者: Pituitary-Gland 時(shí)間: 2025-3-29 07:21
Food Security and Agriculture Sector,esistance are discussed, with specific examples for human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Prospects for new antiviral designs aimed at counteracting the adaptive potential of viral quasispecies are presented.作者: Redundant 時(shí)間: 2025-3-29 12:50
Drug Resistance in ,,ly endemic areas including amphotericin B, paromomycin, and miltefosine. This chapter is presenting our current understanding of the mode of action and underlying resistance mechanisms of the few therapeutic drugs used against ..作者: Allergic 時(shí)間: 2025-3-29 16:56
HBV Therapy and the Problem of Drug Resistance,drug resistance is an important clinical concern. In this chapter, we discuss the principles of HBV antiviral resistance and clinical pathways for preventing the selection of drug-resistant variants, as well as appropriate management strategies for antiviral treatment failure.作者: interrogate 時(shí)間: 2025-3-29 21:11
Quasispecies and Drug Resistance,esistance are discussed, with specific examples for human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Prospects for new antiviral designs aimed at counteracting the adaptive potential of viral quasispecies are presented.作者: 帶子 時(shí)間: 2025-3-30 00:21
he microbe, but on the specific drug (target), are highly diverse, and are covered in great detail. This work also discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.?.978-1-4939-0667-3作者: 四海為家的人 時(shí)間: 2025-3-30 07:07
Paula Maurutto,Kelly Hannah-Moffatn but also in susceptibility to HIV-1 Vif-mediated degradation. The interplay between these intracellular host defenses and HIV counterstrategies is discussed in this chapter with a special emphasis on viral evolution and drug resistance.作者: 失敗主義者 時(shí)間: 2025-3-30 12:06 作者: RENAL 時(shí)間: 2025-3-30 15:39
The Waking Dream of T.E. Lawrencemechanisms governing the relationship between the antibacterial and the bacterium. This review examines this relationship from the particular perspective of the eventual need to circumvent resistance mechanisms in order to reclaim the lifesaving value of the antibacterial chemical.作者: 一再煩擾 時(shí)間: 2025-3-30 18:36 作者: 謊言 時(shí)間: 2025-3-31 00:13
HIV Drug Resistance in Mothers and Infants Following Use of Antiretrovirals to Prevent Mother-to-Che rates of MTCT, selection of HIV drug resistance (.) has been detected in both mothers and infected infants. This chapter reviews prominent studies that provide insight into HIV-DR related to use of ARV for PMTCT and discusses how recent findings and therapeutic advances have led to policy changes and new directions in this developing field.作者: STAT 時(shí)間: 2025-3-31 04:39
Strategies for Circumventing Bacterial Resistance Mechanisms,mechanisms governing the relationship between the antibacterial and the bacterium. This review examines this relationship from the particular perspective of the eventual need to circumvent resistance mechanisms in order to reclaim the lifesaving value of the antibacterial chemical.作者: 的是兄弟 時(shí)間: 2025-3-31 06:22
Vitreous Changes in Ocular Inflammation,e of antimicrobial compounds and disinfectants, and the mechanisms underlying this resistance are likely multifactorial. This chapter will review the cellular processes and pathways implicated in antibiotic resistance and tolerance of bacterial biofilms.作者: 重畫只能放棄 時(shí)間: 2025-3-31 10:25 作者: Missile 時(shí)間: 2025-3-31 17:20
Kevin Buterbaugh,Richard Fulton to escape from drug pressure with subsequent treatment failure. The emergence of RAVs depends on a number of drug-, host-, and virus-related factors that are reviewed here. In addition, detailed resistance profiles of approved protease inhibitors and those that are still in clinical development are also discussed.作者: Esophagitis 時(shí)間: 2025-3-31 19:56
The Final Phase: The Turkish Security Wall,ncy against mutational ensemble of quasispecies of the target. The Substrate envelope hypothesis, based on structural studies on the proteases of HIV-1 and hepatitis C, provides a structural basis for the specificity of natural substrate recognition and mechanisms for the resistance mutations in the active site.作者: 很像弓] 時(shí)間: 2025-4-1 00:12
Liberalism and the Social Question This issue is even more critical for controlling chloroquine-resistant ., about which even less is known. This review summarizes key features of quinoline antimalarial drug resistance in . malaria and suggests concepts relevant for “staying ahead of the resistance curve.”作者: senile-dementia 時(shí)間: 2025-4-1 01:55
Antibiotic Resistance and Tolerance in Bacterial Biofilms,e of antimicrobial compounds and disinfectants, and the mechanisms underlying this resistance are likely multifactorial. This chapter will review the cellular processes and pathways implicated in antibiotic resistance and tolerance of bacterial biofilms.作者: 濕潤(rùn) 時(shí)間: 2025-4-1 09:02
Azole Resistance in ,: Mechanisms, Route of Resistance Selection, and Clinical Implications,oses an emerging global threat as mutations associated with environmental resistance have now been detected with increasing frequency in multiple European countries, Asia, the Middle East, and Africa.
