標(biāo)題: Titlebook: HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design; A Review of 20 Years Marc H V Van Regenmortel Book 2019 Springer Nature Switzer [打印本頁] 作者: 掩飾 時間: 2025-3-21 17:28
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書目名稱HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design讀者反饋學(xué)科排名
作者: 細(xì)微的差異 時間: 2025-3-21 22:42
HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design978-3-030-32459-9作者: 專橫 時間: 2025-3-22 01:59 作者: 緯線 時間: 2025-3-22 07:25
Reductionism and the Search for Structure: Function Relationships in Antibody Moleculesthe search should be for correlations rather than for causal relations. Methods used to find correlations between the atomic structure of antibody binding sites and their binding activity are mostly based on mutagenesis studies. Since the effect of any mutation depends on the molecular context, it i作者: 神圣在玷污 時間: 2025-3-22 10:34 作者: Graves’-disease 時間: 2025-3-22 13:23
Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinkingre discussed. These include (1) the failure to distinguish between the chemical nature of antigenicity and the biological nature of immunogenicity, (2) the belief that when an HIV-1 epitope is reconstructed by rational design to better fit a neutralizing monoclonal antibody (nMab), this will produce作者: lymphoma 時間: 2025-3-22 17:55
Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseaserectionality of temporal changes that occur along the line. To validate the patterns detected by non-reductionist operations, reductionist procedures are needed. Integrated (non-reductionist and reductionist) methods can (i) distinguish data subsets that differ immunologically and statistically; (ii作者: 貿(mào)易 時間: 2025-3-22 22:25
Limitations to the Structure-Based Design of HIV-1 Vaccine Immunogensd to several different epitopes. It is concluded that only trial and error, empirical investigations using numerous immunization protocols may eventually allow us to identify which mixtures of immunogens are likely to be the best candidates for an HIV-1 vaccine.作者: 經(jīng)典 時間: 2025-3-23 03:13
Requirements for Empirical Immunogenicity Trials, Rather than Structure-Based Design, for Developingannot be expected to be present in identical form in the host to be vaccinated. It is possible to rationally design and optimize an epitope to fit one particular antibody molecule or to improve the paratope binding efficacy of a monoclonal antibody intended for passive immunotherapy. What is not pos作者: Instantaneous 時間: 2025-3-23 09:22 作者: 漸變 時間: 2025-3-23 10:07 作者: Laconic 時間: 2025-3-23 14:54 作者: 馬具 時間: 2025-3-23 20:39 作者: 我的巨大 時間: 2025-3-23 23:26 作者: 懦夫 時間: 2025-3-24 05:10
https://doi.org/10.1007/978-4-431-56478-2d to several different epitopes. It is concluded that only trial and error, empirical investigations using numerous immunization protocols may eventually allow us to identify which mixtures of immunogens are likely to be the best candidates for an HIV-1 vaccine.作者: exigent 時間: 2025-3-24 09:57
https://doi.org/10.1007/978-90-6704-927-6annot be expected to be present in identical form in the host to be vaccinated. It is possible to rationally design and optimize an epitope to fit one particular antibody molecule or to improve the paratope binding efficacy of a monoclonal antibody intended for passive immunotherapy. What is not pos作者: 松軟 時間: 2025-3-24 14:14
Marc H V Van RegenmortelProvides a broad overview to the attempts to design a preventive HIV vaccine.Broadens the understanding of reasons for the failure to develop a preventive HIV vaccine.Includes numerous critical commen作者: 聯(lián)想 時間: 2025-3-24 14:53 作者: AND 時間: 2025-3-24 19:19 作者: aggressor 時間: 2025-3-25 00:34
Two Meanings of Reverse Vaccinology and the Empirical Nature of Vaccine Sciencentists are no longer aware of the empirical foundations of all experimental science. This is evident from published statements that claim, for instance, that rational design represents “the only approach that can elevate vaccine research from an empirical exercise to a scientific discipline” (Karlsson-Hedestam et al. 2008).作者: Endoscope 時間: 2025-3-25 07:16 作者: 革新 時間: 2025-3-25 09:17
978-3-030-32461-2Springer Nature Switzerland AG 2019作者: MANIA 時間: 2025-3-25 14:38 作者: 他去就結(jié)束 時間: 2025-3-25 16:33 作者: Cholagogue 時間: 2025-3-25 21:51
Qualitative and Quantitative Analysis,rational bias is introduced when monoclonal antibodies are used to characterize epitopes and, 4) a tendency to underestimate the difference between antigenicity and immunogenicity. There clearly is a need to overcome these misconceptions if synthetic peptide vaccines are ever to become a reality.作者: 暖昧關(guān)系 時間: 2025-3-26 03:02
https://doi.org/10.1007/978-1-349-13814-2earch strategy for dissecting and analysing the constituents of biological systems has never been questioned. The outstanding success of molecular biology in unravelling the structural and chemical basis of living processes is indeed a clear testimony of the value of reductionism as an analytical methodology.作者: 致詞 時間: 2025-3-26 06:20
Molecular Design Versus Empirical Discovery in Peptide-Based Vaccines: Coming to Terms with Fuzzy Response depends on many extrinsic factors and regulatory mechanisms of the recipient host which are not amenable to molecular design of the peptide immunogen. It seems safe to predict that the development of peptide-based vaccines will continue to be driven by empirical discovery rather than by so-called rational design.作者: Heterodoxy 時間: 2025-3-26 10:50 作者: 空氣 時間: 2025-3-26 13:23
Editorial: Biological Complexity Emerges from the Ashes of Genetic Reductionismearch strategy for dissecting and analysing the constituents of biological systems has never been questioned. The outstanding success of molecular biology in unravelling the structural and chemical basis of living processes is indeed a clear testimony of the value of reductionism as an analytical methodology.作者: STALL 時間: 2025-3-26 20:14
p a preventive HIV vaccine.Includes numerous critical commen.This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer 作者: locus-ceruleus 時間: 2025-3-26 23:54 作者: 慷慨不好 時間: 2025-3-27 04:58 作者: dysphagia 時間: 2025-3-27 07:59 作者: 使害羞 時間: 2025-3-27 13:02 作者: 不能和解 時間: 2025-3-27 14:03 作者: 半導(dǎo)體 時間: 2025-3-27 20:59
What Is a B Cell Epitope or ability to induce antibodies in a competent vertebrate host. Failure to make this distinction partly explains why no successful peptide-based vaccines have yet been developed. Methods for predicting the epitopes of proteins are discussed and the reasons for the low success rate of epitope prediction are analyzed.作者: Dna262 時間: 2025-3-28 00:38
Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking tried, without success, to transform Env epitopes of known structure into effective vaccine immunogens, because they thought that epitopes that bind to affinity-matured bnMabs would also be able to induce similar antibodies when used as immunogens (Van Regenmortel 2012a).作者: capsaicin 時間: 2025-3-28 03:19 作者: 他日關(guān)稅重重 時間: 2025-3-28 06:16 作者: 頂點 時間: 2025-3-28 12:42
Book 2019in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments..作者: esculent 時間: 2025-3-28 18:33 作者: Pamphlet 時間: 2025-3-28 22:02
Reductionism and Complexity in Molecular Biology: Scientists Now Have the Tools to Unravel Biologica early days of molecular biology—underestimates this complexity and therefore has an increasingly detrimental influence on many areas of biomedical research, including drug discovery and vaccine development.作者: 仔細(xì)檢查 時間: 2025-3-29 01:03
What Is a B Cell Epitopes, and mimotopes. All epitopes have fuzzy boundaries and can be identified only by their ability to bind to certain antibodies. Antigenic cross-reactivity is a common phenomenon because antibodies are always able to recognize a considerable number of related epitopes. This places severe limits to th作者: 油膏 時間: 2025-3-29 05:49
Molecular Design Versus Empirical Discovery in Peptide-Based Vaccines: Coming to Terms with Fuzzy Rey molecular design strategies to the development of peptide-based vaccines. The stated aim is to transform the development of a vaccine from a trial and error empirical operation into a so-called rational, structure-based process. In the present review, it is argued that it is misleading to oppose r作者: 有幫助 時間: 2025-3-29 09:56
Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopesadopt the structures observed when epitopes of pathogens are bound to neutralizing antibodies. Although more than a thousand synthetic peptides have been examined as potential prophylactic vaccines, only 125 peptides have progressed to phase I clinical trials, 30 have made it to phase II trials but 作者: insightful 時間: 2025-3-29 14:30
Specificity, Polyspecificity and Heterospecificity of Antibody-Antigen Recognitionbody specificity was attributed to sequence differences in complementarity-determining regions (CDRs) but as increasing numbers of crystallographic antibody-antigen complexes were elucidated, specificity was analyzed in terms of six antigen-binding regions (ABRs) that only roughly correspond to CDRs作者: ostensible 時間: 2025-3-29 18:58 作者: 有抱負(fù)者 時間: 2025-3-29 20:34 作者: 切碎 時間: 2025-3-30 03:17
Editorial: Biological Complexity Emerges from the Ashes of Genetic Reductionismng number of biologists have become critical of the reductionist view that biological systems can be fully explained by the physico-chemical properties of their constituent parts. Biology is increasingly regarded as an autonomous discipline requiring its own explanatory concepts not found in chemist作者: 殘暴 時間: 2025-3-30 05:29
The Rational Design of Biological Complexity: A Deceptive Metaphorim implies that their knowledge of the innumerable causal connections present in biological systems is sufficient to allow them to deduce and predict the outcome of their experimental interventions. The design metaphor is shown to originate in human intentionality and in the anthropomorphic fallacy 作者: 談判 時間: 2025-3-30 11:00 作者: ALERT 時間: 2025-3-30 16:06 作者: tangle 時間: 2025-3-30 17:59 作者: 大氣層 時間: 2025-3-31 00:31
Limitations to the Structure-Based Design of HIV-1 Vaccine Immunogensis is that investigators have concentrated mainly on the structural analysis of HIV-1 antigens because they assumed that it should be possible to deduce vaccine-relevant immunogens from the structure of viral antigens bound to neutralizing monoclonal antibodies. This unwarranted assumption arises fr作者: DAMN 時間: 2025-3-31 01:03
Two Meanings of Reverse Vaccinology and the Empirical Nature of Vaccine Sciencentists are no longer aware of the empirical foundations of all experimental science. This is evident from published statements that claim, for instance, that rational design represents “the only approach that can elevate vaccine research from an empirical exercise to a scientific discipline” (Karlss作者: calumniate 時間: 2025-3-31 05:08
Requirements for Empirical Immunogenicity Trials, Rather than Structure-Based Design, for Developing and of immunological specificity. Attempts to use reverse vaccinology to generate an HIV-1 vaccine on the basis of the structure of viral epitopes bound to monoclonal neutralizing antibodies have failed so far because it was not possible to extrapolate from an observed antigenic structure to the im作者: HAVOC 時間: 2025-3-31 12:14
